GREMLIN Database
Q97XS8 - Coenzyme PQQ synthesis protein E (PqqE-2)
UniProt: Q97XS8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 350 (286)
Sequences: 11030 (8480)
Seq/√Len: 501.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
119_S132_K4.3321.00
20_L92_S3.9211.00
44_R77_Y3.4431.00
139_E172_M3.3411.00
39_N42_E2.5291.00
48_E77_Y2.5231.00
123_D129_G2.4941.00
100_M144_Y2.4711.00
19_P90_S2.4531.00
42_E292_K2.2951.00
140_L143_K2.2881.00
72_F98_E2.2741.00
48_E81_L2.2221.00
45_K49_D2.2001.00
72_F101_K2.1591.00
121_T161_E2.1571.00
277_D287_Y2.0741.00
10_V50_I2.0701.00
100_M104_S2.0571.00
277_D290_N2.0511.00
79_K108_R2.0321.00
263_T281_S1.9981.00
40_T73_E1.9631.00
152_T165_V1.9611.00
131_Y168_L1.9161.00
95_L98_E1.8691.00
161_E164_F1.8211.00
295_S298_D1.8161.00
47_L78_A1.8101.00
96_D140_L1.8081.00
77_Y80_S1.8031.00
115_D126_R1.7971.00
17_A37_E1.7881.00
168_L172_M1.7751.00
40_T70_D1.7731.00
117_A161_E1.7711.00
131_Y135_L1.7561.00
117_A121_T1.7451.00
91_P112_I1.6991.00
43_S74_L1.6931.00
139_E142_L1.6901.00
150_V169_L1.6841.00
140_L144_Y1.6761.00
167_K209_A1.6541.00
136_R139_E1.6521.00
273_G277_D1.6511.00
73_E76_E1.6511.00
51_A81_L1.6461.00
139_E143_K1.6411.00
273_G279_Y1.6241.00
133_Y136_R1.6171.00
163_P205_F1.6141.00
98_E101_K1.6021.00
70_D73_E1.6021.00
240_E243_S1.5881.00
132_K136_R1.5811.00
24_H115_D1.5791.00
167_K171_E1.5741.00
290_N293_K1.5721.00
77_Y81_L1.5711.00
294_E298_D1.5711.00
42_E45_K1.5531.00
40_T44_R1.5361.00
112_I138_I1.5301.00
76_E80_S1.5241.00
66_L87_I1.5161.00
164_F167_K1.5061.00
240_E244_T1.5051.00
195_P198_K1.5041.00
60_F78_A1.4951.00
119_S123_D1.4851.00
44_R48_E1.4721.00
58_I78_A1.4501.00
201_D205_F1.4221.00
112_I137_G1.4081.00
116_G121_T1.4051.00
101_K104_S1.4031.00
119_S129_G1.3891.00
44_R73_E1.3721.00
142_L173_G1.3711.00
23_K124_W1.3701.00
135_L139_E1.3491.00
79_K85_V1.3471.00
124_W157_K1.3471.00
14_V60_F1.3371.00
222_P225_R1.3311.00
240_E245_L1.3231.00
69_S72_F1.3221.00
110_M141_G1.3121.00
194_I198_K1.3041.00
156_K198_K1.3041.00
206_L210_T1.3031.00
119_S131_Y1.2861.00
242_V245_L1.2821.00
136_R140_L1.2751.00
243_S246_R1.2631.00
51_A83_L1.2551.00
121_T160_S1.2481.00
134_A137_G1.2441.00
200_K204_D1.2231.00
8_H56_V1.2181.00
78_A85_V1.2151.00
199_Y202_V1.2081.00
60_F85_V1.1941.00
68_R74_L1.1881.00
99_T103_I1.1841.00
88_A111_S1.1821.00
37_E68_R1.1641.00
122_H130_S1.1611.00
96_D136_R1.1601.00
76_E101_K1.1481.00
79_K106_Y1.1441.00
142_L172_M1.1391.00
201_D204_D1.1371.00
38_L42_E1.1211.00
205_F208_E1.1201.00
122_H134_A1.1191.00
49_D295_S1.1151.00
12_W43_S1.1121.00
135_L168_L1.1091.00
72_F105_N1.1051.00
121_T124_W1.0971.00
297_V301_R1.0951.00
123_D130_S1.0931.00
287_Y290_N1.0931.00
298_D302_K1.0921.00
73_E77_Y1.0911.00
75_M107_A1.0751.00
46_L272_I1.0651.00
97_D100_M1.0621.00
167_K170_K1.0621.00
84_V109_Y1.0611.00
197_D200_K1.0611.00
12_W272_I1.0521.00
101_K105_N1.0461.00
57_V84_V1.0451.00
142_L174_V1.0381.00
117_A168_L1.0371.00
96_D143_K1.0361.00
120_Q124_W1.0351.00
103_I144_Y1.0221.00
194_I197_D1.0201.00
95_L100_M1.0191.00
204_D208_E1.0171.00
205_F209_A1.0171.00
278_V299_I1.0121.00
100_M140_L0.9961.00
14_V71_I0.9961.00
142_L148_V0.9931.00
60_F75_M0.9931.00
40_T77_Y0.9861.00
135_L172_M0.9851.00
163_P167_K0.9851.00
50_I58_I0.9831.00
66_L71_I0.9831.00
47_L81_L0.9791.00
150_V174_V0.9751.00
169_L174_V0.9731.00
103_I146_I0.9721.00
70_D74_L0.9691.00
304_E308_K0.9641.00
15_T37_E0.9641.00
36_G275_N0.9631.00
137_G140_L0.9621.00
116_G131_Y0.9591.00
95_L103_I0.9571.00
66_L137_G0.9551.00
57_V86_S0.9541.00
49_D53_F0.9521.00
122_H126_R0.9511.00
71_I75_M0.9491.00
19_P64_D0.9481.00
279_Y287_Y0.9451.00
198_K201_D0.9441.00
16_K274_Y0.9401.00
125_L155_W0.9391.00
203_I207_V0.9361.00
130_S133_Y0.9351.00
19_P92_S0.9351.00
304_E307_K0.9341.00
110_M146_I0.9331.00
294_E302_K0.9311.00
152_T177_W0.9301.00
47_L58_I0.9301.00
305_V308_K0.9101.00
209_A212_Y0.9101.00
111_S151_N0.9081.00
316_G319_G0.9081.00
44_R80_S0.9041.00
117_A164_F0.9031.00
38_L43_S0.9011.00
138_I174_V0.9001.00
20_L130_S0.8931.00
163_P209_A0.8911.00
123_D126_R0.8871.00
112_I141_G0.8841.00
197_D201_D0.8801.00
45_K292_K0.8781.00
165_V169_L0.8731.00
45_K48_E0.8701.00
306_L310_K0.8681.00
99_T137_G0.8641.00
133_Y137_G0.8611.00
138_I148_V0.8601.00
241_L245_L0.8591.00
10_V272_I0.8561.00
24_H125_L0.8541.00
48_E52_R0.8501.00
87_I110_M0.8501.00
50_I55_K0.8501.00
147_Q175_K0.8501.00
141_G148_V0.8461.00
286_L289_G0.8451.00
141_G146_I0.8371.00
76_E106_Y0.8341.00
193_D196_R0.8321.00
99_T140_L0.8261.00
203_I206_L0.8261.00
74_L78_A0.8231.00
75_M105_N0.8201.00
14_V74_L0.8181.00
89_P112_I0.8161.00
96_D144_Y0.8151.00
150_V177_W0.8151.00
154_V162_L0.8081.00
97_D140_L0.8061.00
114_L150_V0.8061.00
138_I150_V0.8051.00
10_V270_I0.8051.00
23_K125_L0.8021.00
196_R199_Y0.8011.00
221_A224_F0.8001.00
113_S153_L0.7981.00
49_D52_R0.7931.00
58_I83_L0.7931.00
206_L209_A0.7921.00
241_L246_R0.7911.00
116_G161_E0.7911.00
300_Y310_K0.7881.00
72_F76_E0.7851.00
241_L244_T0.7821.00
44_R81_L0.7781.00
14_V68_R0.7761.00
116_G122_H0.7761.00
96_D99_T0.7751.00
207_V210_T0.7741.00
199_Y206_L0.7741.00
13_E61_T0.7731.00
207_V211_R0.7621.00
26_R61_T0.7601.00
71_I87_I0.7601.00
66_L94_R0.7591.00
40_T74_L0.7551.00
97_D101_K0.7521.00
38_L46_L0.7521.00
12_W47_L0.7501.00
132_K135_L0.7491.00
122_H129_G0.7481.00
289_G299_I0.7481.00
240_E246_R0.7471.00
13_E271_F0.7451.00
123_D131_Y0.7441.00
75_M85_V0.7441.00
94_R99_T0.7401.00
99_T144_Y0.7391.00
43_S68_R0.7371.00
180_F183_I0.7371.00
221_A225_R0.7331.00
43_S46_L0.7311.00
137_G141_G0.7291.00
204_D207_V0.7271.00
41_E44_R0.7261.00
289_G294_E0.7261.00
64_D67_S0.7241.00
95_L137_G0.7191.00
12_W46_L0.7191.00
122_H131_Y0.7181.00
308_K311_D0.7171.00
182_L188_G0.7141.00
87_I107_A0.7131.00
289_G292_K0.7131.00
40_T68_R0.7131.00
95_L99_T0.7121.00
13_E274_Y0.7081.00
100_M103_I0.7071.00
52_R297_V0.7061.00
59_V86_S0.7031.00
64_D90_S0.7031.00
166_V170_K0.7001.00
307_K310_K0.6991.00
168_L171_E0.6961.00
84_V108_R0.6921.00
169_L172_M0.6871.00
294_E299_I0.6871.00
163_P166_V0.6871.00
23_K127_G0.6851.00
316_G320_I0.6851.00
270_I300_Y0.6841.00
296_L300_Y0.6841.00
287_Y292_K0.6781.00
116_G126_R0.6781.00
104_S144_Y0.6761.00
270_I296_L0.6751.00
114_L135_L0.6751.00
96_D100_M0.6751.00
196_R200_K0.6731.00
114_L131_Y0.6711.00
163_P208_E0.6701.00
191_E194_I0.6661.00
307_K311_D0.6661.00
76_E105_N0.6631.00
142_L175_K0.6611.00
15_T68_R0.6611.00
103_I108_R0.6561.00
28_N127_G0.6561.00
289_G293_K0.6541.00
109_Y147_Q0.6541.00
200_K203_I0.6531.00
198_K207_V0.6531.00
114_L134_A0.6501.00
60_F74_L0.6501.00
280_P284_L0.6491.00
199_Y203_I0.6401.00
288_L306_L0.6381.00
152_T179_V0.6381.00
49_D297_V0.6381.00
68_R71_I0.6341.00
61_T282_G0.6341.00
59_V88_A0.6321.00
46_L50_I0.6311.00
287_Y293_K0.6301.00
58_I85_V0.6291.00
152_T169_L0.6271.00
123_D128_L0.6261.00
109_Y149_Q0.6251.00
20_L122_H0.6221.00
11_F269_V0.6191.00
42_E46_L0.6171.00
88_A282_G0.6161.00
19_P94_R0.6161.00
295_S299_I0.6111.00
116_G119_S0.6101.00
22_C25_C0.6080.99
306_L309_I0.6070.99
88_A151_N0.6050.99
208_E211_R0.6050.99
94_R97_D0.6030.99
24_H126_R0.6020.99
47_L60_F0.6020.99
61_T88_A0.6020.99
85_V108_R0.6000.99
286_L290_N0.5990.99
285_P288_L0.5990.99
206_L211_R0.5980.99
17_A35_P0.5970.99
18_C22_C0.5960.99
156_K159_Y0.5950.99
34_L37_E0.5950.99
151_N180_F0.5910.99
78_A83_L0.5890.99
182_L186_G0.5850.99
48_E51_A0.5840.99
19_P67_S0.5840.99
158_S161_E0.5830.99
317_K320_I0.5810.99
191_E196_R0.5800.99
14_V43_S0.5760.99
47_L83_L0.5730.99
92_S137_G0.5720.99
11_F282_G0.5720.99
86_S109_Y0.5670.99
43_S47_L0.5650.99
72_F75_M0.5650.99
162_L179_V0.5650.99
278_V296_L0.5610.99
148_V174_V0.5600.99
288_L292_K0.5570.99
271_F282_G0.5570.99
111_S149_Q0.5570.99
27_A61_T0.5560.99
18_C25_C0.5550.99
78_A81_L0.5540.99
94_R98_E0.5540.99
288_L293_K0.5520.99
66_L98_E0.5510.99
292_K295_S0.5510.99
127_G130_S0.5500.99
11_F61_T0.5490.99
202_V206_L0.5470.99
101_K144_Y0.5460.99
103_I145_G0.5430.99
112_I134_A0.5420.99
202_V210_T0.5410.99
160_S163_P0.5390.99
92_S133_Y0.5350.99
13_E27_A0.5310.99
199_Y210_T0.5310.99
68_R73_E0.5290.99
298_D301_R0.5280.99
155_W158_S0.5280.99
200_K207_V0.5250.99
129_G132_K0.5240.98
128_L131_Y0.5240.98
287_Y291_V0.5220.98
98_E102_I0.5220.98
166_V177_W0.5220.98
24_H27_A0.5210.98
9_L57_V0.5210.98
136_R143_K0.5200.98
29_A187_R0.5190.98
191_E195_P0.5180.98
180_F184_P0.5170.98
194_I200_K0.5160.98
75_M78_A0.5160.98
193_D197_D0.5150.98
87_I102_I0.5150.98
91_P137_G0.5140.98
95_L105_N0.5140.98
285_P289_G0.5130.98
64_D89_P0.5110.98
200_K209_A0.5100.98
302_K307_K0.5080.98
117_A131_Y0.5070.98
115_D153_L0.5050.98
288_L291_V0.5050.98
95_L101_K0.5030.98
126_R129_G0.5020.98
272_I278_V0.5020.98
159_Y198_K0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k36A 1 0.9114 100 0.304 Contact Map
1tv8A 2 0.8514 100 0.456 Contact Map
4m7tA 1 0.6629 100 0.467 Contact Map
4rtbA 2 0.8229 100 0.516 Contact Map
4wcxA 1 0.8914 100 0.543 Contact Map
3c8fA 1 0.6086 100 0.565 Contact Map
2yx0A 1 0.6771 100 0.599 Contact Map
2z2uA 1 0.5971 100 0.604 Contact Map
2qgqA 1 0.7257 99.9 0.606 Contact Map
3rfaA 1 0.6686 99.9 0.624 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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