GREMLIN Database
Q97XW2 - Glycerol kinase (GlpK-1)
UniProt: Q97XW2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 294 (264)
Sequences: 189 (133)
Seq/√Len: 8.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_I137_I4.8750.99
118_L215_S4.7450.99
46_I99_V3.6700.96
76_K216_Y3.4270.94
192_T228_S3.2260.92
9_Q233_F2.9580.87
49_T220_K2.7760.84
192_T210_S2.7750.84
62_S71_A2.6660.81
53_W246_S2.6540.81
236_L240_L2.5770.79
120_A139_A2.5290.77
72_T216_Y2.4830.76
83_L216_Y2.4790.76
192_T245_Y2.3010.70
214_T217_R2.2120.67
59_E244_F2.0750.62
268_F272_L2.0420.60
119_D209_R2.0360.60
148_Y151_F2.0210.59
267_L271_D1.9330.56
47_D213_E1.9200.55
195_D207_K1.8820.54
222_L245_Y1.8650.53
106_V116_I1.8600.53
103_V169_K1.8440.52
99_V102_L1.8380.52
48_W113_I1.8270.51
23_L27_G1.8130.51
205_Y212_I1.8060.51
244_F255_A1.8040.50
220_K245_Y1.7410.48
123_Y140_V1.7340.48
89_Q117_T1.7190.47
17_Y29_K1.7160.47
193_N238_F1.6860.46
216_Y226_T1.6850.46
113_I216_Y1.6400.44
121_G247_L1.6350.44
216_Y227_S1.6310.43
66_N76_K1.6210.43
49_T61_S1.6110.43
46_I75_T1.6040.42
11_N14_Q1.6000.42
83_L242_M1.5860.42
34_E131_I1.5540.40
111_F156_M1.5360.40
44_I106_V1.5200.39
252_K256_R1.5160.39
268_F271_D1.5050.38
267_L270_G1.5040.38
224_P237_I1.5030.38
209_R213_E1.5010.38
75_T127_V1.4850.38
115_L221_A1.4750.37
201_A247_L1.4700.37
55_G58_V1.4640.37
123_Y214_T1.4630.37
205_Y213_E1.4480.36
70_Y137_I1.4190.35
49_T228_S1.3950.34
119_D213_E1.3940.34
214_T250_V1.3890.34
68_W239_V1.3770.33
12_T68_W1.3740.33
61_S238_F1.3720.33
46_I193_N1.3630.33
45_S172_L1.3630.33
113_I177_R1.3600.33
10_N14_Q1.3530.33
223_L235_M1.3510.32
121_G141_P1.3470.32
47_D209_R1.3440.32
94_T97_Y1.3360.32
149_E212_I1.3230.31
99_V193_N1.3180.31
113_I219_I1.3110.31
8_H11_N1.3070.31
210_S228_S1.2950.30
47_D205_Y1.2900.30
68_W206_D1.2890.30
89_Q99_V1.2880.30
77_H85_A1.2870.30
61_S192_T1.2860.30
220_K228_S1.2730.30
122_F226_T1.2640.29
263_L267_L1.2580.29
102_L245_Y1.2480.29
75_T81_V1.2450.29
77_H156_M1.2440.29
47_D119_D1.2390.29
260_F263_L1.2200.28
75_T99_V1.2160.28
72_T84_L1.2060.27
111_F116_I1.2030.27
12_T120_A1.1860.27
55_G123_Y1.1800.27
77_H246_S1.1790.27
102_L216_Y1.1780.27
6_L9_Q1.1770.26
175_Y178_E1.1680.26
7_P18_K1.1680.26
92_E199_K1.1550.26
228_S238_F1.1520.26
264_L268_F1.1440.25
145_M195_D1.1330.25
32_N250_V1.1110.24
62_S67_S1.1080.24
102_L193_N1.1070.24
136_Y252_K1.0980.24
206_D246_S1.0970.24
50_T73_E1.0960.24
72_T93_M1.0780.23
9_Q15_I1.0720.23
111_F134_F1.0710.23
165_D187_Y1.0710.23
23_L28_K1.0710.23
75_T102_L1.0670.23
181_K184_K1.0620.23
118_L123_Y1.0580.23
220_K238_F1.0530.23
53_W229_T1.0480.23
123_Y141_P1.0460.22
147_V151_F1.0450.22
176_G233_F1.0420.22
8_H224_P1.0360.22
210_S222_L1.0350.22
261_R266_L1.0330.22
45_S61_S1.0310.22
193_N228_S1.0270.22
174_V216_Y1.0250.22
43_D117_T1.0240.22
122_F213_E1.0240.22
12_T20_L1.0180.22
45_S74_M1.0120.22
261_R264_L1.0090.21
90_V247_L1.0080.21
225_F246_S1.0010.21
234_H248_Y1.0010.21
156_M227_S1.0010.21
87_V175_Y0.9990.21
50_T121_G0.9900.21
116_I182_R0.9890.21
137_I175_Y0.9860.21
99_V106_V0.9850.21
154_E169_K0.9830.21
10_N118_L0.9820.21
233_F237_I0.9820.21
14_Q21_S0.9800.21
259_E262_L0.9800.21
118_L191_G0.9770.21
72_T107_T0.9730.20
249_T252_K0.9730.20
238_F245_Y0.9700.20
206_D211_P0.9620.20
15_I22_I0.9550.20
18_K21_S0.9510.20
192_T220_K0.9500.20
127_V216_Y0.9460.20
83_L215_S0.9420.20
128_L136_Y0.9390.20
6_L13_Q0.9280.19
46_I134_F0.9260.19
97_Y195_D0.9240.19
87_V101_I0.9220.19
52_T186_V0.9220.19
192_T240_L0.9210.19
259_E264_L0.9200.19
24_D34_E0.9170.19
68_W225_F0.9160.19
76_K80_K0.9150.19
56_K153_G0.9140.19
18_K89_Q0.9110.19
111_F176_G0.9100.19
178_E212_I0.9070.19
198_K257_R0.9050.19
214_T218_N0.9040.19
193_N222_L0.9010.19
110_G236_L0.8940.18
79_G248_Y0.8940.18
214_T247_L0.8930.18
67_S146_K0.8930.18
45_S80_K0.8910.18
47_D212_I0.8860.18
219_I238_F0.8850.18
55_G229_T0.8840.18
114_R241_A0.8750.18
128_L214_T0.8660.18
39_E110_G0.8660.18
90_V103_V0.8640.18
47_D122_F0.8620.18
132_S258_E0.8620.18
102_L106_V0.8600.18
122_F205_Y0.8600.18
102_L219_I0.8580.18
133_Q184_K0.8500.17
165_D230_K0.8490.17
190_R238_F0.8430.17
103_V128_L0.8350.17
196_L240_L0.8330.17
172_L197_P0.8310.17
92_E101_I0.8260.17
62_S159_S0.8250.17
85_A186_V0.8230.17
11_N230_K0.8210.17
113_I154_E0.8160.17
245_Y252_K0.8120.16
148_Y174_V0.8090.16
213_E234_H0.8080.16
106_V136_Y0.8070.16
211_P241_A0.8040.16
128_L191_G0.8030.16
16_G23_L0.8020.16
263_L269_P0.7990.16
136_Y230_K0.7970.16
165_D247_L0.7970.16
122_F212_I0.7960.16
49_T67_S0.7950.16
128_L205_Y0.7940.16
35_T112_K0.7850.16
175_Y214_T0.7850.16
214_T232_V0.7850.16
67_S235_M0.7830.16
85_A103_V0.7770.16
205_Y209_R0.7760.16
45_S79_G0.7750.16
258_E261_R0.7750.16
6_L12_T0.7750.16
21_S25_F0.7740.16
190_R210_S0.7690.15
178_E184_K0.7650.15
107_T143_G0.7640.15
40_K112_K0.7580.15
228_S245_Y0.7560.15
207_K232_V0.7550.15
87_V214_T0.7530.15
114_R210_S0.7470.15
190_R193_N0.7420.15
72_T76_K0.7410.15
28_K239_V0.7390.15
198_K202_L0.7390.15
120_A235_M0.7380.15
193_N219_I0.7380.15
50_T71_A0.7360.15
45_S63_E0.7340.15
92_E156_M0.7280.15
55_G247_L0.7270.15
8_H26_Q0.7270.15
45_S127_V0.7220.14
91_N203_K0.7120.14
88_T136_Y0.7110.14
174_V251_F0.7100.14
124_T229_T0.6990.14
72_T78_N0.6970.14
138_I164_R0.6890.14
61_S190_R0.6870.14
67_S76_K0.6870.14
76_K102_L0.6850.14
193_N210_S0.6840.14
67_S72_T0.6830.14
232_V250_V0.6830.14
211_P217_R0.6800.14
247_L268_F0.6760.14
173_L197_P0.6730.14
51_K85_A0.6690.13
119_D205_Y0.6690.13
38_G90_V0.6680.13
131_I134_F0.6670.13
100_K228_S0.6640.13
164_R249_T0.6620.13
83_L107_T0.6590.13
46_I226_T0.6550.13
77_H97_Y0.6550.13
229_T236_L0.6530.13
47_D234_H0.6520.13
181_K197_P0.6490.13
139_A252_K0.6480.13
71_A154_E0.6470.13
105_Q224_P0.6470.13
22_I136_Y0.6470.13
99_V136_Y0.6430.13
38_G247_L0.6390.13
206_D258_E0.6380.13
121_G155_Y0.6340.13
77_H113_I0.6310.13
252_K262_L0.6310.13
51_K199_K0.6300.13
79_G236_L0.6290.13
138_I203_K0.6280.13
154_E167_Q0.6270.13
63_E79_G0.6240.13
117_T139_A0.6240.13
49_T219_I0.6240.13
87_V168_V0.6240.13
112_K146_K0.6230.13
126_D163_R0.6230.13
99_V244_F0.6220.13
161_R167_Q0.6200.13
136_Y193_N0.6170.12
136_Y238_F0.6160.12
265_I268_F0.6150.12
6_L138_I0.6150.12
141_P241_A0.6110.12
96_D150_E0.6100.12
36_L164_R0.6090.12
23_L246_S0.6050.12
53_W82_L0.6040.12
10_N230_K0.6030.12
256_R262_L0.6030.12
89_Q257_R0.5980.12
174_V215_S0.5920.12
9_Q257_R0.5910.12
127_V212_I0.5890.12
16_G92_E0.5820.12
210_S262_L0.5820.12
43_D243_I0.5810.12
34_E79_G0.5800.12
171_R216_Y0.5790.12
137_I205_Y0.5790.12
48_W89_Q0.5770.12
123_Y247_L0.5750.12
112_K135_K0.5740.12
230_K268_F0.5730.12
101_I177_R0.5730.12
129_N201_A0.5720.12
88_T190_R0.5720.12
73_E219_I0.5690.12
206_D225_F0.5680.12
41_E77_H0.5670.12
36_L133_Q0.5670.12
50_T247_L0.5660.12
229_T247_L0.5650.12
257_R261_R0.5640.12
206_D230_K0.5630.12
44_I219_I0.5630.12
201_A206_D0.5620.11
87_V217_R0.5610.11
63_E71_A0.5610.11
7_P220_K0.5600.11
83_L123_Y0.5560.11
59_E162_H0.5550.11
75_T216_Y0.5530.11
89_Q127_V0.5520.11
227_S239_V0.5510.11
87_V211_P0.5480.11
116_I184_K0.5470.11
83_L120_A0.5470.11
16_G116_I0.5460.11
200_E257_R0.5450.11
52_T244_F0.5450.11
134_F239_V0.5440.11
139_A226_T0.5420.11
193_N220_K0.5420.11
258_E263_L0.5420.11
98_I235_M0.5410.11
259_E266_L0.5410.11
79_G113_I0.5390.11
165_D178_E0.5390.11
94_T120_A0.5360.11
26_Q207_K0.5350.11
71_A74_M0.5350.11
68_W249_T0.5340.11
219_I241_A0.5330.11
190_R252_K0.5330.11
174_V250_V0.5300.11
54_Y117_T0.5300.11
196_L217_R0.5290.11
267_L272_L0.5280.11
221_A244_F0.5270.11
55_G118_L0.5270.11
210_S245_Y0.5260.11
118_L121_G0.5250.11
38_G229_T0.5240.11
84_L102_L0.5240.11
206_D248_Y0.5240.11
118_L210_S0.5210.11
241_A258_E0.5200.11
128_L138_I0.5190.11
233_F247_L0.5190.11
192_T214_T0.5170.11
15_I255_A0.5160.11
116_I196_L0.5150.11
67_S212_I0.5150.11
62_S179_K0.5150.11
125_V167_Q0.5140.11
138_I194_L0.5070.11
251_F254_M0.5070.11
44_I62_S0.5060.11
126_D153_G0.5060.11
137_I206_D0.5040.11
111_F140_V0.5040.11
75_T194_L0.5020.11
62_S70_Y0.5020.11
54_Y73_E0.5010.11
39_E145_M0.5000.10
67_S80_K0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.915 99 0.858 Contact Map
4xb4A 1 0.3435 15.7 0.967 Contact Map
2ka4B 1 0.1837 7.3 0.972 Contact Map
4mq3A 1 0.4184 5.3 0.973 Contact Map
3uowA 2 0.3571 5 0.974 Contact Map
4mcwA 2 0.4388 4.5 0.974 Contact Map
2mj2A 1 0.1224 3.9 0.975 Contact Map
1lfpA 1 0.3946 3.7 0.975 Contact Map
2qarB 2 0.1156 3.6 0.975 Contact Map
1konA 1 0.4014 3.5 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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