GREMLIN Database
Q97XV2 - Uncharacterized protein
UniProt: Q97XV2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (213)
Sequences: 879 (740)
Seq/√Len: 50.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_L19_L5.8061.00
9_I12_N4.9621.00
50_V53_Q4.2771.00
36_L39_T4.1951.00
15_L20_A3.7461.00
43_V46_L3.3131.00
35_K40_I3.0341.00
8_E13_P2.9631.00
92_V95_L2.8631.00
81_Q85_I2.7921.00
23_I26_K2.7001.00
29_D33_I2.6651.00
78_V81_Q2.6291.00
22_K27_L2.5061.00
91_A96_Q2.4931.00
85_I88_L2.4731.00
71_I74_L2.4551.00
113_V116_Q2.3291.00
127_V130_L2.2991.00
12_N16_L2.1691.00
120_I123_L2.0401.00
56_A61_Q1.8790.99
140_E145_T1.8750.99
189_G193_E1.8010.99
77_A80_K1.7720.99
57_I60_L1.7620.99
35_K38_E1.6770.98
28_K38_E1.6660.98
76_E80_K1.6360.98
64_V67_H1.6180.98
66_K72_T1.5690.98
51_K54_G1.5500.97
17_S20_A1.5420.97
75_Q79_K1.5380.97
182_E185_V1.4990.97
32_V36_L1.4710.96
31_I35_K1.4440.96
10_L14_Q1.4160.95
23_I31_I1.4080.95
141_V144_F1.3950.95
59_S62_N1.3860.95
91_A94_S1.3800.95
102_H106_I1.3410.94
55_E59_S1.3280.94
86_Q89_Q1.3240.93
49_E53_Q1.3230.93
99_V102_H1.3120.93
19_L23_I1.3090.93
199_T203_V1.3040.93
31_I34_K1.2890.92
173_R177_G1.2860.92
56_A59_S1.2830.92
7_D12_N1.2830.92
60_L64_V1.2800.92
34_K38_E1.2660.92
93_K96_Q1.2590.92
74_L88_L1.2560.91
213_D216_A1.2560.91
169_V175_V1.2350.91
18_A22_K1.2350.91
9_I26_K1.2340.91
202_Y206_F1.2340.91
59_S63_T1.2310.91
72_T76_E1.2180.90
129_K133_A1.2120.90
15_L18_A1.2080.90
84_A89_Q1.2040.90
7_D21_D1.2010.90
70_A73_S1.1970.89
49_E52_R1.1960.89
74_L77_A1.1870.89
10_L28_K1.1870.89
136_K140_E1.1780.89
83_E87_S1.1720.88
67_H85_I1.1710.88
45_A51_K1.1620.88
45_A48_E1.1500.87
11_N15_L1.1270.86
47_Q51_K1.1200.86
14_Q18_A1.1190.86
48_E52_R1.1170.86
194_V197_Y1.1150.86
157_L171_P1.1000.85
120_I131_Q1.0960.85
156_M163_A1.0900.84
157_L163_A1.0800.84
69_E73_S1.0780.84
57_I61_Q1.0620.83
134_V137_L1.0620.83
97_E103_T1.0570.83
86_Q100_N1.0560.82
7_D11_N1.0550.82
56_A60_L1.0280.81
94_S98_T1.0230.80
10_L16_L1.0220.80
13_P17_S1.0210.80
9_I13_P1.0210.80
21_D25_D1.0170.80
208_I213_D1.0100.80
92_V96_Q1.0020.79
152_M156_M1.0000.79
83_E101_K0.9990.79
7_D10_L0.9830.78
190_K198_E0.9810.78
192_F195_D0.9790.77
58_S61_Q0.9770.77
53_Q57_I0.9770.77
26_K35_K0.9760.77
199_T202_Y0.9560.76
155_T158_K0.9560.76
14_Q29_D0.9470.75
30_E34_K0.9460.75
104_E126_A0.9400.74
90_E94_S0.9400.74
11_N14_Q0.9370.74
154_R160_Y0.9360.74
30_E33_I0.9320.74
17_S28_K0.9290.74
121_E137_L0.9190.73
33_I37_E0.9180.73
18_A21_D0.9130.72
72_T79_K0.9060.72
20_A24_Y0.9050.72
130_L134_V0.9040.71
159_L166_L0.9000.71
15_L34_K0.8960.71
8_E23_I0.8950.71
128_R141_V0.8880.70
78_V99_V0.8850.70
160_Y165_E0.8790.69
11_N37_E0.8760.69
200_N204_Y0.8740.69
13_P19_L0.8720.69
186_I189_G0.8690.68
115_K119_A0.8680.68
65_N80_K0.8680.68
84_A88_L0.8670.68
86_Q90_E0.8630.68
106_I109_L0.8590.68
163_A168_G0.8490.67
67_H95_L0.8480.67
20_A25_D0.8470.66
152_M158_K0.8420.66
60_L91_A0.8410.66
160_Y210_N0.8370.66
59_S64_V0.8340.65
160_Y163_A0.8320.65
37_E40_I0.8250.64
10_L30_E0.8220.64
33_I36_L0.8160.64
8_E20_A0.8130.63
210_N213_D0.8100.63
13_P28_K0.8060.63
37_E69_E0.8040.62
12_N17_S0.7970.62
54_G60_L0.7870.61
118_E133_A0.7870.61
189_G196_F0.7870.61
10_L24_Y0.7860.61
11_N30_E0.7850.61
46_L50_V0.7790.60
65_N76_E0.7790.60
14_Q17_S0.7760.60
66_K70_A0.7730.59
23_I37_E0.7700.59
15_L38_E0.7680.59
211_L214_K0.7630.58
155_T168_G0.7630.58
13_P24_Y0.7610.58
10_L15_L0.7600.58
48_E53_Q0.7590.58
72_T75_Q0.7550.58
31_I52_R0.7530.57
31_I38_E0.7520.57
199_T205_V0.7520.57
74_L130_L0.7510.57
39_T43_V0.7500.57
107_T111_E0.7500.57
126_A129_K0.7490.57
36_L41_A0.7440.56
144_F148_A0.7390.56
55_E60_L0.7370.56
13_P21_D0.7360.56
133_A138_S0.7350.56
119_A124_Q0.7280.55
47_Q53_Q0.7250.54
101_K105_A0.7250.54
120_I165_E0.7220.54
11_N36_L0.7160.54
44_K47_Q0.7110.53
161_K165_E0.7100.53
11_N24_Y0.7070.53
24_Y28_K0.7040.52
13_P27_L0.6990.52
179_I182_E0.6980.52
105_A110_Q0.6980.52
28_K33_I0.6960.52
214_K217_Y0.6950.51
13_P22_K0.6940.51
121_E125_K0.6940.51
76_E83_E0.6940.51
68_T82_G0.6930.51
7_D15_L0.6910.51
57_I201_D0.6910.51
177_G181_D0.6880.51
67_H75_Q0.6870.51
68_T71_I0.6860.50
24_Y40_I0.6840.50
83_E86_Q0.6840.50
210_N214_K0.6830.50
106_I116_Q0.6820.50
29_D42_N0.6810.50
131_Q149_G0.6800.50
13_P23_I0.6770.50
161_K175_V0.6770.50
115_K129_K0.6770.50
162_K167_H0.6760.49
176_H179_I0.6740.49
105_A108_S0.6740.49
9_I20_A0.6740.49
161_K164_L0.6730.49
40_I47_Q0.6720.49
162_K166_L0.6700.49
71_I75_Q0.6700.49
45_A49_E0.6700.49
65_N79_K0.6660.48
8_E22_K0.6660.48
101_K113_V0.6540.47
55_E79_K0.6510.47
48_E127_V0.6490.47
7_D25_D0.6450.46
54_G75_Q0.6440.46
164_L176_H0.6420.46
24_Y44_K0.6420.46
74_L78_V0.6390.46
10_L17_S0.6390.46
40_I46_L0.6350.45
25_D31_I0.6340.45
66_K69_E0.6320.45
20_A38_E0.6300.45
79_K82_G0.6250.44
184_G208_I0.6240.44
10_L22_K0.6230.44
175_V208_I0.6190.44
165_E184_G0.6170.43
55_E64_V0.6160.43
143_S147_R0.6140.43
16_L23_I0.6110.43
190_K197_Y0.6100.43
8_E12_N0.6060.42
30_E43_V0.6060.42
88_L92_V0.6050.42
9_I64_V0.6050.42
192_F206_F0.6030.42
114_K132_R0.5990.42
47_Q50_V0.5990.42
74_L79_K0.5950.41
18_A25_D0.5950.41
55_E61_Q0.5940.41
189_G200_N0.5920.41
105_A118_E0.5920.41
73_S77_A0.5880.40
119_A122_G0.5840.40
70_A82_G0.5840.40
11_N23_I0.5810.40
119_A123_L0.5790.40
80_K86_Q0.5770.39
37_E47_Q0.5750.39
35_K43_V0.5750.39
9_I27_L0.5740.39
21_D29_D0.5730.39
63_T124_Q0.5730.39
7_D22_K0.5730.39
25_D28_K0.5720.39
7_D19_L0.5680.38
7_D27_L0.5670.38
83_E90_E0.5670.38
66_K73_S0.5670.38
134_V205_V0.5660.38
72_T100_N0.5640.38
34_K42_N0.5630.38
147_R204_Y0.5610.38
166_L169_V0.5570.37
189_G199_T0.5560.37
40_I50_V0.5560.37
89_Q101_K0.5540.37
164_L208_I0.5530.37
19_L34_K0.5480.37
14_Q26_K0.5420.36
167_H170_D0.5410.36
47_Q52_R0.5410.36
73_S76_E0.5410.36
29_D52_R0.5390.36
179_I199_T0.5350.35
21_D42_N0.5330.35
108_S112_A0.5330.35
22_K25_D0.5320.35
159_L211_L0.5310.35
8_E45_A0.5310.35
162_K165_E0.5270.35
12_N39_T0.5250.34
124_Q129_K0.5250.34
11_N21_D0.5230.34
22_K50_V0.5230.34
59_S99_V0.5220.34
99_V106_I0.5220.34
50_V57_I0.5210.34
14_Q40_I0.5180.34
66_K99_V0.5150.33
112_A117_G0.5140.33
79_K83_E0.5120.33
195_D198_E0.5110.33
192_F196_F0.5090.33
17_S37_E0.5070.33
83_E95_L0.5060.33
71_I87_S0.5050.33
9_I22_K0.5030.32
23_I27_L0.5010.32
119_A144_F0.5010.32
112_A115_K0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i84S 2 0.1573 98.4 0.672 Contact Map
1c1gA 2 0.9738 97.8 0.72 Contact Map
2dfsA 2 0.4906 97.7 0.727 Contact Map
4linA 5 0.8764 97.6 0.731 Contact Map
3ojaB 1 0.4831 96.2 0.78 Contact Map
2v71A 3 0.5206 95.7 0.789 Contact Map
4iloA 3 0.8202 95 0.798 Contact Map
3o0zA 2 0.5805 95 0.799 Contact Map
4rsiB 1 0.4532 94.9 0.8 Contact Map
3na7A 1 0.8202 94.7 0.802 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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