GREMLIN Database
Q97XQ1 - First ORF in transposon ISC1904
UniProt: Q97XQ1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 193 (183)
Sequences: 475 (332)
Seq/√Len: 24.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_V116_R4.1601.00
60_A77_L4.0771.00
81_V118_V3.7371.00
116_R143_E3.5071.00
58_L147_L2.8521.00
7_V11_L2.7850.99
102_F125_L2.7390.99
109_I137_C2.5540.99
17_T21_Y2.4330.98
90_D101_G2.4000.98
13_I21_Y2.3960.98
5_K9_Q2.3550.98
134_E138_K2.3000.98
84_Y145_V2.2030.97
110_L140_H2.1910.97
105_L114_V2.1380.96
16_P19_R2.1270.96
18_L39_F2.0740.96
74_V87_V2.0680.96
97_M131_E1.9220.93
22_V37_W1.9140.93
118_V131_E1.9130.93
58_L77_L1.8720.92
3_R34_S1.8380.92
74_V89_T1.7670.90
55_K108_M1.7280.89
95_L128_F1.7130.89
76_Y120_A1.7050.88
130_F144_I1.6590.87
88_I101_G1.6570.87
126_V130_F1.6480.86
109_I117_V1.6370.86
137_C142_C1.6160.85
109_I114_V1.6060.85
109_I119_I1.6020.85
16_P24_K1.5840.84
130_F146_V1.5390.82
58_L87_V1.5370.82
22_V29_P1.5350.82
26_Y33_Q1.4930.80
4_P19_R1.4830.80
12_G141_G1.4700.79
57_V74_V1.4590.79
97_M168_S1.4590.79
108_M113_E1.4330.78
40_N43_D1.4080.76
167_V178_S1.3700.74
31_I37_W1.3490.73
168_S171_E1.3430.73
156_E160_E1.3350.72
118_V145_V1.3310.72
17_T20_E1.3220.72
95_L129_G1.3160.71
137_C173_L1.3130.71
62_V66_Q1.3120.71
7_V27_I1.2870.69
14_S20_E1.2690.68
27_I30_V1.2620.68
71_V75_K1.2540.67
69_E72_N1.2450.67
94_G125_L1.2330.66
167_V171_E1.2070.64
106_L110_L1.1960.64
4_P18_L1.1960.64
8_C13_I1.1890.63
22_V39_F1.1790.62
75_K78_E1.1760.62
56_V143_E1.1740.62
90_D168_S1.1680.62
58_L81_V1.1510.61
7_V44_V1.1480.60
66_Q69_E1.1380.60
20_E23_K1.1350.59
120_A179_H1.1280.59
121_Y160_E1.1240.59
171_E176_M1.1170.58
15_Y19_R1.1050.57
22_V27_I1.1000.57
88_I117_V1.0890.56
8_C15_Y1.0800.56
3_R38_R1.0780.55
121_Y152_K1.0760.55
160_E171_E1.0650.55
67_K180_K1.0430.53
56_V118_V1.0420.53
57_V88_I1.0350.52
77_L147_L1.0310.52
88_I105_L1.0210.51
116_R145_V1.0200.51
94_G102_F1.0170.51
62_V70_L1.0160.51
74_V106_L1.0070.50
28_K43_D1.0040.50
81_V84_Y1.0000.50
157_E169_F0.9980.50
8_C18_L0.9870.49
90_D120_A0.9810.49
130_F133_L0.9810.49
126_V133_L0.9790.48
63_S66_Q0.9760.48
165_V175_G0.9750.48
171_E178_S0.9590.47
27_I43_D0.9550.47
174_Y177_R0.9470.46
56_V92_G0.9390.46
66_Q72_N0.9180.44
152_K172_K0.9150.44
4_P15_Y0.9140.44
13_I20_E0.9110.44
80_Q145_V0.9100.43
4_P29_P0.9080.43
7_V18_L0.8960.42
54_R141_G0.8950.42
48_M51_V0.8880.42
109_I142_C0.8840.42
3_R33_Q0.8740.41
11_L18_L0.8700.41
26_Y34_S0.8630.40
43_D46_K0.8620.40
137_C170_S0.8470.39
39_F43_D0.8450.39
128_F161_D0.8410.39
7_V38_R0.8380.38
76_Y148_N0.8350.38
19_R22_V0.8320.38
27_I133_L0.8310.38
42_E72_N0.8280.38
90_D184_V0.8260.38
64_S72_N0.8240.38
19_R39_F0.8200.37
18_L22_V0.8160.37
156_E159_V0.8130.37
117_V144_I0.8060.36
22_V31_I0.7970.36
158_L167_V0.7970.36
72_N163_V0.7970.36
147_L155_E0.7920.35
6_E145_V0.7880.35
69_E120_A0.7850.35
162_L175_G0.7850.35
106_L145_V0.7830.35
5_K34_S0.7810.35
71_V74_V0.7800.35
14_S173_L0.7780.34
162_L166_L0.7780.34
71_V185_K0.7680.34
117_V146_V0.7660.34
167_V179_H0.7600.33
97_M126_V0.7590.33
107_R139_A0.7560.33
4_P7_V0.7540.33
8_C172_K0.7530.33
75_K79_E0.7490.33
80_Q148_N0.7400.32
6_E43_D0.7360.32
44_V117_V0.7350.32
78_E87_V0.7330.32
92_G164_S0.7300.31
152_K160_E0.7270.31
57_V105_L0.7240.31
159_V162_L0.7190.31
45_E48_M0.7180.31
77_L150_E0.7140.30
162_L169_F0.7070.30
179_H185_K0.7070.30
133_L137_C0.7050.30
77_L142_C0.7010.30
118_V182_E0.6960.29
100_K155_E0.6850.29
19_R31_I0.6850.29
83_E118_V0.6840.29
23_K31_I0.6820.29
51_V115_S0.6820.29
102_F126_V0.6820.29
33_Q112_N0.6670.28
99_R126_V0.6670.28
72_N75_K0.6640.27
119_I144_I0.6620.27
63_S127_R0.6590.27
46_K121_Y0.6580.27
96_N140_H0.6500.27
133_L154_P0.6470.27
133_L158_L0.6470.27
34_S112_N0.6470.27
119_I146_V0.6450.26
76_Y164_S0.6430.26
4_P8_C0.6410.26
161_D175_G0.6390.26
120_A167_V0.6380.26
98_K172_K0.6370.26
86_L99_R0.6350.26
19_R37_W0.6340.26
110_L136_T0.6320.26
13_I31_I0.6280.25
30_V38_R0.6270.25
158_L169_F0.6250.25
92_G143_E0.6220.25
151_D166_L0.6190.25
64_S175_G0.6190.25
128_F165_V0.6190.25
54_R142_C0.6160.25
6_E158_L0.6150.25
178_S181_Y0.6130.25
154_P176_M0.6090.24
19_R36_K0.6090.24
172_K176_M0.6080.24
95_L132_I0.6080.24
8_C102_F0.6080.24
117_V125_L0.6070.24
179_H183_K0.6060.24
102_F168_S0.6040.24
21_Y38_R0.6030.24
57_V114_V0.6020.24
80_Q84_Y0.6000.24
44_V48_M0.5970.24
31_I36_K0.5960.24
103_L133_L0.5940.24
39_F44_V0.5910.24
14_S22_V0.5880.23
92_G153_T0.5870.23
125_L132_I0.5820.23
3_R36_K0.5810.23
102_F115_S0.5800.23
76_Y179_H0.5710.22
9_Q67_K0.5690.22
119_I161_D0.5690.22
118_V135_E0.5680.22
129_G170_S0.5670.22
146_V166_L0.5660.22
162_L165_V0.5660.22
145_V151_D0.5650.22
128_F175_G0.5630.22
33_Q44_V0.5630.22
13_I16_P0.5610.22
170_S176_M0.5570.22
158_L161_D0.5550.22
22_V32_L0.5530.22
91_I99_R0.5500.21
80_Q147_L0.5490.21
10_R14_S0.5490.21
6_E57_V0.5460.21
126_V164_S0.5460.21
15_Y37_W0.5460.21
5_K8_C0.5440.21
98_K140_H0.5440.21
122_P166_L0.5410.21
58_L148_N0.5370.21
91_I144_I0.5360.21
153_T179_H0.5330.21
136_T139_A0.5330.21
5_K25_G0.5330.21
13_I18_L0.5320.21
138_K172_K0.5260.20
119_I143_E0.5260.20
127_R174_Y0.5180.20
20_E29_P0.5180.20
10_R89_T0.5160.20
88_I103_L0.5150.20
16_P20_E0.5130.20
55_K113_E0.5130.20
161_D165_V0.5130.20
65_K120_A0.5110.20
6_E10_R0.5110.20
76_Y90_D0.5110.20
12_G128_F0.5100.20
123_D127_R0.5080.20
99_R154_P0.5070.19
148_N151_D0.5070.19
10_R144_I0.5040.19
96_N105_L0.5040.19
29_P69_E0.5030.19
117_V151_D0.5020.19
111_N151_D0.5000.19
23_K100_K0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ilxA 2 0.7202 100 0.65 Contact Map
3lhkA 2 0.7306 100 0.659 Contact Map
3g13A 2 0.715 99.8 0.744 Contact Map
3bvpA 4 0.6269 99.8 0.75 Contact Map
3guvA 2 0.6943 99.8 0.754 Contact Map
2mhcA 1 0.5544 99.8 0.758 Contact Map
4bqqA 2 0.6839 99.8 0.759 Contact Map
2gm5A 4 0.6218 99.7 0.766 Contact Map
3pkzA 4 0.5751 99.7 0.771 Contact Map
1gdtA 2 0.6891 99.7 0.771 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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