Q97XS8 - SULSO - GREMLIN Contacts

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Q97XS8 - Coenzyme PQQ synthesis protein E (PqqE-2)

UniProt:	Q97XS8	Sequences: MPFENAPHLVFWEVTKACPLTCKHCRANAIDKPLPGELNTEESRKLLEDIARFGKVVIVFTGGDPLSRSDIFELMEYAKSLGLVVSIAPSPSHRLDDETMKIISNYARYMSISLDGATSQTHDWLRGLGSYKYALRGIELGLKYGIQVQVNTLVWKKSYSELPFVVKLLKEMGVKIWEVFFLIPVGRGTTELDIPRDKYKDVIDFLVEATRYDLIVRTVEAPFFRRAKLEYTPATTNDNELVSTLRELLGEPVKEADKSILPTRDGAGVIFIGYNGDVYPSGFLPLYLGNVKKESLVDIYRKSEVLKKIKDSRFEGKCGICKYNNICGGSRARAFAVYNNPFAEDPMCPY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	350 (286)
Sequences:	11030 (8480)
Seq/√Len:	501.5

ECOLI - ASLB YDEM MOAA
BACSU - ALBA SKFB MOAA YYDG
HALSA - Q9HQF5 MOAA Q9HQF7
SULSO - Q97XS8 Q97XA6 Q97XA7 Q97XS7 Q7LXV3 Q97XZ2 Q97Y04 Q97WK5 MOAA Q97WC3 Q980E0 Q980Q0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
119_S	132_K	4.332	1.00
20_L	92_S	3.921	1.00
44_R	77_Y	3.443	1.00
139_E	172_M	3.341	1.00
39_N	42_E	2.529	1.00
48_E	77_Y	2.523	1.00
123_D	129_G	2.494	1.00
100_M	144_Y	2.471	1.00
19_P	90_S	2.453	1.00
42_E	292_K	2.295	1.00
140_L	143_K	2.288	1.00
72_F	98_E	2.274	1.00
48_E	81_L	2.222	1.00
45_K	49_D	2.200	1.00
72_F	101_K	2.159	1.00
121_T	161_E	2.157	1.00
277_D	287_Y	2.074	1.00
10_V	50_I	2.070	1.00
100_M	104_S	2.057	1.00
277_D	290_N	2.051	1.00
79_K	108_R	2.032	1.00
263_T	281_S	1.998	1.00
40_T	73_E	1.963	1.00
152_T	165_V	1.961	1.00
131_Y	168_L	1.916	1.00
95_L	98_E	1.869	1.00
161_E	164_F	1.821	1.00
295_S	298_D	1.816	1.00
47_L	78_A	1.810	1.00
96_D	140_L	1.808	1.00
77_Y	80_S	1.803	1.00
115_D	126_R	1.797	1.00
17_A	37_E	1.788	1.00
168_L	172_M	1.775	1.00
40_T	70_D	1.773	1.00
117_A	161_E	1.771	1.00
131_Y	135_L	1.756	1.00
117_A	121_T	1.745	1.00
91_P	112_I	1.699	1.00
43_S	74_L	1.693	1.00
139_E	142_L	1.690	1.00
150_V	169_L	1.684	1.00
140_L	144_Y	1.676	1.00
167_K	209_A	1.654	1.00
136_R	139_E	1.652	1.00
273_G	277_D	1.651	1.00
73_E	76_E	1.651	1.00
51_A	81_L	1.646	1.00
139_E	143_K	1.641	1.00
273_G	279_Y	1.624	1.00
133_Y	136_R	1.617	1.00
163_P	205_F	1.614	1.00
98_E	101_K	1.602	1.00
70_D	73_E	1.602	1.00
240_E	243_S	1.588	1.00
132_K	136_R	1.581	1.00
24_H	115_D	1.579	1.00
167_K	171_E	1.574	1.00
290_N	293_K	1.572	1.00
77_Y	81_L	1.571	1.00
294_E	298_D	1.571	1.00
42_E	45_K	1.553	1.00
40_T	44_R	1.536	1.00
112_I	138_I	1.530	1.00
76_E	80_S	1.524	1.00
66_L	87_I	1.516	1.00
164_F	167_K	1.506	1.00
240_E	244_T	1.505	1.00
195_P	198_K	1.504	1.00
60_F	78_A	1.495	1.00
119_S	123_D	1.485	1.00
44_R	48_E	1.472	1.00
58_I	78_A	1.450	1.00
201_D	205_F	1.422	1.00
112_I	137_G	1.408	1.00
116_G	121_T	1.405	1.00
101_K	104_S	1.403	1.00
119_S	129_G	1.389	1.00
44_R	73_E	1.372	1.00
142_L	173_G	1.371	1.00
23_K	124_W	1.370	1.00
135_L	139_E	1.349	1.00
79_K	85_V	1.347	1.00
124_W	157_K	1.347	1.00
14_V	60_F	1.337	1.00
222_P	225_R	1.331	1.00
240_E	245_L	1.323	1.00
69_S	72_F	1.322	1.00
110_M	141_G	1.312	1.00
194_I	198_K	1.304	1.00
156_K	198_K	1.304	1.00
206_L	210_T	1.303	1.00
119_S	131_Y	1.286	1.00
242_V	245_L	1.282	1.00
136_R	140_L	1.275	1.00
243_S	246_R	1.263	1.00
51_A	83_L	1.255	1.00
121_T	160_S	1.248	1.00
134_A	137_G	1.244	1.00
200_K	204_D	1.223	1.00
8_H	56_V	1.218	1.00
78_A	85_V	1.215	1.00
199_Y	202_V	1.208	1.00
60_F	85_V	1.194	1.00
68_R	74_L	1.188	1.00
99_T	103_I	1.184	1.00
88_A	111_S	1.182	1.00
37_E	68_R	1.164	1.00
122_H	130_S	1.161	1.00
96_D	136_R	1.160	1.00
76_E	101_K	1.148	1.00
79_K	106_Y	1.144	1.00
142_L	172_M	1.139	1.00
201_D	204_D	1.137	1.00
38_L	42_E	1.121	1.00
205_F	208_E	1.120	1.00
122_H	134_A	1.119	1.00
49_D	295_S	1.115	1.00
12_W	43_S	1.112	1.00
135_L	168_L	1.109	1.00
72_F	105_N	1.105	1.00
121_T	124_W	1.097	1.00
297_V	301_R	1.095	1.00
123_D	130_S	1.093	1.00
287_Y	290_N	1.093	1.00
298_D	302_K	1.092	1.00
73_E	77_Y	1.091	1.00
75_M	107_A	1.075	1.00
46_L	272_I	1.065	1.00
97_D	100_M	1.062	1.00
167_K	170_K	1.062	1.00
84_V	109_Y	1.061	1.00
197_D	200_K	1.061	1.00
12_W	272_I	1.052	1.00
101_K	105_N	1.046	1.00
57_V	84_V	1.045	1.00
142_L	174_V	1.038	1.00
117_A	168_L	1.037	1.00
96_D	143_K	1.036	1.00
120_Q	124_W	1.035	1.00
103_I	144_Y	1.022	1.00
194_I	197_D	1.020	1.00
95_L	100_M	1.019	1.00
204_D	208_E	1.017	1.00
205_F	209_A	1.017	1.00
278_V	299_I	1.012	1.00
100_M	140_L	0.996	1.00
14_V	71_I	0.996	1.00
142_L	148_V	0.993	1.00
60_F	75_M	0.993	1.00
40_T	77_Y	0.986	1.00
135_L	172_M	0.985	1.00
163_P	167_K	0.985	1.00
50_I	58_I	0.983	1.00
66_L	71_I	0.983	1.00
47_L	81_L	0.979	1.00
150_V	174_V	0.975	1.00
169_L	174_V	0.973	1.00
103_I	146_I	0.972	1.00
70_D	74_L	0.969	1.00
304_E	308_K	0.964	1.00
15_T	37_E	0.964	1.00
36_G	275_N	0.963	1.00
137_G	140_L	0.962	1.00
116_G	131_Y	0.959	1.00
95_L	103_I	0.957	1.00
66_L	137_G	0.955	1.00
57_V	86_S	0.954	1.00
49_D	53_F	0.952	1.00
122_H	126_R	0.951	1.00
71_I	75_M	0.949	1.00
19_P	64_D	0.948	1.00
279_Y	287_Y	0.945	1.00
198_K	201_D	0.944	1.00
16_K	274_Y	0.940	1.00
125_L	155_W	0.939	1.00
203_I	207_V	0.936	1.00
130_S	133_Y	0.935	1.00
19_P	92_S	0.935	1.00
304_E	307_K	0.934	1.00
110_M	146_I	0.933	1.00
294_E	302_K	0.931	1.00
152_T	177_W	0.930	1.00
47_L	58_I	0.930	1.00
305_V	308_K	0.910	1.00
209_A	212_Y	0.910	1.00
111_S	151_N	0.908	1.00
316_G	319_G	0.908	1.00
44_R	80_S	0.904	1.00
117_A	164_F	0.903	1.00
38_L	43_S	0.901	1.00
138_I	174_V	0.900	1.00
20_L	130_S	0.893	1.00
163_P	209_A	0.891	1.00
123_D	126_R	0.887	1.00
112_I	141_G	0.884	1.00
197_D	201_D	0.880	1.00
45_K	292_K	0.878	1.00
165_V	169_L	0.873	1.00
45_K	48_E	0.870	1.00
306_L	310_K	0.868	1.00
99_T	137_G	0.864	1.00
133_Y	137_G	0.861	1.00
138_I	148_V	0.860	1.00
241_L	245_L	0.859	1.00
10_V	272_I	0.856	1.00
24_H	125_L	0.854	1.00
48_E	52_R	0.850	1.00
87_I	110_M	0.850	1.00
50_I	55_K	0.850	1.00
147_Q	175_K	0.850	1.00
141_G	148_V	0.846	1.00
286_L	289_G	0.845	1.00
141_G	146_I	0.837	1.00
76_E	106_Y	0.834	1.00
193_D	196_R	0.832	1.00
99_T	140_L	0.826	1.00
203_I	206_L	0.826	1.00
74_L	78_A	0.823	1.00
75_M	105_N	0.820	1.00
14_V	74_L	0.818	1.00
89_P	112_I	0.816	1.00
96_D	144_Y	0.815	1.00
150_V	177_W	0.815	1.00
154_V	162_L	0.808	1.00
97_D	140_L	0.806	1.00
114_L	150_V	0.806	1.00
138_I	150_V	0.805	1.00
10_V	270_I	0.805	1.00
23_K	125_L	0.802	1.00
196_R	199_Y	0.801	1.00
221_A	224_F	0.800	1.00
113_S	153_L	0.798	1.00
49_D	52_R	0.793	1.00
58_I	83_L	0.793	1.00
206_L	209_A	0.792	1.00
241_L	246_R	0.791	1.00
116_G	161_E	0.791	1.00
300_Y	310_K	0.788	1.00
72_F	76_E	0.785	1.00
241_L	244_T	0.782	1.00
44_R	81_L	0.778	1.00
14_V	68_R	0.776	1.00
116_G	122_H	0.776	1.00
96_D	99_T	0.775	1.00
207_V	210_T	0.774	1.00
199_Y	206_L	0.774	1.00
13_E	61_T	0.773	1.00
207_V	211_R	0.762	1.00
26_R	61_T	0.760	1.00
71_I	87_I	0.760	1.00
66_L	94_R	0.759	1.00
40_T	74_L	0.755	1.00
97_D	101_K	0.752	1.00
38_L	46_L	0.752	1.00
12_W	47_L	0.750	1.00
132_K	135_L	0.749	1.00
122_H	129_G	0.748	1.00
289_G	299_I	0.748	1.00
240_E	246_R	0.747	1.00
13_E	271_F	0.745	1.00
123_D	131_Y	0.744	1.00
75_M	85_V	0.744	1.00
94_R	99_T	0.740	1.00
99_T	144_Y	0.739	1.00
43_S	68_R	0.737	1.00
180_F	183_I	0.737	1.00
221_A	225_R	0.733	1.00
43_S	46_L	0.731	1.00
137_G	141_G	0.729	1.00
204_D	207_V	0.727	1.00
41_E	44_R	0.726	1.00
289_G	294_E	0.726	1.00
64_D	67_S	0.724	1.00
95_L	137_G	0.719	1.00
12_W	46_L	0.719	1.00
122_H	131_Y	0.718	1.00
308_K	311_D	0.717	1.00
182_L	188_G	0.714	1.00
87_I	107_A	0.713	1.00
289_G	292_K	0.713	1.00
40_T	68_R	0.713	1.00
95_L	99_T	0.712	1.00
13_E	274_Y	0.708	1.00
100_M	103_I	0.707	1.00
52_R	297_V	0.706	1.00
59_V	86_S	0.703	1.00
64_D	90_S	0.703	1.00
166_V	170_K	0.700	1.00
307_K	310_K	0.699	1.00
168_L	171_E	0.696	1.00
84_V	108_R	0.692	1.00
169_L	172_M	0.687	1.00
294_E	299_I	0.687	1.00
163_P	166_V	0.687	1.00
23_K	127_G	0.685	1.00
316_G	320_I	0.685	1.00
270_I	300_Y	0.684	1.00
296_L	300_Y	0.684	1.00
287_Y	292_K	0.678	1.00
116_G	126_R	0.678	1.00
104_S	144_Y	0.676	1.00
270_I	296_L	0.675	1.00
114_L	135_L	0.675	1.00
96_D	100_M	0.675	1.00
196_R	200_K	0.673	1.00
114_L	131_Y	0.671	1.00
163_P	208_E	0.670	1.00
191_E	194_I	0.666	1.00
307_K	311_D	0.666	1.00
76_E	105_N	0.663	1.00
142_L	175_K	0.661	1.00
15_T	68_R	0.661	1.00
103_I	108_R	0.656	1.00
28_N	127_G	0.656	1.00
289_G	293_K	0.654	1.00
109_Y	147_Q	0.654	1.00
200_K	203_I	0.653	1.00
198_K	207_V	0.653	1.00
114_L	134_A	0.650	1.00
60_F	74_L	0.650	1.00
280_P	284_L	0.649	1.00
199_Y	203_I	0.640	1.00
288_L	306_L	0.638	1.00
152_T	179_V	0.638	1.00
49_D	297_V	0.638	1.00
68_R	71_I	0.634	1.00
61_T	282_G	0.634	1.00
59_V	88_A	0.632	1.00
46_L	50_I	0.631	1.00
287_Y	293_K	0.630	1.00
58_I	85_V	0.629	1.00
152_T	169_L	0.627	1.00
123_D	128_L	0.626	1.00
109_Y	149_Q	0.625	1.00
20_L	122_H	0.622	1.00
11_F	269_V	0.619	1.00
42_E	46_L	0.617	1.00
88_A	282_G	0.616	1.00
19_P	94_R	0.616	1.00
295_S	299_I	0.611	1.00
116_G	119_S	0.610	1.00
22_C	25_C	0.608	0.99
306_L	309_I	0.607	0.99
88_A	151_N	0.605	0.99
208_E	211_R	0.605	0.99
94_R	97_D	0.603	0.99
24_H	126_R	0.602	0.99
47_L	60_F	0.602	0.99
61_T	88_A	0.602	0.99
85_V	108_R	0.600	0.99
286_L	290_N	0.599	0.99
285_P	288_L	0.599	0.99
206_L	211_R	0.598	0.99
17_A	35_P	0.597	0.99
18_C	22_C	0.596	0.99
156_K	159_Y	0.595	0.99
34_L	37_E	0.595	0.99
151_N	180_F	0.591	0.99
78_A	83_L	0.589	0.99
182_L	186_G	0.585	0.99
48_E	51_A	0.584	0.99
19_P	67_S	0.584	0.99
158_S	161_E	0.583	0.99
317_K	320_I	0.581	0.99
191_E	196_R	0.580	0.99
14_V	43_S	0.576	0.99
47_L	83_L	0.573	0.99
92_S	137_G	0.572	0.99
11_F	282_G	0.572	0.99
86_S	109_Y	0.567	0.99
43_S	47_L	0.565	0.99
72_F	75_M	0.565	0.99
162_L	179_V	0.565	0.99
278_V	296_L	0.561	0.99
148_V	174_V	0.560	0.99
288_L	292_K	0.557	0.99
271_F	282_G	0.557	0.99
111_S	149_Q	0.557	0.99
27_A	61_T	0.556	0.99
18_C	25_C	0.555	0.99
78_A	81_L	0.554	0.99
94_R	98_E	0.554	0.99
288_L	293_K	0.552	0.99
66_L	98_E	0.551	0.99
292_K	295_S	0.551	0.99
127_G	130_S	0.550	0.99
11_F	61_T	0.549	0.99
202_V	206_L	0.547	0.99
101_K	144_Y	0.546	0.99
103_I	145_G	0.543	0.99
112_I	134_A	0.542	0.99
202_V	210_T	0.541	0.99
160_S	163_P	0.539	0.99
92_S	133_Y	0.535	0.99
13_E	27_A	0.531	0.99
199_Y	210_T	0.531	0.99
68_R	73_E	0.529	0.99
298_D	301_R	0.528	0.99
155_W	158_S	0.528	0.99
200_K	207_V	0.525	0.99
129_G	132_K	0.524	0.98
128_L	131_Y	0.524	0.98
287_Y	291_V	0.522	0.98
98_E	102_I	0.522	0.98
166_V	177_W	0.522	0.98
24_H	27_A	0.521	0.98
9_L	57_V	0.521	0.98
136_R	143_K	0.520	0.98
29_A	187_R	0.519	0.98
191_E	195_P	0.518	0.98
180_F	184_P	0.517	0.98
194_I	200_K	0.516	0.98
75_M	78_A	0.516	0.98
193_D	197_D	0.515	0.98
87_I	102_I	0.515	0.98
91_P	137_G	0.514	0.98
95_L	105_N	0.514	0.98
285_P	289_G	0.513	0.98
64_D	89_P	0.511	0.98
200_K	209_A	0.510	0.98
302_K	307_K	0.508	0.98
117_A	131_Y	0.507	0.98
115_D	153_L	0.505	0.98
288_L	291_V	0.505	0.98
95_L	101_K	0.503	0.98
126_R	129_G	0.502	0.98
272_I	278_V	0.502	0.98
159_Y	198_K	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k36A	1	0.9114	100	0.304	Contact Map
1tv8A	2	0.8514	100	0.456	Contact Map
4m7tA	1	0.6629	100	0.467	Contact Map
4rtbA	2	0.8229	100	0.516	Contact Map
4wcxA	1	0.8914	100	0.543	Contact Map
3c8fA	1	0.6086	100	0.565	Contact Map
2yx0A	1	0.6771	100	0.599	Contact Map
2z2uA	1	0.5971	100	0.604	Contact Map
2qgqA	1	0.7257	99.9	0.606	Contact Map
3rfaA	1	0.6686	99.9	0.624	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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