GREMLIN Database
Q97XT4 - Uncharacterized protein
UniProt: Q97XT4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 372 (302)
Sequences: 150 (140)
Seq/√Len: 8.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
290_D317_N4.5030.99
289_F320_S4.2430.98
223_F292_I3.5530.95
203_A233_A3.4580.94
305_M314_I3.3050.92
203_A222_A3.2340.91
201_I253_V2.8560.85
330_E356_E2.6860.81
200_D304_K2.6140.79
161_N164_Y2.4810.75
230_Y248_L2.4550.74
204_N330_E2.4000.73
197_E357_R2.3290.70
287_F291_D2.3100.70
254_G310_C2.2550.68
290_D303_L2.2370.67
202_G206_G2.1580.64
330_E364_K2.1420.63
307_C314_I2.1280.63
201_I330_E2.1230.63
306_D309_G2.0320.59
252_A284_V2.0180.59
202_G224_E2.0170.59
348_R351_K1.9870.57
321_I331_S1.9710.57
354_C366_F1.9660.57
190_Y332_H1.9510.56
289_F343_L1.9270.55
321_I340_D1.9130.54
317_N352_Y1.9020.54
254_G262_V1.9000.54
208_S332_H1.8830.53
198_V302_L1.8720.53
303_L314_I1.8640.52
290_D318_S1.8590.52
320_S354_C1.8560.52
257_E287_F1.8520.52
197_E301_Y1.8510.52
255_S316_L1.8400.51
193_E327_I1.8150.50
321_I330_E1.8030.50
199_I293_V1.7870.49
223_F253_V1.7850.49
359_R367_Y1.7750.49
227_P282_V1.7710.49
311_E332_H1.7690.48
164_Y220_V1.7540.48
226_L264_L1.7430.47
156_G164_Y1.6490.44
220_V263_P1.6360.43
164_Y171_N1.6360.43
229_V303_L1.6210.42
200_D206_G1.6100.42
216_G347_L1.6070.42
198_V220_V1.6040.42
201_I314_I1.6030.42
303_L329_V1.6030.42
206_G224_E1.5910.41
290_D340_D1.5880.41
197_E326_K1.5840.41
303_L317_N1.5690.40
311_E315_I1.5660.40
249_I292_I1.5540.40
164_Y357_R1.5510.40
328_L332_H1.5080.38
290_D311_E1.5020.38
277_T289_F1.5000.38
233_A345_S1.4930.37
200_D224_E1.4670.36
202_G306_D1.4510.36
328_L331_S1.4510.36
332_H336_T1.4270.35
254_G302_L1.4250.35
308_E311_E1.4230.35
255_S313_D1.4210.35
220_V357_R1.4170.34
200_D309_G1.4120.34
254_G258_G1.4050.34
332_H340_D1.3870.33
254_G286_L1.3840.33
250_N300_P1.3770.33
317_N321_I1.3670.33
356_E366_F1.3610.32
336_T340_D1.3600.32
330_E366_F1.3510.32
290_D315_I1.3510.32
189_Q365_L1.3510.32
290_D321_I1.3490.32
320_S338_V1.3410.32
246_I325_E1.3400.32
202_G304_K1.3190.31
204_N340_D1.3100.31
306_D311_E1.3080.31
327_I357_R1.3060.30
257_E291_D1.2980.30
301_Y354_C1.2880.30
307_C318_S1.2730.29
230_Y344_L1.2670.29
159_I164_Y1.2610.29
161_N165_W1.2610.29
303_L307_C1.2610.29
304_K309_G1.2520.29
254_G294_K1.2470.28
201_I305_M1.2350.28
252_A286_L1.2120.27
290_D352_Y1.2060.27
200_D290_D1.2060.27
329_V340_D1.2020.27
90_E253_V1.1980.27
290_D307_C1.1890.27
307_C317_N1.1840.26
151_W243_E1.1790.26
195_Q228_L1.1680.26
204_N331_S1.1660.26
293_V320_S1.1630.26
199_I320_S1.1600.26
249_I295_N1.1530.25
308_E331_S1.1450.25
212_F236_N1.1390.25
332_H344_L1.1380.25
244_N352_Y1.1290.25
203_A308_E1.1230.24
89_G323_Y1.1190.24
321_I332_H1.1170.24
302_L327_I1.1150.24
290_D336_T1.1100.24
202_G311_E1.0990.24
307_C353_K1.0990.24
125_S255_S1.0980.24
230_Y257_E1.0930.24
202_G309_G1.0900.24
200_D311_E1.0900.24
191_Y367_Y1.0880.23
202_G289_F1.0830.23
307_C311_E1.0800.23
329_V332_H1.0760.23
305_M327_I1.0680.23
254_G260_V1.0670.23
219_H247_T1.0660.23
208_S321_I1.0630.23
289_F321_I1.0620.23
314_I329_V1.0610.23
341_K345_S1.0530.22
308_E332_H1.0520.22
199_I302_L1.0460.22
220_V240_N1.0430.22
204_N208_S1.0320.22
330_E340_D1.0310.22
330_E344_L1.0240.22
204_N207_D1.0230.22
303_L353_K1.0210.22
125_S284_V1.0200.21
202_G352_Y1.0200.21
199_I289_F1.0200.21
161_N203_A1.0160.21
223_F264_L1.0100.21
262_V310_C1.0100.21
305_M338_V1.0020.21
200_D317_N0.9990.21
212_F254_G0.9930.21
159_I165_W0.9920.21
312_A343_L0.9910.21
198_V357_R0.9870.21
331_S344_L0.9860.21
288_S291_D0.9780.20
314_I330_E0.9780.20
181_I277_T0.9720.20
120_F315_I0.9640.20
331_S352_Y0.9640.20
289_F314_I0.9580.20
223_F352_Y0.9580.20
317_N325_E0.9580.20
206_G306_D0.9500.20
329_V352_Y0.9470.20
113_L116_I0.9470.20
167_F178_G0.9450.19
159_I284_V0.9450.19
152_L351_K0.9430.19
249_I343_L0.9400.19
203_A207_D0.9400.19
191_Y302_L0.9370.19
139_D199_I0.9360.19
198_V209_A0.9330.19
204_N336_T0.9300.19
307_C315_I0.9260.19
331_S340_D0.9260.19
104_K109_C0.9240.19
301_Y321_I0.9230.19
269_E272_G0.9160.19
294_K319_D0.9150.19
195_Q204_N0.9140.19
224_E233_A0.9130.19
321_I329_V0.9110.19
202_G225_P0.9020.18
202_G308_E0.9000.18
226_L262_V0.8960.18
329_V336_T0.8900.18
252_A351_K0.8890.18
214_L307_C0.8850.18
78_N284_V0.8770.18
301_Y326_K0.8710.18
322_S325_E0.8660.18
202_G317_N0.8630.17
213_A220_V0.8620.17
193_E203_A0.8530.17
250_N313_D0.8530.17
336_T354_C0.8520.17
144_I254_G0.8510.17
216_G284_V0.8480.17
232_A240_N0.8470.17
280_G367_Y0.8460.17
302_L365_L0.8440.17
218_S252_A0.8430.17
200_D306_D0.8390.17
204_N284_V0.8370.17
91_K283_E0.8360.17
209_A318_S0.8360.17
307_C310_C0.8360.17
236_N242_L0.8350.17
76_F101_S0.8310.17
301_Y357_R0.8300.17
204_N321_I0.8250.17
209_A367_Y0.8230.17
168_P252_A0.8230.17
261_K285_P0.8190.16
344_L368_C0.8190.16
231_K351_K0.8170.16
160_K194_I0.8170.16
61_N250_N0.8160.16
224_E306_D0.8160.16
331_S336_T0.8130.16
303_L321_I0.8120.16
362_K368_C0.8120.16
359_R365_L0.8110.16
122_S242_L0.7990.16
122_S149_T0.7920.16
223_F317_N0.7920.16
248_L368_C0.7850.16
206_G304_K0.7850.16
314_I332_H0.7830.16
102_K312_A0.7820.16
233_A262_V0.7820.16
365_L368_C0.7800.16
198_V218_S0.7790.16
305_M311_E0.7760.15
258_G363_T0.7710.15
172_V221_Y0.7710.15
316_L344_L0.7650.15
360_V366_F0.7640.15
69_I205_I0.7610.15
317_N336_T0.7590.15
206_G317_N0.7570.15
203_A219_H0.7560.15
212_F302_L0.7560.15
195_Q323_Y0.7480.15
109_C282_V0.7470.15
331_S357_R0.7460.15
204_N305_M0.7460.15
236_N342_A0.7450.15
208_S341_K0.7450.15
168_P355_E0.7440.15
325_E348_R0.7380.15
205_I368_C0.7380.15
340_D344_L0.7350.15
110_I307_C0.7350.15
130_F194_I0.7350.15
153_L287_F0.7350.15
226_L327_I0.7330.15
254_G301_Y0.7310.15
205_I359_R0.7300.15
329_V354_C0.7280.14
311_E327_I0.7270.14
235_Q319_D0.7270.14
224_E352_Y0.7240.14
164_Y345_S0.7210.14
141_N253_V0.7200.14
190_Y341_K0.7180.14
199_I255_S0.7170.14
224_E317_N0.7150.14
341_K357_R0.7130.14
88_K178_G0.7130.14
194_I285_P0.7130.14
121_S199_I0.7120.14
68_K80_F0.7110.14
340_D354_C0.7090.14
314_I333_P0.7040.14
201_I364_K0.7010.14
65_T71_V0.7000.14
330_E336_T0.6990.14
305_M330_E0.6960.14
218_S248_L0.6960.14
312_A363_T0.6960.14
81_Y195_Q0.6950.14
62_I87_R0.6950.14
185_F212_F0.6940.14
292_I351_K0.6910.14
288_S351_K0.6870.14
204_N314_I0.6870.14
73_R93_I0.6810.14
198_V324_F0.6780.13
205_I307_C0.6760.13
158_F284_V0.6740.13
331_S354_C0.6730.13
75_I93_I0.6710.13
299_D302_L0.6700.13
164_Y168_P0.6700.13
314_I327_I0.6690.13
243_E257_E0.6680.13
103_G123_I0.6660.13
330_E354_C0.6660.13
128_F155_I0.6650.13
244_N295_N0.6650.13
284_V328_L0.6640.13
336_T364_K0.6630.13
224_E304_K0.6570.13
183_E209_A0.6530.13
290_D304_K0.6490.13
256_K328_L0.6480.13
224_E289_F0.6470.13
208_S215_K0.6450.13
288_S365_L0.6440.13
202_G252_A0.6410.13
204_N332_H0.6380.13
356_E364_K0.6380.13
178_G181_I0.6370.13
229_V307_C0.6370.13
195_Q295_N0.6360.13
148_N300_P0.6350.13
151_W225_P0.6350.13
155_I242_L0.6300.13
220_V301_Y0.6270.13
248_L346_K0.6270.13
237_I347_L0.6270.13
154_S274_F0.6260.13
358_Y364_K0.6250.13
300_P316_L0.6230.12
74_K194_I0.6210.12
139_D166_F0.6200.12
315_I321_I0.6190.12
63_Y76_F0.6190.12
112_T319_D0.6180.12
244_N293_V0.6180.12
112_T287_F0.6150.12
209_A240_N0.6140.12
236_N240_N0.6130.12
196_G309_G0.6130.12
300_P342_A0.6130.12
179_Y203_A0.6120.12
357_R367_Y0.6110.12
332_H354_C0.6110.12
84_H334_H0.6110.12
222_A225_P0.6100.12
133_N299_D0.6100.12
239_L305_M0.6100.12
205_I305_M0.6100.12
110_I117_I0.6040.12
195_Q286_L0.6020.12
309_G330_E0.6020.12
196_G277_T0.6020.12
91_K363_T0.6010.12
66_L349_K0.5990.12
164_Y341_K0.5980.12
306_D331_S0.5970.12
117_I214_L0.5950.12
143_I253_V0.5890.12
102_K237_I0.5890.12
337_K367_Y0.5880.12
293_V366_F0.5870.12
114_T123_I0.5860.12
186_I204_N0.5860.12
155_I218_S0.5860.12
122_S133_N0.5860.12
164_Y260_V0.5840.12
193_E326_K0.5830.12
197_E286_L0.5830.12
78_N299_D0.5810.12
194_I366_F0.5800.12
115_T351_K0.5780.12
272_G303_L0.5780.12
300_P345_S0.5770.12
207_D332_H0.5760.12
201_I332_H0.5760.12
88_K128_F0.5750.12
317_N326_K0.5740.12
248_L262_V0.5730.12
332_H341_K0.5710.12
198_V365_L0.5690.12
254_G342_A0.5680.12
232_A239_L0.5680.12
160_K299_D0.5680.12
198_V311_E0.5670.11
213_A292_I0.5660.11
234_L272_G0.5660.11
161_N326_K0.5640.11
69_I92_D0.5640.11
255_S258_G0.5640.11
121_S257_E0.5640.11
110_I120_F0.5630.11
66_L101_S0.5630.11
198_V336_T0.5630.11
116_I328_L0.5610.11
104_K270_D0.5600.11
132_D292_I0.5600.11
144_I158_F0.5590.11
226_L252_A0.5590.11
97_L252_A0.5550.11
227_P250_N0.5530.11
206_G309_G0.5520.11
337_K340_D0.5500.11
86_L252_A0.5500.11
164_Y204_N0.5500.11
159_I252_A0.5500.11
212_F326_K0.5490.11
130_F256_K0.5490.11
63_Y246_I0.5490.11
202_G303_L0.5470.11
223_F318_S0.5470.11
329_V363_T0.5450.11
262_V317_N0.5440.11
252_A314_I0.5430.11
290_D338_V0.5430.11
206_G311_E0.5420.11
307_C324_F0.5410.11
165_W176_T0.5400.11
201_I358_Y0.5380.11
85_K90_E0.5370.11
218_S301_Y0.5360.11
190_Y314_I0.5340.11
64_Y335_I0.5310.11
199_I248_L0.5290.11
300_P318_S0.5280.11
66_L69_I0.5270.11
96_V283_E0.5260.11
307_C332_H0.5250.11
198_V340_D0.5240.11
329_V365_L0.5230.11
302_L368_C0.5190.11
186_I231_K0.5180.11
352_Y363_T0.5180.11
198_V333_P0.5160.11
64_Y69_I0.5150.11
131_D253_V0.5140.11
199_I328_L0.5130.11
210_I236_N0.5110.11
98_K155_I0.5100.11
106_N289_F0.5100.11
208_S330_E0.5070.11
239_L355_E0.5060.11
149_T193_E0.5040.10
78_N204_N0.5040.10
209_A289_F0.5020.10
128_F349_K0.5010.10
177_I325_E0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2py6A 4 0.879 100 0.564 Contact Map
3lecA 2 0.422 87.5 0.94 Contact Map
3kr9A 1 0.414 86.4 0.941 Contact Map
2esrA 2 0.4274 86.4 0.941 Contact Map
3gnlA 1 0.4194 85.3 0.941 Contact Map
4m37A 2 0.5511 83.3 0.943 Contact Map
2fhpA 1 0.4946 83.3 0.943 Contact Map
4c4aA 1 0.4892 82.9 0.943 Contact Map
3dh0A 1 0.5 81.8 0.944 Contact Map
4ikpA 3 0.4866 81.8 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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