GREMLIN Database
Q97XQ0 - Second ORF in transposon ISC1904
UniProt: Q97XQ0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 422 (345)
Sequences: 4387 (2822)
Seq/√Len: 151.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
264_D268_K5.4201.00
288_D291_S4.4821.00
340_P367_N4.2331.00
320_A327_V3.7241.00
283_A376_M3.0651.00
206_L312_I3.0021.00
313_H329_E2.9721.00
19_F322_L2.9411.00
284_V316_L2.9351.00
311_S315_V2.8181.00
271_N275_D2.7211.00
347_R350_G2.6911.00
338_S345_V2.4821.00
173_P182_L2.4801.00
312_I316_L2.4681.00
317_E329_E2.4161.00
274_L320_A2.4091.00
311_S314_K2.3561.00
334_L337_R2.2991.00
226_K302_R2.2861.00
330_V372_I2.2761.00
293_F305_S2.2251.00
171_G187_K2.1761.00
375_K378_G2.1531.00
282_F320_A2.1041.00
232_K247_G2.0711.00
225_L261_R2.0681.00
267_H315_V2.0641.00
284_V327_V2.0561.00
354_E361_K2.0451.00
267_H318_Y2.0301.00
335_T372_I2.0171.00
298_D301_S1.9971.00
263_L311_S1.9621.00
206_L265_F1.9491.00
49_L97_I1.9461.00
28_R31_S1.9291.00
270_V315_V1.9251.00
342_C358_C1.9211.00
54_K120_K1.9031.00
36_K180_V1.8801.00
317_E321_P1.8601.00
37_E87_H1.8591.00
266_V315_V1.8471.00
247_G251_L1.8261.00
353_F362_L1.8081.00
280_T325_S1.8061.00
351_K364_R1.7821.00
339_C342_C1.7821.00
341_R360_F1.7641.00
339_C358_C1.7511.00
342_C355_C1.7451.00
355_C358_C1.7201.00
50_W100_A1.7201.00
242_K245_K1.7181.00
267_H319_K1.7111.00
337_R346_S1.7021.00
267_H270_V1.6851.00
232_K235_K1.6791.00
44_K84_K1.6741.00
284_V329_E1.6541.00
266_V311_S1.6231.00
339_C355_C1.6091.00
245_K248_R1.5891.00
199_I207_D1.5861.00
286_K329_E1.5651.00
68_L72_R1.5531.00
284_V313_H1.5421.00
35_I180_V1.5351.00
20_T183_P1.5311.00
352_T361_K1.5211.00
33_E37_E1.5041.00
208_A366_L1.5031.00
101_F105_T1.5021.00
106_S118_I1.4981.00
344_F356_E1.4931.00
236_V248_R1.4781.00
32_K36_K1.4721.00
353_F360_F1.4661.00
196_F373_Y1.4641.00
49_L100_A1.4571.00
110_R118_I1.4471.00
39_R180_V1.4471.00
270_V318_Y1.4371.00
348_K351_K1.4321.00
69_P72_R1.4111.00
205_T208_A1.3901.00
317_E327_V1.3701.00
285_E332_P1.3641.00
370_L374_L1.3381.00
270_V319_K1.3361.00
111_A118_I1.3291.00
91_H131_K1.3271.00
256_H260_N1.3251.00
57_V61_N1.3201.00
304_I309_W1.3191.00
209_Y213_K1.3081.00
197_L209_Y1.3041.00
232_K254_Y1.2981.00
105_T109_K1.2961.00
177_E256_H1.2931.00
142_V145_T1.2611.00
139_G142_V1.2531.00
179_K256_H1.2511.00
229_M255_S1.2401.00
288_D332_P1.2141.00
196_F281_F1.2081.00
102_S106_S1.1951.00
104_I120_K1.1901.00
27_E31_S1.1901.00
29_E32_K1.1751.00
225_L258_E1.1701.00
366_L370_L1.1661.00
270_V312_I1.1651.00
79_R93_V1.1611.00
24_K179_K1.1591.00
99_N129_K1.1591.00
229_M251_L1.1551.00
95_K98_N1.1541.00
70_K73_E1.1481.00
274_L323_Y1.1461.00
233_R237_Q1.1441.00
340_P370_L1.1431.00
42_L96_A1.1411.00
272_T276_L1.1391.00
240_A244_T1.1381.00
276_L279_V1.1311.00
201_S309_W1.1271.00
59_K62_G1.1261.00
263_L315_V1.1241.00
91_H133_T1.1140.99
340_P362_L1.1080.99
266_V312_I1.1030.99
138_V141_S1.1030.99
59_K63_N1.1010.99
295_D301_S1.1010.99
259_R263_L1.0990.99
203_L307_T1.0990.99
199_I209_Y1.0950.99
201_S313_H1.0940.99
315_V318_Y1.0920.99
46_I96_A1.0880.99
145_T151_Y1.0860.99
106_S111_A1.0860.99
214_F363_D1.0850.99
110_R119_E1.0800.99
335_T375_K1.0750.99
198_A373_Y1.0750.99
89_A92_Y1.0730.99
270_V316_L1.0700.99
71_K74_V1.0640.99
362_L370_L1.0640.99
128_V131_K1.0580.99
295_D299_S1.0530.99
228_S232_K1.0510.99
271_N323_Y1.0500.99
337_R345_V1.0420.99
275_D323_Y1.0400.99
348_K364_R1.0390.99
319_K322_L1.0320.99
21_Y186_Y1.0260.99
71_K75_Y1.0220.99
274_L282_F1.0170.99
266_V270_V1.0170.99
338_S375_K1.0140.99
196_F377_C1.0130.99
62_G65_K1.0090.99
295_D298_D1.0080.99
330_V375_K1.0060.99
27_E35_I1.0010.99
205_T216_T0.9980.99
57_V60_K0.9980.99
134_L137_V0.9970.99
286_K332_P0.9900.99
230_E233_R0.9880.99
289_K310_G0.9870.99
274_L325_S0.9830.99
232_K250_L0.9780.99
41_L84_K0.9780.99
213_K272_T0.9780.99
52_L74_V0.9700.99
362_L366_L0.9680.99
233_R251_L0.9670.99
106_S110_R0.9650.98
347_R351_K0.9610.98
69_P73_E0.9600.98
283_A372_I0.9600.98
232_K251_L0.9570.98
193_P280_T0.9550.98
128_V132_S0.9540.98
236_V251_L0.9530.98
340_P368_A0.9470.98
330_V376_M0.9460.98
344_F357_R0.9460.98
340_P360_F0.9430.98
50_W104_I0.9420.98
144_I182_L0.9380.98
68_L98_N0.9350.98
58_R62_G0.9320.98
273_L282_F0.9320.98
351_K363_D0.9310.98
107_W121_P0.9290.98
208_A214_F0.9280.98
76_K80_D0.9260.98
244_T248_R0.9180.98
44_K48_Y0.9150.98
40_T43_Q0.9130.98
66_I71_K0.9120.98
347_R364_R0.9100.98
314_K317_E0.9100.98
346_S350_G0.9090.98
107_W120_K0.9060.98
207_D269_F0.9030.98
254_Y258_E0.9020.98
76_K79_R0.9000.98
63_N66_I0.8990.98
366_L369_S0.8980.98
350_G364_R0.8950.98
129_K172_E0.8940.98
320_A325_S0.8940.98
332_P335_T0.8930.97
106_S109_K0.8880.97
99_N174_I0.8840.97
281_F326_F0.8840.97
142_V146_V0.8840.97
95_K129_K0.8810.97
218_S307_T0.8800.97
352_T362_L0.8800.97
46_I100_A0.8780.97
221_Q261_R0.8740.97
136_K145_T0.8730.97
197_L210_D0.8700.97
266_V308_V0.8690.97
196_F283_A0.8690.97
230_E234_A0.8660.97
53_T101_F0.8650.97
197_L282_F0.8640.97
91_H95_K0.8570.97
134_L147_R0.8570.97
32_K180_V0.8550.97
67_T70_K0.8550.97
46_I103_I0.8530.97
250_L253_K0.8520.97
229_M258_E0.8510.97
341_R370_L0.8480.97
334_L375_K0.8430.96
77_P81_E0.8400.96
281_F328_K0.8400.96
73_E76_K0.8390.96
271_N319_K0.8380.96
54_K104_I0.8340.96
236_V247_G0.8340.96
18_Y185_R0.8330.96
91_H132_S0.8330.96
203_L303_K0.8270.96
368_A371_N0.8270.96
257_R261_R0.8260.96
289_K309_W0.8250.96
201_S207_D0.8240.96
70_K75_Y0.8150.96
59_K64_Y0.8140.96
338_S371_N0.8000.95
344_F353_F0.7990.95
143_R151_Y0.7980.95
146_V175_I0.7960.95
248_R252_R0.7940.95
367_N371_N0.7940.95
353_F364_R0.7920.95
48_Y52_L0.7920.95
25_N182_L0.7900.95
370_L373_Y0.7850.95
291_S304_I0.7840.95
34_L38_Y0.7830.95
233_R255_S0.7820.95
291_S332_P0.7760.94
350_G353_F0.7760.94
52_L78_L0.7750.94
53_T104_I0.7740.94
94_D98_N0.7740.94
18_Y187_K0.7740.94
67_T71_K0.7730.94
340_P374_L0.7700.94
66_I70_K0.7700.94
241_S244_T0.7690.94
204_Y208_A0.7670.94
221_Q225_L0.7660.94
85_I93_V0.7650.94
135_R170_L0.7650.94
293_F301_S0.7610.94
194_V280_T0.7610.94
229_M237_Q0.7610.94
91_H134_L0.7610.94
205_T214_F0.7570.94
328_K376_M0.7560.94
91_H94_D0.7550.94
265_F269_F0.7510.93
231_V235_K0.7470.93
230_E237_Q0.7450.93
41_L88_L0.7450.93
375_K379_F0.7420.93
174_I183_P0.7420.93
29_E33_E0.7420.93
175_I182_L0.7390.93
334_L338_S0.7380.93
200_D365_Q0.7350.93
74_V78_L0.7350.93
75_Y79_R0.7340.93
146_V149_H0.7330.93
136_K139_G0.7330.93
144_I173_P0.7320.92
95_K131_K0.7300.92
229_M233_R0.7280.92
60_K63_N0.7280.92
214_F366_L0.7280.92
95_K99_N0.7250.92
154_F157_S0.7250.92
283_A328_K0.7240.92
45_A96_A0.7210.92
149_H152_I0.7200.92
176_K179_K0.7190.92
195_N211_G0.7150.92
269_F272_T0.7150.92
72_R97_I0.7150.92
23_I182_L0.7140.92
222_L225_L0.7140.92
40_T44_K0.7130.91
58_R61_N0.7130.91
276_L280_T0.7090.91
283_A373_Y0.7090.91
37_E41_L0.7090.91
97_I101_F0.7080.91
100_A104_I0.7080.91
68_L97_I0.7060.91
258_E306_R0.7060.91
287_L332_P0.7050.91
310_G314_K0.7040.91
129_K132_S0.7030.91
346_S353_F0.7000.91
300_L304_I0.6990.91
202_N208_A0.6990.91
35_I39_R0.6940.90
75_Y78_L0.6920.90
172_E185_R0.6890.90
169_E187_K0.6880.90
103_I121_P0.6870.90
104_I107_W0.6870.90
44_K82_L0.6860.90
376_M380_P0.6840.90
96_A100_A0.6830.90
23_I164_R0.6830.90
232_K236_V0.6790.89
92_Y128_V0.6750.89
41_L85_I0.6750.89
206_L270_V0.6740.89
88_L91_H0.6740.89
192_T195_N0.6730.89
72_R76_K0.6720.89
334_L345_V0.6710.89
72_R75_Y0.6710.89
24_K181_Y0.6710.89
41_L44_K0.6700.89
286_K313_H0.6680.89
235_K247_G0.6620.88
190_W325_S0.6610.88
275_D281_F0.6560.88
75_Y97_I0.6560.88
263_L267_H0.6550.88
38_Y42_L0.6540.88
51_S123_L0.6530.87
236_V244_T0.6520.87
209_Y215_V0.6510.87
90_S131_K0.6500.87
234_A238_S0.6500.87
70_K74_V0.6480.87
237_Q251_L0.6450.87
23_I165_V0.6440.87
215_V265_F0.6440.87
206_L307_T0.6420.87
289_K292_M0.6420.87
195_N280_T0.6410.87
218_S221_Q0.6400.86
372_I375_K0.6360.86
356_E364_R0.6350.86
127_Y131_K0.6340.86
207_D312_I0.6330.86
68_L73_E0.6320.86
48_Y78_L0.6320.86
17_V187_K0.6320.86
104_I108_R0.6290.85
245_K249_E0.6270.85
38_Y130_V0.6260.85
127_Y130_V0.6260.85
316_L327_V0.6230.85
68_L71_K0.6230.85
131_K134_L0.6210.85
283_A375_K0.6200.85
129_K174_I0.6180.84
190_W193_P0.6170.84
282_F316_L0.6160.84
93_V96_A0.6160.84
27_E32_K0.6140.84
18_Y171_G0.6130.84
25_N154_F0.6130.84
262_V306_R0.6130.84
38_Y89_A0.6120.84
374_L377_C0.6110.84
235_K238_S0.6110.84
179_K260_N0.6100.84
133_T136_K0.6100.84
75_Y94_D0.6100.84
347_R363_D0.6100.84
362_L367_N0.6090.84
30_K33_E0.6090.84
225_L257_R0.6080.84
346_S351_K0.6080.84
338_S343_G0.6080.84
38_Y88_L0.6070.83
26_S155_S0.6070.83
200_D336_S0.6040.83
63_N67_T0.6040.83
206_L266_V0.6030.83
298_D305_S0.6030.83
289_K304_I0.5970.82
244_T251_L0.5970.82
320_A323_Y0.5960.82
66_I69_P0.5950.82
74_V77_P0.5940.82
107_W110_R0.5940.82
269_F312_I0.5940.82
138_V143_R0.5900.82
20_T185_R0.5860.81
313_H317_E0.5850.81
66_I75_Y0.5830.81
53_T71_K0.5830.81
90_S133_T0.5820.81
255_S259_R0.5810.81
234_A237_Q0.5810.81
230_E238_S0.5810.81
225_L254_Y0.5790.80
128_V134_L0.5780.80
22_S183_P0.5750.80
69_P75_Y0.5730.80
151_Y157_S0.5730.80
223_Y302_R0.5710.80
255_S262_V0.5710.80
22_S263_L0.5700.79
146_V152_I0.5690.79
204_Y351_K0.5690.79
66_I74_V0.5680.79
156_W164_R0.5680.79
90_S134_L0.5680.79
97_I100_A0.5670.79
37_E40_T0.5660.79
346_S364_R0.5650.79
144_I147_R0.5590.78
71_K79_R0.5590.78
223_Y226_K0.5590.78
377_C380_P0.5580.78
374_L379_F0.5580.78
109_K118_I0.5570.78
76_K97_I0.5570.78
181_Y256_H0.5550.78
350_G356_E0.5540.77
58_R63_N0.5540.77
34_L37_E0.5530.77
143_R146_V0.5530.77
341_R362_L0.5530.77
70_K78_L0.5510.77
23_I163_R0.5460.76
338_S353_F0.5430.76
260_N263_L0.5420.76
62_G66_I0.5420.76
244_T247_G0.5420.76
348_K363_D0.5420.76
57_V62_G0.5410.76
88_L93_V0.5410.76
223_Y303_K0.5390.76
235_K250_L0.5390.76
92_Y130_V0.5380.75
71_K94_D0.5360.75
293_F298_D0.5340.75
203_L294_K0.5340.75
65_K71_K0.5320.75
243_H246_R0.5310.75
318_Y322_L0.5310.75
138_V145_T0.5300.74
39_R128_V0.5290.74
260_N264_D0.5260.74
233_R238_S0.5240.74
65_K70_K0.5210.73
315_V319_K0.5200.73
222_L226_K0.5200.73
342_C345_V0.5190.73
74_V97_I0.5180.73
225_L229_M0.5170.73
30_K34_L0.5160.72
300_L303_K0.5150.72
157_S163_R0.5140.72
39_R42_L0.5130.72
27_E152_I0.5130.72
363_D368_A0.5110.72
360_F366_L0.5110.72
69_P79_R0.5110.72
181_Y260_N0.5100.72
164_R167_E0.5100.72
333_Y337_R0.5100.72
236_V240_A0.5090.71
67_T98_N0.5070.71
354_E360_F0.5070.71
258_E262_V0.5070.71
310_G313_H0.5060.71
334_L353_F0.5050.71
64_Y70_K0.5050.71
171_G185_R0.5050.71
48_Y84_K0.5030.71
210_D366_L0.5010.70
291_S294_K0.5000.70
283_A377_C0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3081 95.9 0.93 Contact Map
1vhxA 2 0.3246 95.3 0.933 Contact Map
1iv0A 1 0.2299 93.2 0.939 Contact Map
4aybP 1 0.0948 82.8 0.95 Contact Map
1qypA 1 0.1019 81.9 0.95 Contact Map
2k4xA 1 0.1256 81.5 0.951 Contact Map
1ffkW 1 0.1564 81.2 0.951 Contact Map
3j20Y 1 0.1137 79.6 0.951 Contact Map
3j3w0 1 0.1303 70.1 0.955 Contact Map
4ep4A 2 0.3768 69.7 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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