GREMLIN Database
Q97XX9 - Molybdopterin oxidoreductase, iron-sulfur binding subunit
UniProt: Q97XX9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 228 (182)
Sequences: 2464 (1378)
Seq/√Len: 102.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_E158_G3.1231.00
23_F155_F2.8711.00
167_P170_V2.8241.00
94_T124_R2.6581.00
201_V204_P2.4461.00
86_Y94_T2.4101.00
63_G66_P2.1521.00
83_P96_I2.1421.00
113_L126_F2.0951.00
54_R151_D2.0551.00
19_K184_D2.0021.00
116_V150_V1.9781.00
22_G183_L1.9691.00
24_V190_V1.9491.00
155_F212_V1.9481.00
170_V178_R1.8801.00
97_V161_P1.8441.00
30_C36_C1.8431.00
157_Y161_P1.8011.00
30_C33_C1.7861.00
113_L128_T1.7831.00
88_V114_Y1.7691.00
88_V118_A1.7571.00
81_E211_K1.7521.00
76_L212_V1.7221.00
30_C173_C1.6931.00
185_D188_S1.6871.00
44_N158_G1.6821.00
105_D108_K1.6671.00
188_S191_S1.6561.00
187_N192_I1.6551.00
179_V193_L1.6431.00
189_E192_I1.6351.00
19_K182_C1.6291.00
127_Y151_D1.6141.00
89_C115_C1.6141.00
201_V209_Q1.6091.00
94_T104_V1.6001.00
89_C109_C1.5621.00
20_H81_E1.5521.00
33_C36_C1.5421.00
101_I160_A1.5191.00
33_C173_C1.5161.00
25_V178_R1.5111.00
109_C115_C1.5011.00
159_T171_R1.5001.00
44_N154_T1.4971.00
84_P208_V1.4891.00
113_L116_V1.4671.00
31_L175_G1.4621.00
159_T164_T1.4461.00
24_V193_L1.4361.00
192_I196_T1.4271.00
39_A172_T1.4231.00
86_Y96_I1.4211.00
126_F150_V1.3891.00
25_V212_V1.3841.00
189_E193_L1.3620.99
182_C185_D1.3590.99
179_V189_E1.3530.99
34_D37_V1.3450.99
36_C173_C1.3040.99
83_P86_Y1.2770.99
75_R202_L1.2680.99
199_A215_V1.2550.99
74_P178_R1.2510.99
43_E159_T1.2470.99
95_Q105_D1.2450.99
97_V101_I1.2420.99
63_G67_N1.2300.99
160_A180_F1.2240.99
55_T178_R1.2130.99
24_V215_V1.1760.98
28_D197_G1.1760.98
81_E209_Q1.1660.98
166_T170_V1.1630.98
25_V74_P1.1600.98
95_Q103_V1.1590.98
201_V206_L1.1560.98
39_A168_A1.1510.98
128_T146_V1.1440.98
90_P109_C1.1330.98
103_V154_T1.1220.98
76_L178_R1.1170.98
188_S192_I1.1170.98
90_P115_C1.1140.98
203_N206_L1.1060.98
74_P214_Y1.1000.98
20_H211_K1.0850.97
194_V213_F1.0840.97
91_T94_T1.0810.97
109_C112_C1.0790.97
197_G215_V1.0730.97
28_D215_V1.0680.97
22_G186_P1.0650.97
194_V199_A1.0620.97
97_V157_Y1.0520.97
96_I211_K1.0390.97
191_S195_N1.0330.96
81_E96_I1.0310.96
27_V74_P1.0270.96
22_G190_V1.0180.96
183_L187_N1.0040.96
62_L69_Q1.0030.96
88_V94_T0.9930.96
35_A172_T0.9800.95
112_C115_C0.9570.95
125_Y151_D0.9470.94
20_H184_D0.9450.94
106_E149_H0.9410.94
21_W180_F0.9410.94
54_R57_V0.9310.94
46_T54_R0.9270.94
101_I157_Y0.9140.93
89_C112_C0.9130.93
18_C184_D0.9120.93
25_V76_L0.9070.93
104_V124_R0.9040.93
43_E168_A0.9010.93
82_N87_Y0.9010.93
154_T158_G0.8950.92
84_P118_A0.8880.92
82_N209_Q0.8870.92
192_I195_N0.8850.92
99_G161_P0.8800.92
166_T171_R0.8790.92
104_V150_V0.8700.91
164_T171_R0.8690.91
35_A38_A0.8680.91
56_H75_R0.8650.91
96_I102_V0.8600.91
167_P178_R0.8580.91
201_V213_F0.8570.91
32_G177_A0.8560.91
88_V117_E0.8490.90
113_L150_V0.8430.90
190_V193_L0.8420.90
91_T108_K0.8420.90
63_G68_T0.8410.90
194_V198_Q0.8380.90
91_T112_C0.8370.90
181_G185_D0.8340.89
187_N191_S0.8330.89
59_D70_R0.8280.89
186_P191_S0.8260.89
103_V157_Y0.8210.89
114_Y117_E0.8210.89
55_T59_D0.8200.89
90_P110_M0.8190.89
35_A42_I0.8140.88
64_E67_N0.8100.88
116_V128_T0.8000.87
126_F148_P0.7970.87
41_T46_T0.7860.86
53_F56_H0.7680.85
29_Q193_L0.7570.84
159_T168_A0.7550.84
76_L155_F0.7510.84
97_V103_V0.7470.84
24_V194_V0.7470.84
55_T74_P0.7460.83
93_A108_K0.7450.83
40_C153_C0.7360.83
191_S194_V0.7350.83
186_P190_V0.7310.82
26_K215_V0.7230.81
124_R150_V0.7200.81
91_T110_M0.7180.81
23_F170_V0.7170.81
45_Q151_D0.7130.81
63_G69_Q0.7120.80
28_D217_N0.7100.80
25_V214_Y0.7090.80
155_F180_F0.7070.80
42_I172_T0.7060.80
22_G211_K0.7050.80
20_H183_L0.7010.79
89_C111_G0.7010.79
113_L151_D0.6980.79
61_E64_E0.6960.79
55_T76_L0.6950.79
41_T53_F0.6870.78
84_P206_L0.6830.78
121_Y208_V0.6830.78
65_Y68_T0.6810.77
23_F180_F0.6740.77
207_N210_P0.6730.77
194_V197_G0.6730.77
176_H179_V0.6720.77
21_W101_I0.6700.76
61_E68_T0.6670.76
183_L191_S0.6660.76
60_L66_P0.6620.75
23_F55_T0.6620.75
51_G55_T0.6550.75
61_E70_R0.6500.74
110_M115_C0.6450.74
101_I155_F0.6440.73
153_C156_C0.6400.73
40_C156_C0.6400.73
182_C186_P0.6320.72
42_I171_R0.6300.72
38_A41_T0.6300.72
121_Y210_P0.6270.71
27_V73_V0.6270.71
128_T148_P0.6200.71
78_M123_A0.6170.70
201_V205_E0.6160.70
31_L174_P0.6140.70
90_P112_C0.6100.69
38_A83_P0.6100.69
193_L196_T0.6100.69
51_G59_D0.6100.69
75_R78_M0.6030.69
202_L208_V0.6030.69
23_F76_L0.6010.68
32_G36_C0.6010.68
82_N92_G0.6010.68
111_G115_C0.5980.68
51_G57_V0.5940.67
185_D190_V0.5940.67
91_T104_V0.5920.67
55_T58_E0.5860.66
21_W160_A0.5840.66
126_F147_V0.5830.66
172_T175_G0.5810.66
122_G125_Y0.5780.65
202_L206_L0.5760.65
99_G157_Y0.5730.65
35_A174_P0.5720.64
37_V57_V0.5700.64
47_P52_L0.5700.64
21_W99_G0.5680.64
32_G123_A0.5670.64
58_E149_H0.5670.64
29_Q176_H0.5630.63
51_G56_H0.5610.63
22_G213_F0.5580.63
127_Y146_V0.5560.62
23_F212_V0.5550.62
50_R54_R0.5550.62
183_L186_P0.5470.61
92_G98_A0.5470.61
76_L214_Y0.5460.61
57_V74_P0.5390.60
89_C110_M0.5380.60
44_N54_R0.5370.60
58_E62_L0.5360.60
21_W182_C0.5320.59
70_R123_A0.5310.59
182_C188_S0.5290.59
152_K156_C0.5290.59
45_Q48_F0.5270.58
193_L197_G0.5260.58
87_Y114_Y0.5250.58
86_Y90_P0.5240.58
32_G173_C0.5230.58
112_C150_V0.5220.58
21_W122_G0.5180.57
179_V188_S0.5170.57
56_H125_Y0.5160.57
106_E147_V0.5150.57
43_E171_R0.5150.57
96_I100_G0.5140.56
127_Y147_V0.5140.56
34_D38_A0.5110.56
52_L126_F0.5110.56
78_M202_L0.5080.56
110_M114_Y0.5080.56
86_Y95_Q0.5030.55
206_L211_K0.5030.55
106_E180_F0.5010.54
88_V124_R0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ivfB 1 0.8465 100 0.398 Contact Map
1ti6B 2 0.8333 100 0.408 Contact Map
1kqfB 3 0.9167 100 0.453 Contact Map
2vpzB 2 0.8289 100 0.469 Contact Map
1h0hB 1 0.8333 100 0.473 Contact Map
1q16B 2 0.8596 100 0.518 Contact Map
4z3xE 2 0.7237 100 0.633 Contact Map
3mm5B 2 0.9167 99.8 0.743 Contact Map
1jnrB 1 0.6228 99.5 0.796 Contact Map
3gyxB 1 0.4649 99.4 0.812 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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