GREMLIN Database
Q97XR1 - Transposase ISC1217
UniProt: Q97XR1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 354 (299)
Sequences: 1060 (822)
Seq/√Len: 47.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
189_F205_G3.4741.00
154_E157_K3.3631.00
129_I179_L3.2471.00
145_I178_S3.1551.00
154_E158_R3.1381.00
155_E158_R3.1261.00
43_G46_A2.8691.00
36_L303_F2.7381.00
166_K174_E2.7281.00
89_I172_L2.7061.00
91_D192_W2.5961.00
221_P227_Q2.5601.00
287_L307_K2.5501.00
155_E160_G2.5261.00
155_E159_R2.4991.00
153_E158_R2.4571.00
87_L179_L2.3711.00
44_R47_T2.3431.00
90_D274_R2.3341.00
89_I187_K2.3181.00
90_D278_E2.1981.00
72_L75_V2.1841.00
143_H178_S2.1671.00
222_V228_G2.0941.00
156_L159_R2.0851.00
204_V271_W2.0631.00
88_I132_K2.0441.00
154_E160_G2.0331.00
142_I182_L2.0130.99
220_V223_S2.0060.99
223_S228_G1.9990.99
128_V281_I1.9870.99
153_E159_R1.9760.99
222_V227_Q1.9110.99
127_L193_Y1.9080.99
220_V227_Q1.8790.99
220_V232_V1.8790.99
143_H175_F1.8770.99
222_V226_P1.8300.99
43_G47_T1.8250.99
274_R278_E1.8130.99
157_K160_G1.7940.99
85_V131_V1.7780.99
91_D168_K1.7690.99
91_D193_Y1.7630.99
224_E228_G1.7490.98
240_K244_I1.7320.98
153_E157_K1.6940.98
278_E285_K1.6920.98
228_G232_V1.6900.98
221_P226_P1.6820.98
220_V229_E1.6480.98
223_S227_Q1.6340.98
153_E160_G1.6330.98
294_F299_R1.6130.97
145_I174_E1.6030.97
154_E159_R1.6000.97
26_T30_K1.5930.97
221_P225_F1.5810.97
62_N65_D1.5790.97
130_G139_I1.5580.97
145_I301_S1.5570.97
220_V228_G1.5480.97
64_L306_L1.5390.97
90_D285_K1.5250.96
293_S299_R1.5220.96
72_L76_V1.5190.96
63_N292_G1.5100.96
221_P228_G1.4900.96
150_R154_E1.4860.96
32_V59_T1.4790.96
194_V205_G1.4680.95
22_I25_M1.4480.95
22_I30_K1.4210.95
275_W278_E1.4200.95
202_N258_T1.3770.94
240_K243_V1.3630.93
231_L234_Y1.3600.93
193_Y274_R1.3540.93
147_Y165_F1.3520.93
49_I52_E1.3490.93
224_E227_Q1.3470.93
93_H121_E1.3460.93
224_E229_E1.3430.93
95_H117_H1.3290.92
274_R285_K1.3230.92
240_K245_D1.3190.92
220_V226_P1.3160.92
91_D275_W1.3100.92
296_T307_K1.3090.92
86_L270_T1.3080.92
168_K193_Y1.2990.91
89_I129_I1.2850.91
93_H114_C1.2830.91
130_G281_I1.2510.90
129_I175_F1.2490.90
90_D275_W1.2400.89
303_F310_S1.2400.89
223_S226_P1.2330.89
244_I247_Y1.2300.89
279_V283_E1.2290.89
21_V24_S1.2230.89
194_V200_Q1.2210.89
69_Q302_G1.2120.88
243_V246_D1.1990.88
115_R192_W1.1970.88
157_K162_E1.1970.88
211_A256_F1.1940.88
222_V229_E1.1830.87
199_L205_G1.1780.87
92_T278_E1.1680.86
193_Y285_K1.1670.86
206_E253_R1.1650.86
221_P224_E1.1630.86
19_N23_L1.1520.86
275_W285_K1.1500.86
24_S71_N1.1490.85
154_E161_E1.1480.85
239_I243_V1.1430.85
114_C121_E1.1400.85
109_A122_S1.1370.85
103_P300_N1.1360.85
295_L303_F1.1210.84
28_T33_A1.1170.84
297_W301_S1.1150.84
39_G49_I1.1090.83
86_L188_V1.1040.83
33_A37_L1.0960.83
48_E51_Q1.0940.83
77_K80_V1.0910.82
94_D102_M1.0840.82
102_M124_I1.0820.82
20_E25_M1.0780.82
93_H112_F1.0710.81
239_I242_L1.0680.81
190_D278_E1.0650.81
227_Q232_V1.0600.80
228_G231_L1.0560.80
38_L41_V1.0490.80
204_V257_S1.0480.80
63_N69_Q1.0410.79
203_T258_T1.0390.79
22_I29_R1.0300.79
304_V307_K1.0250.78
292_G300_N1.0200.78
230_Y233_E1.0160.78
306_L310_S1.0160.78
90_D277_I1.0140.77
63_N67_A1.0070.77
108_G148_I1.0040.77
170_D173_L1.0040.77
220_V224_E1.0030.77
82_D136_N1.0000.76
195_N210_S0.9910.76
276_D311_L0.9870.76
155_E161_E0.9870.76
171_A175_F0.9810.75
242_L267_I0.9740.75
285_K314_V0.9720.74
110_Q151_K0.9710.74
28_T31_D0.9690.74
186_S270_T0.9650.74
205_G256_F0.9600.73
114_C125_Q0.9580.73
75_V80_V0.9520.73
71_N76_V0.9510.73
246_D249_G0.9500.73
33_A36_L0.9460.72
249_G257_S0.9460.72
103_P297_W0.9450.72
275_W314_V0.9430.72
112_F115_R0.9410.72
220_V225_F0.9360.72
145_I171_A0.9340.71
130_G280_L0.9320.71
150_R187_K0.9230.70
128_V141_V0.9180.70
96_K109_A0.9160.70
75_V79_L0.9110.69
94_D126_L0.9100.69
241_L254_Y0.9100.69
188_V270_T0.9080.69
108_G288_G0.9060.69
125_Q168_K0.9030.69
88_I188_V0.9020.69
129_I187_K0.9000.69
57_Y61_L0.8980.68
32_V35_R0.8960.68
29_R67_A0.8920.68
181_G215_E0.8910.68
25_M29_R0.8870.67
101_A129_I0.8860.67
153_E156_L0.8830.67
211_A254_Y0.8780.67
167_T170_D0.8770.67
91_D277_I0.8740.66
159_R163_V0.8700.66
91_D281_I0.8690.66
274_R281_I0.8690.66
40_A306_L0.8690.66
71_N75_V0.8650.65
139_I276_D0.8630.65
141_V311_L0.8610.65
103_P124_I0.8600.65
189_F194_V0.8590.65
223_S232_V0.8590.65
127_L171_A0.8590.65
114_C117_H0.8580.65
141_V312_L0.8560.65
226_P229_E0.8560.65
34_K38_L0.8560.65
139_I280_L0.8550.65
147_Y168_K0.8540.64
277_I285_K0.8530.64
126_L304_V0.8520.64
112_F124_I0.8470.64
111_I122_S0.8440.64
58_E62_N0.8350.63
102_M146_A0.8340.63
281_I285_K0.8330.62
126_L300_N0.8320.62
92_T275_W0.8310.62
90_D168_K0.8310.62
166_K177_S0.8290.62
221_P233_E0.8280.62
255_F268_I0.8270.62
225_F228_G0.8270.62
36_L40_A0.8260.62
255_F271_W0.8250.62
127_L172_L0.8250.62
141_V280_L0.8210.61
39_G60_V0.8150.61
168_K192_W0.8150.61
189_F192_W0.8120.60
92_T274_R0.8110.60
127_L168_K0.8100.60
18_V34_K0.8080.60
40_A45_N0.8060.60
221_P229_E0.8050.60
102_M292_G0.8010.59
26_T29_R0.7990.59
26_T32_V0.7980.59
129_I176_L0.7950.59
17_A21_V0.7950.59
152_V158_R0.7930.59
98_Y109_A0.7930.59
77_K182_L0.7890.58
127_L145_I0.7870.58
193_Y278_E0.7870.58
71_N77_K0.7870.58
170_D234_Y0.7800.57
21_V27_G0.7740.57
93_H120_F0.7740.57
124_I300_N0.7730.57
21_V25_M0.7700.56
20_E24_S0.7680.56
124_I148_I0.7670.56
37_L309_L0.7580.55
94_D128_V0.7570.55
28_T36_L0.7540.55
27_G31_D0.7510.55
96_K102_M0.7470.54
94_D304_V0.7420.54
132_K273_N0.7420.54
87_L184_V0.7420.54
23_L30_K0.7420.54
299_R303_F0.7410.54
48_E293_S0.7380.53
117_H121_E0.7310.53
115_R121_E0.7310.53
90_D193_Y0.7260.52
281_I284_L0.7260.52
70_V310_S0.7220.52
18_V21_V0.7220.52
207_L211_A0.7200.51
21_V34_K0.7150.51
156_L162_E0.7110.51
17_A20_E0.7110.51
114_C120_F0.7110.51
127_L147_Y0.7070.50
271_W274_R0.7030.50
111_I253_R0.7030.50
17_A31_D0.7010.50
207_L256_F0.7010.50
142_I179_L0.6980.49
122_S149_P0.6960.49
44_R280_L0.6950.49
64_L302_G0.6950.49
200_Q205_G0.6930.49
131_V189_F0.6920.49
36_L46_A0.6890.48
69_Q305_A0.6870.48
98_Y295_L0.6820.48
40_A284_L0.6820.48
114_C275_W0.6820.48
76_V80_V0.6800.47
92_T285_K0.6780.47
92_T304_V0.6750.47
127_L274_R0.6720.47
44_R288_G0.6690.46
161_E164_K0.6670.46
277_I287_L0.6670.46
102_M126_L0.6650.46
239_I248_K0.6640.46
279_V282_R0.6610.46
154_E164_K0.6600.45
190_D274_R0.6580.45
81_G207_L0.6580.45
289_L304_V0.6560.45
284_L289_L0.6550.45
18_V33_A0.6510.45
192_W208_K0.6500.44
278_E281_I0.6450.44
95_H114_C0.6440.44
32_V63_N0.6440.44
153_E161_E0.6430.44
112_F121_E0.6430.44
123_A271_W0.6430.44
278_E314_V0.6420.44
191_S207_L0.6400.43
224_E230_Y0.6370.43
36_L293_S0.6360.43
257_S293_S0.6360.43
103_P301_S0.6350.43
116_A290_E0.6350.43
129_I199_L0.6350.43
199_L313_V0.6330.43
45_N118_K0.6310.43
168_K171_A0.6300.43
115_R120_F0.6270.42
248_K264_A0.6260.42
298_V302_G0.6260.42
193_Y275_W0.6260.42
74_E210_S0.6220.42
240_K257_S0.6190.41
29_R296_T0.6180.41
93_H125_Q0.6170.41
207_L278_E0.6150.41
95_H121_E0.6140.41
275_W281_I0.6140.41
215_E218_R0.6110.41
135_V138_Q0.6060.40
302_G305_A0.6040.40
208_K212_R0.6030.40
76_V308_A0.6020.40
148_I152_V0.5980.39
252_R309_L0.5970.39
46_A303_F0.5970.39
20_E178_S0.5950.39
240_K246_D0.5920.39
26_T33_A0.5920.39
92_T289_L0.5910.39
111_I118_K0.5900.39
227_Q233_E0.5900.39
282_R285_K0.5900.39
36_L45_N0.5880.38
76_V79_L0.5850.38
192_W275_W0.5810.38
157_K161_E0.5810.38
160_G266_D0.5790.38
239_I244_I0.5780.38
189_F208_K0.5780.38
53_A307_K0.5770.37
97_L121_E0.5750.37
45_N109_A0.5750.37
316_Y322_G0.5740.37
184_V282_R0.5720.37
194_V266_D0.5700.37
44_R50_A0.5690.37
257_S267_I0.5690.37
222_V225_F0.5650.36
120_F308_A0.5640.36
19_N27_G0.5630.36
21_V182_L0.5630.36
73_I76_V0.5630.36
102_M293_S0.5600.36
223_S230_Y0.5590.36
288_G291_G0.5590.36
145_I166_K0.5570.36
95_H116_A0.5570.36
196_S290_E0.5560.35
72_L77_K0.5550.35
69_Q98_Y0.5550.35
225_F229_E0.5540.35
154_E162_E0.5540.35
98_Y108_G0.5530.35
301_S305_A0.5530.35
31_D236_G0.5520.35
48_E52_E0.5480.35
168_K191_S0.5480.35
67_A302_G0.5460.35
300_N307_K0.5460.35
150_R235_L0.5440.34
32_V62_N0.5430.34
102_M300_N0.5420.34
29_R33_A0.5410.34
49_I249_G0.5410.34
225_F233_E0.5410.34
112_F125_Q0.5410.34
73_I77_K0.5410.34
29_R32_V0.5400.34
68_A302_G0.5400.34
25_M30_K0.5390.34
94_D303_F0.5390.34
46_A291_G0.5370.34
18_V37_L0.5360.34
74_E78_K0.5340.34
111_I120_F0.5330.33
36_L299_R0.5320.33
227_Q231_L0.5320.33
98_Y102_M0.5310.33
91_D191_S0.5290.33
111_I121_E0.5270.33
223_S231_L0.5260.33
57_Y275_W0.5260.33
112_F149_P0.5250.33
245_D251_G0.5250.33
19_N34_K0.5240.33
18_V22_I0.5240.33
98_Y283_E0.5240.33
29_R68_A0.5230.33
260_L263_T0.5230.33
67_A148_I0.5230.33
242_L265_E0.5220.32
66_K248_K0.5210.32
100_R176_L0.5210.32
27_G313_V0.5190.32
164_K234_Y0.5190.32
102_M118_K0.5170.32
300_N304_V0.5160.32
295_L310_S0.5120.32
123_A203_T0.5120.32
179_L182_L0.5110.31
90_D190_D0.5110.31
58_E292_G0.5110.31
62_N67_A0.5090.31
299_R306_L0.5080.31
114_C123_A0.5070.31
266_D269_T0.5060.31
168_K274_R0.5050.31
17_A313_V0.5050.31
124_I303_F0.5030.31
225_F232_V0.5030.31
48_E257_S0.5030.31
33_A300_N0.5020.31
177_S213_V0.5020.31
210_S250_Y0.5010.31
283_E286_A0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9322 99.9 0.719 Contact Map
3hdeA 2 0.2712 21.5 0.964 Contact Map
2kkoA 2 0.3023 18.7 0.965 Contact Map
3hdfA 1 0.2684 15 0.967 Contact Map
1xjuA 2 0.2966 12.4 0.968 Contact Map
2zkzA 2 0.2514 12.3 0.968 Contact Map
3mzyA 1 0.2119 11.2 0.969 Contact Map
1xjtA 1 0.2966 11 0.969 Contact Map
3frwA 2 0.2316 10.3 0.969 Contact Map
3rqiA 2 0.1723 8.5 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0098 seconds.