GREMLIN Database
Q97XZ3 - Dihydrolipoamide dehydrogenase (PdhD-3)
UniProt: Q97XZ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 456 (431)
Sequences: 15807 (10246)
Seq/√Len: 493.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_V259_T4.4091.00
291_D295_K4.0981.00
172_D195_Q3.2471.00
282_S289_V3.0551.00
113_D116_H2.9701.00
197_H229_N2.9431.00
407_A421_L2.9361.00
195_Q227_K2.8211.00
34_K108_Y2.7121.00
369_E400_G2.6701.00
219_L223_K2.6521.00
3_Y103_T2.6071.00
141_E273_P2.5481.00
369_E399_R2.5281.00
398_E401_S2.4671.00
141_E271_V2.4551.00
3_Y29_L2.4551.00
275_G278_E2.4401.00
17_G135_I2.3941.00
29_L105_Y2.3811.00
169_L194_V2.3781.00
143_A269_R2.3551.00
420_E439_E2.3401.00
402_M432_K2.2531.00
212_Q361_S2.2521.00
131_T134_M2.2471.00
403_R428_G2.2431.00
237_K248_S2.1991.00
371_V399_R2.1921.00
172_D260_N2.1741.00
6_V129_A2.1641.00
174_V199_I2.1621.00
5_V21_L2.1421.00
148_P237_K2.1031.00
239_K248_S2.0911.00
133_Y300_N2.0741.00
13_A304_T2.0551.00
324_A328_I2.0391.00
246_I256_S2.0361.00
358_I366_M2.0331.00
4_D27_N2.0261.00
358_I363_A2.0141.00
31_A129_A1.9991.00
183_L198_I1.9811.00
6_V31_A1.9501.00
424_A429_L1.9081.00
141_E269_R1.8821.00
112_K118_I1.8761.00
203_D231_P1.8661.00
110_K118_I1.8521.00
114_P298_I1.8451.00
409_M414_S1.8431.00
174_V247_Y1.8421.00
155_T158_D1.8231.00
6_V117_V1.8021.00
360_P364_R1.7881.00
246_I258_F1.7871.00
118_I126_E1.7841.00
236_K248_S1.7711.00
295_K299_P1.7561.00
370_I396_I1.7541.00
361_S365_K1.6961.00
395_L407_A1.6931.00
201_M234_E1.6831.00
135_I328_I1.6821.00
190_R195_Q1.6761.00
117_V121_T1.6641.00
239_K246_I1.6601.00
111_I134_M1.6411.00
244_E258_F1.6251.00
4_D132_R1.6251.00
173_M194_V1.6241.00
6_V131_T1.6221.00
8_I109_V1.6161.00
117_V300_N1.6081.00
302_F327_N1.5991.00
116_H130_E1.5971.00
136_I307_A1.5811.00
190_R226_I1.5771.00
293_T327_N1.5761.00
282_S297_N1.5741.00
27_N103_T1.5721.00
154_L158_D1.5681.00
183_L349_T1.5661.00
173_M189_F1.5541.00
121_T125_K1.5511.00
73_D76_T1.5461.00
6_V29_L1.5451.00
204_R215_V1.5381.00
197_H227_K1.5371.00
368_I405_I1.5361.00
234_E250_K1.5351.00
241_D246_I1.5211.00
171_Q195_Q1.5181.00
154_L261_S1.5151.00
5_V26_Y1.5151.00
284_S309_G1.5081.00
430_N433_Q1.5051.00
105_Y129_A1.4861.00
292_E337_Y1.4851.00
171_Q260_N1.4811.00
360_P394_K1.4751.00
363_A370_I1.4631.00
213_D374_E1.4571.00
229_N233_T1.4491.00
31_A109_V1.4431.00
76_T79_D1.4421.00
248_S256_S1.4391.00
233_T251_D1.4361.00
138_S307_A1.4281.00
217_T410_I1.4271.00
362_K365_K1.4261.00
153_C238_I1.4211.00
120_K126_E1.4191.00
352_S415_Q1.4121.00
20_R326_N1.4071.00
29_L129_A1.4061.00
294_M308_N1.4051.00
94_R106_K1.4001.00
241_D244_E1.3941.00
211_D394_K1.3931.00
154_L166_F1.3841.00
133_Y328_I1.3831.00
212_Q216_N1.3651.00
158_D161_G1.3591.00
5_V135_I1.3501.00
284_S289_V1.3471.00
8_I136_I1.3441.00
363_A396_I1.3401.00
111_I278_E1.3381.00
149_G152_Y1.3371.00
295_K300_N1.3341.00
58_T61_R1.3251.00
135_I304_T1.3201.00
37_L104_F1.3191.00
236_K250_K1.3091.00
191_L224_L1.3011.00
369_E398_E1.2921.00
220_S223_K1.2901.00
147_L150_V1.2901.00
372_E396_I1.2801.00
298_I301_V1.2761.00
152_Y240_D1.2751.00
3_Y105_Y1.2671.00
427_Y433_Q1.2511.00
395_L421_L1.2411.00
204_R212_Q1.2351.00
288_I307_A1.2231.00
398_E403_R1.2201.00
107_G119_V1.2121.00
146_R150_V1.2061.00
110_K120_K1.2051.00
321_S325_A1.2031.00
178_A205_A1.2021.00
219_L228_F1.1991.00
159_I189_F1.1901.00
213_D394_K1.1891.00
219_L230_S1.1881.00
176_I262_V1.1861.00
214_I410_I1.1711.00
360_P372_E1.1691.00
44_S157_D1.1641.00
214_I392_V1.1391.00
279_I298_I1.1391.00
200_E230_S1.1351.00
172_D258_F1.1351.00
82_D86_E1.1321.00
94_R98_Q1.1281.00
120_K124_G1.1251.00
115_T300_N1.1231.00
210_E355_Y1.1211.00
144_K155_T1.1191.00
360_P370_I1.1151.00
13_A317_A1.1111.00
154_L159_I1.1091.00
111_I117_V1.1061.00
421_L448_I1.1051.00
204_R219_L1.1021.00
78_Q82_D1.1001.00
281_L288_I1.0991.00
238_I262_V1.0951.00
199_I257_I1.0931.00
353_L410_I1.0921.00
24_A326_N1.0901.00
114_P301_V1.0901.00
393_L447_I1.0861.00
54_E58_T1.0841.00
294_M324_A1.0781.00
276_A281_L1.0771.00
377_M411_G1.0771.00
229_N257_I1.0761.00
74_F78_Q1.0751.00
419_N440_Q1.0751.00
354_S418_I1.0731.00
210_E345_V1.0671.00
173_M261_S1.0641.00
362_K366_M1.0601.00
241_D258_F1.0561.00
111_I136_I1.0541.00
108_Y274_E1.0541.00
19_F100_E1.0521.00
240_D245_V1.0461.00
172_D197_H1.0421.00
374_E392_V1.0421.00
342_S425_V1.0401.00
272_I283_I1.0381.00
93_K97_S1.0351.00
368_I398_E1.0341.00
218_L410_I1.0341.00
95_N99_Y1.0321.00
359_L362_K1.0261.00
304_T324_A1.0231.00
172_D244_E1.0231.00
363_A368_I1.0181.00
346_T440_Q1.0171.00
223_K227_K1.0131.00
110_K275_G1.0091.00
198_I228_F1.0071.00
133_Y302_F1.0071.00
174_V257_I1.0061.00
275_G279_I1.0061.00
429_L433_Q1.0031.00
283_I289_V0.9991.00
30_M97_S0.9981.00
371_V402_M0.9961.00
218_L353_L0.9921.00
325_A329_M0.9901.00
176_I264_L0.9821.00
402_M431_A0.9781.00
97_S102_L0.9781.00
358_I362_K0.9741.00
345_V355_Y0.9741.00
20_R24_A0.9721.00
324_A327_N0.9711.00
249_T257_I0.9691.00
216_N219_L0.9681.00
112_K116_H0.9671.00
92_H96_M0.9661.00
239_K256_S0.9641.00
240_D244_E0.9641.00
393_L409_M0.9641.00
148_P151_E0.9591.00
419_N445_N0.9571.00
221_I224_L0.9561.00
183_L222_L0.9551.00
364_R370_I0.9531.00
289_V297_N0.9501.00
21_L325_A0.9481.00
83_Y87_L0.9481.00
346_T415_Q0.9471.00
281_L298_I0.9461.00
290_V308_N0.9451.00
295_K327_N0.9421.00
249_T252_G0.9421.00
374_E394_K0.9401.00
178_A200_E0.9371.00
79_D83_Y0.9371.00
356_V425_V0.9341.00
205_A230_S0.9301.00
75_S167_R0.9241.00
398_E405_I0.9231.00
26_Y132_R0.9221.00
217_T221_I0.9211.00
3_Y27_N0.9191.00
295_K302_F0.9181.00
176_I266_A0.9141.00
172_D194_V0.9111.00
24_A329_M0.9101.00
404_L421_L0.9051.00
326_N331_N0.9031.00
26_Y133_Y0.9021.00
7_V18_A0.9011.00
142_T145_L0.9011.00
93_K96_M0.8971.00
134_M301_V0.8951.00
10_A30_M0.8941.00
205_A228_F0.8921.00
413_H416_Y0.8911.00
114_P300_N0.8911.00
245_V262_V0.8871.00
111_I131_T0.8861.00
293_T332_G0.8851.00
214_I408_W0.8851.00
323_A338_V0.8841.00
114_P280_G0.8841.00
31_A105_Y0.8831.00
229_N253_S0.8801.00
55_V80_R0.8771.00
143_A266_A0.8761.00
168_K261_S0.8761.00
360_P396_I0.8751.00
148_P152_Y0.8721.00
222_L226_I0.8701.00
290_V303_A0.8691.00
311_A343_I0.8691.00
221_I390_E0.8681.00
217_T220_S0.8671.00
420_E423_L0.8651.00
107_G122_D0.8641.00
110_K274_E0.8631.00
172_D259_T0.8601.00
339_D426_A0.8591.00
273_P277_R0.8581.00
424_A434_L0.8561.00
35_G44_S0.8551.00
97_S104_F0.8551.00
182_G200_E0.8551.00
41_C46_C0.8541.00
60_W224_L0.8541.00
147_L151_E0.8521.00
4_D26_Y0.8521.00
26_Y329_M0.8511.00
323_A327_N0.8491.00
204_R361_S0.8461.00
176_I235_V0.8431.00
173_M263_V0.8431.00
10_A37_L0.8421.00
303_A307_A0.8401.00
57_Q61_R0.8391.00
84_V88_R0.8391.00
87_L384_Q0.8361.00
203_D212_Q0.8351.00
16_H318_V0.8351.00
26_Y328_I0.8341.00
279_I301_V0.8341.00
55_V77_V0.8341.00
199_I229_N0.8331.00
56_I191_L0.8331.00
204_R216_N0.8321.00
281_L297_N0.8321.00
292_E336_D0.8301.00
296_T303_A0.8291.00
91_Q95_N0.8251.00
17_G325_A0.8241.00
216_N220_S0.8221.00
354_S414_S0.8181.00
111_I279_I0.8171.00
197_H259_T0.8171.00
221_I410_I0.8151.00
145_L264_L0.8141.00
368_I396_I0.8121.00
86_E91_Q0.8111.00
187_S191_L0.8081.00
17_G321_S0.8041.00
175_I182_G0.8011.00
53_R188_I0.8001.00
371_V397_F0.8001.00
111_I120_K0.7991.00
205_A219_L0.7981.00
143_A146_R0.7971.00
364_R367_G0.7961.00
233_T250_K0.7961.00
222_L228_F0.7951.00
20_R325_A0.7941.00
288_I303_A0.7921.00
426_A436_S0.7911.00
356_V422_G0.7871.00
175_I263_V0.7861.00
190_R224_L0.7851.00
21_L26_Y0.7841.00
31_A121_T0.7841.00
135_I324_A0.7771.00
75_S79_D0.7761.00
66_A76_T0.7761.00
20_R23_K0.7731.00
186_A198_I0.7721.00
210_E353_L0.7681.00
295_K298_I0.7681.00
43_Y89_F0.7651.00
186_A226_I0.7651.00
170_P194_V0.7611.00
114_P279_I0.7581.00
319_R322_I0.7571.00
238_I245_V0.7571.00
79_D167_R0.7571.00
218_L349_T0.7551.00
214_I353_L0.7531.00
52_V78_Q0.7521.00
6_V134_M0.7511.00
280_G298_I0.7511.00
24_A331_N0.7501.00
423_L429_L0.7501.00
144_K150_V0.7491.00
115_T130_E0.7451.00
279_I283_I0.7431.00
22_A102_L0.7431.00
316_A343_I0.7411.00
429_L434_L0.7411.00
62_L70_I0.7411.00
244_E260_N0.7401.00
5_V325_A0.7371.00
153_C264_L0.7341.00
29_L103_T0.7341.00
180_Y347_I0.7331.00
35_G107_G0.7321.00
8_I117_V0.7301.00
91_Q94_R0.7301.00
110_K278_E0.7301.00
3_Y6_V0.7291.00
121_T126_E0.7281.00
144_K264_L0.7281.00
17_G324_A0.7271.00
359_L408_W0.7221.00
115_T298_I0.7211.00
199_I249_T0.7201.00
279_I297_N0.7181.00
60_W191_L0.7181.00
376_N379_E0.7181.00
76_T80_R0.7171.00
276_A279_I0.7171.00
97_S101_T0.7131.00
31_A107_G0.7101.00
363_A405_I0.7091.00
272_I307_A0.7091.00
35_G106_K0.7091.00
373_A397_F0.7081.00
54_E57_Q0.7061.00
134_M300_N0.7051.00
352_S413_H0.7031.00
389_K412_V0.7031.00
249_T253_S0.7021.00
22_A28_V0.7011.00
78_Q81_K0.7001.00
403_R430_N0.7001.00
111_I275_G0.6941.00
137_A304_T0.6931.00
233_T253_S0.6921.00
404_L425_V0.6911.00
243_Y246_I0.6901.00
380_D383_A0.6891.00
409_M417_L0.6881.00
407_A425_V0.6871.00
294_M327_N0.6841.00
85_Q88_R0.6831.00
211_D408_W0.6831.00
397_F431_A0.6821.00
423_L427_Y0.6821.00
157_D161_G0.6821.00
233_T249_T0.6821.00
294_M323_A0.6801.00
217_T392_V0.6791.00
15_Y30_M0.6781.00
122_D125_K0.6761.00
423_L437_F0.6751.00
377_M447_I0.6741.00
431_A435_A0.6721.00
166_F261_S0.6701.00
83_Y86_E0.6671.00
240_D243_Y0.6661.00
81_K161_G0.6641.00
293_T337_Y0.6641.00
421_L425_V0.6641.00
49_S185_I0.6601.00
183_L205_A0.6581.00
116_H126_E0.6581.00
238_I247_Y0.6571.00
80_R83_Y0.6571.00
36_E89_F0.6541.00
19_F23_K0.6531.00
107_G123_E0.6511.00
191_L350_I0.6511.00
423_L434_L0.6491.00
82_D161_G0.6471.00
21_L328_I0.6461.00
281_L301_V0.6451.00
39_G42_L0.6441.00
23_K100_E0.6441.00
188_I192_M0.6431.00
433_Q436_S0.6421.00
4_D29_L0.6421.00
214_I217_T0.6411.00
32_D36_E0.6391.00
150_V264_L0.6391.00
206_L218_L0.6391.00
75_S78_Q0.6381.00
370_I405_I0.6371.00
397_F402_M0.6371.00
54_E61_R0.6351.00
82_D85_Q0.6351.00
152_Y245_V0.6351.00
95_N98_Q0.6321.00
416_Y445_N0.6311.00
147_L152_Y0.6301.00
121_T124_G0.6251.00
150_V153_C0.6231.00
182_G201_M0.6221.00
426_A437_F0.6201.00
326_N336_D0.6201.00
172_D190_R0.6191.00
154_L157_D0.6181.00
21_L329_M0.6171.00
72_L77_V0.6161.00
320_M340_V0.6161.00
210_E347_I0.6161.00
145_L150_V0.6151.00
166_F170_P0.6130.99
189_F194_V0.6130.99
7_V14_G0.6120.99
361_S364_R0.6120.99
304_T321_S0.6090.99
401_S428_G0.6080.99
49_S53_R0.6070.99
86_E89_F0.6060.99
55_V68_V0.6030.99
157_D160_F0.6030.99
202_L208_T0.6010.99
92_H95_N0.6000.99
21_L28_V0.5990.99
142_T146_R0.5980.99
22_A101_T0.5970.99
290_V294_M0.5970.99
422_G426_A0.5950.99
153_C158_D0.5940.99
185_I263_V0.5940.99
352_S444_T0.5930.99
187_S222_L0.5930.99
54_E386_Y0.5930.99
358_I368_I0.5920.99
404_L407_A0.5910.99
135_I325_A0.5900.99
187_S224_L0.5880.99
302_F328_I0.5880.99
36_E44_S0.5870.99
194_V260_N0.5870.99
396_I399_R0.5850.99
119_V129_A0.5840.99
258_F261_S0.5840.99
382_S386_Y0.5830.99
17_G304_T0.5830.99
379_E383_A0.5810.99
13_A137_A0.5810.99
341_K366_M0.5770.99
358_I406_G0.5770.99
326_N333_M0.5770.99
57_Q350_I0.5770.99
356_V407_A0.5770.99
156_S159_I0.5760.99
407_A448_I0.5740.99
407_A418_I0.5740.99
235_V247_Y0.5730.99
79_D82_D0.5700.99
153_C262_V0.5690.99
147_L235_V0.5690.99
409_M418_I0.5680.99
53_R57_Q0.5670.99
78_Q167_R0.5660.99
201_M266_A0.5650.99
381_V385_I0.5650.99
233_T257_I0.5650.99
283_I288_I0.5650.99
81_K85_Q0.5630.99
197_H257_I0.5620.99
88_R384_Q0.5610.99
342_S426_A0.5610.99
97_S100_E0.5600.99
398_E402_M0.5600.99
316_A320_M0.5600.99
18_A102_L0.5590.99
288_I296_T0.5580.99
38_G42_L0.5570.99
432_K436_S0.5560.99
146_R151_E0.5560.99
276_A283_I0.5550.99
77_V192_M0.5550.99
326_N330_A0.5550.99
322_I326_N0.5550.99
180_Y345_V0.5540.99
112_K126_E0.5530.99
20_R322_I0.5530.99
227_K230_S0.5520.99
140_A268_R0.5520.99
7_V17_G0.5510.99
383_A444_T0.5510.99
47_V381_V0.5510.99
319_R323_A0.5500.99
80_R84_V0.5500.99
59_A70_I0.5490.99
4_D129_A0.5490.99
376_N390_E0.5480.99
85_Q89_F0.5480.99
376_N392_V0.5470.99
309_G312_P0.5460.99
382_S385_I0.5460.99
108_Y121_T0.5460.99
96_M100_E0.5440.99
368_I372_E0.5440.99
388_Q412_V0.5420.99
157_D268_R0.5420.99
359_L396_I0.5410.99
350_I412_V0.5400.99
391_G409_M0.5390.99
422_G437_F0.5370.99
277_R283_I0.5360.99
381_V384_Q0.5350.99
215_V219_L0.5350.99
183_L228_F0.5340.99
205_A215_V0.5330.99
441_H446_E0.5320.99
182_G265_A0.5310.99
423_L439_E0.5300.99
156_S268_R0.5290.99
10_A32_D0.5280.98
224_L350_I0.5270.98
285_K289_V0.5270.98
106_K122_D0.5260.98
22_A27_N0.5260.98
77_V80_R0.5250.98
417_L444_T0.5250.98
377_M444_T0.5230.98
84_V87_L0.5210.98
236_K249_T0.5200.98
270_P283_I0.5190.98
342_S422_G0.5190.98
92_H97_S0.5190.98
316_A340_V0.5190.98
370_I399_R0.5180.98
5_V328_I0.5160.98
375_Y379_E0.5160.98
425_V429_L0.5160.98
199_I259_T0.5160.98
120_K125_K0.5150.98
326_N332_G0.5150.98
6_V119_V0.5150.98
118_I130_E0.5140.98
24_A325_A0.5120.98
308_N320_M0.5120.98
136_I288_I0.5110.98
319_R449_S0.5110.98
57_Q386_Y0.5110.98
156_S160_F0.5090.98
339_D342_S0.5070.98
132_R300_N0.5060.98
36_E43_Y0.5060.98
58_T62_L0.5060.98
103_T106_K0.5060.98
133_Y295_K0.5050.98
355_Y362_K0.5040.98
337_Y340_V0.5040.98
56_I59_A0.5030.98
418_I440_Q0.5020.98
112_K278_E0.5020.98
118_I124_G0.5010.98
121_T129_A0.5010.98
304_T328_I0.5010.98
185_I188_I0.5010.98
187_S350_I0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ojtA 2 0.9759 100 0.19 Contact Map
3l8kA 3 0.9803 100 0.191 Contact Map
3ladA 2 0.9781 100 0.2 Contact Map
3urhA 2 0.9693 100 0.2 Contact Map
1xdiA 3 0.9693 100 0.207 Contact Map
3ic9A 2 0.9715 100 0.209 Contact Map
1zmdA 4 0.9781 100 0.211 Contact Map
2wpfA 2 0.9759 100 0.211 Contact Map
2a8xA 2 0.9737 100 0.211 Contact Map
2hqmA 2 0.9693 100 0.214 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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