GREMLIN Database
Q97XZ7 - Oxidoreductase
UniProt: Q97XZ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 289 (277)
Sequences: 11451 (7339)
Seq/√Len: 440.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_E151_K3.6401.00
71_E103_K3.3801.00
140_E144_K3.2691.00
27_T47_A3.0941.00
40_G46_V2.8761.00
114_E142_V2.8661.00
114_E145_R2.7011.00
17_S42_M2.6871.00
75_F107_R2.5671.00
234_A274_E2.2761.00
48_H52_E2.2521.00
37_E41_K2.2141.00
4_G53_V2.1931.00
144_K147_E2.1851.00
36_A46_V2.1851.00
108_L113_M2.1391.00
89_I146_V2.0671.00
20_L44_A2.0571.00
211_N216_Q1.9691.00
49_S52_E1.9611.00
13_F38_K1.9321.00
197_D200_K1.9221.00
24_Y152_A1.9201.00
140_E159_H1.8911.00
81_V108_L1.8841.00
105_T163_V1.8331.00
114_E139_K1.8201.00
99_E249_S1.8151.00
62_S90_F1.8131.00
246_I249_S1.8001.00
25_D45_K1.7831.00
18_N21_K1.7611.00
34_E37_E1.7461.00
22_A152_A1.7451.00
85_K88_L1.7231.00
32_T35_K1.7021.00
234_A268_V1.6861.00
191_A201_L1.6771.00
106_K110_E1.6691.00
109_S139_K1.6661.00
74_L90_F1.6381.00
139_K142_V1.6281.00
134_I153_M1.6271.00
33_I37_E1.6191.00
107_R110_E1.5941.00
63_M93_M1.5921.00
28_V44_A1.5851.00
116_L138_G1.5761.00
89_I142_V1.5751.00
84_N88_L1.5711.00
134_I154_G1.5431.00
143_F147_E1.5091.00
105_T109_S1.5001.00
272_I275_L1.4991.00
118_A134_I1.4981.00
103_K107_R1.4791.00
116_L146_V1.4761.00
53_V57_S1.4761.00
199_D203_S1.4631.00
18_N130_G1.4511.00
61_I93_M1.4411.00
27_T45_K1.4401.00
75_F79_G1.4301.00
143_F159_H1.4261.00
66_D69_D1.4141.00
37_E40_G1.3951.00
51_K55_E1.3841.00
124_D128_R1.3731.00
27_T56_V1.3711.00
51_K83_S1.3671.00
125_K129_E1.3661.00
179_L183_S1.3651.00
171_L242_Y1.3641.00
160_V169_L1.3631.00
67_A100_F1.3621.00
220_P224_K1.3511.00
261_L265_N1.3391.00
233_A267_M1.3281.00
33_I48_H1.3281.00
258_S262_Q1.3121.00
101_A115_F1.2981.00
89_I145_R1.2981.00
58_E85_K1.2931.00
275_L282_K1.2881.00
21_K42_M1.2871.00
192_R198_D1.2841.00
206_S216_Q1.2781.00
131_T155_K1.2761.00
79_G82_K1.2691.00
234_A273_G1.2661.00
50_P83_S1.2641.00
116_L143_F1.2631.00
91_V146_V1.2541.00
259_L262_Q1.2411.00
63_M120_V1.2381.00
108_L115_F1.2381.00
237_K268_V1.2311.00
14_P128_R1.2301.00
56_V85_K1.2301.00
17_S128_R1.2271.00
21_K128_R1.2241.00
4_G57_S1.2171.00
68_P72_E1.1981.00
248_N258_S1.1971.00
71_E75_F1.1961.00
59_I89_I1.1961.00
39_L44_A1.1871.00
88_L113_M1.1781.00
245_E249_S1.1731.00
146_V150_F1.1671.00
81_V111_Y1.1661.00
139_K162_D1.1651.00
54_A83_S1.1631.00
5_F15_M1.1621.00
247_A254_L1.1621.00
189_L193_S1.1581.00
102_K168_A1.1571.00
82_K111_Y1.1561.00
16_A26_L1.1541.00
93_M134_I1.1511.00
194_L250_K1.1511.00
178_A236_L1.1411.00
59_I149_I1.1381.00
178_A240_L1.1351.00
71_E107_R1.1211.00
5_F16_A1.1161.00
5_F61_I1.1161.00
97_S100_F1.1151.00
38_K41_K1.1111.00
84_N113_M1.1011.00
253_P258_S1.0961.00
17_S21_K1.0901.00
262_Q265_N1.0891.00
64_V73_V1.0821.00
90_F108_L1.0741.00
27_T57_S1.0741.00
20_L43_G1.0711.00
10_I124_D1.0541.00
102_K106_K1.0521.00
162_D165_S1.0521.00
244_M258_S1.0461.00
93_M153_M1.0461.00
67_A97_S1.0421.00
102_K163_V1.0411.00
237_K265_N1.0351.00
105_T139_K1.0311.00
71_E100_F1.0281.00
136_V143_F1.0201.00
30_N35_K1.0191.00
159_H162_D1.0191.00
61_I149_I1.0161.00
241_K261_L1.0141.00
107_R111_Y1.0111.00
51_K79_G1.0061.00
106_K109_S1.0061.00
176_V187_G0.9961.00
245_E248_N0.9911.00
231_F235_H0.9891.00
47_A52_E0.9851.00
61_I91_V0.9771.00
38_K42_M0.9771.00
74_L80_V0.9711.00
84_N90_F0.9711.00
117_D164_G0.9691.00
116_L136_V0.9661.00
200_K203_S0.9641.00
213_F217_Y0.9591.00
33_I46_V0.9441.00
172_C191_A0.9441.00
233_A268_V0.9411.00
188_L202_F0.9371.00
47_A53_V0.9331.00
74_L108_L0.9331.00
127_A132_L0.9291.00
206_S215_V0.9271.00
160_V165_S0.9271.00
172_C187_G0.9251.00
69_D72_E0.9231.00
151_K157_I0.9211.00
86_R112_G0.9201.00
121_T173_N0.9191.00
138_G143_F0.9171.00
144_K159_H0.9131.00
135_M204_V0.9101.00
70_V96_N0.9091.00
265_N269_S0.8981.00
31_R69_D0.8961.00
18_N153_M0.8961.00
179_L256_G0.8951.00
202_F219_L0.8941.00
241_K245_E0.8931.00
230_G233_A0.8921.00
75_F104_V0.8871.00
34_E38_K0.8871.00
8_L39_L0.8841.00
101_A167_Q0.8831.00
121_T135_M0.8811.00
100_F103_K0.8791.00
193_S252_L0.8731.00
13_F17_S0.8731.00
71_E104_V0.8731.00
52_E55_E0.8701.00
168_A194_L0.8691.00
97_S245_E0.8621.00
241_K265_N0.8611.00
5_F26_L0.8591.00
237_K261_L0.8581.00
15_M153_M0.8411.00
89_I114_E0.8411.00
103_K106_K0.8391.00
96_N100_F0.8391.00
168_A246_I0.8381.00
117_D166_G0.8381.00
91_V118_A0.8351.00
148_P151_K0.8351.00
35_K38_K0.8331.00
169_L196_I0.8291.00
228_N275_L0.8271.00
19_L61_I0.8251.00
268_V273_G0.8251.00
59_I145_R0.8241.00
160_V204_V0.8231.00
275_L279_G0.8231.00
8_L28_V0.8131.00
182_V256_G0.8121.00
142_V145_R0.8101.00
232_K235_H0.8041.00
62_S70_V0.8001.00
3_V24_Y0.7991.00
180_N212_S0.7931.00
27_T53_V0.7921.00
60_V80_V0.7901.00
256_G260_A0.7901.00
102_K164_G0.7871.00
185_V280_L0.7861.00
140_E162_D0.7781.00
199_D224_K0.7771.00
266_A269_S0.7771.00
142_V146_V0.7761.00
95_T242_Y0.7751.00
137_G166_G0.7731.00
219_L222_I0.7711.00
206_S211_N0.7701.00
267_M279_G0.7691.00
65_T69_D0.7681.00
99_E102_K0.7661.00
31_R35_K0.7651.00
175_V257_T0.7631.00
180_N184_V0.7611.00
193_S250_K0.7571.00
246_I250_K0.7521.00
191_A196_I0.7521.00
114_E141_D0.7491.00
59_I91_V0.7481.00
15_M132_L0.7481.00
272_I282_K0.7471.00
20_L42_M0.7451.00
116_L142_V0.7441.00
28_V36_A0.7421.00
202_F206_S0.7391.00
15_M93_M0.7391.00
176_V184_V0.7371.00
92_D115_F0.7351.00
262_Q266_A0.7311.00
13_F42_M0.7311.00
175_V243_A0.7291.00
147_E157_I0.7291.00
75_F81_V0.7251.00
80_V84_N0.7251.00
266_A270_L0.7231.00
64_V69_D0.7231.00
123_G126_G0.7221.00
6_I50_P0.7191.00
232_K274_E0.7151.00
143_F157_I0.7131.00
233_A279_G0.7111.00
62_S74_L0.7111.00
19_L26_L0.7101.00
5_F63_M0.7091.00
24_Y149_I0.7091.00
150_F157_I0.7091.00
81_V113_M0.7081.00
244_M261_L0.7061.00
52_E56_V0.7061.00
15_M63_M0.7061.00
3_V149_I0.7021.00
227_L282_K0.7021.00
219_L223_M0.6971.00
199_D223_M0.6951.00
184_V215_V0.6941.00
104_V115_F0.6891.00
6_I29_Y0.6871.00
156_N207_T0.6841.00
70_V94_S0.6771.00
189_L192_R0.6771.00
20_L26_L0.6721.00
118_A136_V0.6691.00
169_L201_L0.6671.00
248_N261_L0.6661.00
3_V19_L0.6651.00
158_I204_V0.6641.00
81_V107_R0.6641.00
279_G282_K0.6621.00
36_A40_G0.6601.00
115_F163_V0.6571.00
53_V56_V0.6561.00
33_I36_A0.6551.00
176_V183_S0.6531.00
141_D144_K0.6531.00
176_V180_N0.6490.99
100_F104_V0.6480.99
190_L254_L0.6470.99
50_P54_A0.6470.99
196_I201_L0.6460.99
85_K113_M0.6400.99
60_V84_N0.6360.99
179_L260_A0.6330.99
30_N33_I0.6310.99
171_L243_A0.6290.99
136_V150_F0.6260.99
51_K82_K0.6260.99
70_V92_D0.6260.99
137_G159_H0.6250.99
64_V70_V0.6250.99
180_N214_T0.6250.99
72_E79_G0.6220.99
57_S60_V0.6210.99
97_S242_Y0.6200.99
168_A196_I0.6190.99
68_P71_E0.6180.99
237_K241_K0.6170.99
221_K226_D0.6170.99
172_C190_L0.6160.99
86_R111_Y0.6140.99
181_M277_T0.6130.99
75_F82_K0.6110.99
126_G131_T0.6100.99
118_A150_F0.6100.99
202_F205_L0.6100.99
13_F39_L0.6060.99
96_N101_A0.6050.99
70_V100_F0.6050.99
11_M15_M0.6020.99
241_K248_N0.6010.99
176_V205_L0.6010.99
16_A28_V0.5990.99
140_E143_F0.5990.99
96_N167_Q0.5990.99
8_L16_A0.5980.99
147_E159_H0.5970.99
6_I53_V0.5960.99
37_E46_V0.5920.99
150_F154_G0.5880.99
73_V79_G0.5850.99
101_A163_V0.5830.99
9_G65_T0.5820.99
60_V88_L0.5810.99
136_V157_I0.5800.99
244_M248_N0.5790.99
17_S20_L0.5790.99
14_P124_D0.5750.99
253_P269_S0.5750.99
267_M272_I0.5750.99
156_N203_S0.5720.99
62_S92_D0.5720.99
30_N69_D0.5700.99
126_G129_E0.5690.99
55_E83_S0.5690.99
29_Y50_P0.5670.99
59_I146_V0.5640.99
149_I152_A0.5620.99
213_F216_Q0.5610.99
226_D229_P0.5590.98
202_F223_M0.5580.98
253_P266_A0.5580.98
185_V222_I0.5540.98
45_K56_V0.5530.98
61_I153_M0.5440.98
98_P168_A0.5430.98
72_E75_F0.5430.98
205_L210_A0.5410.98
148_P152_A0.5410.98
177_V214_T0.5410.98
218_Y276_G0.5400.98
74_L104_V0.5390.98
158_I207_T0.5370.98
17_S38_K0.5370.98
91_V150_F0.5360.98
54_A80_V0.5350.98
256_G259_L0.5350.98
141_D145_R0.5310.98
70_V104_V0.5310.98
189_L252_L0.5310.98
175_V190_L0.5310.98
30_N36_A0.5300.98
58_E88_L0.5300.98
36_A39_L0.5240.98
214_T218_Y0.5240.98
18_N22_A0.5230.98
160_V200_K0.5220.98
165_S168_A0.5220.98
50_P53_V0.5210.98
188_L219_L0.5200.98
14_P130_G0.5150.97
92_D101_A0.5130.97
61_I150_F0.5130.97
173_N208_G0.5080.97
99_E103_K0.5080.97
4_G27_T0.5060.97
140_E147_E0.5050.97
145_R148_P0.5040.97
16_A44_A0.5020.97
190_L247_A0.5020.97
122_G132_L0.5020.97
221_K278_Q0.5020.97
133_T208_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dojA 3 0.9965 100 0.347 Contact Map
3pefA 5 0.9896 100 0.348 Contact Map
3obbA 4 0.9931 100 0.348 Contact Map
3pduA 4 0.9896 100 0.349 Contact Map
1vpdA 1 1 100 0.349 Contact Map
3ckyA 4 1 100 0.349 Contact Map
3g0oA 3 0.9758 100 0.356 Contact Map
1yb4A 4 0.9965 100 0.359 Contact Map
2uyyA 3 0.9896 100 0.36 Contact Map
3zgyA 2 0.9758 100 0.361 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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