GREMLIN Database
Q97XT0 - Partial transposase ISC1225
UniProt: Q97XT0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 324 (293)
Sequences: 185 (129)
Seq/√Len: 7.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_T245_Y5.6671.00
142_I166_I4.3880.98
147_L244_S4.1230.97
77_I128_V3.9730.97
80_T91_G3.4030.92
92_S98_S3.3450.91
41_R262_F3.1610.89
112_L245_Y2.9430.85
265_L269_L2.8750.83
221_T257_S2.8620.83
91_G257_S2.7070.79
80_T249_K2.6920.79
42_N186_T2.6750.78
221_T239_G2.5900.76
221_T274_Y2.3370.68
243_T246_R2.2820.66
293_L297_F2.2720.65
224_D236_K2.2410.64
142_I245_Y2.1820.62
148_D238_R2.0200.56
78_D242_E2.0130.56
135_V145_I1.9870.55
284_V298_P1.9070.51
209_V212_K1.8830.50
102_A131_L1.8570.49
20_C29_K1.8450.49
263_R277_Y1.8210.48
84_W275_S1.8170.48
152_Y243_T1.8160.48
96_G142_I1.8140.48
128_V131_L1.7940.47
140_F185_T1.7780.46
281_K285_G1.7740.46
89_V128_V1.7660.46
81_T100_N1.7130.44
104_T135_V1.7010.43
135_V165_Y1.6920.43
152_Y169_V1.6680.42
264_T304_E1.6580.42
251_F274_Y1.6410.41
79_W142_I1.6360.41
245_Y255_T1.6130.40
52_I209_V1.6130.40
19_A29_K1.5970.39
149_A168_A1.5760.38
140_F145_I1.5690.38
299_D306_F1.5400.37
290_R293_L1.5370.37
142_I248_I1.5290.37
110_V246_R1.5160.36
222_N267_F1.5130.36
234_Y241_I1.5110.36
288_E291_L1.4920.35
238_R242_E1.4760.35
78_D238_R1.4760.35
160_I163_F1.4600.34
96_G290_R1.4590.34
103_T268_V1.4460.34
296_L300_L1.4460.34
305_N308_F1.4350.33
267_F274_Y1.4350.33
234_Y242_E1.4280.33
78_D234_Y1.4280.33
131_L245_Y1.4270.33
131_L222_N1.4240.33
273_L284_V1.4220.33
249_K274_Y1.4150.33
104_T114_A1.4010.32
248_I267_F1.4010.32
23_N30_S1.3920.32
295_L303_P1.3860.32
90_K130_V1.3790.31
292_L303_P1.3760.31
148_D242_E1.3750.31
78_D148_D1.3750.31
101_Y192_R1.3620.31
102_A165_Y1.3520.30
57_E89_V1.3470.30
288_E293_L1.3470.30
12_V20_C1.3400.30
136_M172_G1.3380.30
293_L308_F1.3330.30
297_F302_N1.3210.29
89_V114_A1.3160.29
50_E118_Q1.3130.29
128_V222_N1.3050.29
146_T168_A1.2990.29
122_M166_I1.2940.29
112_L271_L1.2830.28
77_I222_N1.2760.28
129_K257_S1.2720.28
144_L250_A1.2620.27
21_L25_S1.2440.27
245_Y256_G1.2370.27
292_L297_F1.2370.27
26_V132_V1.2340.27
17_I165_Y1.2290.26
303_P306_F1.2260.26
91_G221_T1.2250.26
43_Y259_K1.2250.26
301_F305_N1.2240.26
131_L248_I1.2200.26
221_T269_L1.2160.26
97_N160_I1.2140.26
262_F266_I1.2030.26
286_R297_F1.1980.25
166_I235_N1.1970.25
87_K224_D1.1970.25
249_K267_F1.1910.25
304_E307_T1.1860.25
15_T21_L1.1850.25
278_T281_K1.1660.25
50_E289_F1.1640.24
243_T279_I1.1600.24
20_C250_A1.1580.24
280_F291_L1.1510.24
86_G152_Y1.1460.24
273_L277_Y1.1440.24
243_T247_N1.1430.24
75_L135_V1.1240.23
300_L306_F1.1190.23
108_G158_N1.1160.23
257_S267_F1.1160.23
295_L308_F1.1130.23
98_S239_G1.1080.23
194_D259_K1.1070.23
128_V135_V1.1060.23
58_R156_V1.1030.23
39_T249_K1.0990.23
76_S91_G1.0980.23
145_I170_L1.0910.22
109_K143_R1.0840.22
120_N185_T1.0680.22
302_N305_N1.0620.22
301_F308_F1.0580.21
293_L299_D1.0570.21
60_R251_F1.0540.21
20_C40_V1.0530.21
160_I196_Q1.0530.21
125_D159_F1.0510.21
171_V175_K1.0490.21
293_L296_L1.0460.21
216_Y292_L1.0390.21
86_G258_T1.0380.21
99_W245_Y1.0370.21
150_G276_L1.0240.21
206_K212_K1.0160.20
53_E57_E1.0130.20
150_G170_L1.0060.20
114_A215_V1.0030.20
87_K171_V1.0010.20
118_Q146_T0.9970.20
44_V97_N0.9930.20
15_T29_K0.9870.20
104_T124_K0.9820.20
16_L25_S0.9800.19
38_Q167_I0.9760.19
293_L303_P0.9700.19
249_K257_S0.9660.19
110_V143_R0.9650.19
69_G99_W0.9650.19
131_L165_Y0.9640.19
80_T110_V0.9630.19
276_L303_P0.9550.19
221_T249_K0.9540.19
78_D151_F0.9530.19
151_F242_E0.9530.19
167_I305_N0.9530.19
77_I168_A0.9510.19
222_N257_S0.9500.19
288_E295_L0.9470.19
44_V114_A0.9470.19
78_D241_I0.9450.19
84_W258_T0.9430.19
19_A150_G0.9420.19
128_V165_Y0.9410.19
76_S156_V0.9350.18
222_N248_I0.9340.18
79_W118_Q0.9330.18
147_L152_Y0.9220.18
270_A298_P0.9180.18
40_V152_Y0.9140.18
253_P266_I0.9130.18
101_Y197_V0.9120.18
106_Y277_Y0.9100.18
12_V29_K0.9060.18
157_L165_Y0.9050.18
156_V243_T0.9040.18
47_Q270_A0.9040.18
131_L274_Y0.9010.18
129_K196_Q0.8990.18
123_T153_T0.8920.17
77_I156_V0.8920.17
297_F303_P0.8910.17
15_T19_A0.8910.17
235_N275_S0.8900.17
35_V86_G0.8840.17
101_Y234_Y0.8780.17
104_T275_S0.8770.17
235_N240_P0.8730.17
261_V279_I0.8710.17
304_E308_F0.8680.17
296_L305_N0.8680.17
183_D193_R0.8670.17
99_W251_F0.8660.17
157_L220_A0.8650.17
274_Y281_K0.8590.17
58_R245_Y0.8580.17
219_R267_F0.8570.17
257_S274_Y0.8530.16
132_V151_F0.8490.16
80_T248_I0.8480.16
59_A265_L0.8450.16
92_S269_L0.8370.16
20_C170_L0.8280.16
89_V276_L0.8230.16
131_L180_F0.8230.16
236_K261_V0.8190.16
50_E86_G0.8160.16
142_I162_Q0.8150.16
151_F255_T0.8140.16
12_V26_V0.8140.16
71_K141_K0.8130.16
36_S302_N0.8120.16
169_V233_L0.8110.16
102_A127_I0.8110.16
52_I101_Y0.8040.15
46_K275_S0.8040.15
147_L220_A0.8000.15
239_G257_S0.7990.15
91_G117_P0.7970.15
257_S263_R0.7960.15
14_K28_N0.7950.15
299_D308_F0.7940.15
289_F292_L0.7920.15
80_T257_S0.7750.15
105_K245_Y0.7730.15
156_V241_I0.7700.15
80_T165_Y0.7680.15
55_L265_L0.7660.15
234_Y238_R0.7630.15
96_G241_I0.7600.15
291_L296_L0.7590.15
152_Y170_L0.7550.14
42_N259_K0.7540.14
258_T265_L0.7520.14
176_V224_D0.7520.14
298_P304_E0.7470.14
230_V276_L0.7460.14
254_F275_S0.7460.14
12_V132_V0.7400.14
99_W136_M0.7400.14
242_E263_R0.7390.14
78_D263_R0.7390.14
252_L264_T0.7330.14
77_I255_T0.7290.14
17_I31_R0.7280.14
222_N239_G0.7270.14
37_P40_V0.7270.14
192_R196_Q0.7250.14
289_F293_L0.7220.14
25_S31_R0.7210.14
48_G52_I0.7180.14
204_Y268_V0.7170.14
119_V276_L0.7170.14
119_V132_V0.7170.14
36_S169_V0.7150.14
163_F204_Y0.7150.14
151_F246_R0.7130.14
112_L244_S0.7120.14
131_L135_V0.7110.14
288_E305_N0.7110.14
295_L299_D0.7110.14
271_L274_Y0.7100.14
107_K161_S0.7100.14
50_E291_L0.7090.14
167_I174_V0.7070.14
168_A172_G0.7030.13
124_K177_Y0.7020.13
88_P260_F0.6990.13
24_D198_K0.6950.13
58_R189_K0.6940.13
49_M118_Q0.6900.13
243_T276_L0.6900.13
136_M166_I0.6850.13
27_E41_R0.6840.13
83_T98_S0.6830.13
206_K209_V0.6810.13
56_L61_K0.6810.13
38_Q204_Y0.6800.13
16_L243_T0.6800.13
294_I302_N0.6780.13
99_W111_L0.6780.13
59_A64_L0.6740.13
19_A179_E0.6740.13
61_K138_M0.6720.13
143_R239_G0.6700.13
175_K178_E0.6700.13
37_P251_F0.6690.13
29_K132_V0.6670.13
265_L273_L0.6660.13
256_G268_V0.6640.13
99_W200_R0.6630.13
219_R239_G0.6630.13
19_A157_L0.6600.13
123_T142_I0.6600.13
191_H194_D0.6590.13
59_A270_A0.6550.13
168_A258_T0.6550.13
114_A132_V0.6550.13
81_T103_T0.6530.13
35_V103_T0.6510.13
155_D191_H0.6490.12
302_N306_F0.6490.12
113_L131_L0.6480.12
41_R90_K0.6480.12
148_D234_Y0.6460.12
12_V19_A0.6460.12
135_V278_T0.6440.12
272_V300_L0.6420.12
74_D146_T0.6400.12
97_N278_T0.6400.12
100_N248_I0.6370.12
186_T202_L0.6350.12
167_I232_D0.6350.12
240_P270_A0.6340.12
81_T150_G0.6320.12
151_F234_Y0.6310.12
118_Q128_V0.6310.12
167_I223_L0.6300.12
224_D228_R0.6280.12
222_N251_F0.6270.12
28_N132_V0.6270.12
149_A264_T0.6270.12
136_M170_L0.6270.12
43_Y246_R0.6260.12
251_F300_L0.6240.12
293_L306_F0.6240.12
21_L40_V0.6240.12
144_L166_I0.6220.12
103_T267_F0.6210.12
147_L179_E0.6210.12
214_L301_F0.6200.12
13_A91_G0.6140.12
159_F225_L0.6140.12
265_L298_P0.6120.12
288_E298_P0.6120.12
64_L307_T0.6110.12
270_A291_L0.6110.12
203_V246_R0.6100.12
165_Y281_K0.6090.12
81_T98_S0.6080.12
300_L308_F0.6070.12
99_W103_T0.6060.12
158_N230_V0.6050.12
280_F283_E0.6050.12
28_N82_K0.6040.12
142_I224_D0.6040.12
128_V276_L0.6020.12
157_L167_I0.6020.12
25_S28_N0.6020.12
39_T50_E0.6010.12
219_R222_N0.6010.12
181_D189_K0.6000.12
173_D236_K0.5980.12
86_G111_L0.5970.12
87_K200_R0.5950.12
73_I127_I0.5950.12
157_L166_I0.5940.12
302_N308_F0.5940.12
279_I303_P0.5910.12
189_K201_F0.5890.11
68_K228_R0.5880.11
53_E265_L0.5840.11
132_V198_K0.5820.11
48_G207_E0.5820.11
108_G115_F0.5820.11
67_L90_K0.5780.11
236_K293_L0.5780.11
104_T132_V0.5750.11
111_L173_D0.5740.11
294_I308_F0.5730.11
12_V41_R0.5710.11
296_L308_F0.5710.11
275_S294_I0.5690.11
41_R100_N0.5680.11
225_L269_L0.5670.11
298_P301_F0.5610.11
158_N235_N0.5610.11
221_T251_F0.5600.11
276_L299_D0.5590.11
230_V306_F0.5590.11
203_V244_S0.5560.11
142_I174_V0.5510.11
66_I185_T0.5510.11
103_T142_I0.5480.11
21_L24_D0.5470.11
20_C273_L0.5470.11
112_L152_Y0.5450.11
139_G265_L0.5450.11
94_E245_Y0.5440.11
85_Y95_K0.5430.11
219_R281_K0.5420.11
97_N125_D0.5400.11
165_Y222_N0.5400.11
22_W34_D0.5400.11
29_K158_N0.5380.11
82_K160_I0.5350.11
68_K225_L0.5350.11
61_K89_V0.5350.11
39_T221_T0.5350.11
44_V149_A0.5350.11
104_T126_E0.5350.11
92_S208_E0.5320.11
42_N261_V0.5320.11
175_K246_R0.5290.11
142_I261_V0.5280.11
38_Q124_K0.5240.10
287_E299_D0.5230.10
147_L239_G0.5230.10
124_K253_P0.5220.10
91_G206_K0.5210.10
146_T253_P0.5210.10
86_G276_L0.5200.10
83_T245_Y0.5180.10
239_G251_F0.5170.10
153_T258_T0.5150.10
151_F241_I0.5130.10
165_Y259_K0.5130.10
140_F163_F0.5120.10
99_W220_A0.5080.10
97_N243_T0.5070.10
103_T241_I0.5070.10
185_T189_K0.5060.10
174_V217_F0.5040.10
33_Y66_I0.5020.10
169_V248_I0.5010.10
103_T112_L0.5010.10
156_V245_Y0.5000.10
106_Y175_K0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9321 99.4 0.849 Contact Map
1f6yA 2 0.6636 29.7 0.966 Contact Map
2jn6A 1 0.2593 16.5 0.97 Contact Map
2m8eA 1 0.1698 16.2 0.97 Contact Map
4xb4A 1 0.3796 9.7 0.973 Contact Map
2vxzA 1 0.4475 9.1 0.973 Contact Map
2ao9A 7 0.3086 9 0.973 Contact Map
2elhA 1 0.2191 8.8 0.973 Contact Map
2yciX 2 0.6667 8.6 0.973 Contact Map
2mj2A 1 0.1111 6.6 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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