GREMLIN Database
Q97XZ6 - Uncharacterized protein
UniProt: Q97XZ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 287 (230)
Sequences: 3542 (2928)
Seq/√Len: 193.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_C111_L4.2341.00
124_L140_V4.0791.00
51_P54_V3.8141.00
45_S128_F3.7641.00
271_N275_F3.4921.00
74_R106_S3.1411.00
60_L141_T3.0131.00
59_Y163_F2.9071.00
60_L139_Y2.7391.00
44_E221_A2.6741.00
61_K78_F2.6001.00
175_F212_E2.5141.00
48_I60_L2.5031.00
125_L129_N2.3411.00
64_I110_F2.3301.00
51_P219_F2.3001.00
48_I163_F2.2731.00
62_T65_K2.1501.00
54_V163_F2.1121.00
31_H59_Y2.0941.00
166_L174_S2.0831.00
168_F213_Y2.0271.00
83_A130_A2.0201.00
89_E92_G1.9321.00
30_E167_N1.9321.00
37_V66_T1.9131.00
251_S255_V1.9061.00
172_F209_A1.8621.00
45_S124_L1.8551.00
53_Q155_G1.8321.00
60_L110_F1.8321.00
209_A212_E1.8121.00
272_T275_F1.8011.00
222_T231_L1.7841.00
259_K263_S1.7671.00
29_D32_V1.7451.00
236_K240_L1.7001.00
165_P218_G1.6961.00
83_A126_H1.5071.00
117_V120_W1.5001.00
78_F110_F1.4931.00
124_L138_V1.4701.00
29_D33_K1.4641.00
109_I138_V1.4571.00
75_S103_R1.4561.00
75_S107_A1.4491.00
49_L160_K1.4361.00
58_T62_T1.4341.00
95_N99_T1.4261.00
249_K252_V1.4231.00
82_D125_L1.4071.00
110_F139_Y1.4031.00
109_I136_S1.4001.00
47_L157_P1.3961.00
33_K37_V1.3811.00
223_S229_L1.3711.00
235_Y257_I1.3691.00
93_L117_V1.3591.00
177_K180_I1.3571.00
49_L162_V1.3301.00
30_E34_R1.3271.00
168_F171_Y1.3221.00
177_K209_A1.3151.00
83_A129_N1.2921.00
171_Y212_E1.2851.00
67_L108_Y1.2801.00
90_L94_V1.2791.00
168_F172_F1.2761.00
244_L250_E1.2571.00
273_S277_K1.2521.00
89_E93_L1.2431.00
30_E169_R1.2421.00
271_N281_Y1.2361.00
154_P245_K1.2191.00
96_E100_L1.2181.00
177_K205_E1.2131.00
197_L200_L1.2081.00
211_L215_R1.2011.00
200_L203_I1.1831.00
210_L214_V1.1741.00
75_S105_E1.1691.00
208_K212_E1.1671.00
115_T142_G1.1631.00
96_E99_T1.1461.00
43_D128_F1.1441.00
271_N274_A1.1241.00
272_T276_R1.1121.00
175_F209_A1.1121.00
142_G155_G1.1101.00
31_H163_F1.0941.00
94_V98_R1.0941.00
223_S226_E1.0931.00
168_F209_A1.0891.00
146_I149_R1.0791.00
29_D34_R1.0691.00
172_F213_Y1.0681.00
30_E33_K1.0621.00
224_F227_N1.0601.00
171_Y216_R1.0591.00
76_I110_F1.0511.00
216_R222_T1.0491.00
236_K254_K1.0481.00
171_Y213_Y1.0411.00
113_E156_R1.0391.00
268_I273_S1.0341.00
223_S227_N1.0311.00
252_V256_I1.0241.00
233_E237_D1.0221.00
224_F229_L1.0201.00
223_S228_P1.0201.00
64_I108_Y1.0081.00
150_K241_S1.0051.00
47_L140_V1.0031.00
92_G95_N1.0021.00
169_R173_D0.9991.00
67_L76_I0.9961.00
127_L138_V0.9961.00
64_I76_I0.9941.00
198_K202_Y0.9830.99
90_L97_Y0.9830.99
125_L146_I0.9780.99
110_F141_T0.9740.99
113_E142_G0.9710.99
125_L128_F0.9690.99
142_G156_R0.9630.99
203_I206_L0.9590.99
52_R242_E0.9540.99
114_I121_N0.9520.99
250_E254_K0.9500.99
154_P237_D0.9490.99
105_E135_N0.9430.99
256_I273_S0.9430.99
35_A67_L0.9410.99
35_A38_I0.9370.99
47_L160_K0.9330.99
90_L93_L0.9300.99
46_A139_Y0.9290.99
54_V165_P0.9280.99
61_K64_I0.9270.99
225_S228_P0.9260.99
205_E208_K0.9260.99
44_E128_F0.9250.99
46_A137_L0.9230.99
43_D221_A0.9220.99
157_P237_D0.9190.99
113_E143_S0.9180.99
80_S129_N0.9120.99
274_A278_F0.9120.99
82_D126_H0.9110.99
128_F138_V0.9060.99
267_R270_E0.9000.99
32_V59_Y0.8980.99
157_P160_K0.8960.99
212_E223_S0.8860.99
226_E229_L0.8790.99
109_I127_L0.8790.99
212_E216_R0.8780.99
129_N156_R0.8740.99
81_C117_V0.8700.99
51_P164_Y0.8650.99
213_Y218_G0.8570.99
265_G268_I0.8540.98
241_S245_K0.8450.98
240_L254_K0.8400.98
263_S276_R0.8370.98
51_P57_T0.8320.98
165_P219_F0.8310.98
48_I59_Y0.8270.98
253_F256_I0.8190.98
52_R113_E0.8160.98
40_P139_Y0.8100.98
116_S122_T0.8070.98
80_S83_A0.8020.98
197_L201_P0.8000.98
196_A199_L0.7960.98
255_V258_R0.7940.98
171_Y209_A0.7930.98
57_T129_N0.7900.97
196_A201_P0.7880.97
233_E236_K0.7860.97
101_V136_S0.7850.97
199_L202_Y0.7810.97
68_L137_L0.7760.97
86_K92_G0.7750.97
53_Q221_A0.7730.97
200_L204_S0.7720.97
141_T144_S0.7720.97
149_R152_M0.7710.97
207_N211_L0.7570.97
227_N230_S0.7540.97
107_A137_L0.7520.97
225_S229_L0.7520.97
31_H34_R0.7520.97
259_K273_S0.7490.97
239_I257_I0.7480.97
81_C120_W0.7470.96
82_D116_S0.7450.96
154_P157_P0.7350.96
278_F281_Y0.7340.96
37_V63_T0.7270.96
32_V35_A0.7270.96
57_T112_D0.7240.96
64_I78_F0.7170.96
238_A253_F0.7160.96
263_S266_S0.7160.96
155_G221_A0.7150.96
62_T66_T0.7130.95
196_A200_L0.7120.95
121_N157_P0.7070.95
259_K262_E0.7060.95
154_P238_A0.6970.95
168_F206_L0.6960.95
196_A204_S0.6940.95
153_L156_R0.6930.95
30_E173_D0.6920.95
48_I161_Y0.6890.95
252_V277_K0.6840.94
211_L214_V0.6830.94
85_S119_D0.6830.94
195_N199_L0.6810.94
75_S104_E0.6800.94
263_S268_I0.6790.94
77_L107_A0.6780.94
166_L216_R0.6770.94
61_K130_A0.6740.94
171_Y174_S0.6730.94
196_A202_Y0.6730.94
87_K91_I0.6720.94
198_K201_P0.6710.94
168_F180_I0.6710.94
61_K129_N0.6710.94
41_P225_S0.6690.94
234_T238_A0.6650.93
263_S272_T0.6650.93
46_A161_Y0.6600.93
43_D233_E0.6600.93
198_K203_I0.6590.93
149_R246_T0.6560.93
76_I108_Y0.6540.93
126_H130_A0.6540.93
269_S272_T0.6540.93
77_L97_Y0.6530.93
119_D122_T0.6490.93
87_K92_G0.6470.92
127_L137_L0.6450.92
167_N213_Y0.6410.92
47_L121_N0.6390.92
111_L124_L0.6380.92
47_L115_T0.6360.92
82_D129_N0.6350.92
232_Y236_K0.6330.92
118_S178_K0.6270.91
240_L258_R0.6270.91
143_S155_G0.6240.91
205_E209_A0.6230.91
52_R142_G0.6220.91
102_N105_E0.6220.91
116_S245_K0.6210.91
166_L171_Y0.6190.91
147_N151_E0.6190.91
57_T153_L0.6140.90
230_S233_E0.6130.90
93_L96_E0.6120.90
87_K94_V0.6050.90
90_L123_A0.6050.90
38_I226_E0.6030.90
143_S156_R0.6020.90
259_K276_R0.6000.89
120_W124_L0.5990.89
275_F278_F0.5970.89
57_T78_F0.5950.89
274_A281_Y0.5940.89
34_R38_I0.5930.89
91_I94_V0.5910.89
157_P238_A0.5910.89
115_T155_G0.5890.89
203_I207_N0.5890.89
60_L76_I0.5870.88
121_N144_S0.5860.88
53_Q174_S0.5840.88
144_S149_R0.5830.88
195_N202_Y0.5810.88
53_Q153_L0.5810.88
77_L109_I0.5790.88
258_R262_E0.5790.88
80_S126_H0.5790.88
145_S150_K0.5780.88
128_F156_R0.5740.87
90_L98_R0.5730.87
259_K277_K0.5700.87
31_H170_V0.5690.87
153_L157_P0.5690.87
175_F224_F0.5680.87
204_S208_K0.5670.87
97_Y102_N0.5660.86
91_I95_N0.5650.86
42_I234_T0.5640.86
87_K122_T0.5630.86
81_C115_T0.5620.86
33_K66_T0.5620.86
197_L202_Y0.5610.86
201_P205_E0.5590.86
108_Y124_L0.5560.86
32_V66_T0.5550.85
89_E94_V0.5530.85
195_N198_K0.5490.85
80_S116_S0.5490.85
141_T156_R0.5470.85
240_L244_L0.5440.84
29_D37_V0.5440.84
35_A161_Y0.5430.84
274_A279_M0.5430.84
39_V161_Y0.5430.84
226_E230_S0.5420.84
53_Q238_A0.5420.84
98_R101_V0.5420.84
197_L204_S0.5410.84
111_L117_V0.5380.84
160_K237_D0.5340.83
122_T151_E0.5340.83
167_N173_D0.5330.83
82_D122_T0.5330.83
58_T61_K0.5330.83
257_I261_I0.5300.83
158_I233_E0.5300.83
77_L110_F0.5300.83
97_Y127_L0.5280.83
212_E230_S0.5270.82
261_I264_Y0.5240.82
48_I139_Y0.5230.82
74_R104_E0.5190.81
147_N243_F0.5170.81
77_L90_L0.5150.81
116_S125_L0.5140.81
54_V219_F0.5130.81
114_I144_S0.5120.81
43_D158_I0.5120.81
39_V158_I0.5090.80
174_S178_K0.5080.80
33_K38_I0.5070.80
116_S146_I0.5060.80
244_L253_F0.5040.80
167_N170_V0.5030.79
63_T163_F0.5010.79
108_Y137_L0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qenA 1 0.8537 99.9 0.666 Contact Map
2fnaA 1 0.8397 99.9 0.669 Contact Map
3pfiA 3 0.8153 99.6 0.765 Contact Map
1hqcA 1 0.8397 99.5 0.78 Contact Map
1w5sA 1 0.9199 99.3 0.797 Contact Map
1l8qA 1 0.9233 99.3 0.797 Contact Map
1fnnA 1 0.9199 99.3 0.8 Contact Map
2z4sA 1 0.7526 99.3 0.801 Contact Map
1sxjB 1 0.9059 99.3 0.803 Contact Map
4xgcE 1 0.8153 99.3 0.803 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0093 seconds.