Q97XQ0 - SULSO - GREMLIN Contacts

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Q97XQ0 - Second ORF in transposon ISC1904

UniProt:	Q97XQ0	Sequences: MLKNLRIRKFEPEEEYVYFTYSIKNSEREKSKELIKEYRTLLQKAIDYLWSLTKIQVRKKNGNYKITLPKKREVYKPLRDELEKINHLASHYVDKAINNAFSIITSWRKRAIKGRASIEKPTLKKAYVKVKSTLRKVVGESVRITVRPHEYITFSWSKSWFSRRVRELELGEPIIKEEKVYLPFRYKLPWATPVNFLAIDSNLYTLDAYDGEKFVTISLKQLYSLKYSMEVKRAKVQSFASKHTKRGRELLRKYSHRERNRVLDFVHKFVNTLLDLYPVTFFAVEKLDKESMFKDANDSLSRKISRTVWGSIHKVLEYKAPLYGSFVKEVNPYLTSRSCPRCGFVSRKVGKTFECERCGFKLDRQLNASLNIYLKMCGFPHIRDVPRVWVGVIPLMGRRGMNVRDFGEAQGLRIDIKYHEIL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	422 (345)
Sequences:	4387 (2822)
Seq/√Len:	151.9

ECOLI - INSQ
HALSA - Q9HSW9 Q9HM87 Q9HHJ9 Q9HSW7 Q9HHG8 Q9HSZ6 Q9HSD4 Q9HHU6 Q9HSY4 Q9HHX8
SULSO - Q97XQ0 Q97U51 Q97Z61 Q97YI5 Q97YW9 Q97YU1 Q97U68 Q97UQ8 Q97XB6 Q97Y48 Q97XQ8 Q97YI2 Q97WZ3 Q97V25 Q97V47 Q97X39 Q97Y44 Q97XP1 Q97Y67 Q97YW4 Q97XA4 Q97V53 Q7LXH2 Q7LXD9 Q97WY6 Q7LXH6 Q97YF7 Q97U09 Y2105 Q7LX59

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
264_D	268_K	5.420	1.00
288_D	291_S	4.482	1.00
340_P	367_N	4.233	1.00
320_A	327_V	3.724	1.00
283_A	376_M	3.065	1.00
206_L	312_I	3.002	1.00
313_H	329_E	2.972	1.00
19_F	322_L	2.941	1.00
284_V	316_L	2.935	1.00
311_S	315_V	2.818	1.00
271_N	275_D	2.721	1.00
347_R	350_G	2.691	1.00
338_S	345_V	2.482	1.00
173_P	182_L	2.480	1.00
312_I	316_L	2.468	1.00
317_E	329_E	2.416	1.00
274_L	320_A	2.409	1.00
311_S	314_K	2.356	1.00
334_L	337_R	2.299	1.00
226_K	302_R	2.286	1.00
330_V	372_I	2.276	1.00
293_F	305_S	2.225	1.00
171_G	187_K	2.176	1.00
375_K	378_G	2.153	1.00
282_F	320_A	2.104	1.00
232_K	247_G	2.071	1.00
225_L	261_R	2.068	1.00
267_H	315_V	2.064	1.00
284_V	327_V	2.056	1.00
354_E	361_K	2.045	1.00
267_H	318_Y	2.030	1.00
335_T	372_I	2.017	1.00
298_D	301_S	1.997	1.00
263_L	311_S	1.962	1.00
206_L	265_F	1.949	1.00
49_L	97_I	1.946	1.00
28_R	31_S	1.929	1.00
270_V	315_V	1.925	1.00
342_C	358_C	1.921	1.00
54_K	120_K	1.903	1.00
36_K	180_V	1.880	1.00
317_E	321_P	1.860	1.00
37_E	87_H	1.859	1.00
266_V	315_V	1.847	1.00
247_G	251_L	1.826	1.00
353_F	362_L	1.808	1.00
280_T	325_S	1.806	1.00
351_K	364_R	1.782	1.00
339_C	342_C	1.782	1.00
341_R	360_F	1.764	1.00
339_C	358_C	1.751	1.00
342_C	355_C	1.745	1.00
355_C	358_C	1.720	1.00
50_W	100_A	1.720	1.00
242_K	245_K	1.718	1.00
267_H	319_K	1.711	1.00
337_R	346_S	1.702	1.00
267_H	270_V	1.685	1.00
232_K	235_K	1.679	1.00
44_K	84_K	1.674	1.00
284_V	329_E	1.654	1.00
266_V	311_S	1.623	1.00
339_C	355_C	1.609	1.00
245_K	248_R	1.589	1.00
199_I	207_D	1.586	1.00
286_K	329_E	1.565	1.00
68_L	72_R	1.553	1.00
284_V	313_H	1.542	1.00
35_I	180_V	1.535	1.00
20_T	183_P	1.531	1.00
352_T	361_K	1.521	1.00
33_E	37_E	1.504	1.00
208_A	366_L	1.503	1.00
101_F	105_T	1.502	1.00
106_S	118_I	1.498	1.00
344_F	356_E	1.493	1.00
236_V	248_R	1.478	1.00
32_K	36_K	1.472	1.00
353_F	360_F	1.466	1.00
196_F	373_Y	1.464	1.00
49_L	100_A	1.457	1.00
110_R	118_I	1.447	1.00
39_R	180_V	1.447	1.00
270_V	318_Y	1.437	1.00
348_K	351_K	1.432	1.00
69_P	72_R	1.411	1.00
205_T	208_A	1.390	1.00
317_E	327_V	1.370	1.00
285_E	332_P	1.364	1.00
370_L	374_L	1.338	1.00
270_V	319_K	1.336	1.00
111_A	118_I	1.329	1.00
91_H	131_K	1.327	1.00
256_H	260_N	1.325	1.00
57_V	61_N	1.320	1.00
304_I	309_W	1.319	1.00
209_Y	213_K	1.308	1.00
197_L	209_Y	1.304	1.00
232_K	254_Y	1.298	1.00
105_T	109_K	1.296	1.00
177_E	256_H	1.293	1.00
142_V	145_T	1.261	1.00
139_G	142_V	1.253	1.00
179_K	256_H	1.251	1.00
229_M	255_S	1.240	1.00
288_D	332_P	1.214	1.00
196_F	281_F	1.208	1.00
102_S	106_S	1.195	1.00
104_I	120_K	1.190	1.00
27_E	31_S	1.190	1.00
29_E	32_K	1.175	1.00
225_L	258_E	1.170	1.00
366_L	370_L	1.166	1.00
270_V	312_I	1.165	1.00
79_R	93_V	1.161	1.00
24_K	179_K	1.159	1.00
99_N	129_K	1.159	1.00
229_M	251_L	1.155	1.00
95_K	98_N	1.154	1.00
70_K	73_E	1.148	1.00
274_L	323_Y	1.146	1.00
233_R	237_Q	1.144	1.00
340_P	370_L	1.143	1.00
42_L	96_A	1.141	1.00
272_T	276_L	1.139	1.00
240_A	244_T	1.138	1.00
276_L	279_V	1.131	1.00
201_S	309_W	1.127	1.00
59_K	62_G	1.126	1.00
263_L	315_V	1.124	1.00
91_H	133_T	1.114	0.99
340_P	362_L	1.108	0.99
266_V	312_I	1.103	0.99
138_V	141_S	1.103	0.99
59_K	63_N	1.101	0.99
295_D	301_S	1.101	0.99
259_R	263_L	1.099	0.99
203_L	307_T	1.099	0.99
199_I	209_Y	1.095	0.99
201_S	313_H	1.094	0.99
315_V	318_Y	1.092	0.99
46_I	96_A	1.088	0.99
145_T	151_Y	1.086	0.99
106_S	111_A	1.086	0.99
214_F	363_D	1.085	0.99
110_R	119_E	1.080	0.99
335_T	375_K	1.075	0.99
198_A	373_Y	1.075	0.99
89_A	92_Y	1.073	0.99
270_V	316_L	1.070	0.99
71_K	74_V	1.064	0.99
362_L	370_L	1.064	0.99
128_V	131_K	1.058	0.99
295_D	299_S	1.053	0.99
228_S	232_K	1.051	0.99
271_N	323_Y	1.050	0.99
337_R	345_V	1.042	0.99
275_D	323_Y	1.040	0.99
348_K	364_R	1.039	0.99
319_K	322_L	1.032	0.99
21_Y	186_Y	1.026	0.99
71_K	75_Y	1.022	0.99
274_L	282_F	1.017	0.99
266_V	270_V	1.017	0.99
338_S	375_K	1.014	0.99
196_F	377_C	1.013	0.99
62_G	65_K	1.009	0.99
295_D	298_D	1.008	0.99
330_V	375_K	1.006	0.99
27_E	35_I	1.001	0.99
205_T	216_T	0.998	0.99
57_V	60_K	0.998	0.99
134_L	137_V	0.997	0.99
286_K	332_P	0.990	0.99
230_E	233_R	0.988	0.99
289_K	310_G	0.987	0.99
274_L	325_S	0.983	0.99
232_K	250_L	0.978	0.99
41_L	84_K	0.978	0.99
213_K	272_T	0.978	0.99
52_L	74_V	0.970	0.99
362_L	366_L	0.968	0.99
233_R	251_L	0.967	0.99
106_S	110_R	0.965	0.98
347_R	351_K	0.961	0.98
69_P	73_E	0.960	0.98
283_A	372_I	0.960	0.98
232_K	251_L	0.957	0.98
193_P	280_T	0.955	0.98
128_V	132_S	0.954	0.98
236_V	251_L	0.953	0.98
340_P	368_A	0.947	0.98
330_V	376_M	0.946	0.98
344_F	357_R	0.946	0.98
340_P	360_F	0.943	0.98
50_W	104_I	0.942	0.98
144_I	182_L	0.938	0.98
68_L	98_N	0.935	0.98
58_R	62_G	0.932	0.98
273_L	282_F	0.932	0.98
351_K	363_D	0.931	0.98
107_W	121_P	0.929	0.98
208_A	214_F	0.928	0.98
76_K	80_D	0.926	0.98
244_T	248_R	0.918	0.98
44_K	48_Y	0.915	0.98
40_T	43_Q	0.913	0.98
66_I	71_K	0.912	0.98
347_R	364_R	0.910	0.98
314_K	317_E	0.910	0.98
346_S	350_G	0.909	0.98
107_W	120_K	0.906	0.98
207_D	269_F	0.903	0.98
254_Y	258_E	0.902	0.98
76_K	79_R	0.900	0.98
63_N	66_I	0.899	0.98
366_L	369_S	0.898	0.98
350_G	364_R	0.895	0.98
129_K	172_E	0.894	0.98
320_A	325_S	0.894	0.98
332_P	335_T	0.893	0.97
106_S	109_K	0.888	0.97
99_N	174_I	0.884	0.97
281_F	326_F	0.884	0.97
142_V	146_V	0.884	0.97
95_K	129_K	0.881	0.97
218_S	307_T	0.880	0.97
352_T	362_L	0.880	0.97
46_I	100_A	0.878	0.97
221_Q	261_R	0.874	0.97
136_K	145_T	0.873	0.97
197_L	210_D	0.870	0.97
266_V	308_V	0.869	0.97
196_F	283_A	0.869	0.97
230_E	234_A	0.866	0.97
53_T	101_F	0.865	0.97
197_L	282_F	0.864	0.97
91_H	95_K	0.857	0.97
134_L	147_R	0.857	0.97
32_K	180_V	0.855	0.97
67_T	70_K	0.855	0.97
46_I	103_I	0.853	0.97
250_L	253_K	0.852	0.97
229_M	258_E	0.851	0.97
341_R	370_L	0.848	0.97
334_L	375_K	0.843	0.96
77_P	81_E	0.840	0.96
281_F	328_K	0.840	0.96
73_E	76_K	0.839	0.96
271_N	319_K	0.838	0.96
54_K	104_I	0.834	0.96
236_V	247_G	0.834	0.96
18_Y	185_R	0.833	0.96
91_H	132_S	0.833	0.96
203_L	303_K	0.827	0.96
368_A	371_N	0.827	0.96
257_R	261_R	0.826	0.96
289_K	309_W	0.825	0.96
201_S	207_D	0.824	0.96
70_K	75_Y	0.815	0.96
59_K	64_Y	0.814	0.96
338_S	371_N	0.800	0.95
344_F	353_F	0.799	0.95
143_R	151_Y	0.798	0.95
146_V	175_I	0.796	0.95
248_R	252_R	0.794	0.95
367_N	371_N	0.794	0.95
353_F	364_R	0.792	0.95
48_Y	52_L	0.792	0.95
25_N	182_L	0.790	0.95
370_L	373_Y	0.785	0.95
291_S	304_I	0.784	0.95
34_L	38_Y	0.783	0.95
233_R	255_S	0.782	0.95
291_S	332_P	0.776	0.94
350_G	353_F	0.776	0.94
52_L	78_L	0.775	0.94
53_T	104_I	0.774	0.94
94_D	98_N	0.774	0.94
18_Y	187_K	0.774	0.94
67_T	71_K	0.773	0.94
340_P	374_L	0.770	0.94
66_I	70_K	0.770	0.94
241_S	244_T	0.769	0.94
204_Y	208_A	0.767	0.94
221_Q	225_L	0.766	0.94
85_I	93_V	0.765	0.94
135_R	170_L	0.765	0.94
293_F	301_S	0.761	0.94
194_V	280_T	0.761	0.94
229_M	237_Q	0.761	0.94
91_H	134_L	0.761	0.94
205_T	214_F	0.757	0.94
328_K	376_M	0.756	0.94
91_H	94_D	0.755	0.94
265_F	269_F	0.751	0.93
231_V	235_K	0.747	0.93
230_E	237_Q	0.745	0.93
41_L	88_L	0.745	0.93
375_K	379_F	0.742	0.93
174_I	183_P	0.742	0.93
29_E	33_E	0.742	0.93
175_I	182_L	0.739	0.93
334_L	338_S	0.738	0.93
200_D	365_Q	0.735	0.93
74_V	78_L	0.735	0.93
75_Y	79_R	0.734	0.93
146_V	149_H	0.733	0.93
136_K	139_G	0.733	0.93
144_I	173_P	0.732	0.92
95_K	131_K	0.730	0.92
229_M	233_R	0.728	0.92
60_K	63_N	0.728	0.92
214_F	366_L	0.728	0.92
95_K	99_N	0.725	0.92
154_F	157_S	0.725	0.92
283_A	328_K	0.724	0.92
45_A	96_A	0.721	0.92
149_H	152_I	0.720	0.92
176_K	179_K	0.719	0.92
195_N	211_G	0.715	0.92
269_F	272_T	0.715	0.92
72_R	97_I	0.715	0.92
23_I	182_L	0.714	0.92
222_L	225_L	0.714	0.92
40_T	44_K	0.713	0.91
58_R	61_N	0.713	0.91
276_L	280_T	0.709	0.91
283_A	373_Y	0.709	0.91
37_E	41_L	0.709	0.91
97_I	101_F	0.708	0.91
100_A	104_I	0.708	0.91
68_L	97_I	0.706	0.91
258_E	306_R	0.706	0.91
287_L	332_P	0.705	0.91
310_G	314_K	0.704	0.91
129_K	132_S	0.703	0.91
346_S	353_F	0.700	0.91
300_L	304_I	0.699	0.91
202_N	208_A	0.699	0.91
35_I	39_R	0.694	0.90
75_Y	78_L	0.692	0.90
172_E	185_R	0.689	0.90
169_E	187_K	0.688	0.90
103_I	121_P	0.687	0.90
104_I	107_W	0.687	0.90
44_K	82_L	0.686	0.90
376_M	380_P	0.684	0.90
96_A	100_A	0.683	0.90
23_I	164_R	0.683	0.90
232_K	236_V	0.679	0.89
92_Y	128_V	0.675	0.89
41_L	85_I	0.675	0.89
206_L	270_V	0.674	0.89
88_L	91_H	0.674	0.89
192_T	195_N	0.673	0.89
72_R	76_K	0.672	0.89
334_L	345_V	0.671	0.89
72_R	75_Y	0.671	0.89
24_K	181_Y	0.671	0.89
41_L	44_K	0.670	0.89
286_K	313_H	0.668	0.89
235_K	247_G	0.662	0.88
190_W	325_S	0.661	0.88
275_D	281_F	0.656	0.88
75_Y	97_I	0.656	0.88
263_L	267_H	0.655	0.88
38_Y	42_L	0.654	0.88
51_S	123_L	0.653	0.87
236_V	244_T	0.652	0.87
209_Y	215_V	0.651	0.87
90_S	131_K	0.650	0.87
234_A	238_S	0.650	0.87
70_K	74_V	0.648	0.87
237_Q	251_L	0.645	0.87
23_I	165_V	0.644	0.87
215_V	265_F	0.644	0.87
206_L	307_T	0.642	0.87
289_K	292_M	0.642	0.87
195_N	280_T	0.641	0.87
218_S	221_Q	0.640	0.86
372_I	375_K	0.636	0.86
356_E	364_R	0.635	0.86
127_Y	131_K	0.634	0.86
207_D	312_I	0.633	0.86
68_L	73_E	0.632	0.86
48_Y	78_L	0.632	0.86
17_V	187_K	0.632	0.86
104_I	108_R	0.629	0.85
245_K	249_E	0.627	0.85
38_Y	130_V	0.626	0.85
127_Y	130_V	0.626	0.85
316_L	327_V	0.623	0.85
68_L	71_K	0.623	0.85
131_K	134_L	0.621	0.85
283_A	375_K	0.620	0.85
129_K	174_I	0.618	0.84
190_W	193_P	0.617	0.84
282_F	316_L	0.616	0.84
93_V	96_A	0.616	0.84
27_E	32_K	0.614	0.84
18_Y	171_G	0.613	0.84
25_N	154_F	0.613	0.84
262_V	306_R	0.613	0.84
38_Y	89_A	0.612	0.84
374_L	377_C	0.611	0.84
235_K	238_S	0.611	0.84
179_K	260_N	0.610	0.84
133_T	136_K	0.610	0.84
75_Y	94_D	0.610	0.84
347_R	363_D	0.610	0.84
362_L	367_N	0.609	0.84
30_K	33_E	0.609	0.84
225_L	257_R	0.608	0.84
346_S	351_K	0.608	0.84
338_S	343_G	0.608	0.84
38_Y	88_L	0.607	0.83
26_S	155_S	0.607	0.83
200_D	336_S	0.604	0.83
63_N	67_T	0.604	0.83
206_L	266_V	0.603	0.83
298_D	305_S	0.603	0.83
289_K	304_I	0.597	0.82
244_T	251_L	0.597	0.82
320_A	323_Y	0.596	0.82
66_I	69_P	0.595	0.82
74_V	77_P	0.594	0.82
107_W	110_R	0.594	0.82
269_F	312_I	0.594	0.82
138_V	143_R	0.590	0.82
20_T	185_R	0.586	0.81
313_H	317_E	0.585	0.81
66_I	75_Y	0.583	0.81
53_T	71_K	0.583	0.81
90_S	133_T	0.582	0.81
255_S	259_R	0.581	0.81
234_A	237_Q	0.581	0.81
230_E	238_S	0.581	0.81
225_L	254_Y	0.579	0.80
128_V	134_L	0.578	0.80
22_S	183_P	0.575	0.80
69_P	75_Y	0.573	0.80
151_Y	157_S	0.573	0.80
223_Y	302_R	0.571	0.80
255_S	262_V	0.571	0.80
22_S	263_L	0.570	0.79
146_V	152_I	0.569	0.79
204_Y	351_K	0.569	0.79
66_I	74_V	0.568	0.79
156_W	164_R	0.568	0.79
90_S	134_L	0.568	0.79
97_I	100_A	0.567	0.79
37_E	40_T	0.566	0.79
346_S	364_R	0.565	0.79
144_I	147_R	0.559	0.78
71_K	79_R	0.559	0.78
223_Y	226_K	0.559	0.78
377_C	380_P	0.558	0.78
374_L	379_F	0.558	0.78
109_K	118_I	0.557	0.78
76_K	97_I	0.557	0.78
181_Y	256_H	0.555	0.78
350_G	356_E	0.554	0.77
58_R	63_N	0.554	0.77
34_L	37_E	0.553	0.77
143_R	146_V	0.553	0.77
341_R	362_L	0.553	0.77
70_K	78_L	0.551	0.77
23_I	163_R	0.546	0.76
338_S	353_F	0.543	0.76
260_N	263_L	0.542	0.76
62_G	66_I	0.542	0.76
244_T	247_G	0.542	0.76
348_K	363_D	0.542	0.76
57_V	62_G	0.541	0.76
88_L	93_V	0.541	0.76
223_Y	303_K	0.539	0.76
235_K	250_L	0.539	0.76
92_Y	130_V	0.538	0.75
71_K	94_D	0.536	0.75
293_F	298_D	0.534	0.75
203_L	294_K	0.534	0.75
65_K	71_K	0.532	0.75
243_H	246_R	0.531	0.75
318_Y	322_L	0.531	0.75
138_V	145_T	0.530	0.74
39_R	128_V	0.529	0.74
260_N	264_D	0.526	0.74
233_R	238_S	0.524	0.74
65_K	70_K	0.521	0.73
315_V	319_K	0.520	0.73
222_L	226_K	0.520	0.73
342_C	345_V	0.519	0.73
74_V	97_I	0.518	0.73
225_L	229_M	0.517	0.73
30_K	34_L	0.516	0.72
300_L	303_K	0.515	0.72
157_S	163_R	0.514	0.72
39_R	42_L	0.513	0.72
27_E	152_I	0.513	0.72
363_D	368_A	0.511	0.72
360_F	366_L	0.511	0.72
69_P	79_R	0.511	0.72
181_Y	260_N	0.510	0.72
164_R	167_E	0.510	0.72
333_Y	337_R	0.510	0.72
236_V	240_A	0.509	0.71
67_T	98_N	0.507	0.71
354_E	360_F	0.507	0.71
258_E	262_V	0.507	0.71
310_G	313_H	0.506	0.71
334_L	353_F	0.505	0.71
64_Y	70_K	0.505	0.71
171_G	185_R	0.505	0.71
48_Y	84_K	0.503	0.71
210_D	366_L	0.501	0.70
291_S	294_K	0.500	0.70
283_A	377_C	0.500	0.70

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1nu0A	1	0.3081	95.9	0.93	Contact Map
1vhxA	2	0.3246	95.3	0.933	Contact Map
1iv0A	1	0.2299	93.2	0.939	Contact Map
4aybP	1	0.0948	82.8	0.95	Contact Map
1qypA	1	0.1019	81.9	0.95	Contact Map
2k4xA	1	0.1256	81.5	0.951	Contact Map
1ffkW	1	0.1564	81.2	0.951	Contact Map
3j20Y	1	0.1137	79.6	0.951	Contact Map
3j3w0	1	0.1303	70.1	0.955	Contact Map
4ep4A	2	0.3768	69.7	0.955	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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