Q97XZ2 - SULSO - GREMLIN Contacts

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Q97XZ2 - Heme biosynthesis related protein

UniProt:	Q97XZ2	Sequences: MALSKFNLFIGDILFNTLTGYAIKLESWEIEKLRKGVVPEHLKDIIEEGFSATDEDLDEEIEKFLRKPVLEPTLVLTYNCNFDCIYCFQKGFRKNISVSDKVTRGFVNYIRKNEKGRKVRVTYFGGEPILQLRKIEEISRELSDLKYSFSVVTNGSLLTRKIVERLIPLGLTHVQITLDGPKEVHDKRRFFVSGEGTFDVIVKNLKEIQDMVKVVLRINIDVKNLNEIGELLNELKMEGINRVRLDPHLVHSNVFRNEWWDFTISSKAEGDVMVKFWEIARKYGFEVPQDVLRLGLCVAYSSEDIVVDPEGNIYPCWAFTGNPLYVKGKLEEDGSVKVTNKSLWWKVKIEDKCRECPFLPLCMGGCKFLATINGDDCKREAYEKIVRSIRWVMG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	394 (307)
Sequences:	5493 (4187)
Seq/√Len:	238.9

ECOLI - ASLB YDEM MOAA
BACSU - ALBA SKFB MOAA YYDG
HALSA - Q9HQF5 MOAA Q9HQF7
SULSO - Q97XZ2 Q97XA7 Q97XS7 Q7LXV3 Q97XA6 Q97XS8 Q97Y04 Q97WC3 Q97WK5 MOAA Q980E0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
182_K	199_D	5.681	1.00
82_F	156_S	3.799	1.00
160_R	207_E	3.408	1.00
102_V	331_E	3.346	1.00
164_E	211_M	3.339	1.00
186_D	196_G	3.336	1.00
108_N	141_E	3.144	1.00
104_R	141_E	3.063	1.00
312_N	329_K	3.055	1.00
99_S	102_V	2.940	1.00
198_F	234_E	2.760	1.00
100_D	137_E	2.641	1.00
206_K	238_E	2.598	1.00
105_G	109_Y	2.582	1.00
136_E	165_R	2.534	1.00
312_N	326_V	2.451	1.00
81_N	154_N	2.320	1.00
316_C	366_C	2.285	1.00
334_G	337_K	2.285	1.00
160_R	210_D	2.225	1.00
155_G	176_I	2.211	1.00
297_C	316_C	2.201	1.00
227_E	230_E	2.185	1.00
72_P	110_I	2.178	1.00
229_G	275_K	2.152	1.00
104_R	137_E	2.149	1.00
181_P	184_V	2.127	1.00
160_R	211_M	1.970	1.00
108_N	145_L	1.944	1.00
308_D	312_N	1.935	1.00
233_N	237_M	1.919	1.00
103_T	138_I	1.913	1.00
182_K	186_D	1.907	1.00
179_D	189_R	1.893	1.00
329_K	332_E	1.880	1.00
164_E	168_P	1.880	1.00
207_E	210_D	1.853	1.00
200_V	203_K	1.824	1.00
167_I	211_M	1.797	1.00
333_D	337_K	1.779	1.00
159_T	162_I	1.753	1.00
79_N	97_S	1.742	1.00
185_H	197_T	1.725	1.00
163_V	207_E	1.725	1.00
165_R	169_L	1.714	1.00
141_E	144_D	1.707	1.00
98_V	102_V	1.686	1.00
187_K	223_K	1.667	1.00
140_R	165_R	1.656	1.00
233_N	279_I	1.638	1.00
140_R	144_D	1.626	1.00
184_V	227_E	1.620	1.00
176_I	205_L	1.587	1.00
216_L	235_L	1.585	1.00
181_P	227_E	1.583	1.00
222_V	268_A	1.560	1.00
230_E	233_N	1.558	1.00
97_S	131_Q	1.554	1.00
206_K	210_D	1.554	1.00
206_K	209_Q	1.541	1.00
297_C	366_C	1.527	1.00
158_L	163_V	1.522	1.00
102_V	105_G	1.520	1.00
143_S	169_L	1.515	1.00
123_Y	149_F	1.511	1.00
176_I	204_N	1.502	1.00
141_E	145_L	1.491	1.00
294_L	297_C	1.486	1.00
100_D	104_R	1.484	1.00
137_E	140_R	1.448	1.00
182_K	198_F	1.445	1.00
313_I	338_V	1.437	1.00
234_E	238_E	1.422	1.00
203_K	207_E	1.420	1.00
81_N	157_L	1.397	1.00
140_R	169_L	1.384	1.00
265_S	268_A	1.376	1.00
186_D	197_T	1.367	1.00
121_V	142_L	1.366	1.00
202_V	238_E	1.358	1.00
104_R	108_N	1.351	1.00
199_D	203_K	1.346	1.00
152_V	175_Q	1.338	1.00
188_R	221_D	1.336	1.00
274_V	278_E	1.333	1.00
271_D	275_K	1.329	1.00
203_K	206_K	1.318	1.00
201_I	204_N	1.317	1.00
350_E	376_D	1.312	1.00
174_V	208_I	1.301	1.00
136_E	162_I	1.295	1.00
129_I	151_V	1.269	1.00
218_I	243_V	1.254	1.00
98_V	103_T	1.244	1.00
202_V	234_E	1.231	1.00
105_G	331_E	1.227	1.00
142_L	149_F	1.223	1.00
107_V	145_L	1.209	1.00
74_L	103_T	1.209	1.00
279_I	283_Y	1.209	1.00
180_G	198_F	1.205	1.00
180_G	184_V	1.205	1.00
308_D	314_Y	1.198	1.00
107_V	142_L	1.191	1.00
216_L	240_I	1.187	1.00
336_V	340_N	1.177	1.00
143_S	172_T	1.165	1.00
139_S	171_L	1.159	1.00
151_V	166_L	1.156	1.00
78_Y	309_P	1.152	1.00
85_I	187_K	1.149	1.00
229_G	279_I	1.147	1.00
163_V	211_M	1.145	1.00
160_R	164_E	1.144	1.00
353_C	362_C	1.143	1.00
132_L	136_E	1.143	1.00
88_F	124_F	1.141	1.00
109_Y	334_G	1.141	1.00
178_L	216_L	1.137	1.00
207_E	211_M	1.136	1.00
82_F	197_T	1.129	1.00
337_K	341_K	1.119	1.00
136_E	168_P	1.119	1.00
162_I	166_L	1.117	1.00
81_N	127_E	1.117	1.00
163_V	167_I	1.111	1.00
165_R	168_P	1.105	1.00
161_K	164_E	1.095	1.00
96_I	310_E	1.092	1.00
344_W	348_K	1.092	1.00
291_V	294_L	1.091	1.00
111_R	145_L	1.083	1.00
163_V	204_N	1.081	1.00
129_I	157_L	1.075	1.00
271_D	274_V	1.073	1.00
106_F	307_V	1.073	1.00
107_V	121_V	1.068	1.00
139_S	169_L	1.066	1.00
323_P	326_V	1.065	1.00
76_L	123_Y	1.061	1.00
342_S	346_K	1.059	1.00
202_V	206_K	1.053	1.00
86_Y	188_R	1.053	1.00
279_I	282_K	1.051	1.00
232_L	236_K	1.051	1.00
74_L	106_F	1.046	1.00
198_F	202_V	1.044	1.00
235_L	240_I	1.037	1.00
218_I	231_L	1.034	1.00
81_N	156_S	1.028	1.00
267_K	271_D	1.023	1.00
86_Y	179_D	1.019	1.00
185_H	196_G	1.016	1.00
200_V	204_N	1.015	1.00
319_F	368_F	1.013	1.00
151_V	174_V	1.009	1.00
374_G	379_R	1.003	1.00
129_I	204_N	1.003	1.00
137_E	141_E	1.001	1.00
110_I	121_V	1.001	1.00
175_Q	217_R	1.001	1.00
295_G	298_V	0.995	1.00
233_N	236_K	0.991	1.00
351_D	355_E	0.989	1.00
270_G	274_V	0.987	1.00
135_I	139_S	0.987	1.00
314_Y	326_V	0.987	1.00
181_P	230_E	0.974	1.00
139_S	165_R	0.972	1.00
382_Y	385_I	0.970	1.00
383_E	386_V	0.970	1.00
208_I	212_V	0.960	1.00
236_K	283_Y	0.959	1.00
180_G	189_R	0.959	1.00
209_Q	239_G	0.955	1.00
85_I	188_R	0.950	1.00
118_K	146_K	0.948	1.00
132_L	162_I	0.942	1.00
133_R	137_E	0.938	1.00
379_R	383_E	0.938	1.00
174_V	212_V	0.935	1.00
105_G	108_N	0.934	1.00
268_A	271_D	0.929	1.00
177_T	219_N	0.922	1.00
290_D	297_C	0.921	1.00
185_H	198_F	0.920	1.00
120_R	150_S	0.920	1.00
382_Y	386_V	0.915	1.00
204_N	207_E	0.915	1.00
333_D	338_V	0.914	1.00
120_R	148_S	0.906	1.00
77_T	97_S	0.906	1.00
205_L	214_V	0.903	1.00
194_G	197_T	0.902	1.00
342_S	345_W	0.901	1.00
163_V	174_V	0.897	1.00
123_Y	142_L	0.891	1.00
138_I	142_L	0.875	0.99
313_I	335_S	0.867	0.99
156_S	204_N	0.865	0.99
328_G	333_D	0.862	0.99
139_S	142_L	0.858	0.99
129_I	162_I	0.854	0.99
226_N	268_A	0.852	0.99
351_D	354_R	0.851	0.99
185_H	201_I	0.850	0.99
294_L	298_V	0.850	0.99
367_K	370_A	0.849	0.99
131_Q	138_I	0.847	0.99
293_R	297_C	0.844	0.99
276_F	280_A	0.842	0.99
248_H	254_V	0.841	0.99
158_L	204_N	0.841	0.99
149_F	171_L	0.837	0.99
189_R	194_G	0.836	0.99
143_S	149_F	0.834	0.99
353_C	356_C	0.828	0.99
158_L	208_I	0.824	0.99
350_E	379_R	0.823	0.99
152_V	217_R	0.819	0.99
158_L	166_L	0.819	0.99
275_K	279_I	0.814	0.99
75_V	124_F	0.814	0.99
121_V	149_F	0.811	0.99
124_F	152_V	0.810	0.99
334_G	338_V	0.807	0.99
205_L	216_L	0.807	0.99
219_N	248_H	0.806	0.99
307_V	313_I	0.804	0.99
185_H	189_R	0.803	0.99
103_T	106_F	0.802	0.99
136_E	140_R	0.788	0.99
343_L	346_K	0.786	0.99
291_V	295_G	0.784	0.99
81_N	130_L	0.783	0.99
186_D	189_R	0.782	0.99
124_F	317_W	0.779	0.99
280_A	283_Y	0.776	0.99
152_V	317_W	0.776	0.99
327_K	344_W	0.776	0.99
288_P	294_L	0.774	0.99
293_R	296_L	0.773	0.99
72_P	307_V	0.773	0.99
100_D	133_R	0.771	0.99
218_I	235_L	0.770	0.99
123_Y	138_I	0.770	0.99
221_D	224_N	0.768	0.99
176_I	208_I	0.768	0.99
158_L	162_I	0.768	0.99
349_I	359_L	0.767	0.99
216_L	243_V	0.766	0.98
272_V	280_A	0.764	0.98
76_L	135_I	0.762	0.98
139_S	149_F	0.761	0.98
76_L	131_Q	0.759	0.98
288_P	297_C	0.756	0.98
277_W	280_A	0.754	0.98
163_V	208_I	0.752	0.98
254_V	257_N	0.749	0.98
127_E	154_N	0.747	0.98
102_V	106_F	0.742	0.98
186_D	194_G	0.740	0.98
79_N	95_N	0.740	0.98
107_V	123_Y	0.736	0.98
295_G	299_A	0.736	0.98
98_V	106_F	0.730	0.98
100_D	138_I	0.729	0.98
233_N	283_Y	0.727	0.98
275_K	278_E	0.724	0.98
77_T	131_Q	0.723	0.98
217_R	246_D	0.720	0.98
197_T	201_I	0.719	0.98
159_T	204_N	0.718	0.98
205_L	238_E	0.717	0.98
160_R	163_V	0.716	0.98
111_R	147_Y	0.715	0.98
335_S	338_V	0.715	0.98
217_R	317_W	0.714	0.98
228_I	275_K	0.710	0.98
376_D	379_R	0.706	0.97
178_L	198_F	0.706	0.97
205_L	240_I	0.705	0.97
325_Y	371_T	0.705	0.97
352_K	380_E	0.704	0.97
290_D	293_R	0.700	0.97
315_P	325_Y	0.699	0.97
91_G	253_N	0.698	0.97
103_T	107_V	0.698	0.97
143_S	168_P	0.695	0.97
291_V	297_C	0.693	0.97
136_E	161_K	0.691	0.97
225_L	268_A	0.691	0.97
101_K	105_G	0.691	0.97
142_L	147_Y	0.689	0.97
180_G	227_E	0.689	0.97
132_L	165_R	0.688	0.97
278_E	281_R	0.688	0.97
328_G	338_V	0.686	0.97
189_R	197_T	0.686	0.97
86_Y	189_R	0.685	0.97
273_M	277_W	0.684	0.97
305_I	335_S	0.683	0.97
232_L	283_Y	0.683	0.97
339_T	348_K	0.682	0.97
289_Q	297_C	0.680	0.97
162_I	165_R	0.679	0.97
123_Y	139_S	0.679	0.97
103_T	131_Q	0.677	0.97
118_K	148_S	0.671	0.97
214_V	240_I	0.671	0.97
222_V	265_S	0.667	0.96
75_V	217_R	0.663	0.96
161_K	165_R	0.662	0.96
122_T	150_S	0.662	0.96
266_S	270_G	0.662	0.96
127_E	130_L	0.662	0.96
89_Q	124_F	0.661	0.96
89_Q	219_N	0.659	0.96
277_W	281_R	0.657	0.96
209_Q	214_V	0.656	0.96
75_V	306_V	0.656	0.96
107_V	147_Y	0.656	0.96
72_P	305_I	0.654	0.96
228_I	245_L	0.653	0.96
157_L	204_N	0.652	0.96
100_D	131_Q	0.651	0.96
76_L	103_T	0.648	0.96
73_T	317_W	0.646	0.96
208_I	214_V	0.644	0.96
213_K	241_N	0.641	0.96
127_E	153_T	0.640	0.95
182_K	196_G	0.637	0.95
294_L	299_A	0.635	0.95
352_K	379_R	0.634	0.95
381_A	384_K	0.633	0.95
331_E	334_G	0.633	0.95
199_D	202_V	0.631	0.95
80_C	87_C	0.629	0.95
365_G	370_A	0.628	0.95
284_G	287_V	0.627	0.95
333_D	341_K	0.626	0.95
292_L	298_V	0.624	0.95
109_Y	336_V	0.621	0.95
209_Q	241_N	0.620	0.95
315_P	319_F	0.620	0.95
177_T	301_S	0.619	0.95
196_G	199_D	0.619	0.95
311_G	329_K	0.617	0.95
356_C	362_C	0.616	0.94
228_I	272_V	0.612	0.94
86_Y	124_F	0.612	0.94
176_I	201_I	0.610	0.94
264_I	268_A	0.610	0.94
163_V	212_V	0.609	0.94
288_P	291_V	0.608	0.94
246_D	249_L	0.607	0.94
313_I	333_D	0.607	0.94
209_Q	240_I	0.607	0.94
278_E	282_K	0.606	0.94
235_L	243_V	0.605	0.94
371_T	374_G	0.604	0.94
154_N	157_L	0.604	0.94
73_T	304_D	0.599	0.94
173_H	215_V	0.598	0.94
135_I	151_V	0.598	0.94
273_M	276_F	0.597	0.93
104_R	144_D	0.596	0.93
183_E	227_E	0.596	0.93
73_T	124_F	0.588	0.93
290_D	295_G	0.588	0.93
231_L	235_L	0.587	0.93
124_F	217_R	0.587	0.93
167_I	212_V	0.586	0.93
289_Q	298_V	0.584	0.93
186_D	198_F	0.584	0.93
292_L	295_G	0.582	0.93
289_Q	294_L	0.580	0.93
164_E	167_I	0.580	0.93
86_Y	219_N	0.580	0.93
73_T	76_L	0.579	0.92
74_L	138_I	0.578	0.92
345_W	348_K	0.578	0.92
296_L	299_A	0.577	0.92
183_E	187_K	0.576	0.92
178_L	202_V	0.575	0.92
127_E	155_G	0.575	0.92
204_N	208_I	0.575	0.92
209_Q	238_E	0.573	0.92
80_C	84_C	0.573	0.92
234_E	237_M	0.573	0.92
105_G	334_G	0.572	0.92
84_C	87_C	0.571	0.92
156_S	200_V	0.571	0.92
289_Q	292_L	0.568	0.92
68_P	117_R	0.566	0.92
136_E	139_S	0.566	0.92
236_K	279_I	0.565	0.92
103_T	123_Y	0.564	0.91
75_V	219_N	0.564	0.91
74_L	86_Y	0.564	0.91
178_L	201_I	0.561	0.91
311_G	330_L	0.560	0.91
292_L	296_L	0.559	0.91
152_V	318_A	0.558	0.91
270_G	273_M	0.556	0.91
129_I	156_S	0.556	0.91
79_N	92_F	0.555	0.91
326_V	329_K	0.555	0.91
208_I	211_M	0.555	0.91
293_R	299_A	0.554	0.91
155_G	205_L	0.553	0.91
89_Q	317_W	0.553	0.91
180_G	185_H	0.553	0.91
359_L	363_M	0.552	0.91
293_R	298_V	0.552	0.91
71_E	122_T	0.546	0.90
136_E	169_L	0.542	0.90
342_S	348_K	0.542	0.90
124_F	175_Q	0.542	0.90
232_L	243_V	0.539	0.90
109_Y	335_S	0.539	0.90
200_V	207_E	0.536	0.89
143_S	170_G	0.536	0.89
86_Y	89_Q	0.536	0.89
131_Q	135_I	0.535	0.89
73_T	122_T	0.534	0.89
228_I	232_L	0.533	0.89
257_N	261_D	0.533	0.89
88_F	246_D	0.532	0.89
291_V	296_L	0.531	0.89
153_T	176_I	0.529	0.89
307_V	330_L	0.528	0.89
107_V	111_R	0.528	0.89
292_L	297_C	0.527	0.88
261_D	264_I	0.525	0.88
175_Q	215_V	0.523	0.88
305_I	339_T	0.523	0.88
248_H	251_H	0.523	0.88
75_V	78_Y	0.522	0.88
262_F	266_S	0.521	0.88
98_V	331_E	0.521	0.88
122_T	152_V	0.520	0.88
315_P	327_K	0.520	0.88
179_D	185_H	0.519	0.88
352_K	355_E	0.518	0.88
288_P	292_L	0.518	0.88
138_I	141_E	0.517	0.88
306_V	317_W	0.515	0.87
115_K	336_V	0.510	0.87
248_H	252_S	0.510	0.87
75_V	309_P	0.508	0.87
102_V	109_Y	0.508	0.87
276_F	279_I	0.506	0.86
288_P	295_G	0.505	0.86
252_S	255_F	0.504	0.86
291_V	298_V	0.503	0.86
86_Y	149_F	0.503	0.86
89_Q	306_V	0.502	0.86
181_P	234_E	0.501	0.86
103_T	141_E	0.500	0.86

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k36A	1	0.8173	100	0.356	Contact Map
4m7tA	1	0.5863	100	0.542	Contact Map
1tv8A	2	0.7183	100	0.552	Contact Map
4rtbA	2	0.8807	100	0.6	Contact Map
4wcxA	1	0.9492	100	0.641	Contact Map
3c8fA	1	0.5787	100	0.645	Contact Map
2yx0A	1	0.7335	99.9	0.671	Contact Map
2z2uA	1	0.6168	99.9	0.684	Contact Map
2qgqA	1	0.5964	99.9	0.685	Contact Map
3rfaA	1	0.7716	99.9	0.697	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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