GREMLIN Database
Q97XQ4 - Uncharacterized protein
UniProt: Q97XQ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 217 (172)
Sequences: 619 (383)
Seq/√Len: 29.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_G126_Y5.0661.00
28_Y123_K3.4471.00
24_R50_G3.1171.00
21_R117_D3.0001.00
117_D123_K2.9341.00
28_Y116_P2.9101.00
24_R123_K2.6521.00
44_I132_A2.5840.99
150_N153_E2.5810.99
3_R6_L2.4530.99
50_G116_P2.3900.99
50_G123_K2.3590.99
54_Y123_K2.3420.99
20_G23_S2.2220.98
61_N110_S2.1920.98
89_F93_I2.0550.97
116_P123_K2.0420.97
65_E149_I2.0050.97
64_S67_D1.9260.96
56_V128_V1.9160.96
49_S53_L1.8910.96
21_R123_K1.8800.95
63_L102_I1.8530.95
53_L116_P1.8280.95
9_F146_F1.8260.95
83_S88_K1.8180.94
50_G53_L1.7630.93
168_V171_F1.7260.93
20_G119_Q1.7220.93
68_K149_I1.7080.92
14_R130_L1.6700.91
136_I143_L1.6570.91
9_F133_Y1.6030.90
111_Y145_K1.5950.89
24_R28_Y1.5910.89
16_E131_T1.5450.88
21_R24_R1.5240.87
46_A128_V1.5240.87
54_Y116_P1.5240.87
50_G54_Y1.5220.87
6_L81_L1.4980.86
32_G127_A1.4580.85
68_K136_I1.4390.84
4_G90_P1.4210.83
43_K57_N1.3740.81
90_P97_L1.3680.81
28_Y117_D1.3520.80
94_I97_L1.3110.78
111_Y120_R1.3080.78
10_G14_R1.3040.77
73_N161_K1.2940.77
12_N16_E1.2850.76
51_T123_K1.2800.76
8_D71_V1.2660.75
21_R116_P1.2610.75
28_Y54_Y1.2550.74
21_R50_G1.2520.74
3_R137_S1.2500.74
139_N151_K1.2360.73
159_G162_I1.2340.73
51_T116_P1.2210.72
71_V97_L1.1940.71
14_R26_R1.1640.69
46_A85_L1.1630.69
21_R54_Y1.1620.69
65_E157_E1.1530.68
83_S131_T1.1530.68
54_Y114_T1.1500.68
115_C124_H1.1320.67
13_I126_Y1.1290.66
154_L157_E1.1070.65
20_G27_E1.1060.65
105_I129_Y1.0950.64
157_E160_Q1.0850.63
6_L137_S1.0620.61
12_N17_I1.0570.61
115_C122_C1.0460.60
6_L9_F1.0440.60
166_I169_K1.0350.59
28_Y50_G1.0320.59
7_F76_N1.0110.58
33_A51_T1.0040.57
15_E99_E1.0010.57
68_K85_L0.9950.56
156_Y171_F0.9910.56
34_V56_V0.9900.56
6_L12_N0.9870.56
24_R116_P0.9860.56
51_T117_D0.9850.56
6_L18_D0.9730.55
61_N155_I0.9700.54
23_S27_E0.9700.54
71_V94_I0.9700.54
132_A159_G0.9680.54
24_R117_D0.9420.52
75_I163_M0.9410.52
82_S141_L0.9310.51
28_Y53_L0.9260.51
21_R28_Y0.9190.50
50_G117_D0.9180.50
126_Y130_L0.9140.50
28_Y130_L0.9060.49
67_D99_E0.9010.49
169_K174_K0.8990.49
73_N153_E0.8910.48
43_K160_Q0.8840.48
37_I45_A0.8820.48
56_V119_Q0.8730.47
49_S88_K0.8730.47
153_E157_E0.8550.45
24_R51_T0.8510.45
75_I81_L0.8490.45
6_L83_S0.8490.45
93_I158_K0.8390.44
62_T112_E0.8380.44
38_E47_Q0.8360.44
37_I131_T0.8230.43
74_I99_E0.8180.43
3_R31_N0.8170.43
29_V131_T0.8170.43
35_R49_S0.8110.42
37_I87_Y0.8100.42
10_G131_T0.8100.42
56_V116_P0.8050.42
121_P125_I0.8050.42
82_S90_P0.7940.41
4_G139_N0.7870.40
136_I147_L0.7840.40
8_D103_E0.7770.39
33_A134_D0.7760.39
119_Q144_F0.7730.39
105_I136_I0.7720.39
54_Y117_D0.7710.39
29_V121_P0.7690.39
30_R87_Y0.7620.38
41_P145_K0.7610.38
5_W54_Y0.7550.38
4_G141_L0.7530.38
119_Q135_I0.7490.37
34_V48_V0.7460.37
111_Y125_I0.7450.37
73_N165_E0.7450.37
53_L127_A0.7450.37
168_V173_R0.7410.37
76_N161_K0.7400.37
6_L87_Y0.7350.36
27_E31_N0.7340.36
22_A104_L0.7280.36
42_G63_L0.7260.36
133_Y146_F0.7210.35
99_E165_E0.7140.35
13_I147_L0.7120.35
50_G97_L0.7110.35
68_K158_K0.7060.34
85_L141_L0.6900.33
45_A100_E0.6890.33
6_L14_R0.6880.33
170_D174_K0.6880.33
50_G114_T0.6870.33
114_T123_K0.6860.33
8_D94_I0.6800.33
10_G60_G0.6800.33
79_G89_F0.6780.32
26_R45_A0.6770.32
53_L123_K0.6770.32
11_K28_Y0.6720.32
24_R54_Y0.6710.32
42_G95_D0.6640.31
87_Y151_K0.6640.31
49_S52_K0.6600.31
86_S90_P0.6550.31
132_A163_M0.6550.31
10_G135_I0.6470.30
29_V32_G0.6450.30
4_G82_S0.6430.30
116_P119_Q0.6420.30
10_G133_Y0.6400.30
132_A136_I0.6390.30
166_I172_Q0.6390.30
113_C122_C0.6360.30
12_N107_R0.6340.29
113_C124_H0.6270.29
138_N155_I0.6270.29
106_P130_L0.6250.29
120_R129_Y0.6230.29
22_A130_L0.6200.29
36_K44_I0.6180.28
36_K47_Q0.6170.28
68_K94_I0.6160.28
21_R119_Q0.6140.28
5_W22_A0.6130.28
47_Q153_E0.6050.28
109_L135_I0.6030.27
131_T134_D0.6020.27
26_R161_K0.6010.27
64_S100_E0.6000.27
14_R44_I0.5990.27
91_T99_E0.5960.27
13_I63_L0.5930.27
20_G24_R0.5920.27
83_S94_I0.5900.27
75_I79_G0.5870.26
101_G159_G0.5870.26
25_G58_I0.5860.26
90_P94_I0.5840.26
37_I91_T0.5840.26
58_I129_Y0.5820.26
29_V33_A0.5790.26
30_R51_T0.5780.26
40_N45_A0.5760.26
146_F155_I0.5740.26
12_N19_D0.5730.26
34_V131_T0.5730.26
90_P158_K0.5720.26
9_F105_I0.5720.26
44_I146_F0.5670.25
76_N151_K0.5670.25
112_E173_R0.5620.25
61_N142_L0.5570.25
70_K101_G0.5560.25
98_D103_E0.5540.24
21_R51_T0.5490.24
33_A52_K0.5490.24
82_S139_N0.5470.24
171_F174_K0.5470.24
84_L90_P0.5460.24
95_D99_E0.5440.24
164_Q171_F0.5430.24
62_T65_E0.5420.24
69_R157_E0.5390.24
165_E168_V0.5370.24
66_E100_E0.5360.23
71_V74_I0.5330.23
81_L162_I0.5330.23
89_F97_L0.5310.23
12_N18_D0.5300.23
40_N99_E0.5210.23
45_A69_R0.5210.23
26_R139_N0.5200.23
152_E156_Y0.5190.23
11_K71_V0.5190.23
156_Y166_I0.5180.22
44_I58_I0.5160.22
165_E174_K0.5160.22
60_G132_A0.5150.22
45_A57_N0.5150.22
45_A66_E0.5140.22
16_E20_G0.5130.22
89_F92_S0.5080.22
126_Y137_S0.5070.22
42_G172_Q0.5060.22
101_G158_K0.5060.22
16_E109_L0.5050.22
12_N105_I0.5040.22
152_E160_Q0.5020.22
11_K15_E0.5020.22
30_R86_S0.5000.22
82_S101_G0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w79A 1 0.3779 14.6 0.96 Contact Map
1rjtA 1 0.2719 12.4 0.961 Contact Map
1lv9A 1 0.2304 7.9 0.964 Contact Map
2fo5A 1 0.1889 6.5 0.966 Contact Map
3m0cC 1 0.6774 5.6 0.967 Contact Map
2l74A 1 0.447 5.3 0.967 Contact Map
1rcwA 2 0.5668 5 0.968 Contact Map
1mgsA 2 0.2811 4.9 0.968 Contact Map
4wx0A 2 0.6866 4.1 0.969 Contact Map
1njhA 2 0.4194 4 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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