GREMLIN Database
Q97XT3 - Polysaccharide biosynthesis related protein
UniProt: Q97XT3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 469 (430)
Sequences: 17485 (15076)
Seq/√Len: 727.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
432_V435_L3.9021.00
129_M132_E3.5351.00
41_A236_Q3.2711.00
196_F200_K3.2281.00
340_S343_P3.1261.00
311_I315_I3.1141.00
401_R405_I3.0311.00
342_R346_I2.8451.00
128_D262_F2.8391.00
293_I315_I2.8101.00
100_F103_Y2.7541.00
340_S393_E2.6271.00
297_V301_E2.5601.00
323_L380_T2.5231.00
234_L309_S2.3811.00
296_A311_I2.3471.00
228_G231_Y2.3101.00
316_L369_I2.2951.00
351_N382_S2.2921.00
262_F266_L2.2591.00
66_I126_G2.2361.00
207_L345_L2.1831.00
219_D235_Y2.1651.00
313_V368_I2.1641.00
64_R68_Y2.1251.00
358_T374_S2.1201.00
298_L301_E2.1091.00
219_D359_S2.1081.00
347_L385_F2.0481.00
291_I295_T2.0461.00
296_A315_I2.0461.00
337_A340_S2.0431.00
223_T227_L2.0381.00
156_N159_L2.0321.00
363_I371_G1.9861.00
272_K276_I1.9791.00
33_N36_F1.9781.00
295_T298_L1.9741.00
227_L231_Y1.9541.00
65_E201_E1.9131.00
9_K131_T1.8981.00
312_K369_I1.8621.00
192_F196_F1.8411.00
77_K81_G1.8291.00
286_F410_P1.8211.00
222_T363_I1.8181.00
285_T325_F1.7971.00
42_I224_A1.7971.00
316_L376_A1.7901.00
362_L374_S1.7581.00
370_G374_S1.7551.00
131_T135_I1.7491.00
264_K337_A1.7421.00
354_L381_I1.7401.00
297_V311_I1.7331.00
402_E405_I1.7081.00
291_I413_A1.6951.00
227_L368_I1.6921.00
316_L373_I1.6721.00
40_V44_Q1.6651.00
274_S333_F1.6641.00
112_F115_L1.6621.00
36_F39_K1.6551.00
292_S318_L1.6531.00
361_L364_P1.6531.00
289_V322_T1.6481.00
222_T359_S1.6411.00
300_V310_G1.6311.00
366_I373_I1.6131.00
313_V372_A1.6111.00
211_A349_L1.6061.00
30_K305_P1.6031.00
414_F418_F1.5991.00
300_V314_L1.5951.00
323_L383_S1.5861.00
159_L163_I1.5861.00
128_D259_T1.5831.00
435_L439_F1.5821.00
312_K315_I1.5681.00
191_D194_F1.5591.00
204_P345_L1.5591.00
367_G370_G1.5541.00
123_I127_M1.5381.00
219_D375_Q1.5301.00
384_S388_V1.5161.00
362_L366_I1.5131.00
68_Y339_K1.5061.00
316_L372_A1.5041.00
29_A237_F1.5041.00
144_R167_G1.5011.00
242_A317_L1.4961.00
297_V315_I1.4941.00
320_A376_A1.4931.00
103_Y106_L1.4891.00
275_S279_R1.4721.00
359_S363_I1.4711.00
432_V436_F1.4671.00
223_T371_G1.4531.00
388_V392_K1.4481.00
223_T232_L1.4431.00
75_I78_S1.4411.00
374_S378_V1.4371.00
78_S82_K1.4341.00
309_S312_K1.4301.00
256_L277_S1.4261.00
230_Y234_L1.4221.00
78_S191_D1.4181.00
150_I153_L1.4141.00
238_S310_G1.4061.00
295_T299_V1.4031.00
41_A233_G1.3981.00
222_T360_F1.3931.00
357_L361_L1.3871.00
26_I30_K1.3861.00
346_I350_L1.3791.00
34_P234_L1.3751.00
25_F240_L1.3541.00
218_G356_L1.3531.00
263_Y268_K1.3511.00
102_N106_L1.3471.00
355_V359_S1.3451.00
282_S286_F1.3441.00
231_Y368_I1.3321.00
84_L87_P1.3151.00
61_I201_E1.3131.00
24_F145_W1.2981.00
15_T19_I1.2951.00
271_K275_S1.2891.00
217_Q220_R1.2821.00
330_L387_L1.2781.00
81_G85_S1.2721.00
22_L26_I1.2701.00
222_T226_L1.2691.00
347_L389_Y1.2681.00
369_I372_A1.2661.00
16_T138_N1.2601.00
129_M182_K1.2581.00
238_S313_V1.2521.00
361_L365_R1.2461.00
260_A336_A1.2461.00
263_Y273_M1.2341.00
347_L386_V1.2331.00
143_I170_I1.2281.00
417_V420_D1.2221.00
274_S330_L1.2191.00
109_P112_F1.2121.00
158_Y161_I1.1981.00
204_P342_R1.1951.00
362_L365_R1.1941.00
228_G232_L1.1931.00
292_S314_L1.1921.00
320_A372_A1.1921.00
17_N141_L1.1911.00
65_E68_Y1.1891.00
79_V83_F1.1861.00
414_F417_V1.1861.00
136_T175_N1.1841.00
201_E341_L1.1831.00
19_I23_I1.1781.00
211_A345_L1.1761.00
211_A352_G1.1751.00
203_L207_L1.1671.00
164_W168_G1.1661.00
313_V369_I1.1651.00
42_I232_L1.1651.00
65_E197_K1.1651.00
146_G150_I1.1591.00
234_L310_G1.1581.00
78_S81_G1.1571.00
237_F304_F1.1571.00
418_F421_P1.1561.00
409_M413_A1.1551.00
223_T235_Y1.1541.00
31_I152_V1.1531.00
358_T362_L1.1511.00
319_L376_A1.1481.00
308_I312_K1.1471.00
257_L261_S1.1471.00
55_Y59_G1.1441.00
300_V311_I1.1441.00
208_S344_F1.1441.00
151_A154_S1.1411.00
147_I163_I1.1401.00
29_A304_F1.1371.00
185_L188_P1.1301.00
176_Y180_S1.1261.00
418_F422_P1.1251.00
111_L115_L1.1171.00
415_Y418_F1.1091.00
333_F390_A1.1081.00
37_F41_A1.1021.00
388_V391_L1.0941.00
215_S355_V1.0931.00
354_L358_T1.0881.00
343_P389_Y1.0871.00
67_S126_G1.0861.00
81_G84_L1.0801.00
155_H159_L1.0791.00
355_V375_Q1.0791.00
13_V134_A1.0761.00
353_G357_L1.0751.00
39_K229_S1.0741.00
320_A323_L1.0731.00
259_T262_F1.0721.00
366_I370_G1.0711.00
355_V378_V1.0681.00
101_P105_K1.0641.00
289_V293_I1.0621.00
326_P383_S1.0621.00
173_S177_A1.0601.00
62_I83_F1.0591.00
346_I349_L1.0591.00
40_V160_F1.0581.00
296_A314_L1.0541.00
136_T174_M1.0501.00
79_V82_K1.0431.00
308_I311_I1.0421.00
290_I410_P1.0371.00
349_L353_G1.0341.00
14_T18_V1.0321.00
199_F202_G1.0271.00
69_L72_R1.0271.00
10_S255_V1.0221.00
359_S375_Q1.0201.00
330_L386_V1.0191.00
177_A181_R1.0161.00
27_I31_I1.0131.00
300_V304_F1.0121.00
214_L352_G1.0121.00
315_I319_L1.0111.00
238_S317_L1.0091.00
61_I198_H1.0091.00
61_I65_E1.0081.00
63_T122_S0.9981.00
360_F364_P0.9931.00
64_R339_K0.9901.00
120_M176_Y0.9891.00
197_K339_K0.9871.00
163_I167_G0.9861.00
293_I319_L0.9821.00
317_L372_A0.9791.00
20_V145_W0.9791.00
11_L251_A0.9781.00
7_T255_V0.9761.00
334_I389_Y0.9751.00
359_S362_L0.9681.00
365_R369_I0.9661.00
66_I127_M0.9651.00
25_F304_F0.9641.00
99_L103_Y0.9621.00
44_Q48_V0.9621.00
96_I100_F0.9601.00
130_F255_V0.9591.00
373_I377_I0.9591.00
6_N128_D0.9581.00
236_Q240_L0.9561.00
80_I123_I0.9511.00
376_A379_S0.9511.00
85_S89_L0.9491.00
413_A417_V0.9481.00
162_E165_T0.9481.00
299_V303_F0.9461.00
242_A321_T0.9461.00
219_D355_V0.9451.00
199_F203_L0.9441.00
293_I296_A0.9431.00
167_G171_S0.9421.00
174_M178_F0.9421.00
162_E166_L0.9421.00
301_E308_I0.9411.00
239_A243_G0.9391.00
420_D423_Y0.9361.00
381_I385_F0.9351.00
34_P233_G0.9341.00
335_I344_F0.9291.00
7_T252_L0.9291.00
68_Y72_R0.9241.00
287_L290_I0.9241.00
10_S134_A0.9221.00
433_I437_K0.9211.00
132_E178_F0.9191.00
45_L220_R0.9191.00
35_E229_S0.9161.00
87_P91_L0.9141.00
61_I202_G0.9121.00
226_L363_I0.9091.00
389_Y392_K0.9061.00
343_P346_I0.9061.00
293_I318_L0.9061.00
283_L439_F0.9051.00
200_K203_L0.9051.00
148_S163_I0.9031.00
109_P165_T0.9011.00
369_I373_I0.8991.00
70_Y76_S0.8981.00
281_L325_F0.8971.00
259_T263_Y0.8961.00
26_I304_F0.8911.00
83_F87_P0.8891.00
373_I376_A0.8871.00
223_T368_I0.8861.00
140_F144_R0.8851.00
7_T11_L0.8841.00
293_I297_V0.8791.00
432_V437_K0.8791.00
165_T168_G0.8761.00
20_V24_F0.8721.00
263_Y266_L0.8571.00
34_P307_Y0.8561.00
419_V422_P0.8551.00
319_L323_L0.8531.00
238_S314_L0.8531.00
220_R232_L0.8511.00
101_P104_V0.8491.00
144_R148_S0.8481.00
175_N179_L0.8461.00
344_F348_S0.8461.00
310_G313_V0.8461.00
68_Y265_A0.8461.00
290_I294_P0.8441.00
345_L349_L0.8431.00
91_L95_L0.8421.00
100_F104_V0.8391.00
8_L12_S0.8381.00
142_I146_G0.8371.00
358_T377_I0.8371.00
237_F240_L0.8361.00
83_F198_H0.8361.00
82_K86_F0.8351.00
9_K13_V0.8351.00
233_G237_F0.8351.00
70_Y127_M0.8331.00
62_I66_I0.8311.00
40_V157_I0.8291.00
48_V52_A0.8281.00
276_I279_R0.8281.00
287_L410_P0.8271.00
193_A196_F0.8271.00
213_F217_Q0.8261.00
64_R341_L0.8261.00
125_V133_T0.8251.00
417_V421_P0.8251.00
287_L413_A0.8241.00
358_T361_L0.8231.00
71_A266_L0.8211.00
410_P413_A0.8211.00
28_T160_F0.8211.00
98_L102_N0.8191.00
419_V423_Y0.8131.00
283_L287_L0.8091.00
235_Y317_L0.8061.00
255_V258_P0.8061.00
320_A375_Q0.8011.00
389_Y393_E0.7991.00
6_N255_V0.7991.00
75_I194_F0.7981.00
240_L244_V0.7971.00
5_K131_T0.7961.00
26_I29_A0.7931.00
221_V225_Y0.7901.00
224_A232_L0.7901.00
334_I344_F0.7881.00
432_V438_T0.7851.00
76_S79_V0.7851.00
80_I83_F0.7821.00
69_L75_I0.7791.00
273_M276_I0.7781.00
82_K87_P0.7781.00
165_T169_I0.7781.00
402_E406_L0.7771.00
208_S348_S0.7751.00
168_G172_V0.7741.00
171_S175_N0.7741.00
332_N335_I0.7741.00
211_A348_S0.7741.00
175_N178_F0.7721.00
347_L351_N0.7711.00
116_L120_M0.7691.00
279_R283_L0.7691.00
364_P371_G0.7671.00
96_I99_L0.7671.00
136_T171_S0.7671.00
194_F197_K0.7661.00
320_A379_S0.7651.00
237_F307_Y0.7621.00
25_F29_A0.7621.00
215_S352_G0.7611.00
82_K195_L0.7601.00
249_L253_G0.7581.00
34_P230_Y0.7581.00
88_F92_P0.7551.00
48_V51_S0.7531.00
66_I76_S0.7531.00
84_L88_F0.7531.00
28_T148_S0.7471.00
319_L322_T0.7461.00
145_W149_I0.7451.00
220_R236_Q0.7451.00
27_I149_I0.7451.00
200_K204_P0.7431.00
336_A339_K0.7401.00
217_Q221_V0.7401.00
350_L385_F0.7391.00
100_F105_K0.7391.00
159_L162_E0.7391.00
250_G254_G0.7351.00
241_V304_F0.7321.00
404_A408_M0.7311.00
296_A318_L0.7311.00
204_P341_L0.7311.00
267_G270_E0.7301.00
63_T126_G0.7281.00
414_F420_D0.7271.00
11_L15_T0.7261.00
147_I150_I0.7261.00
435_L438_T0.7241.00
391_L394_D0.7241.00
35_E39_K0.7241.00
37_F237_F0.7231.00
288_A291_I0.7231.00
178_F182_K0.7231.00
121_G125_V0.7221.00
226_L360_F0.7221.00
257_L332_N0.7211.00
273_M277_S0.7191.00
88_F91_L0.7171.00
219_D239_A0.7171.00
132_E135_I0.7161.00
38_G233_G0.7151.00
68_Y197_K0.7151.00
144_R163_I0.7141.00
289_V318_L0.7121.00
4_I8_L0.7101.00
408_M411_L0.7091.00
210_S214_L0.7081.00
201_E205_L0.7081.00
16_T142_I0.7061.00
356_L360_F0.7061.00
97_L100_F0.7051.00
32_T36_F0.7051.00
3_P7_T0.7041.00
385_F389_Y0.7031.00
99_L102_N0.6991.00
217_Q243_G0.6991.00
69_L74_E0.6971.00
33_N307_Y0.6951.00
359_S371_G0.6951.00
200_K342_R0.6951.00
87_P90_V0.6951.00
332_N336_A0.6941.00
227_L363_I0.6911.00
113_L169_I0.6911.00
160_F164_W0.6911.00
172_V176_Y0.6891.00
42_I45_L0.6851.00
97_L105_K0.6841.00
380_T384_S0.6821.00
205_L341_L0.6811.00
195_L199_F0.6771.00
376_A380_T0.6741.00
63_T67_S0.6691.00
12_S16_T0.6671.00
57_I202_G0.6631.00
140_F171_S0.6631.00
407_F410_P0.6621.00
242_A245_P0.6611.00
47_E51_S0.6611.00
37_F233_G0.6601.00
327_I383_S0.6591.00
124_M179_L0.6591.00
26_I303_F0.6581.00
277_S329_S0.6551.00
324_P328_G0.6551.00
8_L15_T0.6541.00
330_L390_A0.6541.00
187_L190_F0.6521.00
334_I390_A0.6511.00
416_E420_D0.6491.00
89_L92_P0.6481.00
330_L383_S0.6481.00
240_L243_G0.6481.00
281_L329_S0.6451.00
269_D337_A0.6451.00
16_T20_V0.6441.00
76_S80_I0.6411.00
436_F439_F0.6381.00
119_V122_S0.6371.00
211_A215_S0.6351.00
117_N172_V0.6351.00
17_N21_A0.6341.00
385_F388_V0.6341.00
235_Y239_A0.6341.00
387_L391_L0.6341.00
259_T273_M0.6331.00
324_P379_S0.6291.00
345_L348_S0.6291.00
227_L367_G0.6281.00
314_L318_L0.6271.00
307_Y310_G0.6261.00
149_I152_V0.6251.00
290_I293_I0.6251.00
32_T157_I0.6221.00
233_G236_Q0.6221.00
110_Y114_Y0.6221.00
218_G222_T0.6211.00
434_L437_K0.6201.00
301_E311_I0.6201.00
136_T178_F0.6201.00
116_L172_V0.6201.00
4_I7_T0.6191.00
85_S88_F0.6171.00
279_R402_E0.6161.00
113_L172_V0.6151.00
205_L335_I0.6141.00
257_L336_A0.6141.00
266_L269_D0.6091.00
141_L144_R0.6081.00
341_L344_F0.6071.00
333_F337_A0.6061.00
331_T344_F0.6051.00
400_K404_A0.6031.00
264_K267_G0.5991.00
284_I288_A0.5991.00
21_A25_F0.5981.00
349_L352_G0.5981.00
406_L410_P0.5981.00
231_Y234_L0.5971.00
40_V161_I0.5941.00
46_L50_T0.5911.00
82_K85_S0.5891.00
28_T32_T0.5881.00
297_V308_I0.5881.00
298_L302_K0.5871.00
208_S212_T0.5861.00
240_L304_F0.5851.00
115_L119_V0.5831.00
252_L256_L0.5821.00
331_T335_I0.5821.00
28_T37_F0.5821.00
343_P347_L0.5811.00
197_K201_E0.5791.00
362_L370_G0.5791.00
354_L357_L0.5761.00
350_L353_G0.5751.00
10_S130_F0.5751.00
337_A393_E0.5751.00
212_T216_S0.5741.00
147_I166_L0.5731.00
86_F195_L0.5731.00
158_Y162_E0.5731.00
260_A274_S0.5731.00
130_F133_T0.5721.00
95_L98_L0.5701.00
80_I84_L0.5701.00
135_I139_I0.5681.00
36_F157_I0.5671.00
46_L221_V0.5661.00
375_Q379_S0.5651.00
18_V247_M0.5641.00
16_T19_I0.5631.00
432_V439_F0.5621.00
42_I220_R0.5621.00
109_P113_L0.5611.00
209_S213_F0.5601.00
276_I280_V0.5561.00
13_V138_N0.5561.00
70_Y73_K0.5551.00
177_A180_S0.5541.00
372_A376_A0.5511.00
42_I225_Y0.5511.00
261_S265_A0.5511.00
354_L378_V0.5501.00
81_G188_P0.5491.00
97_L103_Y0.5481.00
35_E230_Y0.5481.00
121_G137_G0.5471.00
96_I103_Y0.5461.00
282_S322_T0.5441.00
20_V23_I0.5431.00
379_S383_S0.5431.00
318_L321_T0.5411.00
42_I221_V0.5411.00
122_S126_G0.5411.00
49_V213_F0.5401.00
18_V21_A0.5401.00
31_I151_A0.5401.00
10_S14_T0.5381.00
434_L438_T0.5381.00
294_P297_V0.5381.00
125_V130_F0.5371.00
379_S382_S0.5361.00
286_F322_T0.5361.00
316_L319_L0.5361.00
193_A197_K0.5361.00
168_G171_S0.5351.00
288_A292_S0.5341.00
25_F37_F0.5331.00
226_L364_P0.5321.00
351_N378_V0.5301.00
114_Y168_G0.5301.00
99_L104_V0.5271.00
408_M412_I0.5271.00
312_K316_L0.5271.00
347_L350_L0.5261.00
64_R336_A0.5251.00
78_S194_F0.5251.00
75_I79_V0.5251.00
91_L94_F0.5241.00
383_S387_L0.5241.00
248_V251_A0.5231.00
405_I409_M0.5221.00
220_R239_A0.5221.00
141_L145_W0.5221.00
285_T322_T0.5221.00
323_L376_A0.5221.00
157_I161_I0.5221.00
44_Q164_W0.5211.00
287_L291_I0.5211.00
172_V175_N0.5201.00
208_S345_L0.5201.00
322_T325_F0.5191.00
290_I414_F0.5191.00
409_M412_I0.5191.00
208_S211_A0.5181.00
110_Y168_G0.5161.00
214_L218_G0.5161.00
406_L409_M0.5151.00
29_A307_Y0.5151.00
98_L103_Y0.5141.00
231_Y309_S0.5131.00
301_E306_A0.5131.00
237_F310_G0.5121.00
281_L285_T0.5121.00
280_V284_I0.5111.00
109_P114_Y0.5101.00
97_L101_P0.5101.00
375_Q378_V0.5061.00
171_S174_M0.5051.00
251_A254_G0.5040.99
397_V401_R0.5040.99
390_A393_E0.5020.99
67_S261_S0.5020.99
45_L49_V0.5010.99
413_A416_E0.5000.99
89_L93_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4humA 1 0.8614 100 0.431 Contact Map
4lz6A 1 0.8486 100 0.431 Contact Map
3w4tA 1 0.8401 100 0.432 Contact Map
3mktA 1 0.855 100 0.438 Contact Map
1pw4A 1 0.7655 25.3 0.95 Contact Map
3wdoA 1 0.8102 15.9 0.955 Contact Map
4n7wA 2 0.3987 14.6 0.955 Contact Map
3zuxA 1 0.3838 11.1 0.958 Contact Map
2cfqA 1 0.4222 8.8 0.96 Contact Map
2gfpA 2 0.7441 8.5 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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