GREMLIN Database
Q97XY5 - Uncharacterized protein
UniProt: Q97XY5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 127 (108)
Sequences: 292 (222)
Seq/√Len: 21.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_K105_E3.5141.00
70_C104_L2.9940.99
63_V97_I2.9010.99
42_R108_C2.5550.98
23_K50_G2.5230.98
8_N11_E2.4030.97
30_L43_K2.3530.97
24_N47_L2.2950.96
69_K82_R2.2160.95
69_K80_E2.0720.93
71_K80_E2.0630.93
43_K105_E2.0380.93
52_I96_A1.9450.91
47_L103_Q1.8920.90
71_K78_V1.8710.89
39_Y60_Q1.8710.89
41_V109_I1.8660.89
32_T40_A1.8590.89
81_L104_L1.8580.89
14_M28_Q1.8530.89
44_F106_F1.6680.83
71_K98_I1.5940.80
44_F108_C1.5920.80
29_W40_A1.5260.77
73_C96_A1.5050.76
37_A62_T1.4800.75
12_V86_Y1.4590.73
46_L50_G1.4480.73
47_L86_Y1.4200.71
38_N41_V1.3460.67
66_T101_G1.3350.67
7_S86_Y1.3090.65
52_I63_V1.2730.63
40_A55_H1.2370.60
74_V79_Y1.2360.60
27_I110_I1.2330.60
45_T105_E1.2310.60
48_K99_N1.2160.59
7_S10_K1.2120.59
36_G84_G1.1800.57
52_I97_I1.1790.57
71_K100_E1.1460.55
28_Q45_T1.1420.54
17_V22_S1.1340.54
20_N69_K1.1020.52
58_K92_N1.0960.51
13_K98_I1.0750.50
42_R95_H1.0690.49
50_G104_L1.0580.49
95_H108_C1.0290.47
41_V62_T1.0190.46
67_K83_E1.0170.46
76_D107_F1.0130.46
51_I96_A1.0030.45
25_A46_L1.0020.45
42_R110_I1.0000.45
59_Y85_D0.9980.45
45_T100_E0.9870.44
80_E100_E0.9820.44
61_E111_D0.9810.44
74_V93_V0.9720.43
29_W110_I0.9570.42
72_V106_F0.9550.42
38_N62_T0.9250.40
57_H70_C0.9220.40
26_F65_V0.9210.40
25_A109_I0.8790.37
53_P56_I0.8770.37
6_V78_V0.8760.37
43_K67_K0.8640.36
41_V111_D0.8600.36
62_T111_D0.8580.36
46_L107_F0.8480.35
6_V103_Q0.8440.35
22_S105_E0.8220.33
110_I114_D0.8160.33
7_S45_T0.8110.33
57_H63_V0.7970.32
83_E91_S0.7950.32
40_A114_D0.7950.32
17_V99_N0.7900.32
32_T35_N0.7890.32
60_Q109_I0.7890.32
44_F97_I0.7750.31
92_N111_D0.7690.30
31_V77_K0.7660.30
46_L105_E0.7640.30
43_K64_I0.7560.30
21_G29_W0.7530.29
42_R106_F0.7500.29
46_L91_S0.7500.29
39_Y62_T0.7480.29
67_K103_Q0.7460.29
25_A80_E0.7460.29
17_V20_N0.7460.29
61_E108_C0.7420.29
41_V64_I0.7270.28
56_I66_T0.7240.28
16_R66_T0.7190.28
56_I92_N0.7060.27
45_T70_C0.6930.26
46_L114_D0.6850.26
45_T103_Q0.6820.26
90_N93_V0.6800.26
81_L84_G0.6750.25
7_S12_V0.6750.25
106_F110_I0.6680.25
55_H105_E0.6630.25
49_D81_L0.6560.24
63_V96_A0.6380.24
25_A52_I0.6360.23
72_V87_I0.6350.23
13_K102_D0.6290.23
23_K77_K0.6280.23
29_W32_T0.6220.23
88_F112_Y0.6190.23
14_M69_K0.6180.23
21_G57_H0.6160.22
13_K82_R0.6150.22
38_N60_Q0.6140.22
36_G88_F0.6120.22
49_D61_E0.6090.22
95_H106_F0.6060.22
27_I44_F0.6050.22
30_L115_D0.6050.22
10_K24_N0.6040.22
52_I57_H0.5940.21
55_H111_D0.5830.21
70_C109_I0.5810.21
31_V86_Y0.5800.21
8_N107_F0.5770.21
37_A111_D0.5740.21
48_K113_S0.5660.20
17_V78_V0.5650.20
87_I97_I0.5640.20
17_V55_H0.5620.20
37_A88_F0.5610.20
38_N63_V0.5570.20
40_A112_Y0.5550.20
54_M96_A0.5550.20
55_H95_H0.5530.20
20_N83_E0.5510.20
55_H114_D0.5410.19
8_N83_E0.5360.19
37_A104_L0.5350.19
57_H68_G0.5350.19
33_K88_F0.5330.19
49_D56_I0.5320.19
11_E76_D0.5320.19
16_R103_Q0.5280.19
21_G36_G0.5260.19
9_V70_C0.5240.18
13_K16_R0.5240.18
60_Q111_D0.5170.18
22_S99_N0.5150.18
26_F52_I0.5130.18
79_Y89_I0.5090.18
74_V90_N0.5060.18
32_T86_Y0.5050.18
24_N92_N0.5040.18
91_S103_Q0.5020.18
17_V44_F0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vj2A 2 0.8819 99.8 0.598 Contact Map
3ibmA 2 0.9528 99.8 0.608 Contact Map
1sfnA 5 0.9055 99.8 0.611 Contact Map
3jzvA 5 0.9606 99.8 0.616 Contact Map
3ht1A 2 0.9843 99.8 0.623 Contact Map
1rc6A 4 0.8425 99.8 0.624 Contact Map
3kgzA 2 0.9921 99.8 0.624 Contact Map
1sefA 5 0.9134 99.8 0.628 Contact Map
4uxaA 6 0.9764 99.7 0.632 Contact Map
4bifA 4 0.9685 99.7 0.636 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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