GREMLIN Database
Q97XW0 - First ORF in transposon ISC1229
UniProt: Q97XW0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 289 (233)
Sequences: 3712 (2192)
Seq/√Len: 143.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_F99_A4.6401.00
175_A267_L3.5711.00
76_A83_W3.4921.00
16_F95_L3.2341.00
175_A263_I3.1491.00
77_V266_I3.1411.00
184_I208_G3.0901.00
171_A260_P3.0071.00
12_Y88_P2.8711.00
72_T86_V2.8461.00
171_A175_A2.7631.00
20_F103_V2.7581.00
49_G210_V2.5971.00
179_F268_G2.4811.00
90_I262_F2.4771.00
11_R85_D2.4651.00
76_A86_V2.4491.00
12_Y92_F2.3931.00
165_F250_R2.3831.00
231_W235_L2.1751.00
20_F100_A2.1551.00
98_A236_A2.1501.00
73_L262_F2.1301.00
55_A59_V2.1001.00
231_W258_G2.0251.00
24_L103_V1.9851.00
53_V206_G1.9481.00
26_G48_W1.9311.00
59_V67_I1.8211.00
109_G113_T1.8141.00
177_M225_I1.8111.00
213_F223_G1.7851.00
112_I156_I1.7791.00
46_V210_V1.7721.00
73_L90_I1.7431.00
98_A239_L1.7011.00
179_F271_F1.6951.00
170_G221_T1.6781.00
50_F207_I1.6551.00
102_S236_A1.6211.00
66_H89_Y1.6191.00
30_I34_T1.6101.00
59_V65_A1.5661.00
173_A219_Q1.5391.00
79_K273_D1.5361.00
237_L249_F1.4891.00
262_F266_I1.4861.00
103_V176_L1.4681.00
83_W86_V1.4531.00
212_P225_I1.4521.00
98_A232_G1.4351.00
71_V185_V1.4261.00
86_V90_I1.4221.00
87_I91_V1.4201.00
75_F81_I1.4081.00
107_W173_A1.4051.00
45_M214_L1.3771.00
19_T97_A1.3751.00
183_L271_F1.3701.00
182_L265_G1.3591.00
20_F99_A1.3511.00
117_P120_F1.3491.00
50_F211_M1.3401.00
27_D104_L1.3381.00
72_T93_Q1.3131.00
50_F210_V1.3071.00
98_A235_L1.3031.00
101_T233_P1.3001.00
56_I71_V1.2991.00
14_A62_I1.2891.00
97_A232_G1.2801.00
94_I258_G1.2701.00
264_G268_G1.2671.00
167_L256_V1.2651.00
69_P228_A1.2511.00
255_Y259_I1.2461.00
102_S106_V1.2441.00
30_I44_I1.2371.00
25_F51_G1.2351.00
171_A256_V1.2321.00
74_A78_T1.2311.00
174_E221_T1.2241.00
83_W87_I1.2181.00
23_I27_D1.2101.00
56_I202_P1.2051.00
190_D272_W1.2011.00
52_I209_Y1.1841.00
154_A158_Y1.1831.00
173_A177_M1.1711.00
235_L238_Y1.1601.00
82_K85_D1.1380.99
231_W254_F1.1330.99
171_A263_I1.1280.99
110_D169_K1.1170.99
159_S240_F1.1140.99
63_S89_Y1.1110.99
23_I104_L1.1100.99
42_G46_V1.1020.99
185_V205_I1.0930.99
179_F267_L1.0920.99
53_V203_W1.0860.99
66_H72_T1.0790.99
74_A182_L1.0780.99
43_F214_L1.0750.99
55_A65_A1.0700.99
188_V208_G1.0660.99
32_A220_L1.0580.99
42_G45_M1.0540.99
177_M216_F1.0460.99
18_G67_I1.0360.99
224_M230_S1.0290.99
175_A264_G1.0290.99
57_Y204_A1.0200.99
81_I86_V1.0140.99
175_A260_P1.0100.99
153_S156_I1.0040.99
154_A160_Q0.9980.99
21_I180_L0.9940.98
92_F96_G0.9840.98
21_I54_L0.9830.98
99_A102_S0.9800.98
94_I232_G0.9750.98
31_V156_I0.9720.98
210_V214_L0.9710.98
236_A240_F0.9690.98
24_L180_L0.9650.98
14_A64_G0.9620.98
71_V182_L0.9570.98
81_I85_D0.9560.98
209_Y225_I0.9560.98
28_G104_L0.9560.98
70_N227_E0.9510.98
66_H81_I0.9490.98
243_R246_A0.9410.98
25_F180_L0.9400.98
203_W207_I0.9380.98
72_T81_I0.9350.98
14_A63_S0.9290.98
27_D101_T0.9280.98
22_L52_I0.9150.97
230_S234_M0.9070.97
19_T228_A0.9040.97
153_S244_T0.8970.97
94_I231_W0.8930.97
72_T90_I0.8910.97
271_F275_V0.8910.97
90_I94_I0.8910.97
31_V108_W0.8900.97
12_Y16_F0.8830.97
213_F218_A0.8820.97
66_H93_Q0.8800.97
97_A101_T0.8720.97
23_I97_A0.8680.96
78_T186_V0.8520.96
9_L12_Y0.8500.96
37_S114_R0.8490.96
70_N265_G0.8480.96
113_T243_R0.8390.96
161_V170_G0.8300.95
25_F211_M0.8290.95
27_D156_I0.8280.95
74_A269_A0.8210.95
180_L216_F0.8150.95
178_T265_G0.8100.95
254_F258_G0.8090.95
179_F183_L0.8080.95
57_Y202_P0.8020.95
110_D166_P0.8010.94
270_L274_H0.8000.94
177_M181_L0.7990.94
95_L99_A0.7960.94
76_A81_I0.7960.94
78_T269_A0.7920.94
160_Q250_R0.7910.94
54_L184_I0.7860.94
12_Y95_L0.7810.94
66_H71_V0.7770.94
107_W219_Q0.7760.93
251_G254_F0.7750.93
32_A38_Q0.7740.93
33_S43_F0.7690.93
263_I267_L0.7670.93
55_A67_I0.7660.93
98_A102_S0.7650.93
20_F24_L0.7610.93
186_V269_A0.7610.93
42_G214_L0.7550.93
75_F185_V0.7540.93
101_T236_A0.7480.92
46_V214_L0.7480.92
53_V57_Y0.7470.92
111_V164_I0.7430.92
47_S214_L0.7410.92
186_V272_W0.7380.92
173_A220_L0.7360.92
21_I58_A0.7360.92
242_Y246_A0.7350.92
73_L86_V0.7350.92
166_P169_K0.7340.91
16_F92_F0.7320.91
167_L252_E0.7300.91
73_L266_I0.7290.91
224_M257_Y0.7280.91
34_T155_G0.7270.91
18_G22_L0.7190.91
242_Y245_G0.7150.90
173_A221_T0.7140.90
33_S44_I0.7130.90
181_L209_Y0.7120.90
70_N74_A0.7110.90
186_V268_G0.7110.90
12_Y91_V0.7080.90
77_V270_L0.7070.90
266_I270_L0.7040.90
155_G160_Q0.7030.90
212_P223_G0.6990.89
253_Y257_Y0.6960.89
227_E258_G0.6920.89
168_W172_F0.6850.88
76_A87_I0.6830.88
13_F17_V0.6820.88
19_T22_L0.6800.88
40_S43_F0.6800.88
178_T233_P0.6710.87
60_G63_S0.6690.87
24_L216_F0.6630.87
191_P198_Q0.6600.87
29_A44_I0.6590.86
34_T120_F0.6580.86
181_L218_A0.6570.86
75_F80_R0.6530.86
46_V49_G0.6510.86
77_V269_A0.6510.86
156_I160_Q0.6460.85
84_V87_I0.6430.85
116_D120_F0.6410.85
24_L177_M0.6410.85
156_I161_V0.6400.85
96_G100_A0.6380.85
107_W176_L0.6380.85
46_V207_I0.6360.84
157_L161_V0.6350.84
154_A157_L0.6330.84
180_L184_I0.6310.84
64_G89_Y0.6280.84
34_T44_I0.6270.84
32_A108_W0.6240.83
244_T248_N0.6190.83
53_V207_I0.6180.83
58_A184_I0.6180.83
115_I120_F0.6180.83
229_R233_P0.6170.83
120_F155_G0.6120.82
155_G161_V0.6110.82
82_K87_I0.6110.82
53_V204_A0.6100.82
109_G112_I0.6070.82
235_L239_L0.6050.81
41_F44_I0.6030.81
78_T266_I0.6030.81
256_V261_D0.6010.81
165_F169_K0.6000.81
88_P92_F0.5960.80
211_M215_L0.5950.80
118_P242_Y0.5950.80
91_V95_L0.5950.80
171_A259_I0.5940.80
78_T190_D0.5930.80
189_T205_I0.5930.80
105_L243_R0.5880.80
87_I90_I0.5880.80
78_T268_G0.5850.79
119_P246_A0.5830.79
169_K173_A0.5800.79
57_Y199_S0.5720.78
11_R88_P0.5670.77
213_F225_I0.5650.77
45_M223_G0.5650.77
53_V199_S0.5630.77
39_P250_R0.5630.77
187_A272_W0.5620.76
159_S224_M0.5620.76
23_I29_A0.5610.76
52_I56_I0.5590.76
78_T81_I0.5580.76
259_I262_F0.5580.76
200_L203_W0.5570.76
13_F275_V0.5570.76
102_S168_W0.5560.76
34_T38_Q0.5550.76
47_S215_L0.5530.75
81_I93_Q0.5530.75
167_L260_P0.5520.75
110_D113_T0.5520.75
237_L246_A0.5520.75
31_V104_L0.5520.75
237_L240_F0.5490.75
17_V180_L0.5480.75
41_F45_M0.5480.75
183_L275_V0.5470.75
21_I55_A0.5470.75
253_Y256_V0.5460.74
171_A255_Y0.5450.74
197_S202_P0.5430.74
88_P91_V0.5420.74
14_A59_V0.5420.74
237_L241_G0.5420.74
77_V262_F0.5400.74
172_F176_L0.5390.73
26_G221_T0.5390.73
56_I185_V0.5390.73
65_A100_A0.5380.73
115_I119_P0.5370.73
265_G268_G0.5360.73
109_G169_K0.5340.73
56_I65_A0.5340.73
256_V260_P0.5330.73
99_A103_V0.5320.73
49_G206_G0.5320.73
114_R119_P0.5260.72
170_G256_V0.5250.72
116_D153_S0.5220.71
24_L104_L0.5210.71
11_R81_I0.5200.71
11_R14_A0.5190.71
42_G210_V0.5190.71
82_K86_V0.5180.71
167_L171_A0.5180.71
48_W213_F0.5170.70
40_S220_L0.5170.70
164_I177_M0.5160.70
80_R269_A0.5140.70
51_G55_A0.5130.70
187_A190_D0.5120.70
81_I88_P0.5110.70
185_V208_G0.5110.70
30_I47_S0.5110.70
202_P206_G0.5090.69
206_G211_M0.5090.69
165_F170_G0.5080.69
169_K172_F0.5080.69
233_P237_L0.5060.69
273_D277_K0.5030.68
272_W276_L0.5030.68
30_I223_G0.5030.68
51_G211_M0.5020.68
173_A216_F0.5020.68
181_L185_V0.5010.68
110_D163_Q0.5010.68
15_E18_G0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ldfA 3 0.8685 100 0.188 Contact Map
3c02A 3 0.8304 100 0.217 Contact Map
4oj2X 3 0.8028 100 0.265 Contact Map
1j4nA 4 0.8166 100 0.265 Contact Map
3cn5A 3 0.7958 100 0.268 Contact Map
2b6oA 6 0.8028 100 0.271 Contact Map
3iyzA 3 0.7647 100 0.277 Contact Map
3d9sA 3 0.8097 100 0.28 Contact Map
4nefA 4 0.8131 100 0.282 Contact Map
2zz9A 3 0.7647 100 0.285 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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