GREMLIN Database
Q97XZ1 - Uncharacterized protein
UniProt: Q97XZ1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 233 (181)
Sequences: 14127 (10561)
Seq/√Len: 785.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
163_V172_A4.3951.00
41_G71_S3.9931.00
72_D98_Y3.1731.00
75_I86_A3.0751.00
74_V173_L2.5941.00
101_V150_K2.4271.00
43_M72_D2.3311.00
160_V171_I2.2961.00
35_E42_L2.2751.00
202_N205_L2.2131.00
45_I76_T2.2031.00
57_E92_I2.1881.00
32_S222_I2.1341.00
96_K147_F2.1281.00
98_Y147_F2.1181.00
154_D157_G2.0991.00
160_V173_L2.0911.00
177_K219_T2.0261.00
72_D96_K1.9971.00
42_L65_Y1.9291.00
100_H171_I1.9261.00
178_C222_I1.9231.00
154_D159_R1.9121.00
100_H162_H1.8511.00
103_E169_G1.7891.00
159_R174_F1.7331.00
151_G212_Y1.7301.00
174_F177_K1.6911.00
172_A179_L1.6871.00
150_K153_E1.6771.00
32_S180_V1.6231.00
174_F179_L1.6091.00
161_I174_F1.5871.00
59_Y63_W1.5721.00
170_H182_G1.5681.00
37_G40_G1.5631.00
35_E65_Y1.5631.00
41_G72_D1.5451.00
104_L108_E1.5391.00
45_I180_V1.5311.00
42_L70_I1.5241.00
57_E61_K1.5101.00
59_Y62_A1.5021.00
90_K146_D1.4521.00
98_Y149_L1.4491.00
88_A92_I1.4391.00
192_L195_P1.4371.00
70_I95_A1.4241.00
205_L208_N1.3871.00
212_Y215_S1.3571.00
87_M91_R1.3491.00
99_A103_E1.3121.00
104_L148_A1.3091.00
101_V148_A1.3081.00
53_L88_A1.2811.00
43_M74_V1.2601.00
41_G66_S1.2571.00
163_V209_S1.2351.00
44_M70_I1.2301.00
45_I173_L1.2231.00
42_L71_S1.1991.00
149_L171_I1.1891.00
86_A97_I1.1831.00
47_T73_I1.1801.00
220_V228_I1.1781.00
172_A213_L1.1751.00
207_V211_N1.1701.00
76_T182_G1.1671.00
184_A213_L1.1391.00
181_V221_L1.1351.00
163_V170_H1.1301.00
58_S61_K1.1291.00
103_E167_T1.1271.00
161_I212_Y1.1271.00
58_S62_A1.1261.00
147_F153_E1.1081.00
54_D58_S1.0891.00
53_L57_E1.0771.00
87_M90_K1.0771.00
47_T86_A1.0771.00
152_G159_R1.0701.00
102_D162_H1.0651.00
204_E208_N1.0561.00
211_N215_S1.0431.00
33_V42_L1.0431.00
43_M158_F1.0351.00
203_Y207_V1.0331.00
37_G41_G1.0311.00
221_L229_V1.0261.00
34_I45_I1.0211.00
167_T170_H1.0141.00
90_K97_I1.0131.00
165_G209_S1.0121.00
61_K92_I1.0111.00
172_A184_A1.0071.00
35_E59_Y0.9841.00
44_M47_T0.9801.00
206_A210_F0.9701.00
178_C220_V0.9691.00
53_L85_N0.9681.00
102_D105_G0.9621.00
76_T173_L0.9451.00
78_W99_A0.9451.00
151_G162_H0.9361.00
174_F219_T0.9341.00
174_F216_L0.9321.00
45_I74_V0.9191.00
210_F214_I0.9081.00
57_E93_S0.9061.00
55_Q59_Y0.9041.00
75_I97_I0.9001.00
31_I56_I0.8951.00
78_W103_E0.8951.00
60_L70_I0.8861.00
187_N227_D0.8791.00
156_G176_G0.8781.00
101_V105_G0.8751.00
73_I86_A0.8751.00
211_N214_I0.8751.00
161_I172_A0.8711.00
174_F218_Y0.8661.00
36_N156_G0.8641.00
36_N40_G0.8631.00
73_I95_A0.8621.00
105_G109_N0.8611.00
74_V171_I0.8561.00
212_Y216_L0.8551.00
103_E106_D0.8531.00
164_P209_S0.8491.00
208_N211_N0.8481.00
159_R216_L0.8471.00
143_V146_D0.8451.00
32_S224_F0.8301.00
29_H48_G0.8241.00
101_V104_L0.8231.00
109_N112_K0.8151.00
35_E63_W0.8131.00
149_L155_L0.8111.00
157_G175_D0.8101.00
33_V44_M0.8091.00
163_V184_A0.8061.00
179_L221_L0.8031.00
149_L153_E0.7991.00
168_K205_L0.7971.00
30_N226_G0.7851.00
71_S96_K0.7851.00
36_N41_G0.7841.00
199_F202_N0.7811.00
73_I97_I0.7761.00
70_I93_S0.7751.00
184_A206_A0.7751.00
198_I201_W0.7731.00
179_L216_L0.7731.00
44_M56_I0.7711.00
203_Y206_A0.7711.00
74_V158_F0.7591.00
110_P113_Y0.7591.00
85_N88_A0.7461.00
55_Q58_S0.7461.00
42_L60_L0.7451.00
54_D57_E0.7421.00
44_M60_L0.7391.00
181_V185_V0.7321.00
105_G108_E0.7291.00
99_A107_L0.7141.00
112_K115_T0.7131.00
75_I83_A0.7071.00
113_Y116_I0.7041.00
139_H143_V0.6941.00
170_H184_A0.6901.00
96_K146_D0.6851.00
184_A209_S0.6831.00
178_C181_V0.6831.00
31_I47_T0.6811.00
175_D178_C0.6811.00
158_F173_L0.6791.00
89_I92_I0.6791.00
223_P226_G0.6781.00
52_Y55_Q0.6771.00
35_E40_G0.6751.00
61_K64_G0.6731.00
72_D147_F0.6711.00
100_H103_E0.6701.00
88_A91_R0.6691.00
149_L173_L0.6661.00
36_N43_M0.6621.00
187_N229_V0.6621.00
30_N224_F0.6611.00
60_L65_Y0.6611.00
109_N113_Y0.6611.00
99_A104_L0.6591.00
161_I216_L0.6561.00
111_P114_S0.6551.00
91_R141_E0.6551.00
200_S203_Y0.6521.00
135_I138_L0.6491.00
40_G64_G0.6491.00
33_V59_Y0.6481.00
222_I228_I0.6461.00
151_G155_L0.6441.00
149_L160_V0.6421.00
138_L142_P0.6371.00
180_V222_I0.6351.00
108_E144_K0.6341.00
200_S206_A0.6231.00
33_V70_I0.6221.00
73_I89_I0.6221.00
161_I179_L0.6201.00
56_I85_N0.6191.00
83_A86_A0.6181.00
33_V65_Y0.6181.00
47_T85_N0.6181.00
50_P85_N0.6151.00
221_L225_H0.6121.00
149_L152_G0.6121.00
104_L107_L0.6011.00
218_Y221_L0.5991.00
145_V148_A0.5961.00
36_N42_L0.5961.00
172_A209_S0.5961.00
106_D168_K0.5961.00
86_A90_K0.5941.00
66_S71_S0.5891.00
208_N212_Y0.5881.00
27_L80_H0.5871.00
34_I43_M0.5871.00
78_W83_A0.5861.00
31_I48_G0.5791.00
106_D109_N0.5781.00
57_E88_A0.5771.00
144_K148_A0.5771.00
181_V223_P0.5741.00
50_P84_G0.5661.00
174_F217_P0.5661.00
177_K217_P0.5621.00
103_E107_L0.5611.00
181_V184_A0.5601.00
139_H142_P0.5591.00
93_S96_K0.5591.00
61_K66_S0.5561.00
136_N139_H0.5541.00
153_E160_V0.5531.00
142_P145_V0.5531.00
87_M141_E0.5521.00
29_H32_S0.5471.00
48_G56_I0.5471.00
90_K94_D0.5461.00
53_L92_I0.5461.00
99_A148_A0.5441.00
152_G212_Y0.5391.00
213_L216_L0.5381.00
107_L110_P0.5371.00
207_V214_I0.5351.00
162_H171_I0.5331.00
80_H84_G0.5321.00
150_K162_H0.5311.00
147_F150_K0.5301.00
110_P114_S0.5271.00
102_D169_G0.5221.00
33_V60_L0.5211.00
168_K200_S0.5191.00
66_S70_I0.5171.00
106_D111_P0.5171.00
195_P206_A0.5151.00
102_D168_K0.5151.00
44_M89_I0.5111.00
185_V221_L0.5101.00
34_I158_F0.5081.00
197_R200_S0.5061.00
140_Y144_K0.5031.00
77_H183_D0.5011.00
23_F26_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zo4A 1 0.9185 100 0.343 Contact Map
3aj3A 2 0.9485 100 0.387 Contact Map
2fhxA 2 0.9185 100 0.392 Contact Map
1k07A 1 0.8927 100 0.393 Contact Map
2vw8A 2 0.9485 100 0.397 Contact Map
2yheA 3 0.9828 100 0.404 Contact Map
3m8tA 1 0.8884 100 0.406 Contact Map
2zwrA 1 0.8112 100 0.412 Contact Map
1smlA 1 0.9013 100 0.412 Contact Map
4yslA 2 0.8627 100 0.415 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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