GREMLIN Database
Q97XW9 - Uncharacterized protein
UniProt: Q97XW9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 347 (329)
Sequences: 302 (267)
Seq/√Len: 14.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
302_V324_G7.6071.00
40_T103_L6.5981.00
313_K318_G5.2021.00
272_G275_G3.8901.00
98_R290_N3.5560.99
19_F63_T3.4990.99
35_L52_V3.4540.99
321_L328_S3.2080.99
89_V315_N3.0940.98
64_L340_I2.8890.97
117_K123_W2.7090.96
155_H163_F2.6540.95
31_P228_F2.6280.95
121_R125_I2.5730.94
157_G162_T2.5090.93
295_W320_T2.4670.93
195_T308_R2.4290.92
237_S241_W2.4190.92
204_P207_S2.3280.91
301_Y306_D2.3030.90
117_K122_K2.3010.90
26_P215_K2.2730.89
221_I267_Y2.2150.88
117_K125_I2.1870.87
130_A227_V2.1210.86
45_K101_G2.1170.86
117_K121_R2.1010.85
335_V339_V2.0960.85
200_N207_S2.0730.84
132_G269_L2.0660.84
214_F275_G2.0210.83
301_Y322_N2.0040.82
117_K124_I1.9870.82
36_G314_R1.9450.80
214_F272_G1.8870.78
303_N306_D1.8850.78
296_K324_G1.8740.78
17_F96_V1.8350.76
40_T98_R1.8140.75
214_F273_I1.7800.74
273_I277_R1.7710.73
323_F328_S1.7320.72
64_L283_I1.6880.70
303_N322_N1.6690.69
72_F135_I1.6690.69
328_S335_V1.6550.68
298_G322_N1.6550.68
98_R103_L1.6460.68
35_L178_N1.6120.66
92_W96_V1.6050.66
217_E271_I1.6000.65
93_R96_V1.5890.65
29_Q32_D1.5800.64
306_D322_N1.5630.64
325_H329_I1.5610.63
54_K222_A1.5510.63
17_F45_K1.5480.63
40_T175_E1.5420.62
48_G83_I1.4820.59
187_V335_V1.4790.59
35_L48_G1.4650.58
257_I262_T1.4620.58
141_G237_S1.4610.58
190_V262_T1.4600.58
54_K61_G1.4550.58
47_K101_G1.4550.58
131_W255_F1.4300.56
154_T164_L1.4270.56
132_G205_D1.4260.56
34_L48_G1.4260.56
309_I331_I1.4080.55
298_G301_Y1.4000.55
89_V130_A1.3940.54
313_K316_G1.3920.54
79_F94_R1.3880.54
135_I139_V1.3420.52
87_L133_I1.3380.51
289_L308_R1.3160.50
153_P162_T1.3150.50
313_K320_T1.3130.50
313_K317_L1.3070.50
238_L241_W1.2930.49
309_I324_G1.2910.49
80_I341_T1.2900.49
155_H166_K1.2860.48
301_Y311_V1.2710.48
48_G96_V1.2700.48
49_K167_T1.2700.48
320_T323_F1.2660.47
246_L330_L1.2610.47
331_I343_I1.2560.47
38_R96_V1.2530.47
113_I196_T1.2470.46
296_K302_V1.2470.46
237_S312_P1.2410.46
39_V291_D1.2370.46
102_S227_V1.2310.45
89_V162_T1.2290.45
45_K49_K1.2240.45
324_G328_S1.2160.45
186_T333_L1.2130.44
201_P207_S1.2090.44
295_W301_Y1.2050.44
201_P204_P1.2050.44
25_L55_Y1.2020.44
297_G300_I1.2010.44
135_I337_F1.1940.43
32_D109_R1.1910.43
312_P318_G1.1870.43
27_N130_A1.1860.43
327_I331_I1.1710.42
62_L84_L1.1630.42
36_G312_P1.1540.41
238_L335_V1.1500.41
65_L341_T1.1490.41
275_G278_Y1.1460.41
210_A308_R1.1380.40
30_P204_P1.1360.40
65_L72_F1.1340.40
199_I207_S1.1280.40
302_V329_I1.1260.40
189_G237_S1.1260.40
73_V300_I1.1150.39
117_K120_S1.1090.39
167_T207_S1.1050.39
187_V331_I1.1050.39
273_I278_Y1.0930.38
241_W317_L1.0880.38
328_S336_V1.0840.38
62_L266_V1.0790.37
291_D295_W1.0780.37
122_K219_G1.0780.37
59_L80_I1.0700.37
41_T181_V1.0700.37
76_I205_D1.0670.37
168_P260_L1.0650.37
166_K171_F1.0620.36
231_S248_E1.0620.36
196_T214_F1.0620.36
29_Q39_V1.0590.36
185_L219_G1.0580.36
25_L29_Q1.0570.36
159_T259_M1.0520.36
268_V275_G1.0520.36
35_L105_V1.0500.36
274_E312_P1.0500.36
98_R292_D1.0440.35
291_D319_Y1.0420.35
157_G211_F1.0410.35
175_E304_P1.0400.35
65_L305_K1.0370.35
266_V330_L1.0300.35
214_F278_Y1.0290.35
65_L228_F1.0290.35
337_F341_T1.0280.35
80_I337_F1.0250.35
39_V50_D1.0240.34
207_S329_I1.0230.34
37_A98_R1.0150.34
261_F264_I1.0100.34
272_G277_R1.0060.34
311_V325_H1.0060.34
258_S324_G1.0040.33
68_L159_T1.0030.33
183_G260_L1.0020.33
160_G299_I1.0010.33
37_A78_V0.9980.33
44_K338_A0.9940.33
328_S332_I0.9930.33
298_G303_N0.9900.33
211_F294_Y0.9870.33
213_K325_H0.9690.32
184_L335_V0.9670.32
29_Q318_G0.9620.31
184_L188_L0.9600.31
300_I318_G0.9600.31
68_L251_V0.9570.31
167_T336_V0.9520.31
196_T215_K0.9520.31
40_T43_F0.9520.31
34_L52_V0.9470.31
132_G334_A0.9450.31
187_V244_I0.9440.31
77_S200_N0.9430.31
76_I283_I0.9410.30
80_I245_N0.9400.30
249_L330_L0.9380.30
68_L337_F0.9370.30
67_L341_T0.9350.30
136_F331_I0.9280.30
20_I324_G0.9270.30
177_I236_I0.9260.30
85_L88_N0.9230.30
330_L341_T0.9200.29
64_L79_F0.9180.29
10_I64_L0.9150.29
139_V179_T0.9140.29
132_G170_N0.9110.29
93_R268_V0.9020.29
130_A226_G0.8980.28
311_V322_N0.8930.28
51_I309_I0.8910.28
200_N319_Y0.8890.28
29_Q207_S0.8860.28
120_S125_I0.8840.28
134_L296_K0.8810.28
205_D304_P0.8800.28
78_V233_Y0.8790.28
48_G273_I0.8740.27
272_G276_A0.8720.27
54_K68_L0.8720.27
295_W322_N0.8700.27
298_G306_D0.8690.27
203_Y262_T0.8650.27
290_N314_R0.8640.27
81_Y262_T0.8630.27
334_A340_I0.8570.27
211_F304_P0.8540.26
207_S297_G0.8500.26
141_G241_W0.8480.26
68_L135_I0.8480.26
130_A220_I0.8460.26
126_T261_F0.8460.26
278_Y309_I0.8400.26
216_E220_I0.8400.26
33_I38_R0.8350.26
207_S308_R0.8280.25
33_I189_G0.8280.25
8_D80_I0.8250.25
157_G299_I0.8230.25
258_S266_V0.8190.25
113_I116_K0.8170.25
126_T223_G0.8160.25
214_F217_E0.8150.25
17_F185_L0.8140.25
16_T284_A0.8140.25
108_S133_I0.8130.25
31_P276_A0.8120.25
123_W216_E0.8090.25
152_L157_G0.8090.25
183_G199_I0.8090.25
133_I343_I0.8080.25
197_N275_G0.8080.25
78_V208_Y0.8080.25
180_V254_I0.8080.25
111_A269_L0.8070.24
53_N139_V0.8040.24
97_I338_A0.8040.24
97_I216_E0.8030.24
210_A274_E0.8020.24
17_F325_H0.7980.24
200_N204_P0.7980.24
46_N128_I0.7980.24
189_G312_P0.7960.24
231_S324_G0.7960.24
104_P224_I0.7940.24
52_V155_H0.7930.24
129_V166_K0.7920.24
268_V296_K0.7920.24
167_T171_F0.7920.24
311_V340_I0.7920.24
38_R95_I0.7860.24
210_A215_K0.7830.24
231_S271_I0.7790.23
204_P329_I0.7780.23
321_L324_G0.7780.23
267_Y276_A0.7760.23
16_T80_I0.7730.23
67_L311_V0.7700.23
77_S294_Y0.7700.23
312_P316_G0.7690.23
100_R177_I0.7690.23
101_G254_I0.7690.23
26_P207_S0.7670.23
47_K159_T0.7650.23
177_I265_I0.7630.23
295_W314_R0.7610.23
47_K51_I0.7590.23
45_K53_N0.7580.23
139_V337_F0.7570.22
29_Q52_V0.7550.22
210_A271_I0.7500.22
36_G311_V0.7490.22
338_A344_I0.7470.22
88_N325_H0.7460.22
170_N330_L0.7460.22
330_L334_A0.7450.22
37_A84_L0.7440.22
108_S328_S0.7440.22
94_R291_D0.7400.22
32_D201_P0.7370.22
65_L73_V0.7360.22
292_D322_N0.7350.22
169_L264_I0.7350.22
128_I250_E0.7340.22
304_P329_I0.7310.22
17_F140_F0.7310.22
35_L286_D0.7300.21
112_V120_S0.7290.21
163_F180_V0.7280.21
84_L169_L0.7280.21
128_I196_T0.7280.21
294_Y302_V0.7270.21
162_T278_Y0.7230.21
87_L333_L0.7150.21
73_V138_L0.7150.21
132_G180_V0.7120.21
144_V328_S0.7120.21
136_F163_F0.7100.21
102_S317_L0.7090.21
9_I109_R0.7070.21
179_T331_I0.7060.21
10_I74_S0.7030.20
68_L249_L0.7020.20
16_T85_L0.6950.20
55_Y323_F0.6940.20
159_T164_L0.6940.20
52_V138_L0.6940.20
29_Q36_G0.6930.20
118_K129_V0.6920.20
225_V332_I0.6920.20
261_F280_R0.6920.20
118_K125_I0.6910.20
108_S190_V0.6890.20
139_V255_F0.6870.20
29_Q48_G0.6870.20
333_L338_A0.6840.20
197_N215_K0.6830.20
35_L275_G0.6820.20
64_L75_F0.6780.20
95_I139_V0.6760.20
112_V233_Y0.6750.19
26_P30_P0.6730.19
273_I276_A0.6730.19
115_T328_S0.6720.19
8_D171_F0.6700.19
113_I294_Y0.6680.19
329_I332_I0.6660.19
219_G226_G0.6660.19
204_P211_F0.6650.19
178_N319_Y0.6620.19
198_V211_F0.6610.19
247_S340_I0.6570.19
51_I97_I0.6570.19
19_F327_I0.6510.19
48_G117_K0.6500.19
206_R211_F0.6490.19
93_R215_K0.6480.19
49_K338_A0.6480.19
74_S77_S0.6470.19
57_L258_S0.6470.19
103_L288_L0.6460.18
16_T64_L0.6430.18
56_R270_R0.6400.18
92_W185_L0.6400.18
66_S259_M0.6390.18
175_E256_L0.6380.18
11_I241_W0.6380.18
204_P275_G0.6360.18
136_F179_T0.6350.18
132_G234_T0.6320.18
182_L286_D0.6320.18
106_A184_L0.6310.18
218_V264_I0.6310.18
54_K76_I0.6300.18
236_I251_V0.6300.18
223_G227_V0.6280.18
191_F321_L0.6260.18
125_I135_I0.6260.18
324_G343_I0.6260.18
207_S211_F0.6250.18
89_V93_R0.6240.18
41_T233_Y0.6210.18
68_L304_P0.6210.18
56_R60_I0.6200.18
132_G221_I0.6200.18
132_G248_E0.6200.18
164_L294_Y0.6190.18
39_V305_K0.6180.18
140_F144_V0.6180.18
262_T327_I0.6170.18
177_I183_G0.6170.18
55_Y316_G0.6130.17
133_I139_V0.6100.17
33_I190_V0.6100.17
238_L321_L0.6080.17
224_I228_F0.6070.17
253_I271_I0.6030.17
12_Y16_T0.6030.17
28_L62_L0.5980.17
54_K239_F0.5980.17
262_T278_Y0.5980.17
109_R288_L0.5980.17
293_K296_K0.5980.17
316_G320_T0.5970.17
187_V294_Y0.5970.17
69_L340_I0.5960.17
127_F295_W0.5940.17
69_L183_G0.5920.17
72_F238_L0.5900.17
65_L76_I0.5900.17
12_Y245_N0.5860.17
48_G129_V0.5860.17
295_W306_D0.5850.17
26_P222_A0.5850.17
114_D211_F0.5830.16
310_W321_L0.5820.16
18_L188_L0.5820.16
46_N177_I0.5810.16
95_I132_G0.5800.16
87_L317_L0.5800.16
201_P210_A0.5780.16
39_V300_I0.5780.16
76_I259_M0.5740.16
250_E337_F0.5710.16
183_G187_V0.5710.16
141_G175_E0.5660.16
233_Y310_W0.5650.16
137_T175_E0.5600.16
200_N300_I0.5590.16
40_T45_K0.5570.16
55_Y160_G0.5560.16
179_T263_V0.5550.16
329_I343_I0.5550.16
80_I171_F0.5520.16
178_N308_R0.5510.16
215_K313_K0.5500.15
154_T162_T0.5480.15
64_L327_I0.5450.15
118_K338_A0.5450.15
69_L87_L0.5450.15
38_R134_L0.5450.15
249_L309_I0.5440.15
199_I275_G0.5420.15
8_D251_V0.5420.15
215_K342_T0.5420.15
18_L290_N0.5410.15
72_F76_I0.5410.15
79_F339_V0.5400.15
81_Y315_N0.5400.15
37_A324_G0.5390.15
169_L184_L0.5390.15
13_V131_W0.5380.15
188_L234_T0.5380.15
133_I250_E0.5380.15
78_V254_I0.5380.15
32_D344_I0.5340.15
15_F19_F0.5310.15
108_S308_R0.5300.15
314_R322_N0.5280.15
218_V310_W0.5280.15
20_I88_N0.5270.15
168_P215_K0.5270.15
64_L70_Y0.5270.15
59_L184_L0.5270.15
140_F230_T0.5270.15
202_A321_L0.5260.15
20_I24_L0.5260.15
300_I316_G0.5260.15
36_G298_G0.5240.15
231_S328_S0.5230.15
11_I51_I0.5220.15
7_L11_I0.5220.15
68_L309_I0.5210.15
44_K180_V0.5210.15
34_L39_V0.5200.15
9_I203_Y0.5200.15
139_V334_A0.5190.15
73_V344_I0.5190.15
91_Y257_I0.5180.15
254_I310_W0.5180.15
36_G196_T0.5170.15
61_G84_L0.5160.15
247_S337_F0.5150.14
69_L159_T0.5150.14
236_I280_R0.5150.14
120_S211_F0.5140.14
18_L33_I0.5130.14
169_L331_I0.5120.14
163_F192_I0.5120.14
40_T292_D0.5110.14
138_L256_L0.5110.14
135_I290_N0.5110.14
210_A275_G0.5080.14
91_Y99_R0.5050.14
131_W139_V0.5050.14
15_F196_T0.5040.14
36_G313_K0.5030.14
38_R289_L0.5030.14
136_F242_T0.5020.14
26_P166_K0.5020.14
294_Y334_A0.5010.14
45_K232_L0.5010.14
239_F267_Y0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i0uA 4 0.17 15 0.969 Contact Map
3mk7C 2 0.2161 13.4 0.97 Contact Map
4ev6A 3 0.1758 13.1 0.97 Contact Map
3ukmA 2 0.5735 8.5 0.972 Contact Map
3giaA 1 0.6081 8.4 0.972 Contact Map
3tx3A 2 0.2882 8 0.973 Contact Map
4djkA 2 0.6744 6.7 0.974 Contact Map
3dh4A 3 0.196 6.6 0.974 Contact Map
2kncA 1 0.1383 5.8 0.974 Contact Map
2xq2A 2 0.2478 4.6 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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