GREMLIN Database
Q97XT5 - Glycosyltransferase
UniProt: Q97XT5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 419 (364)
Sequences: 15366 (13835)
Seq/√Len: 725.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
248_V317_A4.3981.00
320_N336_S3.1861.00
246_Y279_Y3.0791.00
244_D277_R3.0711.00
203_H225_I3.0161.00
268_L373_L2.8281.00
268_L370_Y2.5981.00
382_N385_E2.5921.00
249_F259_I2.5221.00
245_N380_I2.4181.00
347_Y365_K2.4151.00
355_F361_V2.3921.00
266_F278_L2.3291.00
391_Y395_L2.2881.00
264_K369_K2.2781.00
362_K375_K2.2661.00
281_I313_I2.2541.00
37_Y408_E2.2491.00
247_A319_M2.2031.00
245_N318_Q2.1951.00
365_K371_E2.1891.00
246_Y316_K2.1891.00
378_E382_N2.1801.00
246_Y277_R2.1501.00
393_L397_H2.1351.00
347_Y352_Y2.1291.00
279_Y301_L2.1061.00
283_G287_D2.0841.00
375_K378_E2.0781.00
345_M363_I2.0731.00
340_Y391_Y2.0351.00
264_K295_K2.0201.00
35_I405_N1.9741.00
356_S359_K1.9441.00
387_D390_T1.8961.00
209_R212_I1.8861.00
265_I372_F1.8811.00
402_K406_N1.8721.00
262_A321_I1.8511.00
293_N298_I1.8471.00
295_K298_I1.8421.00
258_G261_E1.8231.00
371_E375_K1.8151.00
368_N371_E1.7821.00
317_A341_T1.7601.00
209_R353_E1.7571.00
293_N296_S1.7541.00
360_L393_L1.7441.00
408_E412_L1.7421.00
266_F276_Q1.7411.00
247_A376_I1.7391.00
378_E385_E1.7321.00
230_G400_W1.7071.00
262_A278_L1.6831.00
296_S299_V1.6721.00
356_S393_L1.6561.00
269_A377_N1.6381.00
369_K373_L1.6341.00
173_E176_A1.6261.00
260_L325_I1.6101.00
320_N341_T1.6061.00
377_N381_N1.6061.00
287_D293_N1.5991.00
147_I150_H1.5981.00
205_L410_H1.5891.00
258_G325_I1.5811.00
365_K368_N1.5751.00
212_I226_F1.5541.00
309_E312_K1.5501.00
35_I408_E1.5411.00
239_S242_N1.5201.00
345_M351_N1.4781.00
256_T326_S1.4761.00
247_A321_I1.4701.00
246_Y318_Q1.4581.00
290_S293_N1.4501.00
346_Y364_V1.4431.00
167_E170_N1.4431.00
253_P280_I1.4391.00
150_H411_L1.4381.00
359_K389_Y1.4321.00
203_H413_N1.4301.00
324_S327_D1.4231.00
295_K299_V1.4231.00
364_V375_K1.4121.00
148_L152_G1.4111.00
31_R34_K1.4011.00
406_N409_E1.3901.00
203_H410_H1.3901.00
250_F310_V1.3891.00
392_N396_S1.3831.00
389_Y392_N1.3701.00
252_R256_T1.3611.00
356_S360_L1.3571.00
31_R404_V1.3501.00
209_R213_K1.3481.00
402_K405_N1.3341.00
268_L369_K1.3321.00
250_F314_L1.3291.00
292_Y296_S1.3271.00
281_I301_L1.3241.00
319_M379_I1.3221.00
287_D290_S1.3191.00
146_G149_Q1.3121.00
345_M355_F1.3041.00
304_I309_E1.2951.00
267_K271_K1.2921.00
192_V196_I1.2901.00
265_I373_L1.2871.00
362_K386_I1.2851.00
249_F262_A1.2851.00
207_P229_V1.2791.00
305_K309_E1.2761.00
206_T212_I1.2721.00
245_N319_M1.2681.00
248_V281_I1.2651.00
236_L311_Y1.2621.00
220_L223_T1.2441.00
310_V314_L1.2431.00
301_L304_I1.2411.00
386_I390_T1.2401.00
245_N275_L1.2391.00
388_E392_N1.2391.00
291_K295_K1.2381.00
26_L30_K1.2371.00
290_S294_N1.2361.00
273_G377_N1.2351.00
333_I351_N1.2351.00
225_I413_N1.2331.00
392_N395_L1.2281.00
31_R401_N1.2251.00
205_L407_I1.2231.00
269_A276_Q1.2101.00
311_Y339_V1.2051.00
148_L411_L1.2041.00
357_K375_K1.2041.00
273_G381_N1.1981.00
342_P393_L1.1951.00
259_I280_I1.1901.00
320_N332_T1.1901.00
254_Y285_I1.1891.00
371_E374_N1.1811.00
201_K204_L1.1781.00
289_T293_N1.1751.00
281_I304_I1.1751.00
206_T215_A1.1731.00
296_S300_N1.1721.00
279_Y313_I1.1681.00
146_G150_H1.1631.00
336_S341_T1.1611.00
170_N173_E1.1541.00
327_D330_G1.1501.00
261_E325_I1.1461.00
294_N298_I1.1441.00
314_L339_V1.1411.00
387_D391_Y1.1401.00
322_Y333_I1.1401.00
393_L396_S1.1391.00
373_L377_N1.1381.00
244_D275_L1.1371.00
307_K310_V1.1321.00
267_K299_V1.1311.00
341_T387_D1.1301.00
319_M344_I1.1291.00
261_E346_Y1.1271.00
260_L264_K1.1211.00
379_I386_I1.1201.00
209_R226_F1.1171.00
279_Y317_A1.1171.00
322_Y332_T1.1121.00
294_N299_V1.1071.00
362_K378_E1.0991.00
24_V331_I1.0891.00
269_A376_I1.0831.00
207_P328_A1.0821.00
325_I367_F1.0801.00
145_I149_Q1.0731.00
33_K36_E1.0731.00
246_Y317_A1.0711.00
203_H223_T1.0711.00
333_I343_V1.0691.00
261_E367_F1.0671.00
344_I364_V1.0671.00
386_I389_Y1.0651.00
311_Y315_S1.0571.00
236_L339_V1.0521.00
192_V195_L1.0481.00
250_F281_I1.0471.00
293_N297_D1.0441.00
29_L41_P1.0411.00
212_I224_V1.0401.00
329_F334_L1.0401.00
304_I313_I1.0391.00
289_T296_S1.0351.00
207_P211_A1.0351.00
144_Y147_I1.0331.00
257_K324_S1.0321.00
403_I407_I1.0311.00
180_Y183_A1.0281.00
205_L227_P1.0281.00
284_N287_D1.0171.00
261_E369_K1.0161.00
405_N409_E1.0101.00
399_D402_K1.0081.00
206_T211_A1.0081.00
232_D236_L1.0011.00
342_P387_D1.0001.00
248_V314_L0.9941.00
177_E180_Y0.9931.00
279_Y316_K0.9901.00
61_I64_I0.9901.00
337_L343_V0.9871.00
342_P379_I0.9811.00
248_V313_I0.9801.00
321_I372_F0.9801.00
147_I151_L0.9791.00
305_K308_N0.9791.00
247_A278_L0.9791.00
400_W403_I0.9741.00
257_K327_D0.9691.00
370_Y374_N0.9681.00
171_Y176_A0.9681.00
247_A266_F0.9641.00
249_F280_I0.9581.00
206_T224_V0.9571.00
344_I376_I0.9531.00
364_V371_E0.9471.00
333_I354_Y0.9411.00
276_Q380_I0.9401.00
146_G152_G0.9401.00
403_I406_N0.9351.00
302_G305_K0.9341.00
245_N276_Q0.9331.00
120_I124_I0.9311.00
227_P410_H0.9291.00
297_D300_N0.9281.00
268_L271_K0.9241.00
374_N378_E0.9201.00
344_I375_K0.9161.00
313_I316_K0.9141.00
74_N78_D0.9121.00
31_R35_I0.9111.00
337_L360_L0.9071.00
73_D76_V0.9041.00
379_I382_N0.8991.00
210_G213_K0.8971.00
227_P407_I0.8971.00
178_L182_L0.8931.00
362_K385_E0.8931.00
399_D403_I0.8921.00
364_V372_F0.8901.00
362_K379_I0.8881.00
173_E177_E0.8831.00
314_L341_T0.8831.00
330_G333_I0.8811.00
33_K39_I0.8801.00
177_E182_L0.8751.00
76_V79_Y0.8751.00
235_I311_Y0.8731.00
29_L39_I0.8711.00
148_L151_L0.8701.00
249_F323_P0.8691.00
145_I150_H0.8691.00
262_A323_P0.8691.00
307_K311_Y0.8681.00
348_N351_N0.8681.00
314_L332_T0.8661.00
23_Y27_N0.8661.00
288_I291_K0.8661.00
360_L390_T0.8641.00
321_I376_I0.8631.00
261_E372_F0.8621.00
93_K97_D0.8621.00
228_Y353_E0.8571.00
390_T393_L0.8551.00
143_K150_H0.8541.00
144_Y149_Q0.8501.00
257_K332_T0.8501.00
312_K316_K0.8491.00
314_L336_S0.8451.00
291_K294_N0.8451.00
145_I148_L0.8441.00
232_D235_I0.8441.00
233_S399_D0.8431.00
315_S339_V0.8431.00
251_A259_I0.8391.00
181_L184_S0.8381.00
177_E181_L0.8371.00
340_Y388_E0.8361.00
208_S211_A0.8331.00
258_G323_P0.8311.00
191_W195_L0.8291.00
269_A380_I0.8291.00
347_Y363_I0.8261.00
336_S343_V0.8251.00
350_A353_E0.8251.00
29_L33_K0.8251.00
156_I159_K0.8241.00
178_L181_L0.8201.00
62_L65_I0.8171.00
319_M376_I0.8171.00
147_I152_G0.8151.00
267_K298_I0.8141.00
245_N248_V0.8141.00
330_G351_N0.8111.00
289_T295_K0.8071.00
267_K270_R0.8051.00
346_Y366_L0.8021.00
322_Y330_G0.7941.00
119_H122_E0.7931.00
210_G352_Y0.7931.00
274_Y377_N0.7911.00
61_I65_I0.7881.00
261_E264_K0.7881.00
323_P372_F0.7861.00
72_V75_V0.7851.00
172_L176_A0.7851.00
265_I369_K0.7791.00
35_I404_V0.7751.00
289_T298_I0.7701.00
71_H75_V0.7661.00
60_N64_I0.7651.00
193_Q196_I0.7651.00
409_E412_L0.7561.00
179_M182_L0.7551.00
400_W404_V0.7531.00
149_Q152_G0.7511.00
182_L185_V0.7511.00
249_F320_N0.7501.00
289_T292_Y0.7461.00
312_K315_S0.7451.00
73_D77_L0.7441.00
249_F278_L0.7431.00
132_D135_Y0.7371.00
401_N405_N0.7361.00
216_G219_K0.7341.00
252_R257_K0.7341.00
266_F269_A0.7301.00
90_D94_K0.7271.00
370_Y373_L0.7271.00
19_G22_E0.7261.00
358_S378_E0.7251.00
352_Y363_I0.7241.00
71_H74_N0.7221.00
253_P284_N0.7201.00
233_S338_A0.7191.00
333_I345_M0.7161.00
94_K97_D0.7151.00
355_F360_L0.7151.00
357_K360_L0.7121.00
228_Y403_I0.7091.00
322_Y351_N0.7061.00
211_A328_A0.7051.00
253_P287_D0.7001.00
171_Y175_L0.7001.00
409_E413_N0.6981.00
156_I160_F0.6981.00
379_I385_E0.6961.00
293_N299_V0.6961.00
57_Q61_I0.6961.00
27_N30_K0.6921.00
146_G151_L0.6921.00
136_Y141_S0.6901.00
405_N408_E0.6871.00
75_V79_Y0.6841.00
177_E184_S0.6821.00
264_K267_K0.6741.00
89_T93_K0.6731.00
144_Y148_L0.6721.00
269_A373_L0.6721.00
207_P331_I0.6691.00
72_V76_V0.6691.00
131_Y135_Y0.6671.00
64_I67_K0.6661.00
230_G403_I0.6661.00
27_N31_R0.6661.00
407_I411_L0.6651.00
340_Y387_D0.6651.00
374_N377_N0.6651.00
255_R325_I0.6631.00
389_Y393_L0.6621.00
379_I383_N0.6611.00
163_Y167_E0.6591.00
136_Y140_Y0.6591.00
248_V341_T0.6581.00
166_K169_L0.6531.00
180_Y184_S0.6531.00
390_T394_I0.6521.00
33_K37_Y0.6521.00
228_Y398_L0.6501.00
175_L178_L0.6491.00
173_E201_K0.6481.00
234_T237_N0.6471.00
394_I397_H0.6451.00
334_L354_Y0.6451.00
245_N383_N0.6451.00
332_T336_S0.6431.00
58_K61_I0.6421.00
74_N77_L0.6411.00
153_D156_I0.6401.00
24_V229_V0.6371.00
76_V80_Y0.6371.00
301_L313_I0.6371.00
260_L292_Y0.6351.00
174_S177_E0.6351.00
337_L387_D0.6331.00
144_Y150_H0.6311.00
289_T299_V0.6301.00
118_K124_I0.6281.00
250_F320_N0.6281.00
273_G276_Q0.6271.00
137_S141_S0.6251.00
171_Y174_S0.6241.00
246_Y313_I0.6241.00
270_R273_G0.6241.00
173_E178_L0.6231.00
153_D157_S0.6211.00
228_Y329_F0.6201.00
172_L175_L0.6191.00
236_L338_A0.6171.00
155_P159_K0.6171.00
88_N91_I0.6161.00
314_L335_E0.6161.00
210_G353_E0.6151.00
404_V408_E0.6151.00
344_I379_I0.6121.00
319_M380_I0.6101.00
283_G303_R0.6101.00
337_L393_L0.6081.00
191_W196_I0.6081.00
294_N297_D0.6051.00
223_T413_N0.6041.00
266_F270_R0.6041.00
247_A276_Q0.6011.00
130_G133_F0.6001.00
40_V73_D0.5981.00
264_K268_L0.5961.00
284_N289_T0.5951.00
181_L185_V0.5951.00
67_K71_H0.5951.00
258_G346_Y0.5951.00
229_V331_I0.5951.00
330_G334_L0.5931.00
252_R332_T0.5921.00
260_L288_I0.5921.00
120_I123_F0.5921.00
255_R260_L0.5921.00
372_F376_I0.5911.00
157_S160_F0.5911.00
349_E352_Y0.5901.00
248_V279_Y0.5841.00
57_Q64_I0.5841.00
155_P158_L0.5841.00
18_V21_A0.5831.00
130_G134_L0.5821.00
57_Q60_N0.5811.00
75_V78_D0.5791.00
263_I292_Y0.5781.00
231_L338_A0.5751.00
270_R274_Y0.5751.00
128_P132_D0.5731.00
34_K401_N0.5731.00
250_F332_T0.5731.00
247_A380_I0.5731.00
253_P259_I0.5711.00
166_K170_N0.5711.00
28_W407_I0.5701.00
72_V79_Y0.5671.00
23_Y307_K0.5651.00
40_V116_F0.5641.00
243_K275_L0.5631.00
21_A24_V0.5631.00
129_V133_F0.5631.00
59_D63_E0.5621.00
265_I376_I0.5621.00
337_L390_T0.5611.00
237_N315_S0.5601.00
377_N380_I0.5591.00
320_N343_V0.5571.00
292_Y295_K0.5551.00
60_N63_E0.5511.00
295_K300_N0.5501.00
170_N176_A0.5491.00
23_Y26_L0.5471.00
378_E381_N0.5461.00
293_N300_N0.5461.00
260_L295_K0.5441.00
243_K318_Q0.5441.00
87_N91_I0.5441.00
258_G367_F0.5441.00
176_A179_M0.5431.00
244_D316_K0.5431.00
155_P160_F0.5391.00
253_P282_G0.5391.00
135_Y139_K0.5381.00
333_I337_L0.5381.00
90_D96_L0.5381.00
215_A224_V0.5381.00
281_I310_V0.5371.00
35_I401_N0.5371.00
118_K121_L0.5371.00
168_L172_L0.5361.00
59_D65_I0.5351.00
269_A274_Y0.5351.00
351_N354_Y0.5351.00
286_N291_K0.5341.00
129_V132_D0.5331.00
31_R400_W0.5321.00
170_N174_S0.5311.00
319_M386_I0.5311.00
207_P330_G0.5291.00
67_K72_V0.5281.00
228_Y406_N0.5271.00
210_G214_K0.5261.00
168_L176_A0.5251.00
355_F363_I0.5241.00
160_F163_Y0.5241.00
372_F375_K0.5231.00
344_I372_F0.5231.00
122_E411_L0.5201.00
262_A266_F0.5201.00
310_V313_I0.5201.00
19_G252_R0.5201.00
337_L394_I0.5191.00
24_V28_W0.5191.00
239_S318_Q0.5191.00
63_E67_K0.5181.00
118_K122_E0.5171.00
367_F372_F0.5171.00
292_Y298_I0.5161.00
388_E391_Y0.5141.00
265_I268_L0.5121.00
230_G404_V0.5121.00
357_K362_K0.5111.00
267_K296_S0.5101.00
233_S395_L0.5081.00
209_R228_Y0.5071.00
152_G155_P0.5061.00
164_H167_E0.5050.99
246_Y319_M0.5030.99
304_I310_V0.5020.99
179_M185_V0.5020.99
314_L320_N0.5020.99
168_L171_Y0.5000.99
59_D64_I0.5000.99
90_D93_K0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rzuA 1 0.9165 100 0.305 Contact Map
2qzsA 1 0.9093 100 0.31 Contact Map
2r60A 1 0.8831 100 0.316 Contact Map
4n9wA 1 0.8162 100 0.317 Contact Map
3froA 3 0.9045 100 0.319 Contact Map
3c48A 2 0.864 100 0.327 Contact Map
3vueA 1 0.9165 100 0.331 Contact Map
4qlbA 3 0.9618 100 0.338 Contact Map
2x6qA 1 0.821 100 0.348 Contact Map
3nb0A 4 0.9666 100 0.349 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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