GREMLIN Database
Q97XS7 - Coenzyme PQQ synthesis protein E (PqqE-3)
UniProt: Q97XS7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 378 (310)
Sequences: 8115 (6274)
Seq/√Len: 356.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_L119_T4.0401.00
145_D160_N3.9131.00
71_L104_Y3.4361.00
167_K200_L3.2771.00
127_K172_V3.2061.00
123_E168_N3.1051.00
75_D104_Y2.9641.00
69_E313_R2.8721.00
66_T69_E2.7431.00
150_D157_G2.7171.00
297_D311_N2.6011.00
47_N117_N2.5581.00
67_T100_E2.4501.00
72_R76_E2.4061.00
159_F196_L2.3971.00
297_D308_K2.2851.00
99_F128_K2.2181.00
168_N171_N2.1711.00
38_V77_M2.1481.00
283_G301_C2.1311.00
144_Y189_Q2.0981.00
75_D108_K2.0971.00
144_Y148_F2.0921.00
148_F189_Q2.0821.00
70_A101_L2.0721.00
301_C353_D2.0521.00
142_D153_R2.0331.00
127_K131_E2.0281.00
118_G139_I2.0251.00
123_E171_N1.9891.00
104_Y107_I1.9811.00
316_P319_E1.9801.00
191_D235_K1.9481.00
189_Q192_E1.9421.00
45_K64_G1.9351.00
104_Y108_K1.8981.00
315_K319_E1.8921.00
103_S107_I1.8551.00
311_N314_E1.8281.00
293_Y297_D1.7791.00
178_L197_A1.7661.00
128_K132_L1.7591.00
47_N120_L1.7381.00
139_I166_I1.7211.00
71_L100_E1.7201.00
96_R99_F1.7151.00
67_T71_L1.6931.00
151_R185_R1.6911.00
180_F193_Y1.6441.00
100_E103_S1.6371.00
123_E172_V1.6321.00
195_K239_Y1.6261.00
161_M164_K1.6241.00
69_E72_R1.6221.00
184_A228_E1.6201.00
106_R135_S1.6181.00
167_K170_I1.6121.00
167_K171_N1.6061.00
164_K167_K1.6041.00
93_L114_L1.6021.00
67_T97_D1.5981.00
225_T228_E1.5931.00
195_K199_E1.5771.00
74_I105_A1.5721.00
122_T125_V1.5641.00
159_F163_V1.5501.00
99_F125_V1.5501.00
293_Y299_Y1.5291.00
78_A108_K1.5251.00
71_L75_D1.5191.00
130_K172_V1.5141.00
196_L200_L1.5051.00
52_H142_D1.5041.00
64_G95_R1.4981.00
103_S128_K1.4921.00
106_R132_L1.4841.00
126_A168_N1.4811.00
168_N172_V1.4751.00
160_N164_K1.4741.00
149_H158_A1.4721.00
87_M112_L1.4481.00
231_G235_K1.4431.00
51_L151_R1.4291.00
65_S69_E1.4241.00
139_I165_G1.4221.00
192_E195_K1.4131.00
105_A112_L1.3731.00
164_K168_N1.3721.00
162_T165_G1.3691.00
180_F205_I1.3611.00
102_A134_F1.3571.00
76_E316_P1.3541.00
128_K131_E1.3461.00
87_M105_A1.3291.00
126_A165_G1.3271.00
143_S148_F1.3221.00
85_I105_A1.3161.00
145_D150_D1.2981.00
93_L120_L1.2981.00
115_S138_G1.2921.00
231_G234_N1.2851.00
42_L87_M1.2771.00
103_S132_L1.2771.00
137_V169_A1.2671.00
178_L202_V1.2421.00
102_A132_L1.2371.00
239_Y243_L1.2341.00
318_K322_K1.2321.00
97_D100_E1.2221.00
170_I201_G1.2201.00
145_D189_Q1.2171.00
40_W70_A1.1941.00
125_V129_L1.1911.00
106_R112_L1.1851.00
95_R101_L1.1811.00
163_V200_L1.1811.00
230_V234_N1.1791.00
152_F183_T1.1701.00
298_V320_I1.1701.00
319_E323_N1.1591.00
324_I327_L1.1531.00
121_I126_A1.1511.00
44_R294_P1.1481.00
235_K239_Y1.1351.00
163_V196_L1.1241.00
149_H162_T1.1041.00
74_I108_K1.0991.00
126_A172_V1.0951.00
139_I169_A1.0941.00
65_S70_A1.0921.00
227_E231_G1.0811.00
47_N91_E1.0791.00
256_F259_V1.0731.00
72_R313_R1.0631.00
317_L321_I1.0621.00
43_T64_G1.0611.00
63_D295_N1.0591.00
130_K173_G1.0391.00
75_D79_E1.0391.00
124_S127_K1.0351.00
51_L152_F1.0321.00
137_V174_L1.0291.00
93_L165_G1.0261.00
255_Q259_V1.0251.00
84_L111_K1.0241.00
236_M240_A1.0231.00
163_V167_K1.0221.00
54_Y88_S1.0211.00
144_Y192_E1.0201.00
72_R75_D1.0201.00
234_N238_D1.0191.00
228_E231_G1.0111.00
138_G179_R1.0091.00
239_Y242_K1.0091.00
121_I165_G1.0041.00
308_K311_N0.9991.00
150_D158_A0.9981.00
161_M165_G0.9941.00
52_H152_F0.9901.00
78_A110_I0.9881.00
36_P83_P0.9871.00
354_R357_A0.9871.00
191_D239_Y0.9851.00
73_L292_I0.9841.00
123_E127_K0.9801.00
114_L129_L0.9801.00
126_A130_K0.9751.00
48_L158_A0.9721.00
197_A202_V0.9711.00
338_E341_D0.9691.00
252_T256_F0.9611.00
95_R98_F0.9541.00
140_S181_T0.9541.00
141_L178_L0.9531.00
77_M85_I0.9531.00
93_L125_V0.9521.00
166_I176_V0.9511.00
125_V128_K0.9461.00
165_G168_N0.9451.00
143_S159_F0.9451.00
38_V290_I0.9401.00
283_G353_D0.9391.00
299_Y308_K0.9321.00
198_L243_L0.9301.00
40_W73_L0.9251.00
144_Y196_L0.9251.00
310_G320_I0.9151.00
76_E80_M0.9081.00
101_L105_A0.9081.00
195_K198_L0.9071.00
100_E104_Y0.9051.00
305_D308_K0.8981.00
111_K135_S0.8961.00
47_N119_T0.8941.00
84_L113_A0.8941.00
226_P230_V0.8931.00
114_L137_V0.8921.00
149_H157_G0.8891.00
149_H159_F0.8861.00
304_I355_A0.8831.00
315_K320_I0.8801.00
279_V282_S0.8781.00
290_I317_L0.8751.00
178_L205_I0.8711.00
150_D153_R0.8631.00
147_E151_R0.8611.00
191_D195_K0.8571.00
42_L95_R0.8571.00
93_L98_F0.8561.00
102_A128_K0.8551.00
124_S128_K0.8541.00
233_I236_M0.8531.00
247_I251_T0.8531.00
76_E318_K0.8531.00
76_E79_E0.8461.00
235_K238_D0.8431.00
148_F151_R0.8381.00
170_I202_V0.8371.00
338_E342_K0.8371.00
67_T104_Y0.8301.00
237_I241_I0.8251.00
145_D159_F0.8241.00
193_Y197_A0.8231.00
328_F331_T0.8141.00
194_V198_L0.8131.00
105_A108_K0.8101.00
310_G315_K0.8071.00
169_A174_L0.8071.00
315_K323_N0.8071.00
166_I202_V0.8061.00
170_I200_L0.8061.00
38_V292_I0.8011.00
71_L107_I0.8001.00
41_N88_S0.7991.00
170_I176_V0.7991.00
149_H153_R0.7971.00
143_S153_R0.7961.00
166_I178_L0.7931.00
130_K174_L0.7921.00
65_S73_L0.7921.00
290_I321_I0.7921.00
169_A176_V0.7901.00
143_S189_Q0.7901.00
279_V285_C0.7861.00
122_T165_G0.7851.00
67_T95_R0.7831.00
196_L199_E0.7791.00
41_N291_S0.7741.00
87_M102_A0.7731.00
208_Y211_S0.7701.00
42_L98_F0.7691.00
279_V283_G0.7661.00
226_P229_Y0.7661.00
324_I328_F0.7641.00
121_I169_A0.7621.00
67_T101_L0.7591.00
187_I228_E0.7591.00
255_Q258_G0.7571.00
141_L163_V0.7561.00
188_H228_E0.7551.00
119_T165_G0.7541.00
88_S302_Q0.7531.00
68_E71_L0.7511.00
229_Y233_I0.7511.00
70_A95_R0.7481.00
195_K236_M0.7451.00
86_I113_A0.7411.00
47_N94_M0.7391.00
105_A110_I0.7371.00
248_E251_T0.7361.00
143_S149_H0.7311.00
43_T95_R0.7311.00
190_I235_K0.7311.00
210_L216_G0.7311.00
112_L134_F0.7301.00
85_I112_L0.7281.00
232_F235_K0.7250.99
102_A105_A0.7230.99
254_G257_D0.7200.99
127_K130_K0.7190.99
91_E116_T0.7180.99
115_S302_Q0.7180.99
310_G314_E0.7160.99
160_N163_V0.7150.99
197_A205_I0.7150.99
141_L159_F0.7150.99
82_I109_G0.7130.99
179_R208_Y0.7120.99
254_G258_G0.7100.99
323_N326_D0.7080.99
170_I203_K0.7070.99
117_N120_L0.7060.99
138_G177_G0.7060.99
115_S179_R0.7040.99
319_E322_K0.7030.99
121_I129_L0.7010.99
183_T186_N0.7010.99
39_T289_M0.6980.99
280_E286_G0.6970.99
42_L101_L0.6970.99
298_V317_L0.6950.99
229_Y232_F0.6950.99
123_E126_A0.6900.99
325_P329_I0.6890.99
247_I250_E0.6880.99
70_A73_L0.6880.99
42_L70_A0.6870.99
41_N294_P0.6850.99
280_E283_G0.6800.99
175_N203_K0.6780.99
102_A112_L0.6760.99
99_F132_L0.6740.99
240_A243_L0.6720.99
91_E94_M0.6720.99
88_S115_S0.6710.99
121_I139_I0.6700.99
52_H153_R0.6680.99
233_I237_I0.6680.99
98_F102_A0.6680.99
86_I115_S0.6660.99
74_I85_I0.6660.99
283_G286_G0.6590.99
55_I88_S0.6560.99
190_I207_F0.6560.99
240_A244_S0.6500.99
71_L108_K0.6460.99
282_S285_C0.6450.99
186_N189_Q0.6450.99
182_I190_I0.6450.99
116_T139_I0.6430.99
327_L331_T0.6420.99
180_F197_A0.6420.99
41_N55_I0.6420.99
94_M120_L0.6410.99
340_C349_C0.6400.99
141_L162_T0.6390.99
232_F236_M0.6390.99
91_E117_N0.6390.99
194_V243_L0.6360.99
325_P328_F0.6350.99
224_Y229_Y0.6350.99
250_E254_G0.6330.99
238_D241_I0.6320.99
57_A215_R0.6310.99
228_E232_F0.6310.99
165_G169_A0.6300.99
93_L129_L0.6300.99
158_A161_M0.6280.99
352_G357_A0.6270.99
51_L154_G0.6270.99
327_L330_N0.6270.99
321_I325_P0.6270.99
225_T233_I0.6240.98
336_R346_K0.6240.98
139_I162_T0.6210.98
106_R133_D0.6210.98
255_Q260_Y0.6200.98
82_I110_I0.6170.98
213_S216_G0.6150.98
190_I194_V0.6140.98
50_C53_C0.6140.98
321_I330_N0.6140.98
181_T208_Y0.6140.98
95_R100_E0.6130.98
144_Y147_E0.6130.98
340_C343_C0.6120.98
148_F188_H0.6110.98
46_C50_C0.6110.98
46_C53_C0.6080.98
39_T88_S0.6070.98
40_W292_I0.6040.98
73_L77_M0.6040.98
307_Y358_Y0.6030.98
69_E73_L0.6010.98
166_I200_L0.6000.98
39_T302_Q0.6000.98
225_T229_Y0.5970.98
115_S303_F0.5940.98
35_R321_I0.5940.98
68_E72_R0.5920.98
67_T70_A0.5910.98
313_R316_P0.5910.98
333_K336_R0.5870.98
191_D194_V0.5860.98
70_A74_I0.5830.98
150_D159_F0.5820.98
237_I240_A0.5820.98
37_V86_I0.5800.98
227_E230_V0.5800.98
36_P288_K0.5790.98
45_K62_E0.5780.98
49_K56_N0.5770.97
136_Y177_G0.5770.97
142_D149_H0.5760.97
296_G311_N0.5760.97
74_I110_I0.5750.97
291_S302_Q0.5740.97
76_E317_L0.5730.97
251_T254_G0.5730.97
52_H181_T0.5720.97
101_L104_Y0.5720.97
145_D192_E0.5700.97
300_P304_I0.5690.97
144_Y159_F0.5680.97
321_I324_I0.5670.97
292_I298_V0.5670.97
188_H232_F0.5660.97
249_I252_T0.5650.97
328_F332_D0.5640.97
87_M101_L0.5620.97
114_L134_F0.5610.97
257_D260_Y0.5560.97
223_M226_P0.5550.97
91_E118_G0.5520.97
79_E318_K0.5510.97
316_P320_I0.5460.97
99_F131_E0.5460.97
238_D242_K0.5460.97
252_T255_Q0.5450.96
77_M82_I0.5440.96
176_V202_V0.5430.96
82_I111_K0.5430.96
169_A173_G0.5430.96
230_V233_I0.5430.96
322_K325_P0.5420.96
216_G219_L0.5380.96
232_F237_I0.5370.96
150_D156_N0.5370.96
52_H55_I0.5360.96
126_A169_A0.5350.96
179_R302_Q0.5330.96
164_K171_N0.5330.96
212_A215_R0.5320.96
184_A225_T0.5310.96
251_T255_Q0.5310.96
339_Y342_K0.5300.96
99_F103_S0.5280.96
74_I87_M0.5280.96
197_A200_L0.5270.96
88_S138_G0.5250.96
154_G158_A0.5240.96
281_N285_C0.5240.96
345_Y348_A0.5240.96
300_P303_F0.5210.95
147_E192_E0.5200.95
119_T161_M0.5200.95
222_W226_P0.5200.95
198_L247_I0.5200.95
224_Y228_E0.5180.95
85_I110_I0.5160.95
273_E276_M0.5130.95
153_R157_G0.5130.95
188_H191_D0.5130.95
48_L162_T0.5110.95
300_P307_Y0.5100.95
109_G112_L0.5070.95
102_A108_K0.5070.95
189_Q193_Y0.5070.95
194_V205_I0.5050.95
352_G356_R0.5050.95
285_C301_C0.5050.95
37_V84_L0.5040.95
244_S247_I0.5030.95
118_G166_I0.5030.95
282_S286_G0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k36A 1 0.8651 100 0.311 Contact Map
1tv8A 2 0.7937 100 0.498 Contact Map
4m7tA 1 0.6217 100 0.505 Contact Map
4rtbA 2 0.8571 100 0.539 Contact Map
4wcxA 1 0.9206 100 0.588 Contact Map
3c8fA 1 0.5952 100 0.61 Contact Map
2qgqA 1 0.6772 99.9 0.638 Contact Map
2yx0A 1 0.6958 99.9 0.639 Contact Map
2z2uA 1 0.627 99.9 0.651 Contact Map
3t7vA 1 0.8307 99.9 0.664 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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