GREMLIN Database
Q97XT6 - Uncharacterized protein
UniProt: Q97XT6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 337 (298)
Sequences: 57215 (48449)
Seq/√Len: 2806.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_G244_F4.7051.00
199_I227_R3.6531.00
123_A145_F3.3101.00
169_K201_E3.1401.00
247_F263_A3.1161.00
192_K296_I2.8661.00
201_E229_M2.8581.00
210_S214_K2.6991.00
72_H330_Y2.6831.00
188_E216_I2.6581.00
167_V199_I2.6551.00
172_Y183_L2.6421.00
313_Y316_K2.6371.00
182_D185_R2.1941.00
132_K136_E2.1661.00
201_E227_R2.1401.00
216_I220_S2.0491.00
274_K279_P2.0411.00
169_K199_I2.0411.00
298_Y301_S2.0331.00
169_K243_S1.9931.00
203_W240_I1.9631.00
168_I245_D1.9581.00
40_E68_Y1.9411.00
170_I246_A1.9341.00
40_E66_S1.9151.00
37_I327_L1.8621.00
282_A286_C1.8581.00
190_F200_F1.8581.00
301_S304_E1.8061.00
182_D252_K1.8041.00
267_G311_R1.7881.00
285_Y313_Y1.7491.00
287_I298_Y1.7301.00
321_I325_N1.7261.00
123_A329_S1.7241.00
186_G200_F1.7221.00
129_S132_K1.7221.00
43_P49_S1.6881.00
191_R220_S1.6851.00
205_N210_S1.6831.00
132_K146_V1.6771.00
145_F332_S1.6771.00
150_G319_L1.6741.00
247_F268_V1.6641.00
173_I237_L1.6481.00
274_K290_N1.6371.00
283_C313_Y1.6371.00
72_H92_T1.6361.00
91_T121_S1.6341.00
195_E300_K1.6261.00
327_L331_G1.6171.00
126_A144_I1.6171.00
290_N294_P1.6031.00
185_R252_K1.5981.00
129_S280_E1.5971.00
287_I301_S1.5761.00
218_K223_D1.5701.00
132_K144_I1.5571.00
32_G323_V1.5121.00
209_D212_I1.5101.00
190_F198_V1.5081.00
186_G248_F1.4771.00
307_N310_L1.4741.00
129_S146_V1.4701.00
272_V278_I1.4611.00
201_E240_I1.4441.00
27_R31_E1.4401.00
194_K300_K1.4401.00
203_W229_M1.4211.00
232_A236_K1.4201.00
184_I216_I1.4181.00
180_R253_E1.4131.00
233_P236_K1.4061.00
177_D180_R1.4061.00
238_V266_R1.3921.00
125_I329_S1.3701.00
300_K303_K1.3681.00
294_P298_Y1.3641.00
201_E244_F1.3631.00
169_K245_D1.3611.00
73_L89_W1.3561.00
244_F268_V1.3501.00
168_I302_F1.3371.00
193_I300_K1.3341.00
126_A132_K1.3321.00
183_L202_L1.3221.00
136_E141_K1.3211.00
32_G320_G1.3181.00
305_K309_A1.3151.00
232_A240_I1.3061.00
203_W232_A1.3051.00
312_K315_S1.3031.00
172_Y186_G1.2961.00
125_I326_I1.2821.00
289_I298_Y1.2791.00
306_Y310_L1.2631.00
242_D266_R1.2541.00
325_N328_N1.2441.00
236_K239_E1.2421.00
35_K324_K1.2331.00
229_M232_A1.2211.00
189_V295_Q1.2091.00
321_I324_K1.2081.00
287_I306_Y1.2071.00
171_G203_W1.2051.00
296_I300_K1.2041.00
216_I219_E1.2011.00
256_F261_V1.2011.00
170_I248_F1.1901.00
123_A332_S1.1781.00
309_A312_K1.1691.00
168_I246_A1.1661.00
156_F266_R1.1601.00
318_S321_I1.1571.00
322_S325_N1.1531.00
294_P297_D1.1521.00
234_D237_L1.1521.00
205_N231_P1.1501.00
176_L202_L1.1501.00
35_K327_L1.1471.00
215_R219_E1.1401.00
185_R273_F1.1401.00
25_Y258_L1.1361.00
155_F238_V1.1331.00
195_E303_K1.1221.00
249_F260_I1.1161.00
184_I188_E1.1161.00
129_S133_E1.1091.00
306_Y309_A1.1001.00
185_R188_E1.0951.00
126_A135_V1.0921.00
319_L322_S1.0911.00
170_I299_I1.0901.00
237_L241_Y1.0891.00
214_K218_K1.0891.00
133_E136_E1.0801.00
168_I198_V1.0671.00
201_E243_S1.0641.00
267_G308_D1.0571.00
127_V149_P1.0471.00
249_F259_P1.0451.00
260_I278_I1.0341.00
169_K244_F1.0331.00
241_Y266_R1.0221.00
170_I190_F1.0221.00
273_F289_I1.0221.00
238_V242_D1.0221.00
185_R292_E1.0221.00
307_N311_R1.0211.00
289_I295_Q1.0211.00
250_P295_Q1.0181.00
55_N59_K1.0151.00
284_N298_Y1.0141.00
127_V131_V1.0101.00
260_I272_V1.0091.00
145_F329_S1.0091.00
229_M240_I1.0081.00
264_Q270_V1.0041.00
28_E31_E1.0001.00
322_S326_I0.9941.00
297_D301_S0.9931.00
251_T254_E0.9931.00
277_R280_E0.9871.00
112_K115_L0.9821.00
94_H258_L0.9811.00
211_E214_K0.9751.00
20_T23_G0.9711.00
62_F66_S0.9711.00
247_F259_P0.9711.00
156_F238_V0.9701.00
211_E215_R0.9661.00
175_R180_R0.9641.00
257_G278_I0.9631.00
171_G240_I0.9621.00
32_G35_K0.9591.00
173_I241_Y0.9571.00
167_V197_N0.9521.00
184_I212_I0.9511.00
126_A131_V0.9511.00
190_F225_R0.9501.00
188_E220_S0.9491.00
73_L91_T0.9481.00
149_P258_L0.9471.00
168_I197_N0.9451.00
30_Y41_A0.9421.00
89_W121_S0.9421.00
268_V307_N0.9371.00
186_G250_P0.9361.00
252_K292_E0.9321.00
153_E318_S0.9301.00
134_D138_L0.9291.00
285_Y310_L0.9281.00
193_I198_V0.9271.00
276_A279_P0.9251.00
184_I252_K0.9201.00
272_V288_R0.9111.00
308_D312_K0.9101.00
185_R295_Q0.9091.00
28_E319_L0.9091.00
150_G322_S0.9061.00
173_I203_W0.9051.00
324_K328_N0.8991.00
217_K222_E0.8981.00
24_R28_E0.8961.00
63_H68_Y0.8931.00
172_Y202_L0.8931.00
134_D137_K0.8921.00
263_A268_V0.8911.00
217_K228_I0.8901.00
199_I225_R0.8891.00
30_Y34_K0.8851.00
50_I53_S0.8801.00
90_I125_I0.8801.00
177_D208_P0.8801.00
234_D238_V0.8771.00
269_P307_N0.8751.00
189_V296_I0.8671.00
121_S124_I0.8671.00
264_Q285_Y0.8651.00
127_V255_G0.8531.00
212_I215_R0.8461.00
152_G155_F0.8461.00
271_I289_I0.8451.00
187_I217_K0.8451.00
195_E198_V0.8431.00
165_K168_I0.8391.00
260_I270_V0.8391.00
264_Q310_L0.8381.00
241_Y268_V0.8381.00
193_I296_I0.8341.00
273_F291_E0.8341.00
260_I281_E0.8331.00
212_I216_I0.8331.00
254_E257_G0.8251.00
249_F278_I0.8221.00
145_F325_N0.8211.00
272_V282_A0.8201.00
282_A288_R0.8201.00
136_E144_I0.8171.00
90_I123_A0.8161.00
130_L133_E0.8161.00
239_E243_S0.8121.00
264_Q313_Y0.8051.00
324_K327_L0.8041.00
271_I298_Y0.8031.00
188_E191_R0.8031.00
181_K254_E0.8021.00
54_I57_I0.7981.00
240_I243_S0.7971.00
88_K122_D0.7971.00
172_Y250_P0.7931.00
318_S322_S0.7931.00
74_L94_H0.7931.00
25_Y94_H0.7881.00
217_K220_S0.7881.00
274_K288_R0.7731.00
275_D278_I0.7701.00
125_I147_I0.7671.00
133_E137_K0.7661.00
28_E152_G0.7651.00
147_I329_S0.7651.00
297_D300_K0.7541.00
248_F299_I0.7531.00
319_L323_V0.7511.00
193_I299_I0.7501.00
54_I58_I0.7491.00
28_E32_G0.7461.00
328_N332_S0.7451.00
130_L134_D0.7421.00
20_T175_R0.7401.00
181_K259_P0.7381.00
108_P111_Q0.7351.00
279_P288_R0.7331.00
171_G241_Y0.7331.00
172_Y200_F0.7311.00
94_H127_V0.7311.00
290_N293_F0.7311.00
239_E242_D0.7291.00
26_V74_L0.7281.00
159_P242_D0.7261.00
191_R222_E0.7251.00
95_D180_R0.7221.00
179_E184_I0.7211.00
181_K251_T0.7211.00
313_Y317_F0.7191.00
232_A237_L0.7181.00
148_N325_N0.7181.00
320_G324_K0.7161.00
215_R218_K0.7151.00
34_K39_V0.7141.00
111_Q115_L0.7101.00
174_G183_L0.7101.00
152_G156_F0.7081.00
310_L313_Y0.7071.00
72_H326_I0.7041.00
24_R27_R0.7031.00
311_R314_A0.7011.00
147_I326_I0.7001.00
127_V258_L0.6961.00
173_I247_F0.6931.00
188_E192_K0.6901.00
261_V317_F0.6771.00
328_N331_G0.6761.00
73_L79_F0.6751.00
326_I330_Y0.6751.00
36_Q327_L0.6741.00
74_L92_T0.6741.00
172_Y247_F0.6731.00
246_A299_I0.6721.00
217_K226_I0.6681.00
174_G181_K0.6671.00
170_I198_V0.6641.00
25_Y92_T0.6641.00
179_E252_K0.6631.00
34_K37_I0.6621.00
329_S332_S0.6601.00
147_I325_N0.6591.00
90_I330_Y0.6551.00
75_S78_P0.6511.00
257_G260_I0.6511.00
51_F55_N0.6491.00
35_K320_G0.6481.00
63_H66_S0.6471.00
25_Y149_P0.6451.00
168_I171_G0.6421.00
305_K308_D0.6411.00
316_K321_I0.6411.00
145_F148_N0.6371.00
73_L82_L0.6361.00
176_L210_S0.6351.00
323_V327_L0.6291.00
190_F193_I0.6281.00
148_N280_E0.6271.00
214_K217_K0.6271.00
284_N287_I0.6271.00
25_Y326_I0.6261.00
256_F317_F0.6261.00
308_D311_R0.6251.00
273_F295_Q0.6251.00
62_F65_Y0.6211.00
214_K228_I0.6191.00
248_F295_Q0.6181.00
240_I244_F0.6151.00
169_K240_I0.6131.00
53_S59_K0.6111.00
213_F216_I0.6111.00
130_L279_P0.6101.00
24_R234_D0.6101.00
185_R189_V0.6071.00
189_V193_I0.6061.00
247_F270_V0.6061.00
249_F257_G0.6031.00
189_V299_I0.5961.00
50_I56_S0.5961.00
52_S55_N0.5961.00
264_Q307_N0.5951.00
309_A313_Y0.5931.00
153_E265_A0.5921.00
187_I226_I0.5921.00
246_A271_I0.5921.00
70_I330_Y0.5911.00
30_Y39_V0.5911.00
19_V231_P0.5901.00
131_V134_D0.5901.00
197_N225_R0.5851.00
171_G247_F0.5851.00
285_Y309_A0.5851.00
157_T242_D0.5841.00
36_Q39_V0.5841.00
282_A285_Y0.5831.00
291_E294_P0.5821.00
196_K303_K0.5751.00
35_K323_V0.5731.00
184_I209_D0.5711.00
148_N317_F0.5711.00
132_K141_K0.5701.00
37_I331_G0.5681.00
52_S56_S0.5671.00
196_K300_K0.5641.00
92_T326_I0.5641.00
193_I196_K0.5631.00
148_N256_F0.5631.00
176_L183_L0.5631.00
182_D273_F0.5621.00
203_W237_L0.5601.00
191_R219_E0.5591.00
50_I57_I0.5591.00
275_D279_P0.5591.00
129_S148_N0.5591.00
54_I59_K0.5581.00
85_G88_K0.5571.00
157_T160_K0.5571.00
29_V32_G0.5531.00
310_L314_A0.5531.00
112_K116_K0.5521.00
131_V255_G0.5521.00
123_A127_V0.5501.00
264_Q314_A0.5491.00
68_Y87_A0.5481.00
63_H67_S0.5481.00
126_A146_V0.5481.00
217_K223_D0.5471.00
70_I90_I0.5471.00
186_G190_F0.5461.00
32_G319_L0.5421.00
92_T125_I0.5411.00
51_F59_K0.5401.00
189_V248_F0.5391.00
289_I294_P0.5381.00
93_V131_V0.5371.00
89_W122_D0.5371.00
94_H149_P0.5361.00
136_E139_G0.5351.00
274_K291_E0.5351.00
179_E209_D0.5341.00
29_V326_I0.5291.00
25_Y29_V0.5291.00
28_E258_L0.5291.00
155_F234_D0.5281.00
22_I75_S0.5281.00
189_V192_K0.5281.00
50_I54_I0.5261.00
267_G307_N0.5251.00
241_Y247_F0.5241.00
241_Y259_P0.5221.00
31_E34_K0.5221.00
182_D292_E0.5201.00
259_P263_A0.5201.00
109_F112_K0.5161.00
28_E150_G0.5161.00
283_C316_K0.5151.00
173_I259_P0.5141.00
136_E143_K0.5131.00
68_Y71_I0.5101.00
148_N322_S0.5091.00
198_V302_F0.5081.00
113_I116_K0.5071.00
194_K296_I0.5071.00
128_S131_V0.5061.00
263_A270_V0.5051.00
250_P273_F0.5041.00
196_K225_R0.5021.00
241_Y263_A0.5021.00
154_E157_T0.5001.00
71_I87_A0.5001.00
53_S57_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r60A 1 0.9733 100 0.271 Contact Map
4n9wA 1 0.911 100 0.272 Contact Map
3froA 3 0.9763 100 0.294 Contact Map
3c48A 2 0.9585 100 0.297 Contact Map
2qzsA 1 0.9496 100 0.302 Contact Map
1rzuA 1 0.9585 100 0.305 Contact Map
3okpA 1 0.9466 100 0.308 Contact Map
2x6qA 1 0.9436 100 0.308 Contact Map
3oy2A 2 0.9318 100 0.315 Contact Map
2jjmA 4 0.9228 100 0.324 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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