GREMLIN Database
Q97XZ2 - Heme biosynthesis related protein
UniProt: Q97XZ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 394 (307)
Sequences: 5493 (4187)
Seq/√Len: 238.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
182_K199_D5.6811.00
82_F156_S3.7991.00
160_R207_E3.4081.00
102_V331_E3.3461.00
164_E211_M3.3391.00
186_D196_G3.3361.00
108_N141_E3.1441.00
104_R141_E3.0631.00
312_N329_K3.0551.00
99_S102_V2.9401.00
198_F234_E2.7601.00
100_D137_E2.6411.00
206_K238_E2.5981.00
105_G109_Y2.5821.00
136_E165_R2.5341.00
312_N326_V2.4511.00
81_N154_N2.3201.00
316_C366_C2.2851.00
334_G337_K2.2851.00
160_R210_D2.2251.00
155_G176_I2.2111.00
297_C316_C2.2011.00
227_E230_E2.1851.00
72_P110_I2.1781.00
229_G275_K2.1521.00
104_R137_E2.1491.00
181_P184_V2.1271.00
160_R211_M1.9701.00
108_N145_L1.9441.00
308_D312_N1.9351.00
233_N237_M1.9191.00
103_T138_I1.9131.00
182_K186_D1.9071.00
179_D189_R1.8931.00
329_K332_E1.8801.00
164_E168_P1.8801.00
207_E210_D1.8531.00
200_V203_K1.8241.00
167_I211_M1.7971.00
333_D337_K1.7791.00
159_T162_I1.7531.00
79_N97_S1.7421.00
185_H197_T1.7251.00
163_V207_E1.7251.00
165_R169_L1.7141.00
141_E144_D1.7071.00
98_V102_V1.6861.00
187_K223_K1.6671.00
140_R165_R1.6561.00
233_N279_I1.6381.00
140_R144_D1.6261.00
184_V227_E1.6201.00
176_I205_L1.5871.00
216_L235_L1.5851.00
181_P227_E1.5831.00
222_V268_A1.5601.00
230_E233_N1.5581.00
97_S131_Q1.5541.00
206_K210_D1.5541.00
206_K209_Q1.5411.00
297_C366_C1.5271.00
158_L163_V1.5221.00
102_V105_G1.5201.00
143_S169_L1.5151.00
123_Y149_F1.5111.00
176_I204_N1.5021.00
141_E145_L1.4911.00
294_L297_C1.4861.00
100_D104_R1.4841.00
137_E140_R1.4481.00
182_K198_F1.4451.00
313_I338_V1.4371.00
234_E238_E1.4221.00
203_K207_E1.4201.00
81_N157_L1.3971.00
140_R169_L1.3841.00
265_S268_A1.3761.00
186_D197_T1.3671.00
121_V142_L1.3661.00
202_V238_E1.3581.00
104_R108_N1.3511.00
199_D203_K1.3461.00
152_V175_Q1.3381.00
188_R221_D1.3361.00
274_V278_E1.3331.00
271_D275_K1.3291.00
203_K206_K1.3181.00
201_I204_N1.3171.00
350_E376_D1.3121.00
174_V208_I1.3011.00
136_E162_I1.2951.00
129_I151_V1.2691.00
218_I243_V1.2541.00
98_V103_T1.2441.00
202_V234_E1.2311.00
105_G331_E1.2271.00
142_L149_F1.2231.00
107_V145_L1.2091.00
74_L103_T1.2091.00
279_I283_Y1.2091.00
180_G198_F1.2051.00
180_G184_V1.2051.00
308_D314_Y1.1981.00
107_V142_L1.1911.00
216_L240_I1.1871.00
336_V340_N1.1771.00
143_S172_T1.1651.00
139_S171_L1.1591.00
151_V166_L1.1561.00
78_Y309_P1.1521.00
85_I187_K1.1491.00
229_G279_I1.1471.00
163_V211_M1.1451.00
160_R164_E1.1441.00
353_C362_C1.1431.00
132_L136_E1.1431.00
88_F124_F1.1411.00
109_Y334_G1.1411.00
178_L216_L1.1371.00
207_E211_M1.1361.00
82_F197_T1.1291.00
337_K341_K1.1191.00
136_E168_P1.1191.00
162_I166_L1.1171.00
81_N127_E1.1171.00
163_V167_I1.1111.00
165_R168_P1.1051.00
161_K164_E1.0951.00
96_I310_E1.0921.00
344_W348_K1.0921.00
291_V294_L1.0911.00
111_R145_L1.0831.00
163_V204_N1.0811.00
129_I157_L1.0751.00
271_D274_V1.0731.00
106_F307_V1.0731.00
107_V121_V1.0681.00
139_S169_L1.0661.00
323_P326_V1.0651.00
76_L123_Y1.0611.00
342_S346_K1.0591.00
202_V206_K1.0531.00
86_Y188_R1.0531.00
279_I282_K1.0511.00
232_L236_K1.0511.00
74_L106_F1.0461.00
198_F202_V1.0441.00
235_L240_I1.0371.00
218_I231_L1.0341.00
81_N156_S1.0281.00
267_K271_D1.0231.00
86_Y179_D1.0191.00
185_H196_G1.0161.00
200_V204_N1.0151.00
319_F368_F1.0131.00
151_V174_V1.0091.00
374_G379_R1.0031.00
129_I204_N1.0031.00
137_E141_E1.0011.00
110_I121_V1.0011.00
175_Q217_R1.0011.00
295_G298_V0.9951.00
233_N236_K0.9911.00
351_D355_E0.9891.00
270_G274_V0.9871.00
135_I139_S0.9871.00
314_Y326_V0.9871.00
181_P230_E0.9741.00
139_S165_R0.9721.00
382_Y385_I0.9701.00
383_E386_V0.9701.00
208_I212_V0.9601.00
236_K283_Y0.9591.00
180_G189_R0.9591.00
209_Q239_G0.9551.00
85_I188_R0.9501.00
118_K146_K0.9481.00
132_L162_I0.9421.00
133_R137_E0.9381.00
379_R383_E0.9381.00
174_V212_V0.9351.00
105_G108_N0.9341.00
268_A271_D0.9291.00
177_T219_N0.9221.00
290_D297_C0.9211.00
185_H198_F0.9201.00
120_R150_S0.9201.00
382_Y386_V0.9151.00
204_N207_E0.9151.00
333_D338_V0.9141.00
120_R148_S0.9061.00
77_T97_S0.9061.00
205_L214_V0.9031.00
194_G197_T0.9021.00
342_S345_W0.9011.00
163_V174_V0.8971.00
123_Y142_L0.8911.00
138_I142_L0.8750.99
313_I335_S0.8670.99
156_S204_N0.8650.99
328_G333_D0.8620.99
139_S142_L0.8580.99
129_I162_I0.8540.99
226_N268_A0.8520.99
351_D354_R0.8510.99
185_H201_I0.8500.99
294_L298_V0.8500.99
367_K370_A0.8490.99
131_Q138_I0.8470.99
293_R297_C0.8440.99
276_F280_A0.8420.99
248_H254_V0.8410.99
158_L204_N0.8410.99
149_F171_L0.8370.99
189_R194_G0.8360.99
143_S149_F0.8340.99
353_C356_C0.8280.99
158_L208_I0.8240.99
350_E379_R0.8230.99
152_V217_R0.8190.99
158_L166_L0.8190.99
275_K279_I0.8140.99
75_V124_F0.8140.99
121_V149_F0.8110.99
124_F152_V0.8100.99
334_G338_V0.8070.99
205_L216_L0.8070.99
219_N248_H0.8060.99
307_V313_I0.8040.99
185_H189_R0.8030.99
103_T106_F0.8020.99
136_E140_R0.7880.99
343_L346_K0.7860.99
291_V295_G0.7840.99
81_N130_L0.7830.99
186_D189_R0.7820.99
124_F317_W0.7790.99
280_A283_Y0.7760.99
152_V317_W0.7760.99
327_K344_W0.7760.99
288_P294_L0.7740.99
293_R296_L0.7730.99
72_P307_V0.7730.99
100_D133_R0.7710.99
218_I235_L0.7700.99
123_Y138_I0.7700.99
221_D224_N0.7680.99
176_I208_I0.7680.99
158_L162_I0.7680.99
349_I359_L0.7670.99
216_L243_V0.7660.98
272_V280_A0.7640.98
76_L135_I0.7620.98
139_S149_F0.7610.98
76_L131_Q0.7590.98
288_P297_C0.7560.98
277_W280_A0.7540.98
163_V208_I0.7520.98
254_V257_N0.7490.98
127_E154_N0.7470.98
102_V106_F0.7420.98
186_D194_G0.7400.98
79_N95_N0.7400.98
107_V123_Y0.7360.98
295_G299_A0.7360.98
98_V106_F0.7300.98
100_D138_I0.7290.98
233_N283_Y0.7270.98
275_K278_E0.7240.98
77_T131_Q0.7230.98
217_R246_D0.7200.98
197_T201_I0.7190.98
159_T204_N0.7180.98
205_L238_E0.7170.98
160_R163_V0.7160.98
111_R147_Y0.7150.98
335_S338_V0.7150.98
217_R317_W0.7140.98
228_I275_K0.7100.98
376_D379_R0.7060.97
178_L198_F0.7060.97
205_L240_I0.7050.97
325_Y371_T0.7050.97
352_K380_E0.7040.97
290_D293_R0.7000.97
315_P325_Y0.6990.97
91_G253_N0.6980.97
103_T107_V0.6980.97
143_S168_P0.6950.97
291_V297_C0.6930.97
136_E161_K0.6910.97
225_L268_A0.6910.97
101_K105_G0.6910.97
142_L147_Y0.6890.97
180_G227_E0.6890.97
132_L165_R0.6880.97
278_E281_R0.6880.97
328_G338_V0.6860.97
189_R197_T0.6860.97
86_Y189_R0.6850.97
273_M277_W0.6840.97
305_I335_S0.6830.97
232_L283_Y0.6830.97
339_T348_K0.6820.97
289_Q297_C0.6800.97
162_I165_R0.6790.97
123_Y139_S0.6790.97
103_T131_Q0.6770.97
118_K148_S0.6710.97
214_V240_I0.6710.97
222_V265_S0.6670.96
75_V217_R0.6630.96
161_K165_R0.6620.96
122_T150_S0.6620.96
266_S270_G0.6620.96
127_E130_L0.6620.96
89_Q124_F0.6610.96
89_Q219_N0.6590.96
277_W281_R0.6570.96
209_Q214_V0.6560.96
75_V306_V0.6560.96
107_V147_Y0.6560.96
72_P305_I0.6540.96
228_I245_L0.6530.96
157_L204_N0.6520.96
100_D131_Q0.6510.96
76_L103_T0.6480.96
73_T317_W0.6460.96
208_I214_V0.6440.96
213_K241_N0.6410.96
127_E153_T0.6400.95
182_K196_G0.6370.95
294_L299_A0.6350.95
352_K379_R0.6340.95
381_A384_K0.6330.95
331_E334_G0.6330.95
199_D202_V0.6310.95
80_C87_C0.6290.95
365_G370_A0.6280.95
284_G287_V0.6270.95
333_D341_K0.6260.95
292_L298_V0.6240.95
109_Y336_V0.6210.95
209_Q241_N0.6200.95
315_P319_F0.6200.95
177_T301_S0.6190.95
196_G199_D0.6190.95
311_G329_K0.6170.95
356_C362_C0.6160.94
228_I272_V0.6120.94
86_Y124_F0.6120.94
176_I201_I0.6100.94
264_I268_A0.6100.94
163_V212_V0.6090.94
288_P291_V0.6080.94
246_D249_L0.6070.94
313_I333_D0.6070.94
209_Q240_I0.6070.94
278_E282_K0.6060.94
235_L243_V0.6050.94
371_T374_G0.6040.94
154_N157_L0.6040.94
73_T304_D0.5990.94
173_H215_V0.5980.94
135_I151_V0.5980.94
273_M276_F0.5970.93
104_R144_D0.5960.93
183_E227_E0.5960.93
73_T124_F0.5880.93
290_D295_G0.5880.93
231_L235_L0.5870.93
124_F217_R0.5870.93
167_I212_V0.5860.93
289_Q298_V0.5840.93
186_D198_F0.5840.93
292_L295_G0.5820.93
289_Q294_L0.5800.93
164_E167_I0.5800.93
86_Y219_N0.5800.93
73_T76_L0.5790.92
74_L138_I0.5780.92
345_W348_K0.5780.92
296_L299_A0.5770.92
183_E187_K0.5760.92
178_L202_V0.5750.92
127_E155_G0.5750.92
204_N208_I0.5750.92
209_Q238_E0.5730.92
80_C84_C0.5730.92
234_E237_M0.5730.92
105_G334_G0.5720.92
84_C87_C0.5710.92
156_S200_V0.5710.92
289_Q292_L0.5680.92
68_P117_R0.5660.92
136_E139_S0.5660.92
236_K279_I0.5650.92
103_T123_Y0.5640.91
75_V219_N0.5640.91
74_L86_Y0.5640.91
178_L201_I0.5610.91
311_G330_L0.5600.91
292_L296_L0.5590.91
152_V318_A0.5580.91
270_G273_M0.5560.91
129_I156_S0.5560.91
79_N92_F0.5550.91
326_V329_K0.5550.91
208_I211_M0.5550.91
293_R299_A0.5540.91
155_G205_L0.5530.91
89_Q317_W0.5530.91
180_G185_H0.5530.91
359_L363_M0.5520.91
293_R298_V0.5520.91
71_E122_T0.5460.90
136_E169_L0.5420.90
342_S348_K0.5420.90
124_F175_Q0.5420.90
232_L243_V0.5390.90
109_Y335_S0.5390.90
200_V207_E0.5360.89
143_S170_G0.5360.89
86_Y89_Q0.5360.89
131_Q135_I0.5350.89
73_T122_T0.5340.89
228_I232_L0.5330.89
257_N261_D0.5330.89
88_F246_D0.5320.89
291_V296_L0.5310.89
153_T176_I0.5290.89
307_V330_L0.5280.89
107_V111_R0.5280.89
292_L297_C0.5270.88
261_D264_I0.5250.88
175_Q215_V0.5230.88
305_I339_T0.5230.88
248_H251_H0.5230.88
75_V78_Y0.5220.88
262_F266_S0.5210.88
98_V331_E0.5210.88
122_T152_V0.5200.88
315_P327_K0.5200.88
179_D185_H0.5190.88
352_K355_E0.5180.88
288_P292_L0.5180.88
138_I141_E0.5170.88
306_V317_W0.5150.87
115_K336_V0.5100.87
248_H252_S0.5100.87
75_V309_P0.5080.87
102_V109_Y0.5080.87
276_F279_I0.5060.86
288_P295_G0.5050.86
252_S255_F0.5040.86
291_V298_V0.5030.86
86_Y149_F0.5030.86
89_Q306_V0.5020.86
181_P234_E0.5010.86
103_T141_E0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k36A 1 0.8173 100 0.356 Contact Map
4m7tA 1 0.5863 100 0.542 Contact Map
1tv8A 2 0.7183 100 0.552 Contact Map
4rtbA 2 0.8807 100 0.6 Contact Map
4wcxA 1 0.9492 100 0.641 Contact Map
3c8fA 1 0.5787 100 0.645 Contact Map
2yx0A 1 0.7335 99.9 0.671 Contact Map
2z2uA 1 0.6168 99.9 0.684 Contact Map
2qgqA 1 0.5964 99.9 0.685 Contact Map
3rfaA 1 0.7716 99.9 0.697 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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