GREMLIN Database
Q97XW6 - Coenzyme F390 synthetase
UniProt: Q97XW6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 180 (172)
Sequences: 540 (404)
Seq/√Len: 30.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_I170_T4.1251.00
128_D168_R3.5381.00
137_V156_G3.4731.00
15_I108_I3.2391.00
98_I171_I3.1811.00
114_L163_I3.1161.00
83_A174_L2.9721.00
76_W169_N2.6701.00
81_I171_I2.5681.00
81_I98_I2.3620.99
100_V163_I2.3010.99
85_I175_L2.1680.98
17_L112_V2.1450.98
36_F66_A2.1410.98
119_T123_A2.1380.98
88_S138_S2.1080.98
115_I141_I2.0710.98
125_A171_I2.0670.98
118_V141_I1.9250.97
62_F142_A1.9130.96
35_I53_W1.8880.96
17_L26_I1.8880.96
10_L32_I1.8490.96
41_Y49_D1.8040.95
112_V115_I1.7740.95
87_R137_V1.7640.94
73_E78_K1.7620.94
79_F100_V1.7530.94
10_L14_Y1.6880.93
89_G131_Y1.6570.92
35_I49_D1.6410.92
85_I136_T1.6410.92
48_G51_I1.5720.90
96_I126_L1.5630.90
49_D53_W1.5590.90
98_I141_I1.5300.89
22_Y50_V1.5170.88
116_R119_T1.4800.87
37_V63_M1.4710.87
89_G137_V1.4600.86
150_E159_L1.4460.86
79_F166_D1.4300.85
105_G146_L1.4080.84
123_A134_T1.3780.83
37_V152_F1.3720.83
71_F80_F1.3430.81
83_A175_L1.3070.79
32_I144_G1.2980.79
76_W165_Y1.2980.79
81_I174_L1.2890.78
85_I96_I1.2860.78
102_V163_I1.2780.78
45_N48_G1.2740.78
72_K173_E1.2700.77
16_I60_I1.2700.77
28_R111_L1.2150.74
88_S137_V1.1910.73
74_T173_E1.1710.71
78_K101_F1.1680.71
89_G124_G1.1670.71
74_T169_N1.1650.71
134_T164_A1.1640.71
111_L145_S1.1620.71
38_D65_A1.1600.71
21_L140_A1.1540.70
37_V140_A1.1490.70
32_I99_G1.1440.70
107_N110_G1.1340.69
113_D156_G1.1330.69
117_T155_P1.1300.69
46_P63_M1.1270.68
102_V159_L1.1060.67
43_S49_D1.0950.66
156_G161_K1.0920.66
75_D78_K1.0880.66
66_A152_F1.0630.64
91_D117_T1.0630.64
48_G151_Y1.0420.62
99_G142_A1.0370.62
137_V155_P1.0320.61
118_V121_A1.0300.61
79_F170_T1.0240.61
115_I119_T1.0230.61
113_D140_A1.0170.60
9_D31_Q1.0150.60
29_V60_I1.0010.59
26_I111_L0.9940.59
49_D156_G0.9790.57
45_N115_I0.9740.57
19_S164_A0.9520.55
122_K140_A0.9450.55
34_S122_K0.9420.54
63_M140_A0.9300.53
100_V118_V0.9280.53
34_S138_S0.9270.53
19_S122_K0.9270.53
128_D172_V0.9230.53
83_A138_S0.9220.53
59_A103_D0.9200.53
88_S91_D0.9190.53
85_I176_F0.9180.52
68_N91_D0.9160.52
89_G156_G0.9120.52
14_Y146_L0.9040.51
60_I142_A0.9010.51
159_L162_K0.9010.51
62_F99_G0.8970.51
49_D54_C0.8970.51
87_R157_T0.8930.50
28_R147_P0.8860.50
39_K65_A0.8850.50
154_G160_G0.8780.49
30_N58_S0.8730.49
34_S62_F0.8650.48
133_F138_S0.8590.48
48_G52_N0.8510.47
113_D137_V0.8400.46
82_S94_C0.8390.46
103_D162_K0.8370.46
6_V73_E0.8250.45
95_T136_T0.8240.45
100_V129_L0.8220.45
85_I131_Y0.8200.45
24_E155_P0.8130.44
37_V157_T0.8060.44
7_R33_C0.8060.44
129_L172_V0.8010.43
41_Y117_T0.7990.43
107_N148_G0.7880.42
125_A168_R0.7860.42
63_M88_S0.7780.41
73_E96_I0.7770.41
19_S112_V0.7720.41
89_G129_L0.7670.40
133_F164_A0.7630.40
123_A127_R0.7610.40
15_I28_R0.7610.40
32_I147_P0.7600.40
73_E143_V0.7580.40
20_A61_M0.7530.39
66_A175_L0.7510.39
9_D30_N0.7510.39
19_S34_S0.7480.39
87_R152_F0.7440.39
56_S169_N0.7410.38
20_A66_A0.7350.38
47_W51_I0.7340.38
33_C54_C0.7320.38
86_G157_T0.7320.38
20_A148_G0.7310.38
34_S94_C0.7240.37
114_L152_F0.7230.37
96_I141_I0.7220.37
111_L143_V0.7210.37
37_V87_R0.7200.37
84_G125_A0.7180.37
161_K165_Y0.7080.36
118_V163_I0.7060.36
126_L131_Y0.7050.36
89_G133_F0.6980.35
38_D123_A0.6980.35
100_V141_I0.6960.35
88_S133_F0.6960.35
33_C61_M0.6920.35
15_I145_S0.6870.34
137_V161_K0.6870.34
56_S173_E0.6850.34
118_V134_T0.6780.34
48_G55_P0.6750.34
137_V162_K0.6710.33
80_F106_L0.6680.33
28_R174_L0.6670.33
82_S95_T0.6630.33
98_I118_V0.6630.33
19_S113_D0.6620.33
110_G119_T0.6580.32
117_T122_K0.6550.32
158_E161_K0.6540.32
36_F70_T0.6510.32
68_N103_D0.6500.32
95_T135_G0.6470.32
21_L63_M0.6430.31
50_V123_A0.6360.31
124_G174_L0.6340.31
66_A122_K0.6330.31
97_N154_G0.6320.31
16_I144_G0.6290.30
142_A145_S0.6280.30
41_Y113_D0.6280.30
89_G136_T0.6250.30
69_Y128_D0.6220.30
62_F124_G0.6220.30
98_I102_V0.6200.30
130_G174_L0.6020.29
37_V41_Y0.6000.28
38_D67_K0.5960.28
143_V158_E0.5910.28
99_G105_G0.5890.28
17_L111_L0.5830.27
16_I38_D0.5830.27
120_E163_I0.5800.27
30_N48_G0.5800.27
171_I174_L0.5800.27
104_K150_E0.5790.27
73_E80_F0.5780.27
7_R14_Y0.5780.27
129_L176_F0.5770.27
72_K174_L0.5770.27
115_I118_V0.5750.27
20_A60_I0.5750.27
65_A112_V0.5740.27
46_P50_V0.5730.27
20_A25_G0.5710.27
87_R113_D0.5700.26
16_I32_I0.5670.26
30_N100_V0.5660.26
23_P41_Y0.5630.26
10_L109_N0.5620.26
11_G30_N0.5560.26
129_L133_F0.5560.26
106_L110_G0.5560.26
7_R21_L0.5550.26
45_N117_T0.5540.25
52_N171_I0.5540.25
135_G160_G0.5530.25
124_G137_V0.5510.25
37_V97_N0.5500.25
44_G73_E0.5500.25
68_N155_P0.5470.25
15_I144_G0.5460.25
7_R30_N0.5440.25
138_S175_L0.5440.25
50_V61_M0.5440.25
24_E33_C0.5350.24
64_T139_D0.5330.24
23_P164_A0.5320.24
32_I63_M0.5320.24
10_L19_S0.5290.24
28_R102_V0.5290.24
108_I138_S0.5270.24
30_N56_S0.5250.24
86_G90_E0.5240.24
20_A87_R0.5180.23
46_P61_M0.5170.23
9_D72_K0.5170.23
62_F140_A0.5140.23
114_L166_D0.5130.23
95_T160_G0.5110.23
104_K117_T0.5100.23
10_L76_W0.5090.23
120_E133_F0.5080.23
34_S99_G0.5070.23
46_P130_G0.5050.23
129_L174_L0.5040.23
8_F17_L0.5040.23
71_F86_G0.5030.22
119_T141_I0.5020.22
23_P68_N0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f6gB 2 0.6056 21 0.951 Contact Map
3axgA 4 0.7944 13.6 0.955 Contact Map
4es6A 1 0.6333 11.9 0.956 Contact Map
3n2wA 4 0.8556 7.7 0.96 Contact Map
1b65A 4 0.8222 7.7 0.96 Contact Map
2drhA 4 0.8111 6.6 0.961 Contact Map
3mw8A 1 0.6278 5.1 0.963 Contact Map
2lr1B 1 0.0722 3.8 0.965 Contact Map
2gaiA 1 0.5722 3.6 0.965 Contact Map
4mgeA 3 0.4556 3.4 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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