Q97XW9 - SULSO - GREMLIN Contacts

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Q97XW9 - Uncharacterized protein

UniProt:	Q97XW9	Sequences: MKNMTLLDIIIYVEFTFLFINLFLLPNLQPPDILLGARVTTEFKKNKGKDIVNKYRLSLIGLTLLSLLLYYFVSFISVFIYVILLLLNVVYWRRIVIRRRGSLPVASSRYAVIDTKKKESRKWIITFIVAWGILIFTLVFGSLVYSSAPKLLPTHVGPTGTTFLVKTPLNFYKVEIINTVVLGLLTVLGVFITRTTNVINPAYPDRSYYAFLKFKEEVGIIAGIVGVFMTSLYTTISLFIWTIINLSELEVFIIFLISMLFTVIIVYVLRIGIEGARYLRDVIANDNLLNDDKYWKGGIIYVNPKDPRIWVPKRNGLGYTLNFGHGISILIILAVVFAVITTIILVR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	347 (329)
Sequences:	302 (267)
Seq/√Len:	14.7

SULSO - Q97XW9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
302_V	324_G	7.607	1.00
40_T	103_L	6.598	1.00
313_K	318_G	5.202	1.00
272_G	275_G	3.890	1.00
98_R	290_N	3.556	0.99
19_F	63_T	3.499	0.99
35_L	52_V	3.454	0.99
321_L	328_S	3.208	0.99
89_V	315_N	3.094	0.98
64_L	340_I	2.889	0.97
117_K	123_W	2.709	0.96
155_H	163_F	2.654	0.95
31_P	228_F	2.628	0.95
121_R	125_I	2.573	0.94
157_G	162_T	2.509	0.93
295_W	320_T	2.467	0.93
195_T	308_R	2.429	0.92
237_S	241_W	2.419	0.92
204_P	207_S	2.328	0.91
301_Y	306_D	2.303	0.90
117_K	122_K	2.301	0.90
26_P	215_K	2.273	0.89
221_I	267_Y	2.215	0.88
117_K	125_I	2.187	0.87
130_A	227_V	2.121	0.86
45_K	101_G	2.117	0.86
117_K	121_R	2.101	0.85
335_V	339_V	2.096	0.85
200_N	207_S	2.073	0.84
132_G	269_L	2.066	0.84
214_F	275_G	2.021	0.83
301_Y	322_N	2.004	0.82
117_K	124_I	1.987	0.82
36_G	314_R	1.945	0.80
214_F	272_G	1.887	0.78
303_N	306_D	1.885	0.78
296_K	324_G	1.874	0.78
17_F	96_V	1.835	0.76
40_T	98_R	1.814	0.75
214_F	273_I	1.780	0.74
273_I	277_R	1.771	0.73
323_F	328_S	1.732	0.72
64_L	283_I	1.688	0.70
303_N	322_N	1.669	0.69
72_F	135_I	1.669	0.69
328_S	335_V	1.655	0.68
298_G	322_N	1.655	0.68
98_R	103_L	1.646	0.68
35_L	178_N	1.612	0.66
92_W	96_V	1.605	0.66
217_E	271_I	1.600	0.65
93_R	96_V	1.589	0.65
29_Q	32_D	1.580	0.64
306_D	322_N	1.563	0.64
325_H	329_I	1.561	0.63
54_K	222_A	1.551	0.63
17_F	45_K	1.548	0.63
40_T	175_E	1.542	0.62
48_G	83_I	1.482	0.59
187_V	335_V	1.479	0.59
35_L	48_G	1.465	0.58
257_I	262_T	1.462	0.58
141_G	237_S	1.461	0.58
190_V	262_T	1.460	0.58
54_K	61_G	1.455	0.58
47_K	101_G	1.455	0.58
131_W	255_F	1.430	0.56
154_T	164_L	1.427	0.56
132_G	205_D	1.426	0.56
34_L	48_G	1.426	0.56
309_I	331_I	1.408	0.55
298_G	301_Y	1.400	0.55
89_V	130_A	1.394	0.54
313_K	316_G	1.392	0.54
79_F	94_R	1.388	0.54
135_I	139_V	1.342	0.52
87_L	133_I	1.338	0.51
289_L	308_R	1.316	0.50
153_P	162_T	1.315	0.50
313_K	320_T	1.313	0.50
313_K	317_L	1.307	0.50
238_L	241_W	1.293	0.49
309_I	324_G	1.291	0.49
80_I	341_T	1.290	0.49
155_H	166_K	1.286	0.48
301_Y	311_V	1.271	0.48
48_G	96_V	1.270	0.48
49_K	167_T	1.270	0.48
320_T	323_F	1.266	0.47
246_L	330_L	1.261	0.47
331_I	343_I	1.256	0.47
38_R	96_V	1.253	0.47
113_I	196_T	1.247	0.46
296_K	302_V	1.247	0.46
237_S	312_P	1.241	0.46
39_V	291_D	1.237	0.46
102_S	227_V	1.231	0.45
89_V	162_T	1.229	0.45
45_K	49_K	1.224	0.45
324_G	328_S	1.216	0.45
186_T	333_L	1.213	0.44
201_P	207_S	1.209	0.44
295_W	301_Y	1.205	0.44
201_P	204_P	1.205	0.44
25_L	55_Y	1.202	0.44
297_G	300_I	1.201	0.44
135_I	337_F	1.194	0.43
32_D	109_R	1.191	0.43
312_P	318_G	1.187	0.43
27_N	130_A	1.186	0.43
327_I	331_I	1.171	0.42
62_L	84_L	1.163	0.42
36_G	312_P	1.154	0.41
238_L	335_V	1.150	0.41
65_L	341_T	1.149	0.41
275_G	278_Y	1.146	0.41
210_A	308_R	1.138	0.40
30_P	204_P	1.136	0.40
65_L	72_F	1.134	0.40
199_I	207_S	1.128	0.40
302_V	329_I	1.126	0.40
189_G	237_S	1.126	0.40
73_V	300_I	1.115	0.39
117_K	120_S	1.109	0.39
167_T	207_S	1.105	0.39
187_V	331_I	1.105	0.39
273_I	278_Y	1.093	0.38
241_W	317_L	1.088	0.38
328_S	336_V	1.084	0.38
62_L	266_V	1.079	0.37
291_D	295_W	1.078	0.37
122_K	219_G	1.078	0.37
59_L	80_I	1.070	0.37
41_T	181_V	1.070	0.37
76_I	205_D	1.067	0.37
168_P	260_L	1.065	0.37
166_K	171_F	1.062	0.36
231_S	248_E	1.062	0.36
196_T	214_F	1.062	0.36
29_Q	39_V	1.059	0.36
185_L	219_G	1.058	0.36
25_L	29_Q	1.057	0.36
159_T	259_M	1.052	0.36
268_V	275_G	1.052	0.36
35_L	105_V	1.050	0.36
274_E	312_P	1.050	0.36
98_R	292_D	1.044	0.35
291_D	319_Y	1.042	0.35
157_G	211_F	1.041	0.35
175_E	304_P	1.040	0.35
65_L	305_K	1.037	0.35
266_V	330_L	1.030	0.35
214_F	278_Y	1.029	0.35
65_L	228_F	1.029	0.35
337_F	341_T	1.028	0.35
80_I	337_F	1.025	0.35
39_V	50_D	1.024	0.34
207_S	329_I	1.023	0.34
37_A	98_R	1.015	0.34
261_F	264_I	1.010	0.34
272_G	277_R	1.006	0.34
311_V	325_H	1.006	0.34
258_S	324_G	1.004	0.33
68_L	159_T	1.003	0.33
183_G	260_L	1.002	0.33
160_G	299_I	1.001	0.33
37_A	78_V	0.998	0.33
44_K	338_A	0.994	0.33
328_S	332_I	0.993	0.33
298_G	303_N	0.990	0.33
211_F	294_Y	0.987	0.33
213_K	325_H	0.969	0.32
184_L	335_V	0.967	0.32
29_Q	318_G	0.962	0.31
184_L	188_L	0.960	0.31
300_I	318_G	0.960	0.31
68_L	251_V	0.957	0.31
167_T	336_V	0.952	0.31
196_T	215_K	0.952	0.31
40_T	43_F	0.952	0.31
34_L	52_V	0.947	0.31
132_G	334_A	0.945	0.31
187_V	244_I	0.944	0.31
77_S	200_N	0.943	0.31
76_I	283_I	0.941	0.30
80_I	245_N	0.940	0.30
249_L	330_L	0.938	0.30
68_L	337_F	0.937	0.30
67_L	341_T	0.935	0.30
136_F	331_I	0.928	0.30
20_I	324_G	0.927	0.30
177_I	236_I	0.926	0.30
85_L	88_N	0.923	0.30
330_L	341_T	0.920	0.29
64_L	79_F	0.918	0.29
10_I	64_L	0.915	0.29
139_V	179_T	0.914	0.29
132_G	170_N	0.911	0.29
93_R	268_V	0.902	0.29
130_A	226_G	0.898	0.28
311_V	322_N	0.893	0.28
51_I	309_I	0.891	0.28
200_N	319_Y	0.889	0.28
29_Q	207_S	0.886	0.28
120_S	125_I	0.884	0.28
134_L	296_K	0.881	0.28
205_D	304_P	0.880	0.28
78_V	233_Y	0.879	0.28
48_G	273_I	0.874	0.27
272_G	276_A	0.872	0.27
54_K	68_L	0.872	0.27
295_W	322_N	0.870	0.27
298_G	306_D	0.869	0.27
203_Y	262_T	0.865	0.27
290_N	314_R	0.864	0.27
81_Y	262_T	0.863	0.27
334_A	340_I	0.857	0.27
211_F	304_P	0.854	0.26
207_S	297_G	0.850	0.26
141_G	241_W	0.848	0.26
68_L	135_I	0.848	0.26
130_A	220_I	0.846	0.26
126_T	261_F	0.846	0.26
278_Y	309_I	0.840	0.26
216_E	220_I	0.840	0.26
33_I	38_R	0.835	0.26
207_S	308_R	0.828	0.25
33_I	189_G	0.828	0.25
8_D	80_I	0.825	0.25
157_G	299_I	0.823	0.25
258_S	266_V	0.819	0.25
113_I	116_K	0.817	0.25
126_T	223_G	0.816	0.25
214_F	217_E	0.815	0.25
17_F	185_L	0.814	0.25
16_T	284_A	0.814	0.25
108_S	133_I	0.813	0.25
31_P	276_A	0.812	0.25
123_W	216_E	0.809	0.25
152_L	157_G	0.809	0.25
183_G	199_I	0.809	0.25
133_I	343_I	0.808	0.25
197_N	275_G	0.808	0.25
78_V	208_Y	0.808	0.25
180_V	254_I	0.808	0.25
111_A	269_L	0.807	0.24
53_N	139_V	0.804	0.24
97_I	338_A	0.804	0.24
97_I	216_E	0.803	0.24
210_A	274_E	0.802	0.24
17_F	325_H	0.798	0.24
200_N	204_P	0.798	0.24
46_N	128_I	0.798	0.24
189_G	312_P	0.796	0.24
231_S	324_G	0.796	0.24
104_P	224_I	0.794	0.24
52_V	155_H	0.793	0.24
129_V	166_K	0.792	0.24
268_V	296_K	0.792	0.24
167_T	171_F	0.792	0.24
311_V	340_I	0.792	0.24
38_R	95_I	0.786	0.24
210_A	215_K	0.783	0.24
231_S	271_I	0.779	0.23
204_P	329_I	0.778	0.23
321_L	324_G	0.778	0.23
267_Y	276_A	0.776	0.23
16_T	80_I	0.773	0.23
67_L	311_V	0.770	0.23
77_S	294_Y	0.770	0.23
312_P	316_G	0.769	0.23
100_R	177_I	0.769	0.23
101_G	254_I	0.769	0.23
26_P	207_S	0.767	0.23
47_K	159_T	0.765	0.23
177_I	265_I	0.763	0.23
295_W	314_R	0.761	0.23
47_K	51_I	0.759	0.23
45_K	53_N	0.758	0.23
139_V	337_F	0.757	0.22
29_Q	52_V	0.755	0.22
210_A	271_I	0.750	0.22
36_G	311_V	0.749	0.22
338_A	344_I	0.747	0.22
88_N	325_H	0.746	0.22
170_N	330_L	0.746	0.22
330_L	334_A	0.745	0.22
37_A	84_L	0.744	0.22
108_S	328_S	0.744	0.22
94_R	291_D	0.740	0.22
32_D	201_P	0.737	0.22
65_L	73_V	0.736	0.22
292_D	322_N	0.735	0.22
169_L	264_I	0.735	0.22
128_I	250_E	0.734	0.22
304_P	329_I	0.731	0.22
17_F	140_F	0.731	0.22
35_L	286_D	0.730	0.21
112_V	120_S	0.729	0.21
163_F	180_V	0.728	0.21
84_L	169_L	0.728	0.21
128_I	196_T	0.728	0.21
294_Y	302_V	0.727	0.21
162_T	278_Y	0.723	0.21
87_L	333_L	0.715	0.21
73_V	138_L	0.715	0.21
132_G	180_V	0.712	0.21
144_V	328_S	0.712	0.21
136_F	163_F	0.710	0.21
102_S	317_L	0.709	0.21
9_I	109_R	0.707	0.21
179_T	331_I	0.706	0.21
10_I	74_S	0.703	0.20
68_L	249_L	0.702	0.20
16_T	85_L	0.695	0.20
55_Y	323_F	0.694	0.20
159_T	164_L	0.694	0.20
52_V	138_L	0.694	0.20
29_Q	36_G	0.693	0.20
118_K	129_V	0.692	0.20
225_V	332_I	0.692	0.20
261_F	280_R	0.692	0.20
118_K	125_I	0.691	0.20
108_S	190_V	0.689	0.20
139_V	255_F	0.687	0.20
29_Q	48_G	0.687	0.20
333_L	338_A	0.684	0.20
197_N	215_K	0.683	0.20
35_L	275_G	0.682	0.20
64_L	75_F	0.678	0.20
95_I	139_V	0.676	0.20
112_V	233_Y	0.675	0.19
26_P	30_P	0.673	0.19
273_I	276_A	0.673	0.19
115_T	328_S	0.672	0.19
8_D	171_F	0.670	0.19
113_I	294_Y	0.668	0.19
329_I	332_I	0.666	0.19
219_G	226_G	0.666	0.19
204_P	211_F	0.665	0.19
178_N	319_Y	0.662	0.19
198_V	211_F	0.661	0.19
247_S	340_I	0.657	0.19
51_I	97_I	0.657	0.19
19_F	327_I	0.651	0.19
48_G	117_K	0.650	0.19
206_R	211_F	0.649	0.19
93_R	215_K	0.648	0.19
49_K	338_A	0.648	0.19
74_S	77_S	0.647	0.19
57_L	258_S	0.647	0.19
103_L	288_L	0.646	0.18
16_T	64_L	0.643	0.18
56_R	270_R	0.640	0.18
92_W	185_L	0.640	0.18
66_S	259_M	0.639	0.18
175_E	256_L	0.638	0.18
11_I	241_W	0.638	0.18
204_P	275_G	0.636	0.18
136_F	179_T	0.635	0.18
132_G	234_T	0.632	0.18
182_L	286_D	0.632	0.18
106_A	184_L	0.631	0.18
218_V	264_I	0.631	0.18
54_K	76_I	0.630	0.18
236_I	251_V	0.630	0.18
223_G	227_V	0.628	0.18
191_F	321_L	0.626	0.18
125_I	135_I	0.626	0.18
324_G	343_I	0.626	0.18
207_S	211_F	0.625	0.18
89_V	93_R	0.624	0.18
41_T	233_Y	0.621	0.18
68_L	304_P	0.621	0.18
56_R	60_I	0.620	0.18
132_G	221_I	0.620	0.18
132_G	248_E	0.620	0.18
164_L	294_Y	0.619	0.18
39_V	305_K	0.618	0.18
140_F	144_V	0.618	0.18
262_T	327_I	0.617	0.18
177_I	183_G	0.617	0.18
55_Y	316_G	0.613	0.17
133_I	139_V	0.610	0.17
33_I	190_V	0.610	0.17
238_L	321_L	0.608	0.17
224_I	228_F	0.607	0.17
253_I	271_I	0.603	0.17
12_Y	16_T	0.603	0.17
28_L	62_L	0.598	0.17
54_K	239_F	0.598	0.17
262_T	278_Y	0.598	0.17
109_R	288_L	0.598	0.17
293_K	296_K	0.598	0.17
316_G	320_T	0.597	0.17
187_V	294_Y	0.597	0.17
69_L	340_I	0.596	0.17
127_F	295_W	0.594	0.17
69_L	183_G	0.592	0.17
72_F	238_L	0.590	0.17
65_L	76_I	0.590	0.17
12_Y	245_N	0.586	0.17
48_G	129_V	0.586	0.17
295_W	306_D	0.585	0.17
26_P	222_A	0.585	0.17
114_D	211_F	0.583	0.16
310_W	321_L	0.582	0.16
18_L	188_L	0.582	0.16
46_N	177_I	0.581	0.16
95_I	132_G	0.580	0.16
87_L	317_L	0.580	0.16
201_P	210_A	0.578	0.16
39_V	300_I	0.578	0.16
76_I	259_M	0.574	0.16
250_E	337_F	0.571	0.16
183_G	187_V	0.571	0.16
141_G	175_E	0.566	0.16
233_Y	310_W	0.565	0.16
137_T	175_E	0.560	0.16
200_N	300_I	0.559	0.16
40_T	45_K	0.557	0.16
55_Y	160_G	0.556	0.16
179_T	263_V	0.555	0.16
329_I	343_I	0.555	0.16
80_I	171_F	0.552	0.16
178_N	308_R	0.551	0.16
215_K	313_K	0.550	0.15
154_T	162_T	0.548	0.15
64_L	327_I	0.545	0.15
118_K	338_A	0.545	0.15
69_L	87_L	0.545	0.15
38_R	134_L	0.545	0.15
249_L	309_I	0.544	0.15
199_I	275_G	0.542	0.15
8_D	251_V	0.542	0.15
215_K	342_T	0.542	0.15
18_L	290_N	0.541	0.15
72_F	76_I	0.541	0.15
79_F	339_V	0.540	0.15
81_Y	315_N	0.540	0.15
37_A	324_G	0.539	0.15
169_L	184_L	0.539	0.15
13_V	131_W	0.538	0.15
188_L	234_T	0.538	0.15
133_I	250_E	0.538	0.15
78_V	254_I	0.538	0.15
32_D	344_I	0.534	0.15
15_F	19_F	0.531	0.15
108_S	308_R	0.530	0.15
314_R	322_N	0.528	0.15
218_V	310_W	0.528	0.15
20_I	88_N	0.527	0.15
168_P	215_K	0.527	0.15
64_L	70_Y	0.527	0.15
59_L	184_L	0.527	0.15
140_F	230_T	0.527	0.15
202_A	321_L	0.526	0.15
20_I	24_L	0.526	0.15
300_I	316_G	0.526	0.15
36_G	298_G	0.524	0.15
231_S	328_S	0.523	0.15
11_I	51_I	0.522	0.15
7_L	11_I	0.522	0.15
68_L	309_I	0.521	0.15
44_K	180_V	0.521	0.15
34_L	39_V	0.520	0.15
9_I	203_Y	0.520	0.15
139_V	334_A	0.519	0.15
73_V	344_I	0.519	0.15
91_Y	257_I	0.518	0.15
254_I	310_W	0.518	0.15
36_G	196_T	0.517	0.15
61_G	84_L	0.516	0.15
247_S	337_F	0.515	0.14
69_L	159_T	0.515	0.14
236_I	280_R	0.515	0.14
120_S	211_F	0.514	0.14
18_L	33_I	0.513	0.14
169_L	331_I	0.512	0.14
163_F	192_I	0.512	0.14
40_T	292_D	0.511	0.14
138_L	256_L	0.511	0.14
135_I	290_N	0.511	0.14
210_A	275_G	0.508	0.14
91_Y	99_R	0.505	0.14
131_W	139_V	0.505	0.14
15_F	196_T	0.504	0.14
36_G	313_K	0.503	0.14
38_R	289_L	0.503	0.14
136_F	242_T	0.502	0.14
26_P	166_K	0.502	0.14
294_Y	334_A	0.501	0.14
45_K	232_L	0.501	0.14
239_F	267_Y	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i0uA	4	0.17	15	0.969	Contact Map
3mk7C	2	0.2161	13.4	0.97	Contact Map
4ev6A	3	0.1758	13.1	0.97	Contact Map
3ukmA	2	0.5735	8.5	0.972	Contact Map
3giaA	1	0.6081	8.4	0.972	Contact Map
3tx3A	2	0.2882	8	0.973	Contact Map
4djkA	2	0.6744	6.7	0.974	Contact Map
3dh4A	3	0.196	6.6	0.974	Contact Map
2kncA	1	0.1383	5.8	0.974	Contact Map
2xq2A	2	0.2478	4.6	0.976	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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