GREMLIN Database
Q97XR5 - Uncharacterized protein
UniProt: Q97XR5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 138 (124)
Sequences: 154 (99)
Seq/√Len: 8.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_L61_Y4.3310.99
44_L100_Y2.7980.87
40_W86_S2.5640.81
19_F107_F2.2010.70
48_M82_N2.1010.66
32_V51_E2.0060.62
40_W113_R1.9960.62
27_E62_N1.9570.60
33_T69_V1.9310.59
14_I53_V1.8510.56
34_L40_W1.8420.55
46_L68_V1.8050.54
43_P53_V1.7890.53
114_D121_T1.7680.52
51_E56_K1.7680.52
3_E60_S1.7490.51
17_M77_L1.7460.51
16_K25_I1.7240.50
34_L116_R1.7230.50
57_L98_N1.6910.49
28_G62_N1.6330.46
70_D103_I1.5880.44
40_W72_H1.5490.43
49_I80_C1.5050.41
25_I57_L1.4830.40
56_K82_N1.4710.40
30_I61_Y1.4610.39
121_T125_N1.4390.38
34_L72_H1.4050.37
39_F73_D1.3800.36
21_R116_R1.3750.36
82_N95_V1.3750.36
29_K63_G1.3500.35
59_E97_G1.3430.34
76_K94_E1.3290.34
44_L107_F1.3170.33
47_Y115_D1.3130.33
20_I48_M1.3110.33
55_R84_G1.2950.33
22_N74_A1.2930.32
43_P112_E1.2340.30
35_S48_M1.2310.30
52_D77_L1.2300.30
66_I83_N1.2260.30
50_L81_I1.2210.30
42_P50_L1.2160.30
73_D90_C1.2100.29
32_V43_P1.2070.29
51_E55_R1.1790.28
50_L61_Y1.1650.28
29_K75_E1.1550.27
35_S44_L1.1450.27
40_W85_K1.1410.27
54_K60_S1.1400.27
4_D56_K1.1270.27
32_V53_V1.1250.26
50_L118_S1.1120.26
85_K89_E1.0870.25
36_P46_L1.0760.25
76_K87_F1.0760.25
67_Q87_F1.0740.25
24_E29_K1.0650.24
23_I93_N1.0560.24
14_I43_P1.0530.24
111_R120_L1.0490.24
64_V100_Y1.0330.23
48_M107_F1.0180.23
59_E63_G1.0170.23
4_D60_S1.0140.23
111_R114_D1.0130.23
76_K81_I1.0030.23
42_P77_L0.9940.22
114_D125_N0.9670.21
31_K122_L0.9660.21
34_L97_G0.9650.21
18_G70_D0.9600.21
13_S103_I0.9550.21
91_Y94_E0.9550.21
11_N78_T0.9540.21
59_E124_I0.9470.21
24_E122_L0.9430.21
35_S107_F0.9390.21
19_F44_L0.9370.21
119_K125_N0.9310.20
48_M51_E0.9210.20
105_E124_I0.9050.20
114_D117_L0.9030.20
36_P49_I0.8990.20
54_K84_G0.8950.19
6_I101_E0.8730.19
56_K104_R0.8670.19
52_D90_C0.8490.18
27_E59_E0.8470.18
11_N49_I0.8470.18
39_F72_H0.8420.18
80_C83_N0.8380.18
53_V72_H0.8310.18
52_D121_T0.8260.18
58_S98_N0.8150.17
102_A106_R0.8130.17
38_T45_F0.8130.17
32_V57_L0.8120.17
60_S99_S0.8040.17
11_N44_L0.8000.17
35_S78_T0.7970.17
69_V98_N0.7790.17
79_S83_N0.7740.16
26_E29_K0.7730.16
77_L90_C0.7700.16
52_D109_V0.7670.16
49_I78_T0.7640.16
22_N85_K0.7630.16
69_V87_F0.7580.16
30_I92_K0.7530.16
65_L125_N0.7520.16
87_F117_L0.7460.16
12_Y98_N0.7390.16
44_L78_T0.7380.16
15_V35_S0.7350.15
5_V9_E0.7340.15
5_V8_P0.7340.15
57_L102_A0.7140.15
84_G108_R0.7110.15
25_I31_K0.7100.15
111_R116_R0.7100.15
47_Y84_G0.7020.15
81_I87_F0.6980.15
21_R34_L0.6890.14
73_D94_E0.6880.14
3_E20_I0.6870.14
115_D119_K0.6870.14
30_I57_L0.6870.14
48_M92_K0.6800.14
68_V79_S0.6780.14
24_E108_R0.6770.14
39_F87_F0.6770.14
36_P80_C0.6760.14
18_G109_V0.6730.14
84_G89_E0.6720.14
34_L53_V0.6690.14
18_G28_G0.6620.14
64_V79_S0.6610.14
70_D116_R0.6470.14
80_C95_V0.6400.13
51_E99_S0.6390.13
68_V78_T0.6330.13
72_H95_V0.6270.13
27_E65_L0.6260.13
27_E84_G0.6240.13
36_P68_V0.6160.13
22_N33_T0.6140.13
107_F115_D0.6130.13
2_L9_E0.6050.13
2_L8_P0.6050.13
2_L7_D0.6050.13
2_L5_V0.6050.13
52_D100_Y0.6040.13
87_F99_S0.5900.12
27_E76_K0.5900.12
56_K61_Y0.5800.12
40_W53_V0.5780.12
28_G63_G0.5730.12
45_F110_K0.5700.12
64_V98_N0.5690.12
13_S66_I0.5620.12
15_V107_F0.5610.12
19_F100_Y0.5610.12
20_I85_K0.5590.12
46_L70_D0.5560.12
12_Y20_I0.5510.12
30_I76_K0.5460.12
3_E23_I0.5440.12
87_F113_R0.5400.12
40_W54_K0.5330.11
11_N77_L0.5300.11
111_R119_K0.5290.11
15_V44_L0.5250.11
6_I74_A0.5250.11
21_R111_R0.5190.11
4_D101_E0.5190.11
26_E120_L0.5170.11
81_I99_S0.5150.11
27_E83_N0.5030.11
6_I50_L0.5010.11
45_F49_I0.5010.11
3_E58_S0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ux2A 2 0.7029 99.3 0.778 Contact Map
3cq1A 2 0.6087 99.1 0.797 Contact Map
3lnoA 1 0.6304 99 0.803 Contact Map
1uwdA 1 0.6159 98.9 0.811 Contact Map
4p3xA 1 0.587 13.3 0.955 Contact Map
4gnxA 1 0.6014 11.1 0.957 Contact Map
2pi2E 1 0.6594 10.5 0.957 Contact Map
1y8xB 1 0.2899 10.4 0.957 Contact Map
4xfdA 1 0.4855 9.4 0.958 Contact Map
3udcA 3 0.4928 7.9 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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