GREMLIN Database
Q97XY2 - Uncharacterized protein
UniProt: Q97XY2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 135 (121)
Sequences: 1035 (782)
Seq/√Len: 71.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_Y71_F3.9661.00
47_L62_A3.3221.00
12_E109_G3.1691.00
96_V123_L3.0521.00
104_L120_K2.9601.00
72_T84_A2.4241.00
65_I96_V2.3761.00
9_V111_Y2.3571.00
99_L103_I2.3161.00
100_I119_L2.2901.00
14_T18_I2.2751.00
30_E34_R2.2641.00
33_Y102_D2.1841.00
46_V50_Y2.1491.00
104_L117_I2.0931.00
71_F87_F1.8991.00
76_L84_A1.8941.00
96_V100_I1.8601.00
30_E91_H1.8441.00
20_D24_V1.8331.00
72_T122_F1.8241.00
55_I74_F1.7891.00
73_S77_F1.7151.00
84_A126_T1.6601.00
103_I116_G1.6070.99
89_K127_I1.6060.99
110_E113_K1.5350.99
115_L119_L1.4800.99
86_K90_E1.4570.99
30_E68_E1.4360.99
30_E46_V1.4340.99
65_I99_L1.4330.99
97_P120_K1.4170.98
29_Y39_Y1.3500.98
68_E71_F1.3460.98
72_T126_T1.3400.98
12_E107_S1.3290.98
27_P32_W1.3090.97
10_A14_T1.2980.97
69_L123_L1.2830.97
29_Y60_Q1.2740.97
64_H118_A1.2610.97
46_V68_E1.2240.96
30_E94_S1.2180.96
72_T88_I1.1870.95
120_K124_D1.1450.94
13_F64_H1.1420.94
101_E120_K1.1200.94
32_W37_T1.0920.93
44_Q47_L1.0890.93
98_K102_D1.0860.93
68_E92_I1.0850.93
122_F126_T1.0590.92
107_S110_E1.0580.92
20_D29_Y1.0270.90
19_N24_V1.0220.90
65_I119_L1.0170.90
46_V71_F1.0160.90
114_L121_Q1.0150.90
45_R90_E1.0090.90
48_E52_K0.9990.89
52_K86_K0.9920.89
107_S113_K0.9920.89
91_H94_S0.9580.87
84_A122_F0.9560.87
43_V62_A0.9560.87
41_I45_R0.9400.86
68_E87_F0.9250.85
69_L119_L0.9200.85
65_I95_W0.9130.84
93_V123_L0.9080.84
37_T40_G0.9020.84
9_V45_R0.8820.82
76_L79_E0.8760.82
53_Y75_L0.8750.82
13_F33_Y0.8580.80
65_I100_I0.8470.79
46_V87_F0.8390.79
70_E74_F0.8230.78
55_I78_V0.8150.77
11_T14_T0.8130.77
8_K82_D0.8110.76
114_L118_A0.8100.76
43_V46_V0.8040.76
70_E77_F0.8020.76
92_I115_L0.7970.75
18_I24_V0.7960.75
12_E103_I0.7920.75
43_V47_L0.7770.73
12_E15_S0.7760.73
79_E83_E0.7740.73
104_L113_K0.7700.73
13_F17_F0.7690.73
17_F95_W0.7650.72
76_L126_T0.7590.72
34_R94_S0.7520.71
22_K38_V0.7510.71
23_H98_K0.7510.71
30_E71_F0.7510.71
28_P102_D0.7260.68
35_E40_G0.7250.68
120_K123_L0.7220.68
29_Y70_E0.7130.67
44_Q62_A0.7100.66
101_E104_L0.6930.65
78_V82_D0.6850.64
90_E105_A0.6790.63
100_I116_G0.6720.62
33_Y112_T0.6700.62
34_R42_S0.6680.62
29_Y36_R0.6650.61
48_E51_I0.6620.61
9_V112_T0.6610.61
98_K101_E0.6430.59
53_Y71_F0.6400.58
12_E25_K0.6400.58
32_W35_E0.6360.58
40_G70_E0.6350.58
110_E121_Q0.6330.58
35_E44_Q0.6330.58
62_A91_H0.6330.58
30_E42_S0.6320.58
13_F99_L0.6320.58
86_K128_Q0.6300.57
27_P61_L0.6280.57
32_W39_Y0.6260.57
117_I124_D0.6200.56
50_Y68_E0.6100.55
31_S38_V0.6060.54
8_K79_E0.6010.54
83_E105_A0.5970.53
49_E53_Y0.5960.53
15_S73_S0.5950.53
26_C118_A0.5920.53
16_C94_S0.5910.53
13_F76_L0.5880.52
12_E108_K0.5870.52
85_R89_K0.5850.52
17_F112_T0.5790.51
8_K52_K0.5780.51
15_S128_Q0.5780.51
8_K104_L0.5720.50
88_I93_V0.5670.50
42_S62_A0.5640.49
39_Y122_F0.5640.49
87_F94_S0.5640.49
72_T75_L0.5630.49
14_T20_D0.5580.49
58_K104_L0.5570.48
78_V81_E0.5540.48
80_Q125_Y0.5510.48
75_L84_A0.5480.47
81_E107_S0.5460.47
75_L105_A0.5450.47
9_V78_V0.5450.47
49_E52_K0.5440.47
97_P127_I0.5440.47
74_F77_F0.5400.46
24_V27_P0.5370.46
49_E86_K0.5370.46
83_E115_L0.5340.46
119_L123_L0.5340.46
32_W43_V0.5340.46
81_E85_R0.5320.45
50_Y67_T0.5310.45
94_S97_P0.5270.45
45_R48_E0.5230.44
67_T91_H0.5220.44
92_I127_I0.5210.44
37_T66_S0.5210.44
57_P70_E0.5170.44
50_Y62_A0.5160.43
45_R81_E0.5150.43
26_C96_V0.5150.43
15_S105_A0.5140.43
13_F28_P0.5110.43
54_G102_D0.5070.42
67_T70_E0.5050.42
13_F81_E0.5030.42
85_R127_I0.5020.42
97_P124_D0.5020.42
100_I126_T0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1n1cA 2 0.963 100 0.25 Contact Map
1s9uA 1 0.9704 100 0.261 Contact Map
2o9xA 2 0.8296 100 0.344 Contact Map
2xolA 2 0.8222 99.9 0.441 Contact Map
1ei9A 1 0.5778 9.9 0.939 Contact Map
4xpcA 1 0.5852 6.8 0.944 Contact Map
4g1qA 2 0.9556 6.4 0.944 Contact Map
4bouA 2 0.7037 6.3 0.945 Contact Map
2vofA 1 0.8741 4.8 0.947 Contact Map
3kdrA 5 0.8593 4 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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