GREMLIN Database
Q97XR6 - Uncharacterized protein
UniProt: Q97XR6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 320 (245)
Sequences: 3386 (2282)
Seq/√Len: 145.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_I80_R5.2591.00
142_F183_S4.3611.00
100_E147_F3.9831.00
149_K186_E3.7011.00
282_T285_I3.6461.00
244_D288_K3.5731.00
287_K292_E3.5021.00
68_E101_E3.2811.00
149_K184_F3.1481.00
142_F184_F3.0991.00
147_F150_S3.0141.00
85_T102_D2.9231.00
99_L144_F2.8441.00
98_K101_E2.7951.00
103_V153_I2.7091.00
291_F295_S2.6471.00
84_G115_H2.2721.00
100_E104_R2.1901.00
83_I113_M2.0321.00
288_K296_K1.9901.00
243_P285_I1.9771.00
47_D291_F1.9481.00
100_E151_L1.8821.00
104_R151_L1.8731.00
285_I288_K1.8671.00
146_E150_S1.8611.00
38_E43_N1.8371.00
101_E105_R1.8251.00
243_P288_K1.7911.00
134_W140_E1.7861.00
247_L297_L1.7691.00
197_P202_F1.7531.00
152_G186_E1.7021.00
92_G96_K1.7021.00
91_D94_E1.6801.00
100_E150_S1.6661.00
74_A83_I1.6561.00
146_E184_F1.6541.00
295_S300_I1.6501.00
235_A239_F1.6141.00
190_V297_L1.5911.00
51_T81_F1.5901.00
103_V151_L1.5881.00
204_W209_D1.5841.00
181_A189_F1.5761.00
288_K292_E1.5541.00
206_A209_D1.5311.00
82_V114_R1.4911.00
102_D113_M1.4871.00
283_L287_K1.4831.00
48_V82_V1.4791.00
142_F146_E1.4331.00
105_R111_W1.4331.00
144_F148_S1.4311.00
32_G35_R1.4301.00
142_F145_I1.3951.00
84_G298_W1.3811.00
147_F151_L1.3781.00
152_G188_K1.3761.00
99_L116_V1.3701.00
64_F98_K1.3491.00
87_W144_F1.3421.00
152_G299_G1.3351.00
115_H157_V1.3351.00
37_I77_N1.3341.00
36_M49_A1.3211.00
247_L293_N1.3161.00
257_P260_I1.3081.00
99_L151_L1.3071.00
159_H251_D1.3061.00
149_K187_I1.3031.00
145_I156_L1.2821.00
288_K293_N1.2821.00
96_K147_F1.2801.00
197_P200_D1.2651.00
71_G75_L1.2561.00
99_L148_S1.2501.00
35_R38_E1.2461.00
40_V80_R1.2461.00
87_W95_G1.2451.00
172_F191_V1.2341.00
181_A212_I1.2301.00
68_E98_K1.2291.00
149_K152_G1.2171.00
204_W208_Q1.2171.00
292_E296_K1.2021.00
85_T113_M1.2011.00
137_D179_A1.1991.00
188_K297_L1.1981.00
143_E146_E1.1891.00
148_S156_L1.1881.00
157_V298_W1.1821.00
134_W141_A1.1811.00
146_E149_K1.1811.00
262_E266_K1.1731.00
93_E97_E1.1721.00
145_I184_F1.1681.00
60_Y94_E1.1561.00
70_F83_I1.1561.00
34_N77_N1.1491.00
238_L281_L1.1380.99
287_K291_F1.0990.99
238_L246_I1.0970.99
71_G113_M1.0920.99
78_P81_F1.0770.99
282_T286_K1.0770.99
175_T181_A1.0760.99
116_V156_L1.0740.99
179_A182_S1.0620.99
69_E72_K1.0620.99
39_D43_N1.0370.99
259_W262_E1.0190.99
71_G111_W1.0130.99
214_A217_A1.0120.99
96_K100_E1.0040.99
286_K290_L1.0000.99
292_E295_S0.9990.99
238_L285_I0.9980.99
64_F101_E0.9970.99
199_L203_V0.9940.99
233_I237_L0.9800.98
216_L220_S0.9780.98
139_K142_F0.9770.98
87_W116_V0.9750.98
34_N38_E0.9700.98
39_D252_Y0.9630.98
244_D296_K0.9600.98
190_V247_L0.9550.98
243_P289_I0.9480.98
97_E100_E0.9450.98
64_F68_E0.9380.98
103_V147_F0.9330.98
52_Q157_V0.9330.98
157_V192_T0.9220.98
215_G219_A0.9220.98
33_S37_I0.9180.98
72_K75_L0.9150.98
238_L243_P0.9130.98
257_P261_L0.9130.98
37_I42_I0.9130.98
94_E97_E0.9110.97
211_N215_G0.9100.97
262_E265_A0.9010.97
231_A235_A0.8940.97
99_L147_F0.8870.97
295_S299_G0.8750.97
284_D288_K0.8730.97
217_A220_S0.8720.97
50_I82_V0.8710.97
38_E42_I0.8680.97
236_E240_W0.8630.97
211_N216_L0.8610.96
263_E267_F0.8580.96
205_T208_Q0.8500.96
179_A183_S0.8460.96
34_N76_N0.8330.96
101_E111_W0.8320.96
210_K216_L0.8310.96
50_I298_W0.8310.96
268_E286_K0.8280.96
71_G105_R0.8230.95
137_D174_I0.8220.95
210_K213_Y0.8220.95
67_T98_K0.8200.95
49_A81_F0.8190.95
283_L286_K0.8120.95
37_I40_V0.8120.95
281_L289_I0.8110.95
102_D111_W0.8090.95
247_L294_A0.8060.95
257_P268_E0.8040.95
92_G95_G0.8010.95
294_A298_W0.7960.95
48_V79_N0.7940.94
190_V298_W0.7940.94
134_W138_S0.7940.94
52_Q193_H0.7920.94
99_L103_V0.7900.94
215_G218_V0.7900.94
196_L200_D0.7880.94
72_K76_N0.7880.94
197_P201_D0.7870.94
96_K143_E0.7850.94
264_F267_F0.7850.94
192_T215_G0.7830.94
118_L158_A0.7820.94
213_Y217_A0.7810.94
175_T180_A0.7800.94
205_T209_D0.7790.94
69_E73_L0.7780.94
66_N69_E0.7730.94
210_K218_V0.7730.94
258_K262_E0.7700.93
198_R202_F0.7660.93
194_I237_L0.7630.93
116_V144_F0.7580.93
236_E239_F0.7570.93
75_L78_P0.7570.93
105_R112_Q0.7540.93
136_L171_A0.7450.92
261_L265_A0.7440.92
52_Q298_W0.7420.92
154_D190_V0.7420.92
293_N296_K0.7410.92
73_L81_F0.7410.92
212_I217_A0.7380.92
143_E147_F0.7370.92
213_Y297_L0.7370.92
196_L202_F0.7370.92
33_S76_N0.7350.92
33_S73_L0.7340.92
193_H254_I0.7330.92
212_I216_L0.7310.92
37_I80_R0.7310.92
188_K296_K0.7290.92
60_Y64_F0.7250.91
40_V81_F0.7240.91
232_Q239_F0.7210.91
268_E281_L0.7160.91
242_G285_I0.7150.91
263_E266_K0.7120.91
84_G157_V0.7100.90
154_D187_I0.7080.90
210_K214_A0.7080.90
212_I215_G0.7060.90
98_K102_D0.7040.90
216_L219_A0.6980.90
210_K215_G0.6980.90
281_L285_I0.6970.90
188_K213_Y0.6900.89
139_K183_S0.6890.89
48_V295_S0.6890.89
260_I263_E0.6870.89
50_I84_G0.6840.89
117_K157_V0.6810.89
246_I289_I0.6800.88
180_A183_S0.6780.88
265_A286_K0.6770.88
57_Q61_R0.6760.88
99_L199_L0.6660.87
74_A113_M0.6640.87
40_V46_V0.6630.87
232_Q235_A0.6630.87
141_A145_I0.6620.87
88_D94_E0.6610.87
209_D216_L0.6610.87
154_D297_L0.6580.87
199_L202_F0.6570.87
215_G249_G0.6540.86
54_Q254_I0.6540.86
40_V49_A0.6540.86
214_A219_A0.6500.86
198_R201_D0.6490.86
97_E186_E0.6460.86
197_P203_V0.6450.86
103_V111_W0.6440.86
211_N217_A0.6430.86
93_E96_K0.6420.85
73_L78_P0.6410.85
214_A241_L0.6410.85
172_F237_L0.6360.85
67_T253_A0.6360.85
210_K217_A0.6340.85
35_R39_D0.6340.85
84_G190_V0.6320.85
259_W263_E0.6300.84
59_F63_S0.6290.84
281_L286_K0.6290.84
89_P92_G0.6280.84
189_F245_R0.6270.84
24_D27_T0.6250.84
258_K261_L0.6150.83
207_V210_K0.6130.83
214_A218_V0.6100.82
232_Q236_E0.6020.82
84_G192_T0.6010.81
257_P264_F0.5980.81
39_D46_V0.5940.81
77_N81_F0.5920.81
216_L248_M0.5900.80
32_G36_M0.5900.80
114_R300_I0.5870.80
148_S153_I0.5850.80
23_M26_N0.5840.80
104_R111_W0.5840.80
71_G85_T0.5820.79
188_K245_R0.5810.79
28_F35_R0.5770.79
103_V112_Q0.5770.79
66_N193_H0.5740.78
39_D44_G0.5740.78
52_Q84_G0.5730.78
136_L195_G0.5720.78
209_D212_I0.5720.78
37_I43_N0.5720.78
156_L187_I0.5680.78
53_P56_L0.5650.77
258_K268_E0.5650.77
204_W211_N0.5650.77
150_S186_E0.5650.77
59_F90_R0.5650.77
182_S204_W0.5620.77
92_G143_E0.5610.77
63_S88_D0.5600.77
120_T163_T0.5590.77
23_M27_T0.5550.76
95_G144_F0.5540.76
116_V148_S0.5540.76
212_I219_A0.5530.76
37_I81_F0.5520.76
212_I218_V0.5510.76
71_G83_I0.5510.76
211_N218_V0.5500.75
150_S184_F0.5490.75
85_T99_L0.5490.75
263_E268_E0.5470.75
117_K192_T0.5470.75
67_T87_W0.5450.75
117_K159_H0.5430.75
176_D179_A0.5420.74
182_S208_Q0.5420.74
157_V190_V0.5410.74
238_L242_G0.5410.74
216_L246_I0.5400.74
119_Y123_W0.5390.74
68_E111_W0.5390.74
234_M237_L0.5380.74
67_T95_G0.5370.74
259_W264_F0.5370.74
198_R203_V0.5360.74
213_Y293_N0.5350.73
102_D105_R0.5340.73
117_K249_G0.5340.73
54_Q192_T0.5340.73
235_A238_L0.5320.73
67_T83_I0.5320.73
178_D209_D0.5310.73
154_D247_L0.5310.73
54_Q119_Y0.5300.73
116_V151_L0.5300.73
234_M238_L0.5290.73
214_A246_I0.5260.72
261_L264_F0.5250.72
175_T179_A0.5240.72
120_T133_G0.5240.72
213_Y296_K0.5240.72
264_F290_L0.5230.72
57_Q94_E0.5230.72
50_I115_H0.5210.72
139_K143_E0.5200.71
160_K191_V0.5190.71
99_L153_I0.5180.71
68_E102_D0.5180.71
159_H215_G0.5170.71
58_Y61_R0.5170.71
52_Q117_K0.5140.71
29_K39_D0.5130.70
81_F189_F0.5130.70
25_Y29_K0.5120.70
61_R65_G0.5090.70
251_D254_I0.5080.70
210_K219_A0.5080.70
71_G102_D0.5050.69
268_E280_E0.5040.69
32_G38_E0.5030.69
136_L160_K0.5020.69
215_G250_S0.5020.69
196_L199_L0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ofcA 4 0.8156 100 0.423 Contact Map
2hbvA 3 0.7969 100 0.425 Contact Map
4lanA 2 0.8344 100 0.425 Contact Map
4dziA 2 0.8406 100 0.425 Contact Map
4qrnA 2 0.8187 100 0.431 Contact Map
3nurA 2 0.7969 100 0.431 Contact Map
4l6dA 4 0.8031 100 0.438 Contact Map
3irsA 3 0.8156 100 0.443 Contact Map
4qroA 5 0.85 100 0.449 Contact Map
2gwgA 2 0.8375 100 0.451 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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