GREMLIN Database
Q97XY1 - Oxidoreductase
UniProt: Q97XY1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 455 (395)
Sequences: 186 (152)
Seq/√Len: 7.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_A81_D5.8971.00
78_W81_D4.7130.99
77_A80_A4.6130.99
76_N80_A4.3360.98
76_N81_D4.0630.97
192_R197_R3.6700.95
279_A285_I3.6700.95
34_V37_D3.6580.95
302_R350_C3.6360.95
73_V80_A3.6190.94
193_N197_R3.5250.94
279_A286_S3.4090.92
74_L80_A3.3070.91
279_A282_R3.2460.90
276_Y279_A3.1430.89
130_S160_S3.0240.87
76_N79_L3.0070.86
75_E78_W2.9760.86
69_Y76_N2.8180.82
69_Y74_L2.7860.82
74_L82_L2.7770.81
389_D405_K2.7280.80
72_V76_N2.7230.80
285_I289_L2.6700.79
73_V76_N2.6220.77
73_V78_W2.6190.77
69_Y77_A2.5440.75
30_K36_G2.5360.75
163_V337_I2.5190.74
69_Y78_W2.4900.73
122_K125_N2.4740.73
73_V77_A2.4590.72
279_A290_P2.3890.70
279_A289_L2.3690.69
237_F241_I2.2990.67
411_K427_E2.2420.65
282_R285_I2.2370.65
77_A83_A2.2340.65
74_L77_A2.2190.64
265_T268_L2.1650.62
72_V80_A2.0970.60
69_Y73_V2.0550.58
227_G230_L2.0430.57
237_F240_V2.0240.57
122_K138_V2.0130.56
74_L81_D2.0050.56
71_K80_A1.9980.56
76_N83_A1.9670.54
78_W83_A1.9290.53
276_Y285_I1.9070.52
75_E79_L1.8940.51
59_G62_S1.8940.51
133_Y152_T1.8900.51
358_S384_R1.8890.51
160_S308_S1.8660.50
392_V427_E1.8180.48
282_R434_A1.7490.46
272_P288_E1.7470.46
71_K74_L1.7440.45
281_A288_E1.6830.43
69_Y72_V1.6780.43
34_V38_G1.6770.43
80_A83_A1.6740.43
71_K76_N1.6590.42
75_E82_L1.6420.41
76_N82_L1.6020.40
392_V408_N1.5980.40
73_V81_D1.5910.39
61_D65_E1.5840.39
33_V37_D1.5750.39
31_A36_G1.5720.39
38_G43_K1.5600.38
297_S354_E1.5560.38
104_A171_L1.5530.38
256_P260_I1.5520.38
404_R437_A1.5330.37
403_S430_P1.5190.37
75_E81_D1.4880.36
67_V387_V1.4830.35
31_A35_I1.4780.35
109_K166_I1.4700.35
32_L37_D1.4690.35
308_S363_N1.4630.35
279_A292_I1.4580.35
314_P433_R1.4580.35
240_V243_E1.4470.34
32_L35_I1.4360.34
279_A283_R1.4290.33
286_S290_P1.4130.33
69_Y81_D1.4060.33
138_V387_V1.4040.33
209_E293_L1.3960.32
120_L160_S1.3890.32
41_R45_S1.3880.32
69_Y80_A1.3770.32
285_I290_P1.3730.32
90_S341_I1.3670.31
300_N387_V1.3590.31
333_P356_K1.3550.31
74_L78_W1.3510.31
350_C386_L1.3450.31
425_W436_Y1.3400.30
39_I43_K1.3350.30
77_A82_L1.3260.30
282_R286_S1.3200.30
194_T200_K1.3170.30
33_V36_G1.3150.30
393_R400_P1.3140.30
179_L184_G1.3020.29
193_N196_N1.3000.29
296_V398_G1.2990.29
34_V40_N1.2960.29
280_E286_S1.2890.29
440_K443_S1.2820.28
201_I221_L1.2750.28
272_P278_R1.2720.28
252_S260_I1.2590.28
74_L79_L1.2510.27
216_R219_G1.2330.27
72_V75_E1.2320.27
271_T276_Y1.2310.27
61_D64_K1.2260.27
102_K170_S1.2220.27
272_P276_Y1.2200.26
107_V146_I1.2190.26
71_K79_L1.1940.26
298_I427_E1.1890.26
321_R328_E1.1880.25
255_S260_I1.1800.25
244_Y438_F1.1770.25
154_C402_G1.1750.25
280_E426_L1.1730.25
299_D302_R1.1720.25
61_D66_E1.1650.25
73_V79_L1.1490.24
179_L352_L1.1480.24
106_K299_D1.1450.24
396_V439_Q1.1440.24
274_S285_I1.1330.24
272_P277_N1.1310.24
208_S428_R1.1060.23
279_A288_E1.1060.23
316_S402_G1.1020.23
180_A223_F1.1020.23
32_L36_G1.1010.23
307_E311_N1.0990.23
190_C390_E1.0980.23
317_A339_C1.0840.22
130_S223_F1.0810.22
192_R353_E1.0590.22
287_D290_P1.0550.22
43_K57_I1.0550.22
310_V405_K1.0510.22
101_V115_E1.0490.21
79_L82_L1.0470.21
124_C162_P1.0440.21
117_C413_I1.0330.21
201_I354_E1.0310.21
162_P317_A1.0250.21
162_P339_C1.0250.21
269_N272_P1.0240.21
161_C317_A1.0220.21
161_C339_C1.0220.21
71_K75_E1.0210.21
286_S289_L1.0140.21
278_R286_S1.0130.21
192_R196_N1.0120.20
318_I428_R1.0090.20
42_E49_E1.0090.20
412_K415_I1.0090.20
283_R286_S1.0080.20
236_D240_V0.9980.20
30_K34_V0.9960.20
36_G43_K0.9920.20
31_A34_V0.9900.20
224_E227_G0.9810.20
283_R290_P0.9760.20
35_I57_I0.9690.19
71_K77_A0.9690.19
124_C317_A0.9690.19
124_C339_C0.9690.19
396_V435_E0.9660.19
221_L224_E0.9660.19
72_V79_L0.9650.19
127_C161_C0.9640.19
124_C161_C0.9560.19
39_I50_L0.9500.19
35_I58_V0.9470.19
116_Y338_G0.9430.19
113_L126_V0.9390.19
271_T288_E0.9370.19
42_E48_L0.9360.19
30_K37_D0.9350.19
128_E147_D0.9340.19
296_V329_I0.9290.18
72_V82_L0.9260.18
38_G41_R0.9200.18
113_L128_E0.9180.18
147_D392_V0.9090.18
140_K158_V0.9070.18
124_C127_C0.8980.18
87_E92_D0.8980.18
75_E83_A0.8960.18
134_N140_K0.8940.18
40_N50_L0.8790.17
207_L239_E0.8790.17
188_I396_V0.8780.17
415_I424_E0.8780.17
285_I288_E0.8750.17
72_V77_A0.8750.17
327_E338_G0.8740.17
146_I315_T0.8660.17
402_G406_S0.8620.17
167_Q438_F0.8610.17
208_S414_M0.8610.17
134_N289_L0.8600.17
256_P259_K0.8540.17
36_G41_R0.8480.17
115_E420_S0.8460.16
241_I246_E0.8440.16
124_C165_A0.8400.16
71_K86_E0.8380.16
90_S404_R0.8360.16
159_A206_M0.8360.16
105_K207_L0.8350.16
224_E230_L0.8340.16
130_S415_I0.8330.16
215_L438_F0.8290.16
257_S260_I0.8280.16
92_D403_S0.8270.16
158_V173_Q0.8270.16
116_Y391_L0.8270.16
69_Y79_L0.8240.16
282_R292_I0.8240.16
123_A434_A0.8240.16
123_A344_N0.8230.16
273_Q276_Y0.8230.16
276_Y289_L0.8210.16
357_T384_R0.8200.16
217_G273_Q0.8200.16
308_S438_F0.8140.16
109_K206_M0.8140.16
349_S386_L0.8090.16
118_N391_L0.8060.16
314_P428_R0.8030.16
145_N217_G0.8020.16
127_C162_P0.7970.15
165_A317_A0.7960.15
165_A339_C0.7960.15
434_A438_F0.7950.15
133_Y210_V0.7950.15
84_P125_N0.7950.15
55_V163_V0.7930.15
170_S315_T0.7930.15
260_I396_V0.7920.15
98_R298_I0.7920.15
127_C339_C0.7920.15
127_C317_A0.7920.15
49_E54_L0.7900.15
123_A126_V0.7900.15
52_P248_I0.7900.15
274_S279_A0.7870.15
176_I228_C0.7860.15
263_K268_L0.7830.15
288_E360_I0.7780.15
42_E354_E0.7750.15
233_N237_F0.7700.15
399_A409_H0.7690.15
286_S292_I0.7670.15
292_I358_S0.7670.15
138_V141_K0.7660.15
32_L69_Y0.7660.15
40_N43_K0.7650.15
73_V82_L0.7650.15
94_R213_V0.7610.15
280_E291_Y0.7600.15
49_E68_E0.7580.15
333_P338_G0.7570.15
109_K204_L0.7550.15
254_Y260_I0.7550.15
192_R205_A0.7540.15
55_V337_I0.7520.15
162_P165_A0.7510.15
87_E301_N0.7500.14
256_P265_T0.7490.14
116_Y327_E0.7470.14
263_K382_E0.7450.14
115_E338_G0.7450.14
280_E283_R0.7440.14
129_F182_V0.7440.14
123_A129_F0.7400.14
222_T412_K0.7370.14
136_I392_V0.7360.14
117_C208_S0.7340.14
312_W315_T0.7340.14
124_C135_A0.7330.14
133_Y143_G0.7330.14
52_P146_I0.7320.14
161_C165_A0.7310.14
257_S261_E0.7310.14
179_L183_K0.7290.14
146_I416_E0.7260.14
109_K387_V0.7250.14
156_L235_K0.7250.14
116_Y333_P0.7250.14
308_S334_M0.7250.14
58_V251_I0.7240.14
154_C316_S0.7210.14
179_L409_H0.7200.14
428_R433_R0.7200.14
154_C444_F0.7190.14
149_T421_C0.7170.14
62_S65_E0.7150.14
315_T350_C0.7110.14
307_E406_S0.7080.14
202_P345_V0.7080.14
43_K224_E0.7070.14
103_K218_S0.7020.14
67_V91_I0.7020.14
40_N205_A0.7010.14
35_I39_I0.7010.14
178_E182_V0.7000.14
269_N290_P0.6980.13
406_S410_V0.6980.13
426_L439_Q0.6970.13
338_G391_L0.6960.13
170_S312_W0.6950.13
140_K208_S0.6950.13
227_G232_D0.6950.13
191_Y197_R0.6940.13
95_S225_C0.6900.13
400_P437_A0.6860.13
206_M362_P0.6850.13
42_E54_L0.6840.13
96_L250_G0.6830.13
171_L420_S0.6810.13
58_V112_Y0.6810.13
179_L251_I0.6780.13
255_S261_E0.6770.13
169_P207_L0.6770.13
59_G63_S0.6750.13
164_S409_H0.6740.13
235_K239_E0.6730.13
309_C346_C0.6720.13
309_C347_P0.6720.13
151_C313_C0.6720.13
309_C394_C0.6720.13
309_C397_C0.6720.13
347_P394_C0.6720.13
151_C155_G0.6720.13
151_C157_C0.6720.13
313_C347_P0.6720.13
347_P429_C0.6720.13
151_C306_C0.6720.13
151_C309_C0.6720.13
347_P397_C0.6720.13
151_C336_C0.6720.13
151_C342_C0.6720.13
309_C429_C0.6720.13
346_C429_C0.6720.13
342_C347_P0.6720.13
342_C346_C0.6720.13
155_G336_C0.6720.13
336_C429_C0.6720.13
336_C397_C0.6720.13
336_C394_C0.6720.13
336_C347_P0.6720.13
336_C346_C0.6720.13
342_C394_C0.6720.13
342_C397_C0.6720.13
313_C429_C0.6720.13
346_C397_C0.6720.13
157_C429_C0.6720.13
346_C394_C0.6720.13
313_C336_C0.6720.13
313_C342_C0.6720.13
342_C429_C0.6720.13
313_C394_C0.6720.13
313_C397_C0.6720.13
336_C342_C0.6720.13
157_C313_C0.6720.13
155_G429_C0.6720.13
155_G397_C0.6720.13
155_G394_C0.6720.13
155_G347_P0.6720.13
155_G309_C0.6720.13
306_C429_C0.6720.13
306_C397_C0.6720.13
155_G346_C0.6720.13
309_C313_C0.6720.13
309_C336_C0.6720.13
157_C306_C0.6720.13
157_C336_C0.6720.13
157_C342_C0.6720.13
157_C346_C0.6720.13
157_C309_C0.6720.13
157_C347_P0.6720.13
157_C394_C0.6720.13
157_C397_C0.6720.13
309_C342_C0.6720.13
306_C394_C0.6720.13
306_C347_P0.6720.13
155_G313_C0.6720.13
394_C397_C0.6720.13
155_G306_C0.6720.13
151_C429_C0.6720.13
151_C397_C0.6720.13
151_C394_C0.6720.13
151_C347_P0.6720.13
151_C346_C0.6720.13
394_C429_C0.6720.13
306_C309_C0.6720.13
306_C346_C0.6720.13
306_C342_C0.6720.13
155_G342_C0.6720.13
306_C336_C0.6720.13
306_C313_C0.6720.13
313_C346_C0.6720.13
397_C429_C0.6720.13
91_I268_L0.6720.13
34_V89_K0.6710.13
261_E265_T0.6700.13
242_K395_R0.6680.13
119_G312_W0.6680.13
253_F260_I0.6670.13
32_L51_N0.6640.13
117_C407_L0.6640.13
276_Y287_D0.6630.13
179_L187_R0.6600.13
163_V315_T0.6560.13
100_E134_N0.6540.13
200_K238_I0.6520.13
109_K146_I0.6520.13
269_N274_S0.6510.13
111_I408_N0.6500.13
204_L214_L0.6490.13
271_T315_T0.6480.13
130_S409_H0.6450.13
125_N437_A0.6430.12
234_L238_I0.6420.12
36_G40_N0.6420.12
109_K113_L0.6410.12
41_R44_I0.6380.12
165_A304_T0.6370.12
127_C165_A0.6340.12
237_F242_K0.6330.12
223_F415_I0.6330.12
158_V167_Q0.6320.12
212_I217_G0.6310.12
103_K115_E0.6280.12
97_L260_I0.6270.12
320_L391_L0.6240.12
166_I300_N0.6230.12
87_E93_R0.6230.12
225_C230_L0.6230.12
312_W345_V0.6230.12
68_E186_K0.6220.12
307_E310_V0.6210.12
185_E194_T0.6200.12
34_V57_I0.6200.12
297_S330_D0.6190.12
314_P317_A0.6190.12
314_P339_C0.6190.12
101_V338_G0.6170.12
127_C135_A0.6160.12
187_R385_K0.6140.12
276_Y282_R0.6140.12
345_V445_N0.6140.12
82_L204_L0.6130.12
128_E389_D0.6110.12
86_E410_V0.6100.12
328_E388_G0.6100.12
202_P206_M0.6070.12
297_S386_L0.6050.12
59_G65_E0.6050.12
228_C387_V0.6030.12
320_L351_K0.6010.12
135_A339_C0.6010.12
135_A317_A0.6010.12
36_G64_K0.6010.12
97_L126_V0.6000.12
183_K251_I0.6000.12
69_Y75_E0.6000.12
199_V330_D0.5970.12
318_I386_L0.5970.12
279_A287_D0.5960.12
123_A433_R0.5950.12
210_V406_S0.5950.12
114_S294_F0.5940.12
90_S395_R0.5940.12
272_P279_A0.5930.12
102_K241_I0.5920.12
308_S430_P0.5910.12
224_E229_E0.5910.12
119_G403_S0.5880.12
259_K320_L0.5870.12
158_V419_A0.5870.12
71_K81_D0.5870.12
99_G433_R0.5860.12
39_I58_V0.5860.12
312_W392_V0.5850.12
197_R320_L0.5850.12
137_K234_L0.5840.11
111_I260_I0.5830.11
392_V419_A0.5820.11
144_V314_P0.5810.11
223_F299_D0.5810.11
393_R440_K0.5810.11
158_V438_F0.5800.11
117_C184_G0.5790.11
283_R292_I0.5790.11
49_E395_R0.5770.11
212_I235_K0.5770.11
159_A363_N0.5760.11
330_D386_L0.5750.11
135_A161_C0.5750.11
175_S410_V0.5740.11
304_T317_A0.5730.11
304_T339_C0.5730.11
212_I220_N0.5710.11
139_D143_G0.5710.11
50_L167_Q0.5700.11
174_N225_C0.5680.11
362_P443_S0.5670.11
102_K121_Y0.5670.11
118_N409_H0.5660.11
106_K308_S0.5640.11
135_A162_P0.5640.11
110_P210_V0.5620.11
207_L210_V0.5600.11
274_S289_L0.5600.11
101_V104_A0.5590.11
385_K388_G0.5580.11
307_E402_G0.5560.11
115_E314_P0.5560.11
38_G46_E0.5550.11
85_V130_S0.5550.11
146_I331_F0.5540.11
144_V433_R0.5530.11
38_G399_A0.5520.11
115_E153_S0.5520.11
63_S437_A0.5490.11
243_E252_S0.5490.11
256_P261_E0.5470.11
159_A335_K0.5470.11
162_P314_P0.5440.11
161_C314_P0.5420.11
164_S329_I0.5420.11
117_C414_M0.5410.11
192_R387_V0.5400.11
150_K189_T0.5390.11
160_S438_F0.5390.11
299_D350_C0.5390.11
208_S413_I0.5380.11
350_C400_P0.5370.11
209_E282_R0.5360.11
78_W352_L0.5350.11
184_G251_I0.5350.11
123_A314_P0.5350.11
57_I206_M0.5330.11
39_I45_S0.5280.11
102_K430_P0.5270.11
58_V249_G0.5270.11
135_A165_A0.5270.11
46_E49_E0.5270.11
215_L218_S0.5260.11
291_Y352_L0.5230.11
321_R380_N0.5220.11
143_G152_T0.5210.10
118_N136_I0.5200.10
69_Y83_A0.5200.10
108_D281_A0.5190.10
165_A314_P0.5180.10
101_V333_P0.5170.10
87_E343_V0.5170.10
101_V116_Y0.5170.10
99_G153_S0.5110.10
303_C432_H0.5110.10
92_D95_S0.5110.10
60_K65_E0.5100.10
128_E353_E0.5100.10
237_F243_E0.5090.10
33_V54_L0.5090.10
143_G172_S0.5090.10
90_S98_R0.5070.10
136_I144_V0.5070.10
285_I292_I0.5060.10
129_F138_V0.5040.10
162_P304_T0.5040.10
146_I219_G0.5030.10
253_F256_P0.5010.10
282_R384_R0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4z3xE 2 0.3626 99.7 0.893 Contact Map
1h0hB 1 0.3582 99.6 0.894 Contact Map
2ivfB 1 0.4549 99.6 0.898 Contact Map
1kqfB 3 0.5033 99.6 0.899 Contact Map
1q16B 2 0.6022 99.5 0.902 Contact Map
2vpzB 2 0.3648 99.5 0.904 Contact Map
2gmhA 1 0.3978 99.3 0.912 Contact Map
1xerA 2 0.2132 99.2 0.916 Contact Map
1gteA 4 0.3824 99.2 0.916 Contact Map
1hfeL 2 0.3714 99.2 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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