GREMLIN Database
Q97XR9 - Second ORF in transposon ISC1229
UniProt: Q97XR9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 209 (202)
Sequences: 4822 (3735)
Seq/√Len: 262.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_K181_G3.4021.00
120_F193_A2.8831.00
175_H178_R2.7601.00
93_V205_P2.6131.00
108_V120_F2.5851.00
124_C150_L2.4601.00
96_T205_P2.3901.00
107_I196_V2.3871.00
61_E83_M2.3701.00
169_L173_E2.2341.00
115_P119_S2.1611.00
142_I186_V2.1571.00
11_I14_K2.1351.00
12_E74_Q2.1091.00
72_E76_R2.1021.00
190_R194_R1.9891.00
65_I76_R1.9661.00
69_N72_E1.9331.00
180_K183_K1.9111.00
124_C193_A1.9071.00
114_F123_Y1.9061.00
93_V199_V1.8631.00
81_R84_I1.8581.00
116_K119_S1.8481.00
11_I18_R1.8321.00
204_R207_E1.8101.00
126_L189_A1.8041.00
132_R137_V1.7941.00
89_P203_N1.7901.00
100_V105_A1.7771.00
199_V205_P1.7531.00
97_I196_V1.7291.00
168_L188_L1.7181.00
69_N76_R1.7171.00
174_T178_R1.7031.00
68_K76_R1.6471.00
198_S202_N1.6471.00
104_A153_L1.6451.00
97_I199_V1.6291.00
95_L102_K1.6141.00
94_L196_V1.5961.00
19_L63_I1.5701.00
121_V127_D1.5511.00
36_R39_R1.5381.00
156_F159_V1.5381.00
171_F191_K1.5311.00
197_W201_Y1.5041.00
173_E177_D1.4941.00
162_Y172_Y1.4761.00
93_V96_T1.4591.00
179_L183_K1.4571.00
6_L152_S1.4561.00
67_A71_L1.4301.00
158_A192_L1.4211.00
155_Y189_A1.4151.00
104_A157_L1.4091.00
68_K75_E1.4031.00
88_V91_D1.4011.00
9_K12_E1.3851.00
11_I69_N1.3821.00
121_V190_R1.3791.00
172_Y188_L1.3771.00
13_T17_N1.3591.00
168_L195_V1.3351.00
97_I192_L1.3181.00
70_L74_Q1.3161.00
78_K81_R1.2741.00
5_Y9_K1.2701.00
175_H184_L1.2631.00
37_L40_L1.2571.00
50_L53_L1.2571.00
90_Q203_N1.2551.00
76_R79_E1.2481.00
152_S156_F1.2351.00
158_A189_A1.2331.00
81_R85_E1.2221.00
171_F175_H1.2111.00
19_L70_L1.2091.00
158_A188_L1.1821.00
157_L192_L1.1681.00
111_I200_W1.1591.00
11_I15_Y1.1521.00
10_D14_K1.1491.00
42_K46_T1.1411.00
5_Y81_R1.1341.00
90_Q200_W1.1281.00
176_K184_L1.1111.00
9_K77_L1.1091.00
7_F18_R1.1071.00
195_V199_V1.1001.00
133_S137_V1.0951.00
166_P170_K1.0931.00
94_L105_A1.0831.00
154_F193_A1.0811.00
4_L8_L1.0741.00
100_V196_V1.0661.00
94_L200_W1.0651.00
172_Y184_L1.0551.00
12_E16_K1.0541.00
198_S201_Y1.0541.00
41_A44_D1.0541.00
66_L69_N1.0481.00
171_F188_L1.0451.00
15_Y19_L1.0401.00
100_V104_A1.0361.00
35_D39_R1.0221.00
12_E77_L1.0221.00
68_K72_E1.0171.00
155_Y186_V1.0091.00
142_I151_R1.0081.00
65_I79_E1.0041.00
155_Y159_V0.9871.00
186_V189_A0.9871.00
16_K34_K0.9811.00
65_I83_M0.9771.00
85_E102_K0.9761.00
42_K45_F0.9741.00
159_V181_G0.9701.00
87_Q91_D0.9651.00
181_G185_Y0.9641.00
40_L43_G0.9611.00
39_R42_K0.9531.00
79_E83_M0.9501.00
171_F187_A0.9351.00
39_R43_G0.9261.00
108_V111_I0.9191.00
127_D143_S0.9111.00
9_K13_T0.8971.00
6_L10_D0.8951.00
144_K151_R0.8951.00
159_V182_R0.8911.00
171_F174_T0.8911.00
62_E65_I0.8861.00
168_L192_L0.8801.00
159_V162_Y0.8651.00
33_N36_R0.8631.00
16_K70_L0.8581.00
158_A185_Y0.8440.99
14_K17_N0.8410.99
123_Y147_N0.8410.99
21_R25_L0.8310.99
182_R185_Y0.8290.99
65_I69_N0.8290.99
75_E79_E0.8280.99
36_R40_L0.8250.99
172_Y181_G0.8200.99
38_E41_A0.8180.99
35_D38_E0.8150.99
40_L44_D0.8140.99
166_P169_L0.8140.99
8_L77_L0.8120.99
74_Q78_K0.8110.99
36_R43_G0.8100.99
130_V137_V0.8100.99
170_K174_T0.8090.99
88_V92_H0.8080.99
160_R164_R0.8040.99
100_V192_L0.8030.99
116_K197_W0.8020.99
127_D144_K0.7990.99
60_L64_K0.7990.99
199_V204_R0.7940.99
129_V143_S0.7920.99
24_F29_N0.7910.99
127_D130_V0.7900.99
119_S122_A0.7860.99
108_V124_C0.7790.99
155_Y182_R0.7780.99
175_H187_A0.7780.99
175_H179_L0.7730.99
95_L105_A0.7720.99
72_E75_E0.7720.99
132_R138_I0.7690.99
40_L45_F0.7670.99
159_V185_Y0.7660.99
15_Y66_L0.7600.99
61_E64_K0.7570.99
37_L41_A0.7560.99
31_K36_R0.7550.99
174_T177_D0.7490.99
36_R42_K0.7490.99
175_H180_K0.7480.99
6_L149_Y0.7470.99
117_P194_R0.7460.99
74_Q77_L0.7310.99
107_I150_L0.7310.99
39_R44_D0.7210.98
33_N37_L0.7170.98
7_F11_I0.7160.98
194_R197_W0.7160.98
4_L7_F0.7150.98
97_I100_V0.7140.98
167_T206_Y0.7140.98
87_Q90_Q0.7120.98
117_P197_W0.7110.98
89_P93_V0.7110.98
118_E190_R0.7100.98
49_E53_L0.7070.98
38_E42_K0.6940.98
126_L190_R0.6900.98
32_V36_R0.6880.98
12_E70_L0.6860.98
159_V189_A0.6780.98
17_N21_R0.6780.98
100_V107_I0.6770.98
109_G113_R0.6720.97
106_G149_Y0.6700.97
7_F14_K0.6660.97
161_N168_L0.6660.97
80_V84_I0.6600.97
30_D34_K0.6560.97
7_F10_D0.6540.97
196_V199_V0.6490.97
41_A45_F0.6490.97
37_L43_G0.6490.97
110_D113_R0.6430.97
43_G46_T0.6420.97
56_T59_V0.6410.97
71_L74_Q0.6400.97
156_F182_R0.6390.97
15_Y69_N0.6380.97
57_P83_M0.6360.96
180_K184_L0.6350.96
21_R27_S0.6340.96
65_I68_K0.6300.96
61_E65_I0.6270.96
125_G151_R0.6270.96
32_V44_D0.6250.96
121_V194_R0.6220.96
32_V38_E0.6210.96
89_P92_H0.6210.96
32_V35_D0.6170.96
58_I61_E0.6140.96
176_K179_L0.6130.96
156_F160_R0.6110.96
58_I62_E0.6090.95
172_Y176_K0.6060.95
153_L157_L0.6060.95
86_G90_Q0.6050.95
93_V203_N0.6030.95
142_I187_A0.6020.95
75_E78_K0.5960.95
30_D33_N0.5950.95
170_K173_E0.5940.95
167_T195_V0.5940.95
154_F189_A0.5930.95
31_K34_K0.5910.95
127_D151_R0.5880.95
58_I83_M0.5880.95
91_D95_L0.5880.95
46_T53_L0.5870.94
157_L189_A0.5860.94
127_D145_R0.5850.94
120_F196_V0.5850.94
99_G160_R0.5840.94
5_Y103_L0.5810.94
122_A127_D0.5800.94
35_D45_F0.5800.94
195_V198_S0.5780.94
136_A141_G0.5780.94
86_G91_D0.5750.94
131_E140_R0.5750.94
151_R186_V0.5710.94
37_L45_F0.5710.94
15_Y18_R0.5700.94
162_Y176_K0.5700.94
32_V43_G0.5680.93
162_Y188_L0.5680.93
61_E72_E0.5660.93
183_K187_A0.5660.93
33_N41_A0.5650.93
109_G112_R0.5650.93
8_L76_R0.5640.93
65_I80_V0.5630.93
146_G151_R0.5600.93
165_N168_L0.5550.93
111_I197_W0.5530.93
77_L81_R0.5480.92
35_D42_K0.5420.92
34_K38_E0.5390.92
32_V41_A0.5390.92
35_D43_G0.5370.91
131_E136_A0.5340.91
129_V140_R0.5320.91
37_L46_T0.5260.91
18_R21_R0.5250.91
4_L18_R0.5250.91
173_E176_K0.5230.90
22_A26_V0.5220.90
163_S181_G0.5210.90
132_R136_A0.5200.90
71_L75_E0.5190.90
53_L56_T0.5110.89
79_E82_R0.5110.89
35_D41_A0.5110.89
165_N206_Y0.5100.89
124_C153_L0.5090.89
152_S155_Y0.5080.89
8_L18_R0.5060.89
30_D40_L0.5050.89
156_F189_A0.5020.89
143_S146_G0.5000.88
130_V139_S0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2duyA 1 0.311 63.3 0.924 Contact Map
3wu2U 1 0.4258 62.9 0.924 Contact Map
4pj0U 1 0.4211 59.6 0.926 Contact Map
4ofaA 1 0.5981 43.6 0.932 Contact Map
1pu6A 1 0.7608 34.6 0.936 Contact Map
2bcqA 1 0.7512 34 0.936 Contact Map
2a1jA 1 0.2919 30.1 0.938 Contact Map
1keaA 2 0.8421 28.8 0.939 Contact Map
2yg9A 1 0.7273 28.7 0.939 Contact Map
3icxA 2 0.8182 28.1 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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