GREMLIN Database
Q97XU3 - Uncharacterized protein
UniProt: Q97XU3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 222 (178)
Sequences: 2212 (2078)
Seq/√Len: 155.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_F97_P3.5611.00
103_G136_V3.3521.00
77_P132_N3.3271.00
158_C165_A3.2351.00
106_E141_S3.0531.00
73_I142_I2.7001.00
108_L133_I2.6961.00
104_N164_D2.6191.00
71_Y98_L2.5151.00
53_A72_A2.4511.00
80_F99_N2.4501.00
50_D155_K2.4191.00
103_G161_C2.3131.00
101_A136_V2.2431.00
138_T141_S2.2101.00
69_E96_I2.1991.00
51_I102_I2.1791.00
108_L135_P2.0501.00
179_Q200_F2.0021.00
110_K133_I1.9801.00
104_N167_Y1.9631.00
76_M79_L1.9581.00
58_S62_F1.9151.00
51_I156_I1.8581.00
100_V137_K1.8551.00
48_V62_F1.8081.00
46_K152_I1.7641.00
110_K131_G1.7571.00
106_E137_K1.7541.00
140_R168_S1.7531.00
98_L142_I1.6761.00
109_I136_V1.6611.00
180_I195_L1.6381.00
53_A83_L1.6061.00
100_V135_P1.6001.00
137_K141_S1.5981.00
80_F84_T1.5831.00
59_S95_I1.5731.00
139_L170_D1.5711.00
87_I95_I1.5701.00
60_I86_N1.5671.00
101_A134_I1.5351.00
140_R173_T1.5171.00
156_I165_A1.5171.00
75_P99_N1.4691.00
163_Y167_Y1.4651.00
49_I151_N1.4611.00
140_R170_D1.4431.00
45_N66_G1.4401.00
76_M111_I1.4361.00
73_I102_I1.4111.00
73_I98_L1.3661.00
80_F83_L1.3611.00
45_N68_K1.3161.00
63_A92_I1.2751.00
63_A94_N1.2661.00
161_C164_D1.2461.00
171_N175_D1.2351.00
87_I97_P1.2121.00
46_K68_K1.2111.00
106_E138_T1.1941.00
51_I158_C1.1771.00
154_L170_D1.1661.00
194_F198_K1.1631.00
83_L97_P1.1561.00
53_A74_E1.1331.00
159_E185_H1.1311.00
158_C162_E1.1291.00
54_N57_D1.1271.00
153_V181_A1.1101.00
163_Y194_F1.1000.99
171_N198_K1.1000.99
102_I139_L1.0980.99
71_Y142_I1.0970.99
103_G109_I1.0610.99
151_N177_I1.0460.99
51_I165_A1.0450.99
142_I146_Y1.0450.99
193_E197_E1.0440.99
158_C161_C1.0430.99
60_I90_N1.0350.99
48_V68_K1.0290.99
164_D167_Y1.0140.99
140_R174_L1.0130.99
157_D183_E1.0130.99
49_I139_L1.0030.99
103_G107_G0.9990.99
139_L173_T0.9740.99
84_T99_N0.9710.99
140_R172_T0.9690.99
96_I146_Y0.9680.99
77_P99_N0.9600.99
102_I137_K0.9590.99
184_Y191_L0.9590.99
72_A83_L0.9590.99
167_Y194_F0.9540.98
165_A168_S0.9540.98
156_I166_I0.9510.98
167_Y190_K0.9470.98
177_I200_F0.9470.98
63_A70_V0.9360.98
76_M113_N0.9330.98
38_Y43_F0.9290.98
70_V95_I0.9280.98
154_L180_I0.9280.98
32_Q38_Y0.9220.98
48_V70_V0.9100.98
75_P101_A0.9080.98
172_T176_K0.9000.98
192_S196_I0.9000.98
170_D174_L0.8930.98
84_T88_R0.8850.98
84_T97_P0.8830.98
31_N34_I0.8680.97
85_E88_R0.8670.97
109_I123_K0.8670.97
54_N183_E0.8660.97
172_T175_D0.8620.97
47_T152_I0.8570.97
59_S70_V0.8560.97
120_A159_E0.8470.97
47_T71_Y0.8450.97
58_S181_A0.8430.97
74_E80_F0.8430.97
173_T176_K0.8340.96
180_I183_E0.8310.96
51_I73_I0.8290.96
101_A109_I0.8290.96
166_I182_L0.8260.96
47_T68_K0.8190.96
102_I165_A0.8170.96
59_S72_A0.8100.96
63_A95_I0.8080.96
57_D61_Y0.8070.96
167_Y171_N0.8000.96
54_N79_L0.7970.95
72_A95_I0.7840.95
193_E196_I0.7820.95
38_Y41_I0.7770.95
171_N194_F0.7770.95
106_E135_P0.7730.95
166_I194_F0.7710.95
51_I168_S0.7690.95
79_L83_L0.7680.94
31_N37_E0.7670.94
143_I173_T0.7640.94
48_V66_G0.7560.94
76_M132_N0.7550.94
137_K145_E0.7540.94
86_N90_N0.7510.94
75_P80_F0.7410.93
103_G164_D0.7310.93
87_I92_I0.7280.93
31_N35_S0.7250.93
154_L179_Q0.7240.93
158_C168_S0.7180.92
151_N154_L0.7120.92
33_F38_Y0.7070.92
104_N138_T0.7070.92
30_Y35_S0.7010.91
49_I73_I0.7000.91
138_T168_S0.6980.91
31_N39_G0.6960.91
189_Y193_E0.6960.91
144_S172_T0.6940.91
102_I138_T0.6930.91
82_Y86_N0.6910.91
58_S61_Y0.6830.90
58_S185_H0.6750.90
175_D198_K0.6750.90
63_A68_K0.6730.90
48_V59_S0.6720.89
49_I71_Y0.6720.89
174_L179_Q0.6710.89
59_S63_A0.6640.89
101_A107_G0.6630.89
163_Y190_K0.6630.89
48_V153_V0.6610.89
185_H188_P0.6570.88
37_E40_K0.6570.88
107_G136_V0.6530.88
159_E162_E0.6500.88
66_G70_V0.6500.88
71_Y96_I0.6480.88
55_I86_N0.6430.87
102_I170_D0.6400.87
51_I139_L0.6340.87
92_I95_I0.6340.87
185_H202_V0.6310.86
35_S42_D0.6280.86
162_E182_L0.6250.86
69_E149_S0.6220.86
178_S200_F0.6220.86
174_L180_I0.6200.85
79_L121_Y0.6190.85
170_D173_T0.6140.85
47_T148_I0.6130.85
81_N84_T0.6080.84
53_A59_S0.6000.83
137_K142_I0.5970.83
86_N89_F0.5970.83
171_N197_E0.5940.83
60_I63_A0.5900.82
73_I138_T0.5900.82
138_T143_I0.5900.82
178_S201_K0.5870.82
195_L202_V0.5870.82
119_D123_K0.5840.82
180_I200_F0.5830.82
60_I83_L0.5820.82
44_K67_A0.5790.81
48_V181_A0.5740.81
115_D130_N0.5740.81
60_I87_I0.5730.81
140_R171_N0.5700.80
73_I100_V0.5690.80
98_L145_E0.5670.80
75_P136_V0.5650.80
34_I37_E0.5630.79
56_G83_L0.5610.79
64_I92_I0.5580.79
39_G43_F0.5560.79
151_N176_K0.5540.78
73_I173_T0.5530.78
57_D62_F0.5520.78
117_G120_A0.5520.78
202_V207_P0.5510.78
86_N183_E0.5490.78
112_P131_G0.5470.78
30_Y34_I0.5460.77
174_L177_I0.5450.77
50_D59_S0.5440.77
30_Y33_F0.5390.76
114_I121_Y0.5340.76
159_E179_Q0.5340.76
118_L123_K0.5330.76
143_I146_Y0.5310.75
111_I132_N0.5310.75
173_T177_I0.5300.75
63_A66_G0.5300.75
29_V35_S0.5290.75
200_F206_K0.5280.75
201_K204_Y0.5270.75
71_Y148_I0.5250.75
158_C185_H0.5250.75
83_L87_I0.5240.74
75_P111_I0.5220.74
117_G122_T0.5210.74
34_I38_Y0.5200.74
49_I154_L0.5200.74
35_S38_Y0.5190.74
190_K193_E0.5180.74
150_E178_S0.5180.74
38_Y185_H0.5140.73
138_T170_D0.5130.73
60_I64_I0.5130.73
35_S40_K0.5120.73
81_N85_E0.5120.73
185_H192_S0.5110.73
87_I90_N0.5110.73
31_N42_D0.5100.72
34_I41_I0.5090.72
109_I134_I0.5050.72
47_T150_E0.5040.72
81_N91_N0.5010.71
113_N132_N0.5000.71
80_F98_L0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2py6A 4 0.8649 100 0.397 Contact Map
3k6rA 1 0.8108 98.5 0.797 Contact Map
3a27A 1 0.8153 98.5 0.801 Contact Map
3v97A 1 0.8378 98.3 0.81 Contact Map
3axsA 2 0.8198 98.3 0.811 Contact Map
2yx1A 2 0.7883 98.3 0.812 Contact Map
3kr9A 1 0.6982 98.3 0.812 Contact Map
3opnA 1 0.7072 98.2 0.816 Contact Map
3evzA 1 0.8018 98.1 0.82 Contact Map
4qdjA 1 0.8378 98.1 0.821 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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