GREMLIN Database
Q97XQ8 - Transposase ISC1316
UniProt: Q97XQ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 408 (354)
Sequences: 4517 (2893)
Seq/√Len: 153.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
257_N261_K5.3551.00
279_H282_Q4.2311.00
331_A361_N4.1341.00
311_L318_L3.5831.00
274_V370_S2.9531.00
198_L303_L2.9461.00
304_R320_L2.8711.00
275_M307_I2.8031.00
302_E306_L2.7131.00
264_K268_E2.6281.00
341_S344_D2.5791.00
159_V171_I2.5461.00
284_I296_S2.5361.00
217_L293_R2.4171.00
302_E305_D2.3921.00
329_T336_V2.3791.00
308_K320_L2.2881.00
303_L307_I2.2721.00
325_Y328_K2.2591.00
267_A311_L2.2321.00
321_V366_I2.2191.00
369_G372_S2.1871.00
223_L240_A2.1171.00
348_V355_I2.1061.00
157_K176_D2.0731.00
275_M318_L2.0701.00
260_M309_Y2.0611.00
273_V311_L2.0561.00
289_R292_R2.0471.00
333_C352_C2.0421.00
330_C333_C2.0181.00
326_T366_I2.0111.00
216_A254_L1.9861.00
13_D16_T1.9771.00
328_K340_L1.9641.00
39_I97_F1.9421.00
260_M306_L1.9311.00
256_S302_E1.9071.00
51_Q55_R1.9011.00
198_L258_L1.8991.00
52_T55_R1.8911.00
345_R358_R1.8741.00
263_G306_L1.8731.00
240_A244_L1.8521.00
36_W40_Y1.8201.00
34_L80_A1.8131.00
333_C349_C1.8091.00
330_C352_C1.8041.00
135_L171_I1.7871.00
349_C352_C1.7831.00
259_Y306_L1.7641.00
271_D316_K1.7641.00
260_M263_G1.7601.00
308_K312_E1.7461.00
332_K354_W1.7371.00
235_N238_F1.7341.00
22_A70_Q1.7251.00
260_M310_Q1.6911.00
347_F356_A1.6821.00
35_R83_Y1.6721.00
21_K169_I1.6531.00
330_C349_C1.6511.00
275_M320_L1.6311.00
9_R168_R1.6141.00
230_K240_A1.5841.00
191_I199_L1.5781.00
51_Q81_D1.5741.00
227_L241_K1.5581.00
20_L169_I1.5521.00
226_E230_K1.5381.00
29_E67_K1.5341.00
277_G320_L1.5321.00
337_K347_F1.5211.00
238_F241_K1.5211.00
82_R110_V1.5001.00
259_Y302_E1.4901.00
89_R95_A1.4891.00
275_M304_R1.4871.00
74_Q113_Q1.4791.00
52_T56_Q1.4681.00
346_V355_I1.4631.00
347_F354_W1.4611.00
188_V367_L1.4591.00
201_T205_E1.4581.00
17_L21_K1.4501.00
74_Q112_P1.4491.00
337_K340_L1.4451.00
18_R22_A1.4371.00
263_G309_Y1.4341.00
340_L344_D1.4301.00
233_L237_W1.4161.00
84_Y88_K1.3911.00
200_V360_Y1.3761.00
364_L368_R1.3741.00
308_K318_L1.3691.00
189_V201_T1.3641.00
223_L226_E1.3571.00
263_G310_Q1.3441.00
342_L345_R1.3351.00
24_L169_I1.3291.00
34_L83_Y1.3121.00
276_E323_P1.3101.00
197_K200_V1.3081.00
5_G172_T1.2991.00
249_E253_N1.2961.00
335_Y350_P1.2881.00
263_G303_L1.2661.00
168_R249_E1.2621.00
39_I43_Q1.2591.00
220_V244_L1.2461.00
216_A251_L1.2431.00
166_S249_E1.2421.00
14_E17_L1.2281.00
295_L300_F1.2251.00
331_A364_L1.2221.00
164_T167_E1.2021.00
55_R81_D1.2011.00
267_A314_Y1.2001.00
88_K92_E1.1911.00
59_L62_R1.1891.00
134_T142_T1.1881.00
85_E89_R1.1871.00
87_K97_F1.1841.00
219_K223_L1.1841.00
189_V270_Y1.1781.00
328_K338_E1.1771.00
220_V248_Y1.1751.00
188_V272_V1.1681.00
337_K350_P1.1561.00
51_Q80_A1.1541.00
37_A57_L1.1541.00
224_H228_S1.1501.00
55_R80_A1.1491.00
279_H323_P1.1471.00
227_L240_A1.1461.00
342_L358_R1.1431.00
78_Q112_P1.1411.00
191_I201_T1.1381.00
356_A364_L1.1381.00
12_T16_T1.1371.00
265_W269_H1.1361.00
193_V300_F1.1341.00
223_L247_A1.1201.00
331_A356_A1.1191.00
137_L161_V1.1181.00
40_Y44_R1.1161.00
27_A79_I1.1130.99
78_Q81_D1.1070.99
38_D54_L1.1020.99
256_S306_L1.1010.99
227_L244_L1.1000.99
263_G307_I1.0960.99
321_V369_G1.0860.99
50_T53_E1.0800.99
264_K314_Y1.0790.99
328_K336_V1.0790.99
58_A80_A1.0770.99
162_K172_T1.0760.99
360_Y364_L1.0730.99
284_I292_R1.0720.99
306_L309_Y1.0720.99
185_T271_D1.0710.99
164_T168_R1.0530.99
310_Q313_K1.0500.99
195_V298_V1.0380.99
326_T369_G1.0370.99
51_Q54_L1.0370.99
259_Y303_L1.0320.99
72_Y75_V1.0290.99
267_A316_K1.0280.99
341_S345_R1.0270.99
280_V301_S1.0210.99
56_Q59_L1.0190.99
58_A77_Q1.0070.99
62_R76_V0.9980.99
12_T20_L0.9930.99
267_A273_V0.9900.99
224_H244_L0.9880.99
190_A367_L0.9860.99
341_S358_R0.9820.99
136_K142_T0.9820.99
259_Y263_G0.9780.99
68_Y76_V0.9770.99
345_R357_D0.9700.99
193_V304_R0.9690.99
206_Y357_D0.9680.99
31_Y79_I0.9660.99
223_L244_L0.9650.99
274_V366_I0.9640.99
329_T369_G0.9590.98
197_K208_P0.9570.98
59_L63_K0.9550.98
6_F175_V0.9540.98
331_A362_A0.9540.98
110_V158_R0.9500.98
356_A360_Y0.9490.98
335_Y351_N0.9480.98
89_R92_E0.9440.98
305_D308_K0.9400.98
117_K120_Q0.9390.98
331_A354_W0.9380.98
340_L347_F0.9370.98
344_D358_R0.9360.98
268_E314_Y0.9330.98
35_R87_K0.9290.98
197_K206_Y0.9250.98
277_G323_P0.9250.98
90_F97_F0.9240.98
321_V370_S0.9230.98
237_W241_K0.9220.98
29_E33_T0.9210.98
89_R94_L0.9210.98
25_K28_C0.9200.98
82_R160_I0.9100.98
221_K224_H0.9060.98
147_V150_D0.9030.98
346_V356_A0.9020.98
164_T249_E0.9020.98
337_K341_S0.9010.98
111_Y114_Y0.9000.98
291_L295_L0.8960.98
188_V371_G0.8950.98
60_D64_Q0.8950.98
205_E265_W0.8910.98
188_V274_V0.8910.98
74_Q78_Q0.8900.98
115_G138_S0.8870.97
26_L67_K0.8870.97
77_Q81_D0.8860.97
8_F171_I0.8830.97
250_Y254_L0.8830.97
230_K236_N0.8810.97
369_G373_E0.8750.97
36_W100_E0.8710.97
220_V251_L0.8710.97
189_V202_S0.8710.97
252_K256_S0.8700.97
31_Y86_A0.8680.97
360_Y363_S0.8680.97
259_Y299_A0.8670.97
90_F98_P0.8670.97
33_T37_A0.8650.97
328_K339_D0.8650.97
74_Q114_Y0.8590.97
195_V284_I0.8560.97
110_V160_I0.8550.97
311_L316_K0.8540.97
272_V317_K0.8520.97
220_V228_S0.8500.97
116_W120_Q0.8500.97
227_L237_W0.8490.97
41_F45_D0.8460.97
247_A251_L0.8430.97
323_P326_T0.8370.96
228_S244_L0.8370.96
212_P254_L0.8360.96
42_Y87_K0.8350.96
266_F273_V0.8330.96
31_Y83_Y0.8320.96
42_Y46_G0.8320.96
187_K203_D0.8280.96
117_K136_K0.8280.96
39_I87_K0.8260.96
78_Q110_V0.8240.96
200_V207_F0.8230.96
222_H226_E0.8230.96
362_A365_N0.8230.96
224_H248_Y0.8180.96
207_F262_L0.8170.96
344_D347_F0.8160.96
364_L367_L0.8150.96
347_F358_R0.8140.96
17_L169_I0.8140.96
23_Q27_A0.8130.96
264_K310_Q0.8130.96
329_T365_N0.8100.96
45_D48_G0.8090.96
223_L243_K0.8080.96
332_K364_L0.8050.96
34_L54_L0.8050.96
331_A368_R0.8040.96
187_K271_D0.8030.95
212_P216_A0.7990.95
272_V319_I0.7960.95
111_Y137_L0.7940.95
40_Y43_Q0.7940.95
216_A220_V0.7930.95
200_V206_Y0.7920.95
160_I172_T0.7910.95
34_L58_A0.7890.95
262_L265_W0.7870.95
25_K29_E0.7850.95
243_K246_R0.7820.95
193_V199_L0.7790.95
71_L74_Q0.7750.95
301_S305_D0.7730.94
30_V79_I0.7720.94
120_Q133_I0.7680.94
289_R296_S0.7650.94
104_H107_Y0.7620.94
258_L262_L0.7610.94
189_V273_V0.7600.94
158_R174_V0.7590.94
74_Q77_Q0.7590.94
227_L230_K0.7560.94
38_D84_Y0.7550.94
319_I370_S0.7520.94
26_L68_Y0.7510.94
361_N365_N0.7490.93
213_L217_L0.7470.93
19_A23_Q0.7460.93
325_Y329_T0.7440.93
72_Y111_Y0.7430.93
12_T143_F0.7410.93
340_L358_R0.7400.93
213_L216_A0.7390.93
273_V307_I0.7360.93
137_L140_L0.7360.93
325_Y369_G0.7350.93
199_L262_L0.7340.93
186_G271_D0.7310.93
37_A54_L0.7300.93
87_K90_F0.7280.93
241_K245_A0.7270.92
83_Y87_K0.7270.92
93_G96_R0.7270.92
78_Q82_R0.7260.92
278_I323_P0.7260.92
274_V319_I0.7260.92
195_V294_R0.7240.92
26_L71_L0.7230.92
10_A171_I0.7220.92
74_Q115_G0.7180.92
135_L138_S0.7130.92
38_D87_K0.7120.92
75_V109_L0.7120.92
196_E200_V0.7120.92
277_G304_R0.7090.92
282_Q323_P0.7090.92
268_E272_V0.7090.92
233_L238_F0.7060.91
370_S374_R0.7050.91
119_L136_K0.7020.91
182_L185_T0.7020.91
21_K164_T0.7000.91
220_V224_H0.6990.91
161_V171_I0.6980.91
80_A84_Y0.6980.91
155_K176_D0.6970.91
87_K91_F0.6970.91
184_N187_K0.6950.91
340_L345_R0.6950.91
47_K50_T0.6950.91
8_F149_R0.6910.90
209_N212_P0.6870.90
54_L57_L0.6870.90
226_E229_R0.6850.90
137_L143_F0.6830.90
9_R170_Y0.6810.90
199_L303_L0.6770.90
22_A26_L0.6770.90
207_F258_L0.6740.89
20_L24_L0.6720.89
221_K225_R0.6720.89
339_D344_D0.6710.89
73_S115_G0.6700.89
115_G118_I0.6690.89
329_T338_E0.6670.89
274_V367_L0.6670.89
266_F270_Y0.6660.89
37_A61_L0.6650.89
5_G174_V0.6640.89
248_Y255_R0.6640.89
216_A247_A0.6610.88
199_L207_F0.6570.88
251_L297_D0.6570.88
236_N239_K0.6520.88
26_L29_E0.6510.88
109_L113_Q0.6500.88
48_G54_L0.6500.88
202_S360_Y0.6480.87
311_L314_Y0.6460.87
140_L143_F0.6460.87
135_L159_V0.6440.87
230_K234_S0.6430.87
41_F49_L0.6400.87
366_I369_G0.6400.87
325_Y336_V0.6390.87
62_R65_D0.6380.87
179_F312_E0.6380.87
255_R297_D0.6380.87
182_L316_K0.6370.87
234_S237_W0.6370.87
309_Y313_K0.6350.86
81_D112_P0.6350.86
307_I318_L0.6340.86
280_V300_F0.6330.86
198_L298_V0.6330.86
221_K228_S0.6320.86
51_Q56_Q0.6310.86
137_L159_V0.6290.86
209_N298_V0.6270.86
73_S112_P0.6270.86
226_E240_A0.6250.85
79_I83_Y0.6230.85
7_R162_K0.6200.85
203_D270_Y0.6190.85
337_K344_D0.6170.85
43_Q46_G0.6160.85
145_V150_D0.6140.84
253_N256_S0.6120.84
14_E18_R0.6110.84
356_A361_N0.6110.84
342_L357_D0.6110.84
114_Y117_K0.6110.84
12_T17_L0.6090.84
15_Q18_R0.6060.84
274_V369_G0.6050.84
256_S260_M0.6050.84
214_E293_R0.6050.84
38_D45_D0.6040.83
59_L80_A0.6030.83
53_E56_Q0.6020.83
332_K356_A0.6010.83
214_E294_R0.5980.83
216_A250_Y0.5970.83
33_T67_K0.5950.83
248_Y252_K0.5940.82
207_F265_W0.5940.82
226_E243_K0.5930.82
342_L346_V0.5930.82
368_R373_E0.5920.82
132_L138_S0.5910.82
19_A22_A0.5910.82
72_Y113_Q0.5900.82
15_Q19_A0.5900.82
47_K53_E0.5860.82
337_K358_R0.5860.82
71_L76_V0.5850.82
33_T61_L0.5850.82
7_R256_S0.5840.81
187_K270_Y0.5830.81
23_Q71_L0.5820.81
36_W39_I0.5810.81
57_L61_L0.5810.81
198_L263_G0.5800.81
328_K337_K0.5780.81
6_F149_R0.5760.81
111_Y115_G0.5750.80
24_L109_L0.5730.80
282_Q291_L0.5720.80
11_Y146_I0.5710.80
270_Y273_V0.5690.80
145_V148_H0.5680.80
283_L295_L0.5680.80
23_Q111_Y0.5670.79
231_K234_S0.5650.79
322_N325_Y0.5640.79
284_I289_R0.5640.79
335_Y339_D0.5630.79
206_Y360_Y0.5620.79
108_S160_I0.5620.79
202_S206_Y0.5620.79
292_R296_S0.5600.79
37_A41_F0.5590.79
304_R308_K0.5590.79
190_A274_V0.5590.79
80_A83_Y0.5570.78
198_L259_Y0.5570.78
253_N257_N0.5550.78
22_A71_L0.5550.78
134_T137_L0.5550.78
53_E57_L0.5540.78
348_V354_W0.5540.78
92_E95_A0.5540.78
193_V280_V0.5530.78
168_R253_N0.5530.78
116_W156_V0.5520.78
37_A40_Y0.5510.78
225_R229_R0.5500.77
232_F237_W0.5490.77
284_I295_L0.5480.77
192_D359_D0.5470.77
194_G200_V0.5470.77
368_R371_G0.5460.77
282_Q295_L0.5460.77
371_G374_R0.5430.77
262_L303_L0.5420.76
214_E217_L0.5420.76
284_I290_S0.5420.76
20_L109_L0.5410.76
306_L310_Q0.5410.76
196_E345_R0.5400.76
221_K289_R0.5390.76
75_V111_Y0.5390.76
136_K140_L0.5360.76
237_W240_A0.5320.75
329_T347_F0.5310.75
38_D48_G0.5300.75
212_P297_D0.5300.75
225_R228_S0.5290.75
23_Q109_L0.5280.75
112_P116_W0.5270.74
7_R172_T0.5270.74
5_G162_K0.5250.74
23_Q72_Y0.5250.74
194_G197_K0.5250.74
274_V371_G0.5230.74
111_Y116_W0.5230.74
367_L371_G0.5220.74
55_R58_A0.5220.74
42_Y91_F0.5220.74
196_E357_D0.5210.74
214_E218_W0.5210.74
38_D41_F0.5200.73
261_K264_K0.5200.73
198_L307_I0.5190.73
41_F47_K0.5180.73
164_T169_I0.5180.73
55_R59_L0.5160.73
76_V79_I0.5150.73
190_A202_S0.5140.73
133_I147_V0.5140.73
22_A25_K0.5130.72
299_A302_E0.5120.72
72_Y140_L0.5090.72
10_A145_V0.5080.72
294_R298_V0.5040.71
291_L294_R0.5030.71
7_R170_Y0.5020.71
72_Y112_P0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhxA 2 0.3358 93.8 0.935 Contact Map
1nu0A 1 0.3186 93.3 0.936 Contact Map
4aybP 1 0.1054 88 0.944 Contact Map
1iv0A 1 0.2377 86.4 0.945 Contact Map
1vq8Z 1 0.1618 86 0.945 Contact Map
1ffkW 1 0.1642 85.2 0.946 Contact Map
3j20Y 1 0.1225 83.9 0.947 Contact Map
1qypA 1 0.1127 82.5 0.948 Contact Map
1vd4A 1 0.1373 81.2 0.948 Contact Map
2k4xA 1 0.1348 81 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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