GREMLIN Database
Q97XY4 - Nitric oxide reductase, subunit I (Cytochrome B) (NorB-1)
UniProt: Q97XY4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 534 (445)
Sequences: 5367 (1924)
Seq/√Len: 91.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_F157_G4.5671.00
467_L504_R4.2931.00
186_F189_Q3.6471.00
183_W188_A3.6411.00
185_I188_A3.6111.00
183_W186_F3.4481.00
372_L449_L3.4121.00
182_Y188_A3.4111.00
462_L507_G3.4091.00
182_Y186_F3.2871.00
289_L429_L3.2681.00
185_I189_Q3.1981.00
80_A131_T3.1761.00
182_Y185_I3.1741.00
83_L163_G3.1601.00
396_L411_T3.1591.00
182_Y189_Q3.0361.00
435_L525_G3.0051.00
183_W189_Q2.9901.00
229_P232_R2.7791.00
372_L446_L2.7771.00
239_L308_D2.7231.00
282_V426_T2.7161.00
455_I514_A2.7151.00
294_N359_W2.6501.00
242_G312_E2.6271.00
191_R194_D2.6151.00
301_A305_A2.4901.00
220_S241_S2.4411.00
184_F188_A2.4341.00
432_I452_M2.4321.00
90_L116_T2.3911.00
455_I517_V2.3751.00
235_A298_P2.3441.00
285_V430_M2.3201.00
184_F189_Q2.2951.00
108_I116_T2.1991.00
140_L220_S2.1401.00
417_L461_I2.1391.00
447_K451_I2.1101.00
74_L138_F2.1061.00
181_P185_I2.1041.00
448_T520_I2.0121.00
293_N433_A1.9961.00
451_I517_V1.9771.00
498_N502_W1.9641.00
459_G510_V1.9591.00
127_W424_G1.9581.00
428_I518_I1.9431.00
445_E524_K1.9371.00
62_P71_R1.8891.00
221_K230_L1.8851.00
452_M456_Y1.8651.00
452_M518_I1.8561.00
359_W374_A1.8431.00
96_H509_I1.8301.00
345_V393_A1.8041.00
314_L344_E1.7761.00
292_V433_A1.7631.00
230_L233_I1.7591.00
477_T480_R1.7511.00
326_F406_H1.7451.00
190_G194_D1.7381.00
376_T452_M1.7371.00
446_L450_R1.7331.00
181_P187_G1.7261.00
524_K528_K1.7181.00
455_I513_F1.7031.00
77_V134_A1.6831.00
401_I405_V1.6661.00
509_I513_F1.6491.00
295_L369_Q1.6301.00
182_Y187_G1.6251.00
465_I469_A1.6211.00
506_V510_V1.5881.00
431_W518_I1.5861.00
180_S183_W1.5841.00
462_L503_L1.5821.00
122_N198_G1.5751.00
520_I524_K1.5641.00
181_P186_F1.5641.00
111_L115_I1.5631.00
377_L429_L1.5591.00
379_S457_A1.5391.00
102_E482_G1.5291.00
477_T483_Y1.5181.00
87_Q123_M1.5111.00
459_G507_G1.5031.00
448_T451_I1.4921.00
448_T517_V1.4771.00
270_I273_F1.4741.00
452_M514_A1.4671.00
242_G309_S1.4621.00
379_S453_I1.4581.00
432_I449_L1.4200.99
269_M273_F1.4140.99
86_I123_M1.4030.99
250_L316_G1.4000.99
456_Y514_A1.3940.99
469_A500_I1.3930.99
441_I529_S1.3890.99
202_L258_N1.3870.99
523_L527_I1.3860.99
101_P498_N1.3820.99
290_L381_I1.3790.99
479_L482_G1.3780.99
110_F481_V1.3770.99
516_T520_I1.3750.99
92_Y512_G1.3740.99
122_N184_F1.3710.99
413_A468_W1.3440.99
278_W419_F1.3410.99
75_I154_A1.3370.99
520_I523_L1.3360.99
267_W270_I1.3310.99
181_P184_F1.3220.99
263_Q407_G1.3180.99
279_P283_I1.3130.99
376_T428_I1.3100.99
291_V298_P1.3040.99
506_V509_I1.3030.99
184_F262_D1.3030.99
479_L483_Y1.3000.99
247_F251_P1.2950.99
181_P188_A1.2930.99
79_F160_L1.2930.99
179_P182_Y1.2880.99
137_I215_L1.2830.99
162_A204_L1.2750.99
327_G407_G1.2750.99
375_T453_I1.2740.99
477_T482_G1.2680.99
93_L108_I1.2650.99
179_P185_I1.2640.99
447_K450_R1.2640.99
293_N373_V1.2590.99
180_S195_A1.2590.99
477_T481_V1.2480.98
452_M521_Y1.2440.98
524_K530_Y1.2440.98
283_I348_I1.2430.98
93_L116_T1.2410.98
154_A158_L1.2320.98
287_L355_A1.2320.98
452_M515_A1.2310.98
217_F241_S1.2280.98
146_P149_R1.2270.98
359_W378_I1.2240.98
151_L155_I1.2220.98
220_S237_G1.2200.98
145_V149_R1.2160.98
152_S211_L1.2120.98
480_R483_Y1.2080.98
338_A399_P1.2060.98
285_V289_L1.2050.98
463_Q508_D1.2000.98
179_P186_F1.1990.98
228_R234_T1.1880.98
183_W187_G1.1870.98
166_L201_W1.1870.98
428_I452_M1.1870.98
179_P183_W1.1800.98
499_L503_L1.1800.98
94_A116_T1.1790.98
467_L470_L1.1780.98
85_G519_I1.1690.98
72_I153_F1.1670.98
304_A308_D1.1630.98
155_I159_T1.1520.97
180_S185_I1.1510.97
180_S189_Q1.1500.97
221_K245_A1.1460.97
388_A418_A1.1440.97
149_R218_K1.1340.97
395_I410_F1.1320.97
470_L500_I1.1300.97
179_P184_F1.1180.97
242_G308_D1.1160.97
155_I211_L1.1160.97
396_L405_V1.1120.97
147_L150_K1.1040.97
341_A397_N1.1020.97
181_P189_Q1.1010.97
402_N411_T1.1000.97
236_I240_G1.0980.96
289_L430_M1.0970.96
127_W131_T1.0950.96
215_L219_A1.0910.96
78_F82_V1.0860.96
89_L93_L1.0810.96
441_I525_G1.0800.96
99_V502_W1.0750.96
426_T429_L1.0690.96
376_T380_A1.0690.96
123_M167_L1.0660.96
143_L237_G1.0650.96
289_L377_L1.0640.96
463_Q511_A1.0630.96
92_Y508_D1.0610.96
228_R233_I1.0600.96
435_L522_T1.0560.96
112_P116_T1.0540.96
97_Y102_E1.0530.96
461_I465_I1.0520.96
421_L460_F1.0520.96
86_I90_L1.0510.96
220_S233_I1.0470.95
97_Y104_I1.0420.95
61_V65_P1.0400.95
459_G514_A1.0370.95
289_L373_V1.0360.95
210_L214_S1.0330.95
132_W427_A1.0320.95
77_V131_T1.0310.95
242_G245_A1.0300.95
221_K241_S1.0290.95
75_I157_G1.0250.95
286_V290_L1.0180.95
456_Y515_A1.0180.95
251_P255_P1.0100.94
253_I268_I1.0080.94
84_A91_G1.0070.94
139_A438_S1.0050.94
178_I184_F1.0040.94
452_M517_V1.0020.94
359_W368_F1.0010.94
81_S85_G0.9990.94
298_P301_A0.9980.94
85_G89_L0.9970.94
150_K215_L0.9960.94
140_L237_G0.9940.94
96_H105_L0.9940.94
84_A127_W0.9920.94
413_A467_L0.9880.94
243_I277_F0.9870.94
68_A71_R0.9860.94
431_W522_T0.9860.94
502_W506_V0.9850.94
341_A396_L0.9750.93
137_I153_F0.9670.93
87_Q124_A0.9620.93
178_I198_G0.9620.93
291_V297_P0.9610.93
368_F374_A0.9590.93
519_I523_L0.9500.92
342_I397_N0.9440.92
322_H414_H0.9410.92
119_L170_I0.9400.92
517_V520_I0.9400.92
311_S351_L0.9390.92
305_A308_D0.9390.92
140_L240_G0.9370.92
436_Y443_E0.9350.92
156_L211_L0.9320.92
456_Y511_A0.9290.92
203_L259_F0.9280.91
287_L351_L0.9250.91
86_I167_L0.9240.91
417_L465_I0.9180.91
140_L144_G0.9140.91
304_A307_I0.9130.91
136_S240_G0.9100.91
66_P71_R0.9090.91
88_G91_G0.9070.91
180_S184_F0.9050.90
449_L521_Y0.9010.90
97_Y482_G0.8910.90
125_V278_W0.8870.90
216_F240_G0.8860.89
384_G461_I0.8810.89
271_H274_V0.8800.89
92_Y505_I0.8770.89
128_I423_W0.8760.89
391_G468_W0.8720.89
286_V426_T0.8710.89
462_L510_V0.8710.89
128_I424_G0.8700.89
285_V434_A0.8700.89
293_N374_A0.8700.89
179_P189_Q0.8690.89
276_G281_I0.8690.89
227_L232_R0.8670.88
326_F403_Y0.8660.88
146_P150_K0.8650.88
162_A201_W0.8640.88
191_R262_D0.8600.88
84_A87_Q0.8600.88
79_F163_G0.8590.88
250_L277_F0.8550.88
202_L205_V0.8540.88
71_R75_I0.8510.88
512_G516_T0.8490.87
213_S244_G0.8480.87
278_W423_W0.8480.87
279_P423_W0.8470.87
136_S216_F0.8470.87
178_I182_Y0.8460.87
417_L468_W0.8450.87
100_D103_G0.8450.87
521_Y525_G0.8430.87
441_I528_K0.8420.87
371_T450_R0.8420.87
123_M163_G0.8390.87
180_S186_F0.8370.87
145_V148_S0.8360.87
409_Q475_L0.8360.87
216_F220_S0.8350.87
79_F83_L0.8310.86
481_V484_W0.8280.86
213_S248_G0.8240.86
475_L501_V0.8240.86
63_L75_I0.8210.86
428_I515_A0.8190.85
74_L438_S0.8190.85
271_H322_H0.8180.85
145_V150_K0.8170.85
286_V377_L0.8130.85
390_I393_A0.8120.85
133_I213_S0.8110.85
184_F191_R0.8100.85
466_D500_I0.8090.85
135_F285_V0.8080.85
290_L359_W0.8070.85
524_K527_I0.8070.85
137_I156_L0.8060.85
451_I455_I0.8030.84
325_Y338_A0.8000.84
273_F278_W0.8000.84
178_I183_W0.7940.84
162_A205_V0.7920.83
283_I355_A0.7910.83
122_N166_L0.7900.83
156_L215_L0.7890.83
231_T306_S0.7880.83
375_T450_R0.7860.83
413_A466_D0.7860.83
271_H416_H0.7850.83
168_L197_Q0.7810.83
390_I421_L0.7810.83
432_I521_Y0.7810.83
144_G233_I0.7800.83
242_G314_L0.7780.82
139_A433_A0.7780.82
456_Y523_L0.7770.82
179_P188_A0.7770.82
180_S188_A0.7760.82
266_L274_V0.7750.82
359_W362_G0.7740.82
86_I163_G0.7740.82
217_F245_A0.7730.82
66_P154_A0.7720.82
128_I278_W0.7700.82
233_I237_G0.7690.82
423_W427_A0.7670.81
109_N112_P0.7660.81
159_T204_L0.7650.81
203_L258_N0.7630.81
224_A227_L0.7620.81
133_I138_F0.7610.81
523_L528_K0.7600.81
405_V411_T0.7600.81
370_K374_A0.7600.81
435_L444_N0.7560.81
230_L241_S0.7560.81
286_V380_A0.7550.80
144_G237_G0.7530.80
225_E228_R0.7520.80
70_Q437_L0.7510.80
63_L71_R0.7480.80
225_E513_F0.7470.80
170_I173_S0.7470.80
85_G441_I0.7460.80
446_L449_L0.7450.80
169_G178_I0.7450.80
131_T427_A0.7450.80
139_A143_L0.7450.80
279_P422_V0.7410.79
375_T454_L0.7390.79
88_G515_A0.7380.79
73_G134_A0.7380.79
443_E449_L0.7370.79
435_L439_N0.7370.79
98_Y501_V0.7360.79
92_Y96_H0.7360.79
271_H414_H0.7350.79
428_I432_I0.7280.78
297_P302_T0.7270.78
79_F82_V0.7250.78
274_V281_I0.7250.78
93_L104_I0.7230.78
72_I75_I0.7220.77
439_N525_G0.7220.77
207_L211_L0.7210.77
82_V85_G0.7180.77
458_I516_T0.7170.77
269_M278_W0.7150.77
375_T379_S0.7140.77
63_L66_P0.7110.76
441_I526_V0.7100.76
119_L178_I0.7090.76
348_I351_L0.7080.76
91_G421_L0.7070.76
435_L526_V0.7070.76
120_H416_H0.7070.76
443_E525_G0.7050.76
293_N371_T0.7020.75
132_W282_V0.7020.75
338_A398_A0.7000.75
235_A304_A0.6990.75
85_G516_T0.6980.75
234_T237_G0.6950.75
351_L355_A0.6930.75
129_A269_M0.6930.75
469_A473_V0.6910.74
257_P262_D0.6900.74
186_F190_G0.6890.74
272_S276_G0.6880.74
96_H100_D0.6880.74
167_L170_I0.6870.74
186_F200_F0.6870.74
445_E520_I0.6850.74
96_H505_I0.6840.74
181_P190_G0.6830.73
184_F190_G0.6830.73
165_G204_L0.6820.73
129_A277_F0.6820.73
267_W274_V0.6800.73
113_F117_R0.6780.73
446_L451_I0.6760.73
209_L247_F0.6760.73
135_F430_M0.6750.73
321_A329_E0.6750.73
150_K218_K0.6720.72
80_A127_W0.6720.72
178_I186_F0.6710.72
177_L184_F0.6700.72
98_Y409_Q0.6690.72
460_F511_A0.6680.72
444_N449_L0.6670.72
77_V438_S0.6660.72
62_P66_P0.6660.72
143_L288_I0.6650.71
372_L450_R0.6640.71
158_L161_F0.6640.71
382_G385_F0.6630.71
382_G387_G0.6620.71
505_I509_I0.6620.71
105_L108_I0.6610.71
72_I154_A0.6610.71
74_L78_F0.6590.71
89_L164_V0.6580.71
138_F340_A0.6560.70
129_A270_I0.6560.70
177_L182_Y0.6550.70
122_N262_D0.6540.70
451_I520_I0.6530.70
427_A431_W0.6530.70
428_I456_Y0.6510.70
121_L415_A0.6510.70
224_A228_R0.6500.70
80_A134_A0.6490.70
168_L172_L0.6480.69
184_F187_G0.6480.69
183_W190_G0.6470.69
454_L458_I0.6470.69
372_L375_T0.6460.69
419_F423_W0.6410.69
526_V530_Y0.6400.69
270_I278_W0.6400.69
100_D502_W0.6360.68
203_L251_P0.6350.68
409_Q501_V0.6350.68
501_V505_I0.6320.68
125_V277_F0.6310.67
76_G215_L0.6310.67
97_Y103_G0.6310.67
425_L453_I0.6290.67
302_T306_S0.6290.67
249_S316_G0.6280.67
151_L154_A0.6270.67
260_T327_G0.6240.67
292_V295_L0.6240.67
161_F204_L0.6210.66
188_A191_R0.6180.66
406_H414_H0.6180.66
338_A504_R0.6170.66
82_V164_V0.6170.66
149_R219_A0.6140.65
203_L207_L0.6130.65
180_S187_G0.6120.65
458_I510_V0.6120.65
345_V351_L0.6110.65
92_Y509_I0.6080.65
147_L153_F0.6080.65
234_T238_L0.6080.65
76_G208_I0.6080.65
103_G370_K0.6070.64
279_P418_A0.6070.64
444_N529_S0.6060.64
352_T381_I0.6060.64
90_L93_L0.6060.64
376_T432_I0.6050.64
526_V529_S0.6050.64
445_E451_I0.6040.64
372_L376_T0.6040.64
82_V204_L0.6030.64
108_I112_P0.6020.64
164_V168_L0.6010.64
104_I482_G0.5980.63
147_L151_L0.5980.63
128_I132_W0.5960.63
90_L167_L0.5960.63
371_T446_L0.5960.63
299_S358_L0.5960.63
131_T428_I0.5950.63
115_I173_S0.5950.63
385_F422_V0.5940.63
138_F438_S0.5940.63
279_P315_S0.5900.62
183_W266_L0.5900.62
323_H414_H0.5890.62
379_S425_L0.5890.62
307_I310_A0.5890.62
424_G438_S0.5880.62
374_A377_L0.5880.62
182_Y190_G0.5870.62
517_V521_Y0.5860.62
187_G262_D0.5860.62
283_I351_L0.5840.62
81_S522_T0.5830.61
127_W431_W0.5830.61
445_E525_G0.5820.61
462_L466_D0.5800.61
221_K237_G0.5800.61
132_W423_W0.5800.61
304_A354_Y0.5790.61
129_A247_F0.5770.61
95_M98_Y0.5760.60
381_I384_G0.5740.60
120_H271_H0.5740.60
148_S212_A0.5730.60
283_I349_L0.5730.60
248_G252_I0.5720.60
373_V433_A0.5720.60
266_L276_G0.5710.60
310_A347_P0.5700.60
81_S519_I0.5690.60
458_I462_L0.5690.60
95_M505_I0.5680.59
315_S407_G0.5680.59
87_Q125_V0.5670.59
134_A200_F0.5670.59
179_P187_G0.5660.59
264_F468_W0.5660.59
91_G420_P0.5660.59
126_V269_M0.5660.59
334_M338_A0.5640.59
199_T262_D0.5640.59
165_G197_Q0.5620.59
129_A273_F0.5610.58
233_I241_S0.5610.58
217_F237_G0.5590.58
94_A117_R0.5590.58
94_A278_W0.5590.58
64_P395_I0.5580.58
398_A401_I0.5570.58
406_H416_H0.5540.58
272_S281_I0.5540.58
455_I510_V0.5540.58
513_F517_V0.5540.58
351_L354_Y0.5530.57
93_L97_Y0.5510.57
278_W305_A0.5510.57
237_G241_S0.5510.57
330_P334_M0.5490.57
251_P273_F0.5490.57
88_G512_G0.5480.57
276_G389_I0.5480.57
120_H414_H0.5470.57
376_T453_I0.5450.56
205_V251_P0.5450.56
346_V382_G0.5440.56
92_Y105_L0.5430.56
462_L506_V0.5420.56
375_T380_A0.5400.56
141_P219_A0.5390.55
346_V350_F0.5390.55
402_N406_H0.5380.55
445_E448_T0.5370.55
242_G269_M0.5370.55
391_G413_A0.5360.55
203_L255_P0.5350.55
395_I401_I0.5350.55
299_S354_Y0.5350.55
67_S154_A0.5350.55
137_I346_V0.5340.55
439_N443_E0.5340.55
224_A232_R0.5330.55
145_V151_L0.5310.54
83_L87_Q0.5310.54
96_H452_M0.5310.54
455_I520_I0.5310.54
228_R231_T0.5300.54
313_I317_M0.5300.54
336_L340_A0.5300.54
82_V86_I0.5300.54
267_W271_H0.5300.54
355_A380_A0.5290.54
237_G522_T0.5290.54
473_V500_I0.5290.54
185_I190_G0.5280.54
474_Q497_L0.5270.54
290_L395_I0.5260.54
161_F164_V0.5250.54
217_F248_G0.5240.53
206_A255_P0.5240.53
279_P287_L0.5240.53
165_G201_W0.5230.53
239_L280_S0.5230.53
294_N374_A0.5220.53
160_L208_I0.5210.53
520_I526_V0.5210.53
447_K527_I0.5200.53
432_I458_I0.5200.53
82_V162_A0.5200.53
309_S516_T0.5190.53
255_P259_F0.5190.53
183_W191_R0.5190.53
206_A351_L0.5190.53
240_G244_G0.5190.53
348_I354_Y0.5190.53
85_G515_A0.5180.53
263_Q266_L0.5180.53
149_R215_L0.5160.52
437_L440_G0.5160.52
327_G348_I0.5150.52
99_V104_I0.5150.52
105_L112_P0.5140.52
113_F265_F0.5140.52
156_L212_A0.5130.52
264_F407_G0.5130.52
84_A421_L0.5120.52
435_L441_I0.5120.52
527_I530_Y0.5110.52
184_F192_P0.5110.52
322_H406_H0.5100.51
122_N163_G0.5100.51
504_R507_G0.5100.51
184_F195_A0.5090.51
319_G337_G0.5090.51
450_R453_I0.5080.51
137_I145_V0.5070.51
127_W240_G0.5070.51
133_I136_S0.5070.51
139_A436_Y0.5070.51
183_W192_P0.5070.51
417_L422_V0.5060.51
257_P266_L0.5040.51
299_S351_L0.5040.51
299_S311_S0.5040.51
207_L528_K0.5040.51
251_P305_A0.5030.51
214_S218_K0.5020.50
207_L210_L0.5010.50
105_L404_Y0.5010.50
77_V155_I0.5010.50
239_L298_P0.5000.50
289_L426_T0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ayfA 2 0.9719 100 0.191 Contact Map
1fftA 1 0.8333 100 0.257 Contact Map
2yevA 1 0.8577 100 0.275 Contact Map
2gsmA 1 0.8502 100 0.28 Contact Map
1v54A 1 0.8464 100 0.295 Contact Map
3wfdB 1 0.8146 100 0.33 Contact Map
3s8fA 1 0.8521 100 0.347 Contact Map
3mk7A 1 0.839 100 0.356 Contact Map
1q16C 2 0.2041 10.1 0.981 Contact Map
2ks1B 1 0.0824 8.9 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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