Q97XW2 - SULSO - GREMLIN Contacts

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Q97XW2 - Glycerol kinase (GlpK-1)

UniProt:	Q97XW2	Sequences: MITLDLPHQNNTQQIGYKLLSILDFQGKKAENLETLKGEKEIDISIDWTTKTWYGKPVEVSSEKGNSWNYATEMTKHNGKVLLLAFVTQVNEMTKDYIVKILVEQVTAMGFKIRLITLDAGFYTVDVLNFISQFKYIIAVPVGDMKVYEEFDGEYMTNSKRHRRDEQVKFRLLVYGREKIKRKKVVYFARGTNLDLPKKEALKLYDKVRSPIETSYRNIKALLPFTSSTKFVFHMLIFVLAMIFYSLYTVFKGMARREEFRLLLILLFPGDLFNLENSLFKLLETLINTIDLFL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	294 (264)
Sequences:	189 (133)
Seq/√Len:	8.2

HALSA - Q9HHP9 O51989 O51959
SULSO - Q97XW2 Q97TV3 Q97YD0 Q97Y40 Q97Y64 Q97UW1 Q97XT0 Q97WW6 Q97YS0 Q7LXX4 Q97UV3 Q97V50

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
113_I	137_I	4.875	0.99
118_L	215_S	4.745	0.99
46_I	99_V	3.670	0.96
76_K	216_Y	3.427	0.94
192_T	228_S	3.226	0.92
9_Q	233_F	2.958	0.87
49_T	220_K	2.776	0.84
192_T	210_S	2.775	0.84
62_S	71_A	2.666	0.81
53_W	246_S	2.654	0.81
236_L	240_L	2.577	0.79
120_A	139_A	2.529	0.77
72_T	216_Y	2.483	0.76
83_L	216_Y	2.479	0.76
192_T	245_Y	2.301	0.70
214_T	217_R	2.212	0.67
59_E	244_F	2.075	0.62
268_F	272_L	2.042	0.60
119_D	209_R	2.036	0.60
148_Y	151_F	2.021	0.59
267_L	271_D	1.933	0.56
47_D	213_E	1.920	0.55
195_D	207_K	1.882	0.54
222_L	245_Y	1.865	0.53
106_V	116_I	1.860	0.53
103_V	169_K	1.844	0.52
99_V	102_L	1.838	0.52
48_W	113_I	1.827	0.51
23_L	27_G	1.813	0.51
205_Y	212_I	1.806	0.51
244_F	255_A	1.804	0.50
220_K	245_Y	1.741	0.48
123_Y	140_V	1.734	0.48
89_Q	117_T	1.719	0.47
17_Y	29_K	1.716	0.47
193_N	238_F	1.686	0.46
216_Y	226_T	1.685	0.46
113_I	216_Y	1.640	0.44
121_G	247_L	1.635	0.44
216_Y	227_S	1.631	0.43
66_N	76_K	1.621	0.43
49_T	61_S	1.611	0.43
46_I	75_T	1.604	0.42
11_N	14_Q	1.600	0.42
83_L	242_M	1.586	0.42
34_E	131_I	1.554	0.40
111_F	156_M	1.536	0.40
44_I	106_V	1.520	0.39
252_K	256_R	1.516	0.39
268_F	271_D	1.505	0.38
267_L	270_G	1.504	0.38
224_P	237_I	1.503	0.38
209_R	213_E	1.501	0.38
75_T	127_V	1.485	0.38
115_L	221_A	1.475	0.37
201_A	247_L	1.470	0.37
55_G	58_V	1.464	0.37
123_Y	214_T	1.463	0.37
205_Y	213_E	1.448	0.36
70_Y	137_I	1.419	0.35
49_T	228_S	1.395	0.34
119_D	213_E	1.394	0.34
214_T	250_V	1.389	0.34
68_W	239_V	1.377	0.33
12_T	68_W	1.374	0.33
61_S	238_F	1.372	0.33
46_I	193_N	1.363	0.33
45_S	172_L	1.363	0.33
113_I	177_R	1.360	0.33
10_N	14_Q	1.353	0.33
223_L	235_M	1.351	0.32
121_G	141_P	1.347	0.32
47_D	209_R	1.344	0.32
94_T	97_Y	1.336	0.32
149_E	212_I	1.323	0.31
99_V	193_N	1.318	0.31
113_I	219_I	1.311	0.31
8_H	11_N	1.307	0.31
210_S	228_S	1.295	0.30
47_D	205_Y	1.290	0.30
68_W	206_D	1.289	0.30
89_Q	99_V	1.288	0.30
77_H	85_A	1.287	0.30
61_S	192_T	1.286	0.30
220_K	228_S	1.273	0.30
122_F	226_T	1.264	0.29
263_L	267_L	1.258	0.29
102_L	245_Y	1.248	0.29
75_T	81_V	1.245	0.29
77_H	156_M	1.244	0.29
47_D	119_D	1.239	0.29
260_F	263_L	1.220	0.28
75_T	99_V	1.216	0.28
72_T	84_L	1.206	0.27
111_F	116_I	1.203	0.27
12_T	120_A	1.186	0.27
55_G	123_Y	1.180	0.27
77_H	246_S	1.179	0.27
102_L	216_Y	1.178	0.27
6_L	9_Q	1.177	0.26
175_Y	178_E	1.168	0.26
7_P	18_K	1.168	0.26
92_E	199_K	1.155	0.26
228_S	238_F	1.152	0.26
264_L	268_F	1.144	0.25
145_M	195_D	1.133	0.25
32_N	250_V	1.111	0.24
62_S	67_S	1.108	0.24
102_L	193_N	1.107	0.24
136_Y	252_K	1.098	0.24
206_D	246_S	1.097	0.24
50_T	73_E	1.096	0.24
72_T	93_M	1.078	0.23
9_Q	15_I	1.072	0.23
111_F	134_F	1.071	0.23
165_D	187_Y	1.071	0.23
23_L	28_K	1.071	0.23
75_T	102_L	1.067	0.23
181_K	184_K	1.062	0.23
118_L	123_Y	1.058	0.23
220_K	238_F	1.053	0.23
53_W	229_T	1.048	0.23
123_Y	141_P	1.046	0.22
147_V	151_F	1.045	0.22
176_G	233_F	1.042	0.22
8_H	224_P	1.036	0.22
210_S	222_L	1.035	0.22
261_R	266_L	1.033	0.22
45_S	61_S	1.031	0.22
193_N	228_S	1.027	0.22
174_V	216_Y	1.025	0.22
43_D	117_T	1.024	0.22
122_F	213_E	1.024	0.22
12_T	20_L	1.018	0.22
45_S	74_M	1.012	0.22
261_R	264_L	1.009	0.21
90_V	247_L	1.008	0.21
225_F	246_S	1.001	0.21
234_H	248_Y	1.001	0.21
156_M	227_S	1.001	0.21
87_V	175_Y	0.999	0.21
50_T	121_G	0.990	0.21
116_I	182_R	0.989	0.21
137_I	175_Y	0.986	0.21
99_V	106_V	0.985	0.21
154_E	169_K	0.983	0.21
10_N	118_L	0.982	0.21
233_F	237_I	0.982	0.21
14_Q	21_S	0.980	0.21
259_E	262_L	0.980	0.21
118_L	191_G	0.977	0.21
72_T	107_T	0.973	0.20
249_T	252_K	0.973	0.20
238_F	245_Y	0.970	0.20
206_D	211_P	0.962	0.20
15_I	22_I	0.955	0.20
18_K	21_S	0.951	0.20
192_T	220_K	0.950	0.20
127_V	216_Y	0.946	0.20
83_L	215_S	0.942	0.20
128_L	136_Y	0.939	0.20
6_L	13_Q	0.928	0.19
46_I	134_F	0.926	0.19
97_Y	195_D	0.924	0.19
87_V	101_I	0.922	0.19
52_T	186_V	0.922	0.19
192_T	240_L	0.921	0.19
259_E	264_L	0.920	0.19
24_D	34_E	0.917	0.19
68_W	225_F	0.916	0.19
76_K	80_K	0.915	0.19
56_K	153_G	0.914	0.19
18_K	89_Q	0.911	0.19
111_F	176_G	0.910	0.19
178_E	212_I	0.907	0.19
198_K	257_R	0.905	0.19
214_T	218_N	0.904	0.19
193_N	222_L	0.901	0.19
110_G	236_L	0.894	0.18
79_G	248_Y	0.894	0.18
214_T	247_L	0.893	0.18
67_S	146_K	0.893	0.18
45_S	80_K	0.891	0.18
47_D	212_I	0.886	0.18
219_I	238_F	0.885	0.18
55_G	229_T	0.884	0.18
114_R	241_A	0.875	0.18
128_L	214_T	0.866	0.18
39_E	110_G	0.866	0.18
90_V	103_V	0.864	0.18
47_D	122_F	0.862	0.18
132_S	258_E	0.862	0.18
102_L	106_V	0.860	0.18
122_F	205_Y	0.860	0.18
102_L	219_I	0.858	0.18
133_Q	184_K	0.850	0.17
165_D	230_K	0.849	0.17
190_R	238_F	0.843	0.17
103_V	128_L	0.835	0.17
196_L	240_L	0.833	0.17
172_L	197_P	0.831	0.17
92_E	101_I	0.826	0.17
62_S	159_S	0.825	0.17
85_A	186_V	0.823	0.17
11_N	230_K	0.821	0.17
113_I	154_E	0.816	0.17
245_Y	252_K	0.812	0.16
148_Y	174_V	0.809	0.16
213_E	234_H	0.808	0.16
106_V	136_Y	0.807	0.16
211_P	241_A	0.804	0.16
128_L	191_G	0.803	0.16
16_G	23_L	0.802	0.16
263_L	269_P	0.799	0.16
136_Y	230_K	0.797	0.16
165_D	247_L	0.797	0.16
122_F	212_I	0.796	0.16
49_T	67_S	0.795	0.16
128_L	205_Y	0.794	0.16
35_T	112_K	0.785	0.16
175_Y	214_T	0.785	0.16
214_T	232_V	0.785	0.16
67_S	235_M	0.783	0.16
85_A	103_V	0.777	0.16
205_Y	209_R	0.776	0.16
45_S	79_G	0.775	0.16
258_E	261_R	0.775	0.16
6_L	12_T	0.775	0.16
21_S	25_F	0.774	0.16
190_R	210_S	0.769	0.15
178_E	184_K	0.765	0.15
107_T	143_G	0.764	0.15
40_K	112_K	0.758	0.15
228_S	245_Y	0.756	0.15
207_K	232_V	0.755	0.15
87_V	214_T	0.753	0.15
114_R	210_S	0.747	0.15
190_R	193_N	0.742	0.15
72_T	76_K	0.741	0.15
28_K	239_V	0.739	0.15
198_K	202_L	0.739	0.15
120_A	235_M	0.738	0.15
193_N	219_I	0.738	0.15
50_T	71_A	0.736	0.15
45_S	63_E	0.734	0.15
92_E	156_M	0.728	0.15
55_G	247_L	0.727	0.15
8_H	26_Q	0.727	0.15
45_S	127_V	0.722	0.14
91_N	203_K	0.712	0.14
88_T	136_Y	0.711	0.14
174_V	251_F	0.710	0.14
124_T	229_T	0.699	0.14
72_T	78_N	0.697	0.14
138_I	164_R	0.689	0.14
61_S	190_R	0.687	0.14
67_S	76_K	0.687	0.14
76_K	102_L	0.685	0.14
193_N	210_S	0.684	0.14
67_S	72_T	0.683	0.14
232_V	250_V	0.683	0.14
211_P	217_R	0.680	0.14
247_L	268_F	0.676	0.14
173_L	197_P	0.673	0.14
51_K	85_A	0.669	0.13
119_D	205_Y	0.669	0.13
38_G	90_V	0.668	0.13
131_I	134_F	0.667	0.13
100_K	228_S	0.664	0.13
164_R	249_T	0.662	0.13
83_L	107_T	0.659	0.13
46_I	226_T	0.655	0.13
77_H	97_Y	0.655	0.13
229_T	236_L	0.653	0.13
47_D	234_H	0.652	0.13
181_K	197_P	0.649	0.13
139_A	252_K	0.648	0.13
71_A	154_E	0.647	0.13
105_Q	224_P	0.647	0.13
22_I	136_Y	0.647	0.13
99_V	136_Y	0.643	0.13
38_G	247_L	0.639	0.13
206_D	258_E	0.638	0.13
121_G	155_Y	0.634	0.13
77_H	113_I	0.631	0.13
252_K	262_L	0.631	0.13
51_K	199_K	0.630	0.13
79_G	236_L	0.629	0.13
138_I	203_K	0.628	0.13
154_E	167_Q	0.627	0.13
63_E	79_G	0.624	0.13
117_T	139_A	0.624	0.13
49_T	219_I	0.624	0.13
87_V	168_V	0.624	0.13
112_K	146_K	0.623	0.13
126_D	163_R	0.623	0.13
99_V	244_F	0.622	0.13
161_R	167_Q	0.620	0.13
136_Y	193_N	0.617	0.12
136_Y	238_F	0.616	0.12
265_I	268_F	0.615	0.12
6_L	138_I	0.615	0.12
141_P	241_A	0.611	0.12
96_D	150_E	0.610	0.12
36_L	164_R	0.609	0.12
23_L	246_S	0.605	0.12
53_W	82_L	0.604	0.12
10_N	230_K	0.603	0.12
256_R	262_L	0.603	0.12
89_Q	257_R	0.598	0.12
174_V	215_S	0.592	0.12
9_Q	257_R	0.591	0.12
127_V	212_I	0.589	0.12
16_G	92_E	0.582	0.12
210_S	262_L	0.582	0.12
43_D	243_I	0.581	0.12
34_E	79_G	0.580	0.12
171_R	216_Y	0.579	0.12
137_I	205_Y	0.579	0.12
48_W	89_Q	0.577	0.12
123_Y	247_L	0.575	0.12
112_K	135_K	0.574	0.12
230_K	268_F	0.573	0.12
101_I	177_R	0.573	0.12
129_N	201_A	0.572	0.12
88_T	190_R	0.572	0.12
73_E	219_I	0.569	0.12
206_D	225_F	0.568	0.12
41_E	77_H	0.567	0.12
36_L	133_Q	0.567	0.12
50_T	247_L	0.566	0.12
229_T	247_L	0.565	0.12
257_R	261_R	0.564	0.12
206_D	230_K	0.563	0.12
44_I	219_I	0.563	0.12
201_A	206_D	0.562	0.11
87_V	217_R	0.561	0.11
63_E	71_A	0.561	0.11
7_P	220_K	0.560	0.11
83_L	123_Y	0.556	0.11
59_E	162_H	0.555	0.11
75_T	216_Y	0.553	0.11
89_Q	127_V	0.552	0.11
227_S	239_V	0.551	0.11
87_V	211_P	0.548	0.11
116_I	184_K	0.547	0.11
83_L	120_A	0.547	0.11
16_G	116_I	0.546	0.11
200_E	257_R	0.545	0.11
52_T	244_F	0.545	0.11
134_F	239_V	0.544	0.11
139_A	226_T	0.542	0.11
193_N	220_K	0.542	0.11
258_E	263_L	0.542	0.11
98_I	235_M	0.541	0.11
259_E	266_L	0.541	0.11
79_G	113_I	0.539	0.11
165_D	178_E	0.539	0.11
94_T	120_A	0.536	0.11
26_Q	207_K	0.535	0.11
71_A	74_M	0.535	0.11
68_W	249_T	0.534	0.11
219_I	241_A	0.533	0.11
190_R	252_K	0.533	0.11
174_V	250_V	0.530	0.11
54_Y	117_T	0.530	0.11
196_L	217_R	0.529	0.11
267_L	272_L	0.528	0.11
221_A	244_F	0.527	0.11
55_G	118_L	0.527	0.11
210_S	245_Y	0.526	0.11
118_L	121_G	0.525	0.11
38_G	229_T	0.524	0.11
84_L	102_L	0.524	0.11
206_D	248_Y	0.524	0.11
118_L	210_S	0.521	0.11
241_A	258_E	0.520	0.11
128_L	138_I	0.519	0.11
233_F	247_L	0.519	0.11
192_T	214_T	0.517	0.11
15_I	255_A	0.516	0.11
116_I	196_L	0.515	0.11
67_S	212_I	0.515	0.11
62_S	179_K	0.515	0.11
125_V	167_Q	0.514	0.11
138_I	194_L	0.507	0.11
251_F	254_M	0.507	0.11
44_I	62_S	0.506	0.11
126_D	153_G	0.506	0.11
137_I	206_D	0.504	0.11
111_F	140_V	0.504	0.11
75_T	194_L	0.502	0.11
62_S	70_Y	0.502	0.11
54_Y	73_E	0.501	0.11
39_E	145_M	0.500	0.10
67_S	80_K	0.500	0.10

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1musA	2	0.915	99	0.858	Contact Map
4xb4A	1	0.3435	15.7	0.967	Contact Map
2ka4B	1	0.1837	7.3	0.972	Contact Map
4mq3A	1	0.4184	5.3	0.973	Contact Map
3uowA	2	0.3571	5	0.974	Contact Map
4mcwA	2	0.4388	4.5	0.974	Contact Map
2mj2A	1	0.1224	3.9	0.975	Contact Map
1lfpA	1	0.3946	3.7	0.975	Contact Map
2qarB	2	0.1156	3.6	0.975	Contact Map
1konA	1	0.4014	3.5	0.975	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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