GREMLIN Database
Q97XX0 - Uncharacterized protein
UniProt: Q97XX0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 117 (107)
Sequences: 4644 (3519)
Seq/√Len: 340.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_N37_D3.9081.00
109_L113_S3.5801.00
27_L32_V2.8491.00
25_I66_E2.4301.00
14_K22_N2.3871.00
72_Y75_R2.1001.00
71_V76_F2.0871.00
62_Y65_G2.0521.00
39_L69_V2.0141.00
104_K107_E1.9671.00
90_L97_R1.9401.00
44_E48_M1.9191.00
90_L93_E1.8611.00
36_G70_T1.8471.00
21_A62_Y1.8401.00
21_A66_E1.8361.00
25_I68_F1.8141.00
105_R113_S1.7551.00
69_V76_F1.6641.00
91_M94_A1.5541.00
105_R109_L1.5491.00
36_G80_T1.5451.00
70_T79_K1.5031.00
35_P80_T1.4621.00
21_A25_I1.4601.00
106_D113_S1.4481.00
23_Q27_L1.4431.00
42_V53_M1.4331.00
110_F113_S1.4291.00
27_L33_L1.3981.00
57_E61_K1.3821.00
94_A98_A1.3721.00
35_P81_D1.3251.00
18_E22_N1.3101.00
28_I78_V1.2971.00
58_K62_Y1.2851.00
28_I68_F1.2171.00
31_G34_N1.2141.00
61_K65_G1.2061.00
86_K90_L1.1881.00
99_L105_R1.1751.00
96_Y100_A1.1511.00
23_Q49_L1.1381.00
38_P77_V1.1331.00
95_V108_I1.1271.00
95_V112_I1.1061.00
20_I51_V1.0791.00
14_K18_E1.0731.00
33_L78_V1.0701.00
51_V56_V1.0591.00
91_M108_I1.0551.00
43_R60_Y1.0251.00
38_P44_E1.0081.00
45_M60_Y1.0081.00
26_E30_K0.9901.00
52_N57_E0.9831.00
62_Y66_E0.9821.00
108_I112_I0.9801.00
87_W98_A0.9781.00
93_E97_R0.9761.00
57_E76_F0.9691.00
109_L112_I0.9661.00
106_D110_F0.9601.00
92_K96_Y0.9331.00
103_A108_I0.9211.00
85_E89_E0.9171.00
23_Q26_E0.9111.00
90_L94_A0.9061.00
22_N25_I0.9031.00
61_K64_E0.8931.00
16_I52_N0.8881.00
97_R101_G0.8861.00
9_D12_S0.8701.00
54_L57_E0.8661.00
54_L61_K0.8451.00
88_K111_F0.8391.00
24_I28_I0.8381.00
98_A108_I0.8381.00
97_R100_A0.8341.00
43_R46_A0.8241.00
20_I59_A0.8161.00
64_E71_V0.8141.00
15_Q19_Q0.8121.00
60_Y64_E0.8011.00
60_Y76_F0.7961.00
54_L71_V0.7851.00
86_K89_E0.7711.00
49_L60_Y0.7691.00
85_E88_K0.7661.00
64_E69_V0.7621.00
24_I39_L0.7601.00
74_K77_V0.7541.00
40_P45_M0.7410.99
53_M58_K0.7320.99
38_P41_S0.7290.99
70_T80_T0.7210.99
41_S44_E0.7190.99
42_V57_E0.7040.99
93_E96_Y0.7000.99
67_G79_K0.6900.99
87_W103_A0.6890.99
87_W90_L0.6890.99
95_V99_L0.6840.99
105_R108_I0.6800.99
57_E71_V0.6760.99
10_L20_I0.6740.99
8_I16_I0.6740.99
16_I54_L0.6690.99
24_I63_L0.6650.99
89_E93_E0.6560.99
24_I33_L0.6560.99
87_W94_A0.6520.99
106_D109_L0.6470.99
104_K108_I0.6440.99
42_V58_K0.6410.99
25_I63_L0.6360.98
60_Y69_V0.6290.98
70_T77_V0.6270.98
105_R112_I0.6220.98
45_M56_V0.6190.98
64_E76_F0.6150.98
107_E110_F0.6010.98
25_I59_A0.5980.98
42_V76_F0.5970.98
46_A56_V0.5940.98
89_E92_K0.5910.97
42_V54_L0.5890.97
41_S74_K0.5860.97
27_L30_K0.5840.97
8_I49_L0.5720.97
33_L39_L0.5700.97
43_R49_L0.5690.97
103_A107_E0.5680.97
61_K76_F0.5670.97
96_Y99_L0.5630.97
83_R86_K0.5610.97
38_P54_L0.5570.96
24_I45_M0.5570.96
99_L109_L0.5540.96
21_A59_A0.5520.96
56_V59_A0.5460.96
8_I23_Q0.5410.96
10_L73_K0.5400.96
17_Y59_A0.5390.96
72_Y77_V0.5320.95
52_N58_K0.5300.95
88_K92_K0.5290.95
16_I20_I0.5270.95
73_K76_F0.5240.95
84_D88_K0.5220.95
20_I49_L0.5180.95
86_K97_R0.5170.95
44_E73_K0.5150.95
29_A41_S0.5110.94
56_V60_Y0.5090.94
84_D107_E0.5060.94
13_K18_E0.5050.94
46_A60_Y0.5020.94
57_E60_Y0.5010.94
9_D86_K0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ic7A 2 0.8718 99.8 0.407 Contact Map
2ra5A 2 0.1624 99.8 0.416 Contact Map
3by6A 2 0.9658 99.8 0.422 Contact Map
3neuA 2 0.9487 99.8 0.424 Contact Map
4r1hA 2 0.9231 99.8 0.425 Contact Map
4u0wA 2 0.9573 99.8 0.435 Contact Map
3tqnA 2 0.8547 99.8 0.437 Contact Map
2ek5A 4 0.8889 99.8 0.443 Contact Map
3f8mA 2 0.8376 99.8 0.457 Contact Map
4tv7A 2 0.9573 99.7 0.473 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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