Q97XS7 - SULSO - GREMLIN Contacts

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Q97XS7 - Coenzyme PQQ synthesis protein E (PqqE-3)

UniProt:	Q97XS7	Sequences: MIPISVLVTNAGTVSFHIKGEYNKDRPSKFSDVFRPVVTWNLTRKCNLKCLHCYINASPEGEDGSTTEEALRLIDEMAEMRIPLIIMSGGEPLMRRDFFELASYARIKGIKLALSTNGTLITESVAKKLKELDFSYVGISLDSYDPEFHDRFRGLNGAFNMTVKGIKNAINVGLNVGLRFTITARNIHQIDEYVKLALELGVKRITFYHLSASGRGKELREWMYTPEEYVGFINKMIDYAIKLSGKIEIETTLGQFDGVYIAKKLARDEEELEKYMKFVENSGGCGRKMISIYPNGDVYPCQFIDFYKLGNVREKPLKEIIKNIPDLFINTDKYLRGEYCDKCKYKSACKGGDRARAYYWNGDVYGDDPLCPLKTLHI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	378 (310)
Sequences:	8115 (6274)
Seq/√Len:	356.4

ECOLI - ASLB YDEM MOAA
BACSU - ALBA SKFB MOAA YYDG
HALSA - Q9HQF5 MOAA Q9HQF7
SULSO - Q97XS7 Q97XA7 Q97XS8 Q97XA6 Q7LXV3 Q97XZ2 Q97Y04 Q97WC3 Q97WK5 MOAA Q980E0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
48_L	119_T	4.040	1.00
145_D	160_N	3.913	1.00
71_L	104_Y	3.436	1.00
167_K	200_L	3.277	1.00
127_K	172_V	3.206	1.00
123_E	168_N	3.105	1.00
75_D	104_Y	2.964	1.00
69_E	313_R	2.872	1.00
66_T	69_E	2.743	1.00
150_D	157_G	2.717	1.00
297_D	311_N	2.601	1.00
47_N	117_N	2.558	1.00
67_T	100_E	2.450	1.00
72_R	76_E	2.406	1.00
159_F	196_L	2.397	1.00
297_D	308_K	2.285	1.00
99_F	128_K	2.218	1.00
168_N	171_N	2.171	1.00
38_V	77_M	2.148	1.00
283_G	301_C	2.131	1.00
144_Y	189_Q	2.098	1.00
75_D	108_K	2.097	1.00
144_Y	148_F	2.092	1.00
148_F	189_Q	2.082	1.00
70_A	101_L	2.072	1.00
301_C	353_D	2.052	1.00
142_D	153_R	2.033	1.00
127_K	131_E	2.028	1.00
118_G	139_I	2.025	1.00
123_E	171_N	1.989	1.00
104_Y	107_I	1.981	1.00
316_P	319_E	1.980	1.00
191_D	235_K	1.948	1.00
189_Q	192_E	1.942	1.00
45_K	64_G	1.935	1.00
104_Y	108_K	1.898	1.00
315_K	319_E	1.892	1.00
103_S	107_I	1.855	1.00
311_N	314_E	1.828	1.00
293_Y	297_D	1.779	1.00
178_L	197_A	1.766	1.00
128_K	132_L	1.759	1.00
47_N	120_L	1.738	1.00
139_I	166_I	1.721	1.00
71_L	100_E	1.720	1.00
96_R	99_F	1.715	1.00
67_T	71_L	1.693	1.00
151_R	185_R	1.691	1.00
180_F	193_Y	1.644	1.00
100_E	103_S	1.637	1.00
123_E	172_V	1.632	1.00
195_K	239_Y	1.626	1.00
161_M	164_K	1.624	1.00
69_E	72_R	1.622	1.00
184_A	228_E	1.620	1.00
106_R	135_S	1.618	1.00
167_K	170_I	1.612	1.00
167_K	171_N	1.606	1.00
164_K	167_K	1.604	1.00
93_L	114_L	1.602	1.00
67_T	97_D	1.598	1.00
225_T	228_E	1.593	1.00
195_K	199_E	1.577	1.00
74_I	105_A	1.572	1.00
122_T	125_V	1.564	1.00
159_F	163_V	1.550	1.00
99_F	125_V	1.550	1.00
293_Y	299_Y	1.529	1.00
78_A	108_K	1.525	1.00
71_L	75_D	1.519	1.00
130_K	172_V	1.514	1.00
196_L	200_L	1.505	1.00
52_H	142_D	1.504	1.00
64_G	95_R	1.498	1.00
103_S	128_K	1.492	1.00
106_R	132_L	1.484	1.00
126_A	168_N	1.481	1.00
168_N	172_V	1.475	1.00
160_N	164_K	1.474	1.00
149_H	158_A	1.472	1.00
87_M	112_L	1.448	1.00
231_G	235_K	1.443	1.00
51_L	151_R	1.429	1.00
65_S	69_E	1.424	1.00
139_I	165_G	1.422	1.00
192_E	195_K	1.413	1.00
105_A	112_L	1.373	1.00
164_K	168_N	1.372	1.00
162_T	165_G	1.369	1.00
180_F	205_I	1.361	1.00
102_A	134_F	1.357	1.00
76_E	316_P	1.354	1.00
128_K	131_E	1.346	1.00
87_M	105_A	1.329	1.00
126_A	165_G	1.327	1.00
143_S	148_F	1.322	1.00
85_I	105_A	1.316	1.00
145_D	150_D	1.298	1.00
93_L	120_L	1.298	1.00
115_S	138_G	1.292	1.00
231_G	234_N	1.285	1.00
42_L	87_M	1.277	1.00
103_S	132_L	1.277	1.00
137_V	169_A	1.267	1.00
178_L	202_V	1.242	1.00
102_A	132_L	1.237	1.00
239_Y	243_L	1.234	1.00
318_K	322_K	1.232	1.00
97_D	100_E	1.222	1.00
170_I	201_G	1.220	1.00
145_D	189_Q	1.217	1.00
40_W	70_A	1.194	1.00
125_V	129_L	1.191	1.00
106_R	112_L	1.185	1.00
95_R	101_L	1.181	1.00
163_V	200_L	1.181	1.00
230_V	234_N	1.179	1.00
152_F	183_T	1.170	1.00
298_V	320_I	1.170	1.00
319_E	323_N	1.159	1.00
324_I	327_L	1.153	1.00
121_I	126_A	1.151	1.00
44_R	294_P	1.148	1.00
235_K	239_Y	1.135	1.00
163_V	196_L	1.124	1.00
149_H	162_T	1.104	1.00
74_I	108_K	1.099	1.00
126_A	172_V	1.095	1.00
139_I	169_A	1.094	1.00
65_S	70_A	1.092	1.00
227_E	231_G	1.081	1.00
47_N	91_E	1.079	1.00
256_F	259_V	1.073	1.00
72_R	313_R	1.063	1.00
317_L	321_I	1.062	1.00
43_T	64_G	1.061	1.00
63_D	295_N	1.059	1.00
130_K	173_G	1.039	1.00
75_D	79_E	1.039	1.00
124_S	127_K	1.035	1.00
51_L	152_F	1.032	1.00
137_V	174_L	1.029	1.00
93_L	165_G	1.026	1.00
255_Q	259_V	1.025	1.00
84_L	111_K	1.024	1.00
236_M	240_A	1.023	1.00
163_V	167_K	1.022	1.00
54_Y	88_S	1.021	1.00
144_Y	192_E	1.020	1.00
72_R	75_D	1.020	1.00
234_N	238_D	1.019	1.00
228_E	231_G	1.011	1.00
138_G	179_R	1.009	1.00
239_Y	242_K	1.009	1.00
121_I	165_G	1.004	1.00
308_K	311_N	0.999	1.00
150_D	158_A	0.998	1.00
161_M	165_G	0.994	1.00
52_H	152_F	0.990	1.00
78_A	110_I	0.988	1.00
36_P	83_P	0.987	1.00
354_R	357_A	0.987	1.00
191_D	239_Y	0.985	1.00
73_L	292_I	0.984	1.00
123_E	127_K	0.980	1.00
114_L	129_L	0.980	1.00
126_A	130_K	0.975	1.00
48_L	158_A	0.972	1.00
197_A	202_V	0.971	1.00
338_E	341_D	0.969	1.00
252_T	256_F	0.961	1.00
95_R	98_F	0.954	1.00
140_S	181_T	0.954	1.00
141_L	178_L	0.953	1.00
77_M	85_I	0.953	1.00
93_L	125_V	0.952	1.00
166_I	176_V	0.951	1.00
125_V	128_K	0.946	1.00
165_G	168_N	0.945	1.00
143_S	159_F	0.945	1.00
38_V	290_I	0.940	1.00
283_G	353_D	0.939	1.00
299_Y	308_K	0.932	1.00
198_L	243_L	0.930	1.00
40_W	73_L	0.925	1.00
144_Y	196_L	0.925	1.00
310_G	320_I	0.915	1.00
76_E	80_M	0.908	1.00
101_L	105_A	0.908	1.00
195_K	198_L	0.907	1.00
100_E	104_Y	0.905	1.00
305_D	308_K	0.898	1.00
111_K	135_S	0.896	1.00
47_N	119_T	0.894	1.00
84_L	113_A	0.894	1.00
226_P	230_V	0.893	1.00
114_L	137_V	0.892	1.00
149_H	157_G	0.889	1.00
149_H	159_F	0.886	1.00
304_I	355_A	0.883	1.00
315_K	320_I	0.880	1.00
279_V	282_S	0.878	1.00
290_I	317_L	0.875	1.00
178_L	205_I	0.871	1.00
150_D	153_R	0.863	1.00
147_E	151_R	0.861	1.00
191_D	195_K	0.857	1.00
42_L	95_R	0.857	1.00
93_L	98_F	0.856	1.00
102_A	128_K	0.855	1.00
124_S	128_K	0.854	1.00
233_I	236_M	0.853	1.00
247_I	251_T	0.853	1.00
76_E	318_K	0.853	1.00
76_E	79_E	0.846	1.00
235_K	238_D	0.843	1.00
148_F	151_R	0.838	1.00
170_I	202_V	0.837	1.00
338_E	342_K	0.837	1.00
67_T	104_Y	0.830	1.00
237_I	241_I	0.825	1.00
145_D	159_F	0.824	1.00
193_Y	197_A	0.823	1.00
328_F	331_T	0.814	1.00
194_V	198_L	0.813	1.00
105_A	108_K	0.810	1.00
310_G	315_K	0.807	1.00
169_A	174_L	0.807	1.00
315_K	323_N	0.807	1.00
166_I	202_V	0.806	1.00
170_I	200_L	0.806	1.00
38_V	292_I	0.801	1.00
71_L	107_I	0.800	1.00
41_N	88_S	0.799	1.00
170_I	176_V	0.799	1.00
149_H	153_R	0.797	1.00
143_S	153_R	0.796	1.00
166_I	178_L	0.793	1.00
130_K	174_L	0.792	1.00
65_S	73_L	0.792	1.00
290_I	321_I	0.792	1.00
169_A	176_V	0.790	1.00
143_S	189_Q	0.790	1.00
279_V	285_C	0.786	1.00
122_T	165_G	0.785	1.00
67_T	95_R	0.783	1.00
196_L	199_E	0.779	1.00
41_N	291_S	0.774	1.00
87_M	102_A	0.773	1.00
208_Y	211_S	0.770	1.00
42_L	98_F	0.769	1.00
279_V	283_G	0.766	1.00
226_P	229_Y	0.766	1.00
324_I	328_F	0.764	1.00
121_I	169_A	0.762	1.00
67_T	101_L	0.759	1.00
187_I	228_E	0.759	1.00
255_Q	258_G	0.757	1.00
141_L	163_V	0.756	1.00
188_H	228_E	0.755	1.00
119_T	165_G	0.754	1.00
88_S	302_Q	0.753	1.00
68_E	71_L	0.751	1.00
229_Y	233_I	0.751	1.00
70_A	95_R	0.748	1.00
195_K	236_M	0.745	1.00
86_I	113_A	0.741	1.00
47_N	94_M	0.739	1.00
105_A	110_I	0.737	1.00
248_E	251_T	0.736	1.00
143_S	149_H	0.731	1.00
43_T	95_R	0.731	1.00
190_I	235_K	0.731	1.00
210_L	216_G	0.731	1.00
112_L	134_F	0.730	1.00
85_I	112_L	0.728	1.00
232_F	235_K	0.725	0.99
102_A	105_A	0.723	0.99
254_G	257_D	0.720	0.99
127_K	130_K	0.719	0.99
91_E	116_T	0.718	0.99
115_S	302_Q	0.718	0.99
310_G	314_E	0.716	0.99
160_N	163_V	0.715	0.99
197_A	205_I	0.715	0.99
141_L	159_F	0.715	0.99
82_I	109_G	0.713	0.99
179_R	208_Y	0.712	0.99
254_G	258_G	0.710	0.99
323_N	326_D	0.708	0.99
170_I	203_K	0.707	0.99
117_N	120_L	0.706	0.99
138_G	177_G	0.706	0.99
115_S	179_R	0.704	0.99
319_E	322_K	0.703	0.99
121_I	129_L	0.701	0.99
183_T	186_N	0.701	0.99
39_T	289_M	0.698	0.99
280_E	286_G	0.697	0.99
42_L	101_L	0.697	0.99
298_V	317_L	0.695	0.99
229_Y	232_F	0.695	0.99
123_E	126_A	0.690	0.99
325_P	329_I	0.689	0.99
247_I	250_E	0.688	0.99
70_A	73_L	0.688	0.99
42_L	70_A	0.687	0.99
41_N	294_P	0.685	0.99
280_E	283_G	0.680	0.99
175_N	203_K	0.678	0.99
102_A	112_L	0.676	0.99
99_F	132_L	0.674	0.99
240_A	243_L	0.672	0.99
91_E	94_M	0.672	0.99
88_S	115_S	0.671	0.99
121_I	139_I	0.670	0.99
52_H	153_R	0.668	0.99
233_I	237_I	0.668	0.99
98_F	102_A	0.668	0.99
86_I	115_S	0.666	0.99
74_I	85_I	0.666	0.99
283_G	286_G	0.659	0.99
55_I	88_S	0.656	0.99
190_I	207_F	0.656	0.99
240_A	244_S	0.650	0.99
71_L	108_K	0.646	0.99
282_S	285_C	0.645	0.99
186_N	189_Q	0.645	0.99
182_I	190_I	0.645	0.99
116_T	139_I	0.643	0.99
327_L	331_T	0.642	0.99
180_F	197_A	0.642	0.99
41_N	55_I	0.642	0.99
94_M	120_L	0.641	0.99
340_C	349_C	0.640	0.99
141_L	162_T	0.639	0.99
232_F	236_M	0.639	0.99
91_E	117_N	0.639	0.99
194_V	243_L	0.636	0.99
325_P	328_F	0.635	0.99
224_Y	229_Y	0.635	0.99
250_E	254_G	0.633	0.99
238_D	241_I	0.632	0.99
57_A	215_R	0.631	0.99
228_E	232_F	0.631	0.99
165_G	169_A	0.630	0.99
93_L	129_L	0.630	0.99
158_A	161_M	0.628	0.99
352_G	357_A	0.627	0.99
51_L	154_G	0.627	0.99
327_L	330_N	0.627	0.99
321_I	325_P	0.627	0.99
225_T	233_I	0.624	0.98
336_R	346_K	0.624	0.98
139_I	162_T	0.621	0.98
106_R	133_D	0.621	0.98
255_Q	260_Y	0.620	0.98
82_I	110_I	0.617	0.98
213_S	216_G	0.615	0.98
190_I	194_V	0.614	0.98
50_C	53_C	0.614	0.98
321_I	330_N	0.614	0.98
181_T	208_Y	0.614	0.98
95_R	100_E	0.613	0.98
144_Y	147_E	0.613	0.98
340_C	343_C	0.612	0.98
148_F	188_H	0.611	0.98
46_C	50_C	0.611	0.98
46_C	53_C	0.608	0.98
39_T	88_S	0.607	0.98
40_W	292_I	0.604	0.98
73_L	77_M	0.604	0.98
307_Y	358_Y	0.603	0.98
69_E	73_L	0.601	0.98
166_I	200_L	0.600	0.98
39_T	302_Q	0.600	0.98
225_T	229_Y	0.597	0.98
115_S	303_F	0.594	0.98
35_R	321_I	0.594	0.98
68_E	72_R	0.592	0.98
67_T	70_A	0.591	0.98
313_R	316_P	0.591	0.98
333_K	336_R	0.587	0.98
191_D	194_V	0.586	0.98
70_A	74_I	0.583	0.98
150_D	159_F	0.582	0.98
237_I	240_A	0.582	0.98
37_V	86_I	0.580	0.98
227_E	230_V	0.580	0.98
36_P	288_K	0.579	0.98
45_K	62_E	0.578	0.98
49_K	56_N	0.577	0.97
136_Y	177_G	0.577	0.97
142_D	149_H	0.576	0.97
296_G	311_N	0.576	0.97
74_I	110_I	0.575	0.97
291_S	302_Q	0.574	0.97
76_E	317_L	0.573	0.97
251_T	254_G	0.573	0.97
52_H	181_T	0.572	0.97
101_L	104_Y	0.572	0.97
145_D	192_E	0.570	0.97
300_P	304_I	0.569	0.97
144_Y	159_F	0.568	0.97
321_I	324_I	0.567	0.97
292_I	298_V	0.567	0.97
188_H	232_F	0.566	0.97
249_I	252_T	0.565	0.97
328_F	332_D	0.564	0.97
87_M	101_L	0.562	0.97
114_L	134_F	0.561	0.97
257_D	260_Y	0.556	0.97
223_M	226_P	0.555	0.97
91_E	118_G	0.552	0.97
79_E	318_K	0.551	0.97
316_P	320_I	0.546	0.97
99_F	131_E	0.546	0.97
238_D	242_K	0.546	0.97
252_T	255_Q	0.545	0.96
77_M	82_I	0.544	0.96
176_V	202_V	0.543	0.96
82_I	111_K	0.543	0.96
169_A	173_G	0.543	0.96
230_V	233_I	0.543	0.96
322_K	325_P	0.542	0.96
216_G	219_L	0.538	0.96
232_F	237_I	0.537	0.96
150_D	156_N	0.537	0.96
52_H	55_I	0.536	0.96
126_A	169_A	0.535	0.96
179_R	302_Q	0.533	0.96
164_K	171_N	0.533	0.96
212_A	215_R	0.532	0.96
184_A	225_T	0.531	0.96
251_T	255_Q	0.531	0.96
339_Y	342_K	0.530	0.96
99_F	103_S	0.528	0.96
74_I	87_M	0.528	0.96
197_A	200_L	0.527	0.96
88_S	138_G	0.525	0.96
154_G	158_A	0.524	0.96
281_N	285_C	0.524	0.96
345_Y	348_A	0.524	0.96
300_P	303_F	0.521	0.95
147_E	192_E	0.520	0.95
119_T	161_M	0.520	0.95
222_W	226_P	0.520	0.95
198_L	247_I	0.520	0.95
224_Y	228_E	0.518	0.95
85_I	110_I	0.516	0.95
273_E	276_M	0.513	0.95
153_R	157_G	0.513	0.95
188_H	191_D	0.513	0.95
48_L	162_T	0.511	0.95
300_P	307_Y	0.510	0.95
109_G	112_L	0.507	0.95
102_A	108_K	0.507	0.95
189_Q	193_Y	0.507	0.95
194_V	205_I	0.505	0.95
352_G	356_R	0.505	0.95
285_C	301_C	0.505	0.95
37_V	84_L	0.504	0.95
244_S	247_I	0.503	0.95
118_G	166_I	0.503	0.95
282_S	286_G	0.500	0.94

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k36A	1	0.8651	100	0.311	Contact Map
1tv8A	2	0.7937	100	0.498	Contact Map
4m7tA	1	0.6217	100	0.505	Contact Map
4rtbA	2	0.8571	100	0.539	Contact Map
4wcxA	1	0.9206	100	0.588	Contact Map
3c8fA	1	0.5952	100	0.61	Contact Map
2qgqA	1	0.6772	99.9	0.638	Contact Map
2yx0A	1	0.6958	99.9	0.639	Contact Map
2z2uA	1	0.627	99.9	0.651	Contact Map
3t7vA	1	0.8307	99.9	0.664	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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