GREMLIN Database
Q97XV5 - Third ORF in transposon ISC1229
UniProt: Q97XV5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (156)
Sequences: 4773 (3463)
Seq/√Len: 277.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_H141_R2.6221.00
83_F156_A2.6071.00
20_E42_M2.5241.00
24_V35_R2.5101.00
52_V168_P2.4851.00
55_T168_P2.4451.00
31_E35_R2.4141.00
28_T31_E2.3631.00
27_K35_R2.3001.00
71_V83_F2.2301.00
87_C113_L2.2251.00
67_I159_I2.2141.00
78_P82_S2.0661.00
132_L136_E2.0591.00
153_R157_R2.0261.00
28_T35_R1.9051.00
89_L152_A1.8711.00
95_R100_V1.8671.00
79_K82_S1.8661.00
52_V162_V1.7601.00
29_L33_Q1.7551.00
87_C156_A1.7491.00
131_L151_L1.7461.00
139_K145_R1.7261.00
77_F86_Y1.7161.00
66_I116_L1.6761.00
59_I64_A1.6501.00
167_R170_E1.6451.00
56_I159_I1.6401.00
42_M45_E1.6321.00
84_V90_D1.6301.00
63_A116_L1.6231.00
119_F122_V1.6171.00
26_A30_L1.6111.00
54_L61_R1.6001.00
134_F154_K1.5981.00
161_S165_N1.5961.00
44_E61_R1.5901.00
137_T141_R1.5671.00
142_L146_K1.5651.00
162_V168_P1.5261.00
53_L159_I1.5011.00
84_V153_R1.4801.00
118_Y152_A1.4681.00
131_L158_I1.4661.00
52_V55_T1.4531.00
135_Y151_L1.4341.00
70_I110_N1.4001.00
63_A120_L1.3871.00
160_W164_Y1.3711.00
139_K144_G1.3591.00
136_E140_D1.3561.00
143_K146_K1.3551.00
56_I162_V1.3451.00
121_A151_L1.3081.00
24_V38_E1.3001.00
56_I155_L1.2801.00
125_Y135_Y1.2671.00
134_F138_H1.2561.00
24_V28_T1.2371.00
33_Q36_L1.2311.00
27_K31_E1.2251.00
74_I163_W1.2191.00
143_K147_L1.2041.00
31_E34_E1.2031.00
37_K40_R1.1941.00
121_A152_A1.1861.00
47_V54_L1.1801.00
115_S119_F1.1711.00
45_E49_D1.1561.00
134_F151_L1.1471.00
35_R38_E1.1271.00
121_A155_L1.1261.00
129_P133_K1.1111.00
158_I162_V1.0991.00
36_L40_R1.0981.00
120_L155_L1.0901.00
134_F137_T1.0781.00
70_I112_Y1.0691.00
129_P132_L1.0211.00
138_H147_L1.0111.00
71_V74_I1.0061.00
118_Y122_V0.9971.00
96_S100_V0.9941.00
53_L163_W0.9841.00
161_S164_Y0.9821.00
117_F156_A0.9711.00
33_Q37_K0.9601.00
122_V125_Y0.9541.00
105_I114_R0.9491.00
47_V50_N0.9461.00
54_L64_A0.9371.00
59_I63_A0.9281.00
24_V42_M0.9211.00
59_I159_I0.9201.00
15_T18_V0.9021.00
40_R44_E0.9011.00
133_K137_T0.9001.00
81_E153_R0.8991.00
20_E23_K0.8901.00
131_L155_L0.8871.00
107_K114_R0.8821.00
42_M46_Q0.8811.00
145_R148_Y0.8691.00
93_V100_V0.8611.00
17_I42_M0.8581.00
137_T140_D0.8561.00
20_E24_V0.8561.00
27_K34_E0.8501.00
67_I113_L0.8471.00
138_H142_L0.8461.00
28_T32_T0.8451.00
118_Y149_V0.8381.00
95_R101_I0.8321.00
17_I20_E0.8311.00
90_D106_S0.8240.99
34_E38_E0.8190.99
82_S85_A0.7940.99
53_L64_A0.7910.99
44_E48_P0.7870.99
124_N131_L0.7840.99
123_R127_R0.7810.99
162_V167_R0.7730.99
122_V145_R0.7570.99
92_V106_S0.7500.99
130_T169_Y0.7470.99
134_F150_A0.7470.99
19_V23_K0.7450.99
80_P157_R0.7440.99
40_R43_I0.7410.99
145_R149_V0.7390.99
59_I155_L0.7360.99
21_E24_V0.7350.99
144_G148_Y0.7330.99
133_K136_E0.7300.99
52_V166_N0.7250.99
86_Y110_N0.7240.99
79_K160_W0.7200.99
66_I70_I0.7130.99
32_T36_L0.7120.99
47_V65_G0.7060.98
144_G147_L0.7050.98
34_E37_K0.7040.98
84_V157_R0.6980.98
22_I25_L0.6970.98
37_K41_R0.6940.98
138_H150_A0.6870.98
25_L28_T0.6870.98
90_D107_K0.6860.98
90_D93_V0.6850.98
135_Y139_K0.6830.98
89_L153_R0.6780.98
125_Y139_K0.6770.98
38_E42_M0.6770.98
16_P20_E0.6760.98
109_G114_R0.6710.98
138_H143_K0.6700.98
85_A90_D0.6690.98
62_L66_I0.6690.98
90_D114_R0.6670.98
59_I67_I0.6460.97
157_R160_W0.6460.97
122_V126_S0.6430.97
119_F123_R0.6420.97
158_I161_S0.6420.97
50_N54_L0.6360.97
88_G114_R0.6260.97
122_V152_A0.6260.97
159_I162_V0.6250.97
44_E54_L0.6200.96
105_I150_A0.6160.96
115_S118_Y0.6160.96
94_E99_A0.6140.96
73_D76_R0.6130.96
74_I160_W0.6100.96
135_Y148_Y0.6070.96
41_R45_E0.6070.96
50_N64_A0.6010.96
18_V21_E0.6000.96
101_I104_G0.5950.96
90_D108_R0.5950.96
139_K142_L0.5930.95
120_L152_A0.5910.95
58_G123_R0.5910.95
56_I59_I0.5890.95
66_I112_Y0.5880.95
92_V103_R0.5870.95
30_L34_E0.5850.95
43_I65_G0.5840.95
24_V27_K0.5820.95
116_L120_L0.5810.95
100_V103_R0.5770.95
130_T158_I0.5770.95
117_F159_I0.5740.95
125_Y151_L0.5680.94
29_L32_T0.5670.94
32_T35_R0.5630.94
105_I149_V0.5630.94
17_I21_E0.5610.94
16_P42_M0.5610.94
105_I109_G0.5600.94
38_E41_R0.5590.94
45_E127_R0.5580.94
135_Y147_L0.5550.94
48_P61_R0.5540.94
80_P160_W0.5530.93
93_V102_S0.5470.93
128_N132_L0.5370.92
50_N65_G0.5350.92
84_V89_L0.5350.92
15_T19_V0.5350.92
94_E103_R0.5340.92
77_F83_F0.5300.92
98_R101_I0.5260.92
26_A76_R0.5250.92
122_V146_K0.5240.92
95_R99_A0.5220.91
40_R62_L0.5220.91
120_L124_N0.5220.91
27_K38_E0.5200.91
80_P85_A0.5200.91
99_A104_G0.5180.91
67_I71_V0.5140.91
65_G112_Y0.5130.91
99_A102_S0.5120.91
89_L114_R0.5110.91
119_F152_A0.5100.90
61_R65_G0.5090.90
39_V42_M0.5080.90
146_K149_V0.5050.90
128_N158_I0.5050.90
122_V148_Y0.5050.90
136_E139_K0.5030.90
89_L118_Y0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fhfA 1 0.7442 89.4 0.89 Contact Map
1pu6A 1 0.7791 88.3 0.892 Contact Map
2i5hA 1 0.657 86.7 0.894 Contact Map
1keaA 2 0.8023 85.7 0.896 Contact Map
4b21A 2 0.6628 84.1 0.898 Contact Map
3n0uA 1 0.7558 83.5 0.899 Contact Map
4ofaA 1 0.564 81.9 0.901 Contact Map
2a1jB 2 0.4477 81.6 0.901 Contact Map
2a1jA 1 0.3488 78.1 0.904 Contact Map
3c65A 1 0.1977 77.9 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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