GREMLIN Database
GLPK1 - Glycerol kinase 1
UniProt: Q97XW1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 501 (471)
Sequences: 12503 (8490)
Seq/√Len: 391.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_I146_D3.7571.00
201_R211_E3.6701.00
25_D29_N3.3951.00
21_A62_A3.2581.00
115_W146_D3.2531.00
193_N196_K2.8681.00
386_R480_Y2.8571.00
426_K468_I2.7931.00
127_K200_D2.7761.00
393_Q425_I2.7531.00
386_R390_E2.7451.00
98_V151_V2.6831.00
36_Y61_L2.6821.00
417_Q421_D2.6741.00
41_Y100_N2.6601.00
413_N465_K2.6251.00
361_I373_I2.6131.00
34_G65_K2.5771.00
402_S428_I2.5631.00
333_V372_H2.5451.00
452_N456_E2.5361.00
36_Y65_K2.5351.00
192_F217_V2.5201.00
219_P222_E2.5121.00
453_S456_E2.4841.00
56_W172_R2.4691.00
99_Y148_V2.4421.00
23_L66_A2.4001.00
91_D154_K2.3741.00
92_A156_E2.3741.00
53_E172_R2.3701.00
322_V325_E2.3141.00
386_R477_R2.3081.00
91_D94_S2.2981.00
193_N200_D2.1861.00
204_L211_E2.1381.00
240_A245_A2.1031.00
22_I437_S2.0951.00
12_L59_Q2.0761.00
201_R205_E2.0751.00
176_G216_E2.0741.00
337_G372_H2.0611.00
170_I239_D2.0461.00
198_E211_E2.0241.00
7_K76_V2.0121.00
18_S35_Q2.0011.00
309_A377_I1.9821.00
470_S473_E1.9631.00
115_W119_N1.9211.00
321_D325_E1.9201.00
341_F361_I1.9101.00
123_M126_D1.9051.00
39_P54_E1.9041.00
266_S306_T1.9001.00
53_E96_K1.8841.00
174_T236_I1.8621.00
431_K462_K1.8591.00
9_V445_G1.8581.00
393_Q399_S1.8561.00
332_N371_A1.8561.00
10_L63_V1.8481.00
369_T372_H1.8471.00
44_Q47_Y1.8381.00
340_Y482_G1.8361.00
65_K69_K1.8351.00
254_N458_R1.8281.00
405_V416_M1.8141.00
424_G474_E1.7991.00
480_Y484_K1.7901.00
10_L21_A1.7891.00
14_E19_A1.7751.00
8_F31_V1.7721.00
157_R179_H1.7701.00
325_E328_P1.7631.00
313_F377_I1.7171.00
142_K146_D1.7171.00
428_I466_E1.7081.00
127_K202_E1.6941.00
237_S447_G1.6761.00
421_D473_E1.6701.00
218_K222_E1.6641.00
123_M202_E1.6601.00
114_D118_A1.6531.00
95_G171_W1.6481.00
123_M127_K1.6391.00
8_F23_L1.6331.00
180_V218_K1.6301.00
89_L144_I1.6231.00
421_D470_S1.6081.00
91_D96_K1.5931.00
223_I226_Y1.5831.00
426_K466_E1.5721.00
257_E402_S1.5691.00
311_Q315_D1.5661.00
383_Y479_L1.5551.00
474_E477_R1.5471.00
88_V165_L1.5431.00
117_K121_F1.5361.00
111_P115_W1.5321.00
89_L213_I1.5221.00
223_I237_S1.5181.00
9_V450_L1.5131.00
7_K74_Q1.5091.00
41_Y54_E1.4831.00
328_P332_N1.4731.00
327_E331_S1.4651.00
150_N153_E1.4631.00
122_K126_D1.4461.00
34_G62_A1.4451.00
390_E484_K1.4431.00
60_M229_A1.4411.00
358_R365_T1.4391.00
34_G66_A1.4311.00
472_S475_K1.4221.00
329_L371_A1.4151.00
51_D54_E1.4141.00
329_L332_N1.4081.00
375_R379_E1.4001.00
170_I224_Y1.3881.00
32_N69_K1.3881.00
390_E393_Q1.3821.00
67_I72_A1.3811.00
445_G451_W1.3801.00
414_L418_F1.3711.00
143_W147_N1.3671.00
53_E57_E1.3661.00
26_S450_L1.3651.00
77_A444_A1.3581.00
413_N429_R1.3501.00
226_Y233_L1.3471.00
431_K464_D1.3401.00
32_N66_A1.3351.00
231_G234_I1.3331.00
326_I374_A1.3321.00
56_W60_M1.3301.00
210_P213_I1.3221.00
348_L351_P1.3061.00
258_I400_I1.3001.00
413_N467_F1.2991.00
341_F345_F1.2981.00
303_I384_Q1.2931.00
12_L63_V1.2861.00
168_Y172_R1.2851.00
262_Y419_Q1.2821.00
402_S426_K1.2741.00
84_R241_G1.2721.00
382_A418_F1.2721.00
90_W163_G1.2711.00
110_S114_D1.2661.00
330_A414_L1.2651.00
123_M206_L1.2561.00
218_K224_Y1.2551.00
183_Y197_L1.2551.00
475_K478_A1.2491.00
223_I235_P1.2461.00
473_E476_R1.2441.00
19_A59_Q1.2431.00
329_L370_K1.2391.00
424_G476_R1.2381.00
195_N276_P1.2301.00
382_A419_Q1.2291.00
260_A419_Q1.2171.00
256_G401_N1.2091.00
204_L214_L1.2081.00
429_R467_F1.2071.00
382_A422_I1.2051.00
138_A207_L1.2041.00
328_P331_S1.2021.00
174_T225_G1.1951.00
71_D74_Q1.1911.00
341_F377_I1.1901.00
170_I180_V1.1871.00
202_E205_E1.1831.00
339_V368_T1.1821.00
19_A58_A1.1801.00
145_L152_R1.1761.00
112_I142_K1.1731.00
24_F30_I1.1731.00
240_A443_L1.1631.00
424_G477_R1.1611.00
57_E61_L1.1581.00
176_G180_V1.1571.00
124_I132_P1.1531.00
274_N294_K1.1521.00
416_M467_F1.1511.00
418_F422_I1.1501.00
327_E330_A1.1441.00
86_T101_A1.1411.00
61_L65_K1.1411.00
362_I486_A1.1371.00
148_V151_V1.1351.00
95_G179_H1.1311.00
364_I368_T1.1301.00
390_E480_Y1.1261.00
387_D484_K1.1211.00
51_D100_N1.1211.00
12_L21_A1.1121.00
49_E100_N1.1061.00
254_N257_E1.1041.00
119_N206_L1.1001.00
111_P114_D1.0981.00
255_V273_G1.0981.00
305_I309_A1.0971.00
317_L373_I1.0941.00
7_K26_S1.0891.00
113_T132_P1.0891.00
155_A213_I1.0831.00
254_N455_E1.0821.00
8_F74_Q1.0811.00
386_R423_L1.0791.00
23_L70_I1.0751.00
327_E412_D1.0711.00
324_D327_E1.0691.00
89_L155_A1.0671.00
411_K433_M1.0641.00
446_L457_L1.0631.00
183_Y192_F1.0621.00
55_I165_L1.0621.00
150_N154_K1.0571.00
89_L141_I1.0561.00
59_Q169_L1.0551.00
477_R481_S1.0541.00
77_A448_V1.0471.00
327_E413_N1.0451.00
183_Y217_V1.0431.00
114_D117_K1.0421.00
305_I308_A1.0401.00
204_L209_I1.0361.00
40_Q50_H1.0351.00
223_I447_G1.0341.00
108_R143_W1.0331.00
34_G69_K1.0311.00
257_E404_K1.0311.00
52_P88_V1.0291.00
442_M457_L1.0291.00
24_F441_A1.0281.00
9_V448_V1.0241.00
99_Y151_V1.0231.00
368_T372_H1.0221.00
163_G179_H1.0221.00
80_I170_I1.0211.00
404_K428_I1.0201.00
470_S474_E1.0141.00
181_T186_A1.0111.00
38_F58_A1.0081.00
325_E329_L1.0031.00
456_E459_S1.0011.00
78_I234_I1.0011.00
65_K68_S0.9981.00
48_V105_Q0.9941.00
60_M64_K0.9941.00
389_I423_L0.9931.00
138_A190_M0.9891.00
381_M409_A0.9871.00
254_N401_N0.9841.00
258_I270_M0.9831.00
323_S326_I0.9801.00
383_Y422_I0.9801.00
8_F70_I0.9791.00
192_F196_K0.9791.00
64_K68_S0.9781.00
54_E57_E0.9771.00
59_Q63_V0.9751.00
482_G485_E0.9731.00
112_I115_W0.9701.00
442_M460_I0.9641.00
77_A237_S0.9631.00
21_A66_A0.9621.00
141_I162_F0.9611.00
471_M476_R0.9581.00
359_G364_I0.9561.00
9_V77_A0.9541.00
341_F376_A0.9541.00
180_V224_Y0.9531.00
152_R155_A0.9531.00
445_G450_L0.9521.00
112_I147_N0.9501.00
226_Y235_P0.9481.00
259_K406_D0.9471.00
309_A341_F0.9461.00
67_I75_I0.9371.00
10_L23_L0.9311.00
329_L374_A0.9301.00
330_A333_V0.9301.00
335_D338_G0.9271.00
409_A415_L0.9241.00
386_R422_I0.9221.00
124_I190_M0.9221.00
197_L219_P0.9151.00
463_V466_E0.9131.00
76_V448_V0.9121.00
89_L162_F0.9091.00
25_D31_V0.9091.00
115_W118_A0.9081.00
167_T181_T0.9071.00
24_F438_M0.9061.00
375_R414_L0.9051.00
149_P153_E0.9021.00
289_G295_A0.9021.00
126_D278_R0.9011.00
81_T436_T0.9001.00
197_L295_A0.8981.00
402_S466_E0.8961.00
126_D195_N0.8951.00
155_A162_F0.8941.00
156_E212_S0.8911.00
144_I151_V0.8891.00
183_Y219_P0.8871.00
23_L75_I0.8861.00
471_M474_E0.8831.00
96_K172_R0.8821.00
80_I169_L0.8801.00
237_S448_V0.8801.00
364_I373_I0.8801.00
99_Y144_I0.8741.00
151_V154_K0.8741.00
451_W457_L0.8741.00
70_I74_Q0.8721.00
403_L423_L0.8711.00
383_Y480_Y0.8711.00
266_S385_T0.8711.00
10_L75_I0.8711.00
351_P354_D0.8691.00
73_K231_G0.8691.00
115_W142_K0.8661.00
423_L426_K0.8641.00
268_I389_I0.8621.00
87_T162_F0.8611.00
218_K238_G0.8511.00
446_L453_S0.8461.00
14_E169_L0.8431.00
75_I234_I0.8421.00
320_I326_I0.8341.00
230_L233_L0.8261.00
183_Y289_G0.8251.00
80_I173_L0.8241.00
36_Y62_A0.8231.00
98_V154_K0.8231.00
85_E188_R0.8211.00
79_G237_S0.8211.00
333_V336_N0.8201.00
142_K145_L0.8201.00
230_L234_I0.8161.00
164_T189_T0.8131.00
267_F302_S0.8111.00
113_T134_P0.8101.00
331_S414_L0.8091.00
410_A433_M0.8051.00
14_E59_Q0.8051.00
246_A406_D0.8021.00
446_L454_L0.8011.00
389_I393_Q0.8001.00
312_W315_D0.7981.00
138_A191_L0.7951.00
361_I377_I0.7921.00
117_K132_P0.7911.00
63_V67_I0.7901.00
226_Y232_N0.7901.00
199_C214_L0.7871.00
37_E311_Q0.7871.00
270_M392_M0.7861.00
291_E295_A0.7851.00
471_M475_K0.7841.00
113_T139_S0.7841.00
243_Q267_F0.7821.00
142_K208_K0.7811.00
378_L418_F0.7801.00
64_K229_A0.7791.00
107_R133_D0.7761.00
485_E488_K0.7761.00
338_G479_L0.7751.00
258_I403_L0.7741.00
92_A154_K0.7721.00
33_I434_E0.7711.00
84_R300_E0.7711.00
37_E314_R0.7701.00
478_A482_G0.7681.00
405_V419_Q0.7661.00
336_N340_Y0.7651.00
24_F432_V0.7631.00
422_I476_R0.7611.00
90_W95_G0.7601.00
198_E216_E0.7601.00
417_Q470_S0.7601.00
340_Y362_I0.7601.00
475_K479_L0.7601.00
306_T381_M0.7581.00
171_W179_H0.7581.00
180_V216_E0.7561.00
313_F374_A0.7541.00
198_E201_R0.7541.00
405_V429_R0.7531.00
260_A266_S0.7521.00
193_N198_E0.7521.00
347_G351_P0.7511.00
202_E206_L0.7511.00
326_I330_A0.7511.00
378_L412_D0.7501.00
36_Y58_A0.7491.00
345_F348_L0.7481.00
52_P100_N0.7471.00
186_A199_C0.7441.00
184_S288_W0.7431.00
428_I463_V0.7401.00
84_R185_N0.7401.00
324_D328_P0.7391.00
166_D239_D0.7381.00
111_P147_N0.7381.00
260_A385_T0.7381.00
43_P47_Y0.7371.00
90_W179_H0.7371.00
16_T103_V0.7351.00
104_W265_G0.7341.00
111_P146_D0.7341.00
387_D480_Y0.7321.00
57_E60_M0.7301.00
127_K193_N0.7301.00
76_V450_L0.7271.00
11_A79_G0.7271.00
391_V395_E0.7251.00
271_N296_T0.7251.00
54_E58_A0.7251.00
91_D98_V0.7241.00
228_E232_N0.7231.00
250_Q406_D0.7231.00
30_I33_I0.7221.00
323_S327_E0.7221.00
192_F197_L0.7201.00
383_Y476_R0.7191.00
410_A416_M0.7181.00
49_E108_R0.7171.00
124_I203_I0.7171.00
445_G449_G0.7161.00
38_F50_H0.7161.00
77_A235_P0.7151.00
313_F373_I0.7121.00
90_W157_R0.7111.00
357_A361_I0.7071.00
386_R484_K0.7061.00
301_G388_V0.7051.00
250_Q259_K0.7041.00
337_G368_T0.7041.00
479_L482_G0.7021.00
53_E168_Y0.7021.00
181_T215_P0.7001.00
60_M172_R0.6961.00
478_A481_S0.6951.00
232_N235_P0.6951.00
95_G156_E0.6951.00
89_L98_V0.6951.00
473_E477_R0.6951.00
246_A436_T0.6951.00
91_D156_E0.6951.00
19_A38_F0.6941.00
72_A75_I0.6920.99
122_K125_K0.6920.99
181_T217_V0.6920.99
347_G350_A0.6910.99
14_E58_A0.6910.99
227_S230_L0.6900.99
229_A233_L0.6890.99
273_G296_T0.6890.99
331_S417_Q0.6890.99
382_A415_L0.6890.99
200_D203_I0.6890.99
405_V427_V0.6890.99
291_E294_K0.6890.99
350_A353_W0.6870.99
184_S240_A0.6870.99
357_A360_L0.6850.99
345_F351_P0.6810.99
170_I174_T0.6800.99
88_V101_A0.6800.99
401_N425_I0.6730.99
418_F476_R0.6730.99
318_R321_D0.6720.99
53_E97_P0.6710.99
63_V66_A0.6690.99
455_E458_R0.6690.99
67_I70_I0.6670.99
141_I191_L0.6640.99
224_Y238_G0.6640.99
220_S239_D0.6640.99
318_R370_K0.6640.99
333_V337_G0.6640.99
59_Q62_A0.6600.99
252_A257_E0.6600.99
460_I463_V0.6600.99
354_D357_A0.6590.99
484_K488_K0.6580.99
426_K469_P0.6580.99
223_I448_V0.6560.99
260_A403_L0.6560.99
153_E157_R0.6540.99
22_I30_I0.6520.99
114_D356_Y0.6500.99
128_T203_I0.6500.99
303_I388_V0.6490.99
412_D415_L0.6490.99
348_L354_D0.6470.99
9_V76_V0.6470.99
82_N185_N0.6470.99
168_Y171_W0.6470.99
333_V371_A0.6460.99
321_D370_K0.6450.99
331_S413_N0.6440.99
242_D264_T0.6440.99
102_I108_R0.6440.99
281_N299_L0.6430.99
310_V326_I0.6410.99
61_L64_K0.6410.99
116_L207_L0.6400.99
276_P284_T0.6390.99
403_L427_V0.6390.99
402_S425_I0.6380.99
451_W460_I0.6370.99
132_P190_M0.6370.99
251_V461_W0.6350.99
326_I329_L0.6350.99
24_F437_S0.6340.99
311_Q323_S0.6330.99
313_F317_L0.6320.99
403_L425_I0.6300.99
90_W168_Y0.6290.99
116_L139_S0.6290.99
413_N417_Q0.6280.99
142_K152_R0.6250.99
344_A348_L0.6250.99
352_Y387_D0.6230.99
90_W171_W0.6220.99
477_R480_Y0.6210.99
336_N372_H0.6210.99
266_S419_Q0.6210.99
64_K230_L0.6190.99
272_I276_P0.6190.99
269_L298_A0.6180.99
442_M446_L0.6180.99
379_E418_F0.6180.99
167_T179_H0.6170.99
320_I325_E0.6160.99
197_L289_G0.6150.99
53_E100_N0.6130.99
60_M63_V0.6120.99
314_R323_S0.6100.99
338_G375_R0.6090.99
468_I471_M0.6080.99
26_S76_V0.6080.99
330_A378_L0.6070.99
432_V438_M0.6060.99
417_Q467_F0.6060.99
341_F380_S0.6060.99
345_F349_G0.6040.99
481_S484_K0.6030.99
331_S334_E0.6020.99
257_E401_N0.6010.99
330_A375_R0.6010.99
145_L208_K0.6010.99
257_E458_R0.5990.99
154_K157_R0.5990.99
351_P355_P0.5990.99
53_E56_W0.5980.99
88_V97_P0.5970.99
330_A374_A0.5970.99
110_S134_P0.5970.99
87_T137_S0.5970.99
195_N198_E0.5960.99
83_Q104_W0.5950.98
205_E208_K0.5920.98
424_G471_M0.5920.98
329_L333_V0.5910.98
338_G379_E0.5900.98
327_E414_L0.5900.98
476_R479_L0.5880.98
219_P289_G0.5880.98
82_N165_L0.5880.98
27_D459_S0.5880.98
102_I144_I0.5870.98
416_M429_R0.5870.98
338_G372_H0.5850.98
272_I278_R0.5840.98
120_Y203_I0.5840.98
262_Y405_V0.5840.98
142_K207_L0.5840.98
429_R464_D0.5830.98
241_G244_Q0.5820.98
457_L460_I0.5820.98
49_E99_Y0.5810.98
298_A302_S0.5800.98
243_Q261_T0.5800.98
30_I432_V0.5800.98
216_E222_E0.5800.98
52_P101_A0.5780.98
375_R418_F0.5770.98
335_D372_H0.5760.98
235_P448_V0.5760.98
78_I236_I0.5760.98
342_V486_A0.5720.98
209_I214_L0.5720.98
109_T139_S0.5720.98
249_G435_T0.5700.98
184_S220_S0.5700.98
136_F188_R0.5690.98
337_G367_G0.5680.98
446_L451_W0.5670.98
400_I425_I0.5660.98
108_R147_N0.5660.98
342_V360_L0.5630.98
336_N375_R0.5630.98
358_R362_I0.5620.98
8_F73_K0.5610.98
33_I69_K0.5600.98
86_T103_V0.5600.98
89_L99_Y0.5600.98
342_V487_V0.5590.98
273_G276_P0.5590.98
95_G157_R0.5580.98
247_L287_A0.5580.98
442_M461_W0.5570.98
446_L449_G0.5570.98
381_M415_L0.5560.98
451_W459_S0.5560.98
97_P100_N0.5560.98
29_N431_K0.5540.98
274_N296_T0.5520.98
55_I101_A0.5520.98
266_S303_I0.5520.98
410_A429_R0.5510.98
379_E383_Y0.5490.97
272_I299_L0.5470.97
42_Y48_V0.5460.97
189_T199_C0.5460.97
26_S445_G0.5450.97
28_L460_I0.5450.97
203_I207_L0.5440.97
205_E210_P0.5440.97
17_T20_R0.5430.97
260_A268_I0.5430.97
191_L214_L0.5420.97
141_I213_I0.5410.97
124_I207_L0.5410.97
339_V373_I0.5380.97
346_V366_R0.5380.97
247_L269_L0.5370.97
275_N278_R0.5360.97
176_G218_K0.5350.97
220_S240_A0.5350.97
47_Y102_I0.5350.97
336_N379_E0.5340.97
9_V451_W0.5340.97
311_Q314_R0.5340.97
84_R188_R0.5330.97
420_A427_V0.5330.97
231_G235_P0.5320.97
166_D181_T0.5320.97
9_V26_S0.5320.97
221_S447_G0.5310.97
176_G226_Y0.5310.97
335_D375_R0.5300.97
134_P355_P0.5300.97
248_F442_M0.5290.97
417_Q420_A0.5280.97
163_G171_W0.5280.97
81_T440_V0.5270.97
316_G369_T0.5270.97
186_A189_T0.5270.97
352_Y484_K0.5260.97
195_N278_R0.5260.97
326_I412_D0.5250.97
287_A297_Y0.5250.97
90_W156_E0.5240.97
307_G311_Q0.5240.97
130_L136_F0.5240.97
7_K450_L0.5240.97
121_F125_K0.5240.97
419_Q423_L0.5220.97
438_M442_M0.5210.97
418_F479_L0.5210.97
85_E104_W0.5200.97
352_Y487_V0.5180.96
261_T406_D0.5170.96
437_S440_V0.5170.96
139_S190_M0.5160.96
385_T419_Q0.5150.96
306_T309_A0.5150.96
16_T104_W0.5150.96
205_E211_E0.5140.96
190_M207_L0.5140.96
451_W456_E0.5130.96
334_E337_G0.5130.96
75_I230_L0.5120.96
268_I388_V0.5110.96
85_E265_G0.5110.96
119_N142_K0.5100.96
152_R156_E0.5090.96
58_A61_L0.5080.96
48_V103_V0.5080.96
51_D57_E0.5070.96
453_S457_L0.5060.96
47_Y108_R0.5060.96
83_Q101_A0.5040.96
477_R484_K0.5040.96
261_T267_F0.5040.96
286_I295_A0.5020.96
338_G482_G0.5010.96
401_N426_K0.5000.96
164_T185_N0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ll3A 2 0.9601 100 0.14 Contact Map
3ezwA 3 0.98 100 0.146 Contact Map
3h3nX 3 0.986 100 0.147 Contact Map
2d4wA 2 0.98 100 0.149 Contact Map
3wxlA 2 0.976 100 0.151 Contact Map
2zf5O 3 0.978 100 0.151 Contact Map
3g25A 3 0.98 100 0.153 Contact Map
2itmA 2 0.9281 100 0.16 Contact Map
2w40A 3 0.9721 100 0.164 Contact Map
2dpnA 2 0.9701 100 0.167 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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