GREMLIN Database
Q97XQ5 - Helicase of the snf2/rad54 family (Carboxy end), hypothetical
UniProt: Q97XQ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 124 (114)
Sequences: 6891 (3864)
Seq/√Len: 361.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_Q36_S4.7201.00
42_H56_T3.0681.00
4_L7_D3.0171.00
53_D91_R2.9571.00
40_V59_V2.7681.00
6_D10_S2.7131.00
10_S14_N2.3011.00
56_T70_V2.2201.00
52_E72_K2.1441.00
15_N18_V2.1431.00
39_R69_I2.1391.00
23_L28_G2.1371.00
8_I21_I2.0591.00
7_D11_K2.0461.00
110_T114_R2.0441.00
109_S112_E2.0211.00
9_I13_Q1.9701.00
75_S78_T1.9031.00
39_R71_H1.9021.00
4_L8_I1.8391.00
38_N66_R1.7601.00
59_V68_V1.7241.00
24_S27_A1.7111.00
26_K46_W1.6981.00
46_W51_V1.6501.00
11_K18_V1.5291.00
57_D60_Y1.5141.00
74_I84_D1.5001.00
26_K51_V1.4911.00
41_I73_L1.4631.00
92_S96_D1.4471.00
11_K15_N1.4321.00
84_D87_L1.4181.00
45_R87_L1.3791.00
82_K85_Q1.3781.00
9_I32_I1.3721.00
84_D88_A1.3591.00
111_E114_R1.3171.00
89_F92_S1.3131.00
91_R95_K1.2951.00
85_Q89_F1.2721.00
7_D10_S1.2451.00
112_E115_K1.2361.00
8_I11_K1.2041.00
46_W52_E1.1931.00
88_A91_R1.1711.00
88_A92_S1.1341.00
76_V81_E1.1181.00
53_D56_T1.0991.00
25_V46_W1.0791.00
82_K86_L1.0781.00
108_L112_E1.0561.00
25_V55_A1.0091.00
53_D57_D1.0011.00
37_A59_V0.9941.00
25_V52_E0.9751.00
23_L27_A0.9741.00
6_D13_Q0.9691.00
9_I36_S0.9551.00
49_P52_E0.9321.00
86_L89_F0.9101.00
12_F37_A0.9021.00
81_E85_Q0.9001.00
50_A91_R0.8921.00
28_G32_I0.8821.00
109_S115_K0.8711.00
45_R84_D0.8671.00
94_F99_S0.8631.00
103_S113_L0.8401.00
47_W87_L0.8281.00
13_Q35_T0.8151.00
3_T7_D0.8121.00
85_Q88_A0.8101.00
59_V70_V0.8071.00
14_N17_S0.8051.00
6_D9_I0.8051.00
13_Q33_N0.8021.00
94_F98_I0.8021.00
42_H45_R0.7991.00
14_N18_V0.7931.00
100_S104_W0.7851.00
42_H72_K0.7811.00
38_N65_T0.7801.00
50_A94_F0.7781.00
6_D67_N0.7781.00
45_R72_K0.7731.00
31_G68_V0.7631.00
24_S44_D0.7521.00
104_W107_E0.7431.00
40_V70_V0.7351.00
39_R66_R0.7351.00
23_L33_N0.7341.00
58_R61_R0.7321.00
111_E115_K0.7271.00
49_P91_R0.7221.00
109_S113_L0.7100.99
72_K87_L0.7080.99
41_I71_H0.6880.99
94_F97_I0.6850.99
46_W86_L0.6830.99
105_I110_T0.6790.99
108_L115_K0.6760.99
96_D99_S0.6750.99
105_I108_L0.6740.99
95_K99_S0.6660.99
44_D80_E0.6580.99
74_I81_E0.6420.99
4_L11_K0.6350.99
21_I27_A0.6320.99
107_E112_E0.6260.99
113_L116_V0.6250.99
50_A53_D0.6200.99
47_W86_L0.6140.98
97_I101_G0.6130.98
15_N19_K0.6110.98
103_S106_T0.6080.98
103_S109_S0.5980.98
103_S107_E0.5850.98
83_I86_L0.5840.98
56_T60_Y0.5840.98
83_I87_L0.5810.98
11_K16_P0.5750.98
102_D105_I0.5730.98
102_D107_E0.5730.98
3_T10_S0.5720.97
23_L46_W0.5710.97
74_I82_K0.5700.97
44_D72_K0.5700.97
40_V56_T0.5700.97
44_D73_L0.5580.97
105_I114_R0.5570.97
110_T115_K0.5560.97
23_L32_I0.5550.97
46_W72_K0.5550.97
38_N67_N0.5480.97
57_D62_I0.5480.97
46_W62_I0.5470.97
21_I34_L0.5460.97
33_N62_I0.5440.97
45_R79_L0.5420.97
30_F57_D0.5400.96
29_G51_V0.5400.96
24_S75_S0.5380.96
11_K14_N0.5340.96
37_A62_I0.5290.96
40_V62_I0.5290.96
45_R56_T0.5280.96
22_V45_R0.5270.96
27_A101_G0.5270.96
87_L94_F0.5220.96
46_W55_A0.5190.96
107_E115_K0.5190.96
12_F19_K0.5180.96
52_E87_L0.5160.95
60_Y67_N0.5160.95
106_T113_L0.5160.95
107_E114_R0.5150.95
47_W98_I0.5140.95
109_S114_R0.5120.95
42_H49_P0.5120.95
23_L34_L0.5110.95
29_G57_D0.5100.95
55_A72_K0.5100.95
45_R52_E0.5060.95
5_P27_A0.5050.95
96_D111_E0.5050.95
32_I35_T0.5050.95
19_K86_L0.5030.95
105_I109_S0.5010.95
12_F21_I0.5000.95
10_S110_T0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z63A 1 0.9435 100 0.297 Contact Map
1z3iX 4 1 100 0.298 Contact Map
1z5zA 1 0.8871 100 0.305 Contact Map
3mwyW 2 0.9194 100 0.315 Contact Map
3hgtA 2 0.8226 100 0.361 Contact Map
3dmqA 1 0.9839 99.9 0.505 Contact Map
4ernA 1 0.9919 99.8 0.521 Contact Map
2ykgA 1 0.7097 99.8 0.539 Contact Map
4a2wA 1 0.7097 99.8 0.548 Contact Map
4a2qA 1 0.7016 99.8 0.552 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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