GREMLIN Database
Q97XP8 - N-methylhydantoinase A (HuyA-1)
UniProt: Q97XP8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 683 (647)
Sequences: 2781 (1955)
Seq/√Len: 76.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_F170_V6.3511.00
135_E169_K5.1861.00
139_V176_R4.6731.00
124_K128_D4.6561.00
121_E129_I4.5171.00
171_G185_L4.3711.00
83_K120_T4.0811.00
120_T137_E3.8761.00
392_K396_E3.8701.00
625_K634_E3.8501.00
138_V170_V3.5701.00
400_S404_K3.4361.00
517_E538_R3.2271.00
86_R118_E3.2051.00
135_E173_I3.1641.00
171_G175_K3.0961.00
520_I597_G3.0411.00
143_K147_A3.0191.00
169_K172_E3.0161.00
156_S199_T2.9731.00
673_D677_N2.9411.00
35_D39_N2.9001.00
82_T121_E2.8361.00
139_V177_V2.8121.00
513_F538_R2.7991.00
623_K634_E2.7891.00
78_G145_L2.7191.00
79_L199_T2.6571.00
409_S412_E2.6251.00
78_G117_L2.6011.00
336_R348_R2.5881.00
399_I417_I2.5361.00
124_K130_L2.5231.00
171_G188_E2.4951.00
569_E573_H2.4921.00
74_G207_Y2.4711.00
535_I600_K2.4531.00
98_D101_N2.4491.00
444_T467_K2.4451.00
134_N137_E2.4021.00
494_L515_E2.3921.00
76_K112_P2.3741.00
155_V185_L2.3601.00
335_A417_I2.3261.00
120_T131_T2.3141.00
143_K177_V2.2961.00
391_N394_L2.2921.00
396_E411_E2.2891.00
461_E668_Q2.2821.00
139_V173_I2.2711.00
142_I174_I2.2581.00
146_K177_V2.2101.00
184_T202_A2.1941.00
113_R148_E2.1821.00
668_Q680_I2.1711.00
628_Y635_W2.1631.00
43_E47_E2.1381.00
357_V394_L2.0951.00
639_N642_Y2.0451.00
403_A410_I2.0271.00
146_K151_E2.0241.00
575_A578_I2.0111.00
32_T64_L2.0041.00
627_F632_Y2.0031.00
517_E521_R1.9981.00
626_V635_W1.9921.00
628_Y666_E1.9901.00
672_L678_L1.9891.00
411_E632_Y1.9751.00
360_G391_N1.9711.00
648_Q669_T1.9451.00
394_L398_A1.9391.00
123_I129_I1.9291.00
133_L170_V1.9071.00
133_L166_H1.9011.00
644_P647_Y1.8871.00
155_V174_I1.8791.00
123_I166_H1.8631.00
280_A291_S1.8601.00
270_S278_I1.8501.00
536_M597_G1.8461.00
400_S410_I1.8401.00
169_K173_I1.8281.00
402_I413_V1.8191.00
275_E467_K1.8191.00
529_F599_V1.8121.00
650_V669_T1.8071.00
577_E583_T1.8031.00
137_E141_A1.8001.00
444_T469_I1.8001.00
372_Y455_F1.7951.00
393_R396_E1.7941.00
80_I119_V1.7911.00
494_L512_K1.7741.00
374_V399_I1.7641.00
648_Q671_M1.7431.00
662_S678_L1.7411.00
625_K632_Y1.7401.00
353_Y361_K1.7381.00
155_V170_V1.7381.00
143_K146_K1.7231.00
164_P168_L1.7171.00
268_K271_D1.7091.00
373_I378_L1.6851.00
89_L203_V1.6831.00
133_L169_K1.6821.00
457_P665_L1.6651.00
334_I367_T1.6541.00
73_K348_R1.6421.00
338_D344_K1.6371.00
153_I174_I1.6341.00
168_L172_E1.6341.00
78_G141_A1.6191.00
573_H583_T1.6191.00
287_T326_E1.6151.00
640_K657_D1.6121.00
36_D39_N1.6101.00
34_P352_A1.6101.00
154_A202_A1.6091.00
15_V44_A1.6041.00
422_N455_F1.5981.00
76_K151_E1.5901.00
93_R197_E1.5860.99
120_T134_N1.5860.99
494_L519_K1.5860.99
396_E400_S1.5840.99
182_I209_M1.5840.99
261_A483_M1.5800.99
155_V171_G1.5790.99
567_E571_R1.5770.99
72_R315_Y1.5730.99
75_A151_E1.5690.99
405_Y413_V1.5630.99
72_R207_Y1.5570.99
374_V395_A1.5540.99
374_V410_I1.5450.99
256_E287_T1.5150.99
168_L188_E1.5110.99
608_R674_S1.5040.99
340_T344_K1.5020.99
665_L668_Q1.5000.99
119_V138_V1.4930.99
136_N139_V1.4920.99
173_I177_V1.4860.99
525_I531_E1.4850.99
256_E289_K1.4820.99
172_E176_R1.4810.99
649_I670_G1.4740.99
252_I319_V1.4700.99
336_R344_K1.4680.99
121_E131_T1.4620.99
160_S187_H1.4580.99
123_I163_N1.4540.99
670_G678_L1.4400.99
289_K326_E1.4390.99
60_H215_Y1.4370.99
279_I429_V1.4350.99
394_L397_E1.4320.99
540_A593_F1.4250.99
39_N43_E1.4160.99
492_L520_I1.4100.99
624_R656_E1.4060.99
664_V670_G1.4050.99
537_L598_I1.3970.99
621_V639_N1.3920.99
544_Y576_H1.3900.99
655_I670_G1.3890.99
514_N517_E1.3850.99
654_I663_L1.3820.99
70_V287_T1.3810.99
489_R596_S1.3650.98
402_I405_Y1.3570.98
498_L508_L1.3520.98
447_A453_P1.3350.98
19_N22_N1.3350.98
281_M288_T1.3350.98
194_R550_T1.3340.98
16_V477_V1.3230.98
500_I569_E1.3190.98
569_E588_I1.3180.98
447_A456_A1.3170.98
620_L638_Y1.3150.98
646_N672_L1.3140.98
373_I390_V1.3130.98
168_L187_H1.3110.98
540_A568_I1.3100.98
544_Y573_H1.3070.98
457_P668_Q1.3060.98
358_A373_I1.3050.98
256_E326_E1.3040.98
570_R574_E1.3020.98
377_F418_V1.2950.98
4_V45_I1.2950.98
664_V680_I1.2930.98
395_A399_I1.2790.98
213_S248_K1.2790.98
403_A408_M1.2760.98
467_K679_I1.2760.98
541_E592_N1.2730.98
493_V592_N1.2720.98
564_E567_E1.2700.98
83_K118_E1.2690.98
335_A371_A1.2640.97
401_N405_Y1.2590.97
522_S526_S1.2550.97
514_N518_S1.2550.97
133_L138_V1.2510.97
521_R534_I1.2480.97
135_E139_V1.2470.97
357_V398_A1.2450.97
82_T129_I1.2440.97
517_E536_M1.2420.97
32_T40_G1.2410.97
68_T211_K1.2410.97
536_M595_V1.2360.97
381_E622_G1.2320.97
492_L523_I1.2220.97
384_L388_I1.2180.97
635_W666_E1.2180.97
220_E245_D1.2170.97
368_V421_A1.2140.97
165_I168_L1.2140.97
530_K533_D1.2130.97
83_K137_E1.2120.97
266_A280_A1.2060.97
146_K178_D1.2050.97
46_D226_R1.2030.97
612_D647_Y1.2000.97
540_A590_I1.2000.97
609_I676_G1.2000.97
510_N538_R1.1990.96
415_Y630_G1.1950.96
192_E318_K1.1930.96
212_M254_T1.1890.96
111_V203_V1.1800.96
397_E400_S1.1760.96
649_I653_A1.1750.96
408_M413_V1.1730.96
541_E552_K1.1720.96
539_Y552_K1.1690.96
81_T88_I1.1650.96
512_K515_E1.1630.96
525_I534_I1.1600.96
77_V152_A1.1520.96
543_R589_E1.1480.96
184_T205_N1.1480.96
88_I195_E1.1440.95
173_I176_R1.1430.95
139_V143_K1.1410.95
117_L145_L1.1390.95
28_A31_E1.1380.95
393_R397_E1.1380.95
271_D276_K1.1370.95
80_I141_A1.1340.95
619_A642_Y1.1320.95
186_S202_A1.1300.95
190_T318_K1.1260.95
379_N656_E1.1240.95
618_K642_Y1.1200.95
373_I392_K1.1190.95
372_Y422_N1.1160.95
623_K636_N1.1150.95
640_K678_L1.1140.95
457_P680_I1.1120.95
117_L141_A1.1090.95
545_Y587_P1.1080.95
117_L144_K1.1050.94
379_N383_L1.1030.94
138_V141_A1.1020.94
628_Y663_L1.0970.94
494_L516_L1.0910.94
158_I195_E1.0900.94
275_E679_I1.0880.94
65_A208_V1.0870.94
377_F458_F1.0850.94
142_I170_V1.0840.94
68_T73_K1.0830.94
541_E594_H1.0810.94
277_N442_E1.0800.94
238_N491_D1.0800.94
47_E387_K1.0730.94
571_R575_A1.0710.93
38_S218_K1.0680.93
551_V579_A1.0670.93
620_L623_K1.0640.93
232_Y244_F1.0640.93
35_D353_Y1.0620.93
379_N624_R1.0610.93
129_I132_S1.0580.93
270_S446_V1.0520.93
571_R574_E1.0500.93
119_V141_A1.0480.93
83_K131_T1.0430.93
643_L672_L1.0370.92
510_N514_N1.0360.92
146_K180_N1.0340.92
19_N24_E1.0290.92
576_H583_T1.0290.92
492_L519_K1.0280.92
518_S522_S1.0270.92
637_V654_I1.0220.92
640_K662_S1.0210.92
513_F517_E1.0130.91
279_I440_P1.0110.91
576_H582_F1.0100.91
372_Y377_F1.0090.91
153_I178_D1.0090.91
350_A367_T1.0040.91
42_L46_D1.0030.91
51_N54_Y1.0020.91
488_I529_F0.9990.91
406_Y413_V0.9980.91
419_K629_D0.9940.91
263_V291_S0.9920.91
3_R56_N0.9920.91
193_W495_S0.9890.90
174_I178_D0.9880.90
620_L642_Y0.9840.90
272_I675_Y0.9830.90
422_N458_F0.9820.90
6_I58_I0.9820.90
283_G372_Y0.9810.90
343_L413_V0.9800.90
395_A398_A0.9780.90
415_Y419_K0.9760.90
72_R108_T0.9730.90
403_A413_V0.9730.90
289_K312_N0.9730.90
156_S186_S0.9650.89
477_V659_T0.9590.89
312_N326_E0.9590.89
423_D462_E0.9580.89
144_K148_E0.9560.89
138_V173_I0.9550.89
655_I678_L0.9550.89
534_I597_G0.9550.89
255_L317_V0.9540.89
216_L234_A0.9500.89
624_R637_V0.9490.89
419_K462_E0.9490.89
399_I403_A0.9480.88
645_I676_G0.9470.88
87_D113_R0.9470.88
641_E658_P0.9460.88
65_A254_T0.9450.88
165_I169_K0.9440.88
609_I645_I0.9440.88
475_A660_S0.9440.88
70_V326_E0.9420.88
657_D662_S0.9410.88
357_V364_K0.9410.88
380_Q392_K0.9410.88
638_Y643_L0.9400.88
495_S592_N0.9390.88
276_K295_N0.9390.88
519_K522_S0.9370.88
142_I178_D0.9370.88
41_V219_L0.9360.88
160_S202_A0.9350.88
3_R18_Y0.9340.88
184_T189_V0.9340.88
573_H588_I0.9330.88
521_R531_E0.9330.88
490_H523_I0.9320.88
209_M251_P0.9320.88
447_A470_V0.9310.88
80_I157_F0.9260.87
216_L244_F0.9240.87
136_N140_E0.9210.87
366_V401_N0.9210.87
653_A664_V0.9200.87
145_L150_V0.9190.87
543_R550_T0.9160.87
52_L55_V0.9160.87
78_G150_V0.9140.87
621_V642_Y0.9120.86
40_G44_A0.9090.86
533_D602_K0.9090.86
77_V203_V0.9080.86
112_P150_V0.9060.86
627_F631_K0.9050.86
374_V396_E0.9040.86
256_E324_I0.8990.86
205_N209_M0.8990.86
366_V399_I0.8980.86
487_D603_T0.8960.86
516_L519_K0.8960.86
287_T312_N0.8940.85
81_T195_E0.8930.85
515_E519_K0.8910.85
175_K183_V0.8890.85
620_L636_N0.8880.85
424_N427_N0.8870.85
19_N23_G0.8840.85
500_I542_M0.8830.85
5_G484_L0.8830.85
141_A145_L0.8810.85
542_M588_I0.8810.85
341_S344_K0.8800.84
76_K150_V0.8800.84
79_L156_S0.8780.84
544_Y584_L0.8770.84
138_V142_I0.8720.84
476_G660_S0.8710.84
513_F593_F0.8710.84
619_A638_Y0.8710.84
159_N162_V0.8710.84
415_Y627_F0.8700.84
140_E143_K0.8700.84
4_V55_V0.8680.84
501_D504_S0.8670.84
382_E389_K0.8640.83
33_T40_G0.8630.83
512_K593_F0.8620.83
28_A47_E0.8610.83
626_V654_I0.8610.83
360_G394_L0.8600.83
411_E625_K0.8590.83
201_T252_I0.8590.83
487_D598_I0.8490.82
460_A465_I0.8490.82
395_A410_I0.8480.82
457_P664_V0.8480.82
489_R598_I0.8460.82
616_I619_A0.8450.82
3_R57_T0.8450.82
278_I446_V0.8450.82
78_G153_I0.8440.82
335_A399_I0.8420.82
280_A287_T0.8390.82
88_I199_T0.8370.81
618_K647_Y0.8350.81
290_A327_I0.8340.81
616_I647_Y0.8320.81
475_A659_T0.8320.81
121_E166_H0.8310.81
42_L222_E0.8300.81
132_S169_K0.8300.81
655_I664_V0.8290.81
496_Y512_K0.8290.81
145_L148_E0.8270.81
80_I178_D0.8270.81
15_V28_A0.8270.81
574_E578_I0.8270.81
144_K147_A0.8250.80
142_I177_V0.8240.80
635_W654_I0.8230.80
460_A468_I0.8220.80
236_L253_Y0.8200.80
338_D341_S0.8190.80
30_V43_E0.8180.80
357_V366_V0.8170.80
321_T326_E0.8170.80
151_E180_N0.8170.80
383_L386_G0.8150.80
475_A640_K0.8150.80
119_V170_V0.8140.80
505_S509_I0.8120.79
461_E680_I0.8110.79
135_E172_E0.8090.79
240_G489_R0.8090.79
52_L230_G0.8090.79
61_G261_A0.8080.79
51_N55_V0.8060.79
2_I17_V0.8030.79
507_D511_E0.8030.79
511_E514_N0.8030.79
66_I71_E0.8030.79
397_E401_N0.8020.79
235_M483_M0.8000.78
438_Y443_F0.8000.78
492_L595_V0.8000.78
269_I478_F0.7990.78
288_T326_E0.7990.78
160_S186_S0.7980.78
156_S202_A0.7980.78
275_E444_T0.7970.78
31_E352_A0.7970.78
256_E312_N0.7970.78
86_R113_R0.7960.78
481_W606_L0.7950.78
119_V133_L0.7940.78
164_P187_H0.7940.78
45_I58_I0.7910.78
520_I536_M0.7890.77
4_V17_V0.7880.77
228_F231_N0.7880.77
38_S222_E0.7880.77
506_V510_N0.7880.77
476_G640_K0.7880.77
501_D587_P0.7870.77
37_P64_L0.7870.77
470_V680_I0.7850.77
271_D293_V0.7830.77
521_R525_I0.7790.77
469_I679_I0.7780.76
61_G483_M0.7770.76
553_V575_A0.7750.76
217_S221_N0.7750.76
256_E325_V0.7740.76
283_G421_A0.7710.76
213_S217_S0.7710.76
290_A428_A0.7700.76
283_G455_F0.7660.75
69_I255_L0.7660.75
421_A425_A0.7650.75
192_E493_V0.7640.75
262_G448_Y0.7620.75
236_L242_A0.7610.75
638_Y649_I0.7610.75
537_L554_S0.7600.75
222_E225_N0.7600.75
635_W663_L0.7590.75
70_V212_M0.7570.74
534_I599_V0.7570.74
70_V340_T0.7540.74
649_I655_I0.7530.74
573_H576_H0.7530.74
280_A448_Y0.7520.74
429_V432_I0.7510.74
521_R536_M0.7450.73
119_V137_E0.7430.73
29_K33_T0.7420.73
357_V395_A0.7410.73
292_L438_Y0.7410.73
222_E226_R0.7410.73
398_A401_N0.7410.73
453_P660_S0.7400.73
265_G478_F0.7390.73
80_I170_V0.7390.73
69_I204_L0.7380.73
639_N658_P0.7370.72
279_I433_S0.7370.72
280_A289_K0.7340.72
150_V153_I0.7320.72
283_G451_S0.7310.72
325_V431_L0.7310.72
172_E175_K0.7300.72
498_L505_S0.7280.72
508_L511_E0.7270.71
357_V403_A0.7250.71
37_P40_G0.7230.71
383_L388_I0.7220.71
283_G368_V0.7210.71
337_I402_I0.7200.71
8_I37_P0.7200.71
34_P37_P0.7200.71
337_I405_Y0.7190.71
508_L512_K0.7180.70
530_K534_I0.7170.70
140_E144_K0.7160.70
638_Y647_Y0.7160.70
140_E147_A0.7150.70
43_E46_D0.7150.70
154_A206_A0.7150.70
92_Q96_R0.7130.70
621_V656_E0.7110.70
514_N574_E0.7110.70
70_V256_E0.7090.70
539_Y554_S0.7090.70
549_H580_Y0.7080.69
505_S508_L0.7080.69
174_I177_V0.7060.69
82_T85_F0.7040.69
516_L595_V0.7040.69
396_E410_I0.7030.69
113_R145_L0.7030.69
36_D218_K0.7010.69
621_V638_Y0.7000.69
80_I153_I0.6990.68
205_N252_I0.6990.68
273_L469_I0.6980.68
628_Y631_K0.6980.68
175_K188_E0.6970.68
37_P41_V0.6970.68
110_F207_Y0.6970.68
511_E515_E0.6960.68
134_N138_V0.6960.68
372_Y448_Y0.6950.68
283_G326_E0.6940.68
189_V202_A0.6940.68
177_V180_N0.6930.68
147_A177_V0.6930.68
145_L149_N0.6930.68
504_S509_I0.6880.67
129_I166_H0.6860.67
290_A478_F0.6860.67
185_L188_E0.6810.66
401_N410_I0.6790.66
313_P324_I0.6790.66
151_E177_V0.6790.66
141_A174_I0.6790.66
570_R583_T0.6780.66
141_A144_K0.6770.66
399_I405_Y0.6770.66
280_A479_S0.6770.66
514_N538_R0.6770.66
616_I644_P0.6770.66
142_I173_I0.6760.66
273_L478_F0.6750.66
145_L153_I0.6750.66
77_V154_A0.6750.66
247_A261_A0.6740.66
154_A186_S0.6740.66
80_I174_I0.6730.66
377_F628_Y0.6720.65
626_V663_L0.6720.65
168_L171_G0.6720.65
6_I41_V0.6710.65
402_I578_I0.6700.65
160_S164_P0.6700.65
124_K163_N0.6700.65
364_K398_A0.6690.65
673_D679_I0.6690.65
220_E224_K0.6680.65
92_Q106_K0.6670.65
290_A326_E0.6660.65
81_T156_S0.6650.65
66_I260_V0.6650.65
185_L189_V0.6650.65
624_R654_I0.6640.64
428_A432_I0.6640.64
256_E288_T0.6630.64
608_R675_Y0.6630.64
281_M372_Y0.6620.64
619_A622_G0.6610.64
287_T290_A0.6600.64
88_I102_F0.6600.64
425_A455_F0.6570.64
58_I232_Y0.6570.64
381_E389_K0.6550.63
528_G599_V0.6540.63
425_A459_V0.6530.63
291_S433_S0.6510.63
367_T643_L0.6510.63
456_A468_I0.6510.63
377_F626_V0.6500.63
72_R313_P0.6500.63
509_I593_F0.6500.63
34_P353_Y0.6490.63
372_Y454_M0.6470.62
653_A670_G0.6470.62
499_R545_Y0.6460.62
377_F663_L0.6460.62
368_V417_I0.6430.62
458_F665_L0.6420.62
610_E644_P0.6410.62
403_A409_S0.6410.62
277_N295_N0.6380.61
180_N217_S0.6380.61
550_T576_H0.6380.61
448_Y479_S0.6370.61
294_R438_Y0.6370.61
92_Q97_R0.6370.61
80_I145_L0.6340.61
533_D600_K0.6340.61
492_L527_E0.6330.61
399_I402_I0.6330.61
81_T157_F0.6330.61
513_F536_M0.6320.61
200_S316_P0.6320.61
280_A326_E0.6320.61
30_V44_A0.6310.61
567_E570_R0.6310.61
292_L433_S0.6280.60
119_V153_I0.6280.60
256_E280_A0.6280.60
66_I326_E0.6270.60
495_S549_H0.6270.60
65_A71_E0.6270.60
357_V362_G0.6260.60
608_R612_D0.6250.60
496_Y593_F0.6250.60
152_A209_M0.6240.60
487_D601_A0.6240.60
513_F540_A0.6230.60
542_M568_I0.6230.60
400_S405_Y0.6210.59
52_L228_F0.6210.59
637_V656_E0.6200.59
476_G657_D0.6190.59
655_I672_L0.6180.59
277_N443_F0.6180.59
345_V420_I0.6170.59
399_I413_V0.6170.59
96_R428_A0.6170.59
617_D625_K0.6170.59
268_K485_V0.6170.59
73_K672_L0.6160.59
626_V631_K0.6150.59
35_D361_K0.6140.58
460_A668_Q0.6140.58
575_A579_A0.6140.58
132_S166_H0.6130.58
7_D14_D0.6120.58
483_M550_T0.6120.58
391_N396_E0.6110.58
199_T203_V0.6110.58
628_Y633_E0.6100.58
94_A483_M0.6100.58
266_A278_I0.6100.58
623_K648_Q0.6090.58
504_S507_D0.6090.58
37_P43_E0.6070.58
75_A214_K0.6070.58
470_V662_S0.6070.58
39_N222_E0.6050.57
19_N25_I0.6050.57
9_G14_D0.6040.57
366_V374_V0.6040.57
453_P475_A0.6030.57
421_A455_F0.6030.57
90_E106_K0.6030.57
193_W550_T0.6020.57
69_I314_G0.6010.57
391_N397_E0.6010.57
37_P237_S0.6000.57
66_I454_M0.5980.56
486_S601_A0.5980.56
88_I576_H0.5970.56
66_I288_T0.5970.56
446_V469_I0.5950.56
645_I674_S0.5940.56
126_N130_L0.5930.56
490_H527_E0.5920.56
487_D599_V0.5900.55
123_I133_L0.5900.55
328_G333_S0.5890.55
135_E138_V0.5890.55
143_K172_E0.5890.55
646_N671_M0.5890.55
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235_M261_A0.5870.55
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30_V40_G0.5860.55
215_Y260_V0.5850.55
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136_N147_A0.5830.55
204_L327_I0.5830.55
433_S438_Y0.5820.54
612_D639_N0.5820.54
235_M479_S0.5810.54
613_N618_K0.5800.54
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273_L677_N0.5790.54
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366_V417_I0.5770.54
326_E329_N0.5750.54
537_L596_S0.5750.54
96_R100_Y0.5730.53
491_D594_H0.5730.53
611_R645_I0.5720.53
165_I172_E0.5720.53
214_K218_K0.5710.53
613_N647_Y0.5710.53
570_R650_V0.5700.53
552_K594_H0.5700.53
123_I160_S0.5700.53
574_E577_E0.5690.53
335_A368_V0.5690.53
529_F533_D0.5680.53
237_S256_E0.5670.53
590_I598_I0.5670.53
527_E599_V0.5660.52
39_N45_I0.5660.52
141_A149_N0.5640.52
368_V455_F0.5630.52
191_R202_A0.5630.52
287_T311_Y0.5630.52
68_T71_E0.5620.52
556_M567_E0.5620.52
50_V54_Y0.5600.52
428_A476_G0.5600.52
554_S571_R0.5590.52
235_M463_L0.5590.52
372_Y421_A0.5580.51
639_N655_I0.5580.51
502_K617_D0.5580.51
533_D623_K0.5570.51
242_A246_Y0.5570.51
247_A254_T0.5560.51
337_I413_V0.5560.51
137_E140_E0.5560.51
11_A14_D0.5550.51
58_I228_F0.5550.51
200_S313_P0.5550.51
219_L223_F0.5540.51
110_F204_L0.5530.51
195_E547_Q0.5530.51
8_I41_V0.5530.51
289_K313_P0.5530.51
66_I287_T0.5520.51
396_E570_R0.5520.51
85_F486_S0.5520.51
603_T606_L0.5510.51
524_L565_L0.5500.50
7_D10_G0.5500.50
44_A205_N0.5500.50
374_V414_S0.5500.50
499_R587_P0.5500.50
96_R377_F0.5500.50
401_N404_K0.5490.50
35_D43_E0.5490.50
17_V26_S0.5490.50
366_V398_A0.5480.50
289_K324_I0.5480.50
175_K180_N0.5470.50
45_I516_L0.5470.50
87_D96_R0.5470.50
141_A170_V0.5470.50
174_I183_V0.5460.50
327_I427_N0.5460.50
547_Q576_H0.5460.50
487_D600_K0.5450.50
136_N172_E0.5450.50
664_V668_Q0.5450.50
403_A407_N0.5450.50
94_A548_E0.5440.50
289_K321_T0.5440.50
123_I165_I0.5440.50
524_L534_I0.5430.50
71_E479_S0.5430.50
34_P64_L0.5430.50
529_F534_I0.5420.49
234_A254_T0.5420.49
420_I423_D0.5420.49
372_Y418_V0.5420.49
18_Y23_G0.5410.49
493_V541_E0.5400.49
283_G425_A0.5400.49
82_T131_T0.5400.49
143_K175_K0.5400.49
390_V464_D0.5390.49
420_I427_N0.5390.49
10_G13_T0.5390.49
80_I138_V0.5390.49
18_Y22_N0.5380.49
281_M459_V0.5380.49
61_G324_I0.5380.49
93_R440_P0.5380.49
325_V432_I0.5370.49
94_A99_M0.5370.49
40_G291_S0.5370.49
429_V459_V0.5370.49
53_G638_Y0.5360.49
393_R606_L0.5360.49
168_L511_E0.5360.49
509_I590_I0.5360.49
154_A184_T0.5350.48
237_S324_I0.5350.48
192_E430_R0.5340.48
366_V395_A0.5340.48
133_L157_F0.5340.48
2_I5_G0.5340.48
242_A483_M0.5330.48
2_I41_V0.5330.48
630_G633_E0.5330.48
132_S138_V0.5320.48
263_V280_A0.5320.48
556_M571_R0.5320.48
421_A424_N0.5320.48
525_I528_G0.5300.48
28_A44_A0.5300.48
570_R617_D0.5300.48
8_I384_L0.5300.48
40_G47_E0.5290.48
507_D650_V0.5290.48
617_D620_L0.5290.48
59_I483_M0.5270.47
623_K639_N0.5270.47
205_N247_A0.5270.47
171_G183_V0.5270.47
317_V591_V0.5260.47
657_D660_S0.5260.47
292_L328_G0.5250.47
412_E415_Y0.5240.47
217_S220_E0.5240.47
372_Y430_R0.5230.47
143_K655_I0.5230.47
90_E156_S0.5230.47
401_N565_L0.5230.47
142_I153_I0.5220.47
452_G456_A0.5220.47
54_Y625_K0.5220.47
404_K633_E0.5220.47
422_N443_F0.5210.47
134_N169_K0.5210.47
25_I168_L0.5210.47
289_K325_V0.5210.47
515_E518_S0.5200.47
132_S137_E0.5190.46
37_P45_I0.5190.46
143_K151_E0.5190.46
65_A212_M0.5190.46
129_I165_I0.5190.46
193_W478_F0.5190.46
415_Y631_K0.5180.46
204_L317_V0.5180.46
37_P430_R0.5180.46
620_L647_Y0.5180.46
97_R241_M0.5180.46
143_K173_I0.5180.46
15_V40_G0.5180.46
290_A451_S0.5170.46
264_I485_V0.5160.46
217_S248_K0.5160.46
649_I664_V0.5160.46
495_S580_Y0.5160.46
423_D427_N0.5150.46
500_I590_I0.5140.46
397_E608_R0.5130.46
542_M593_F0.5130.46
411_E627_F0.5130.46
323_D436_R0.5130.46
152_A182_I0.5120.46
643_L649_I0.5120.46
334_I348_R0.5120.46
90_E113_R0.5120.46
143_K180_N0.5120.46
601_A604_I0.5120.46
288_T459_V0.5120.46
364_K407_N0.5110.45
583_T588_I0.5110.45
525_I532_K0.5110.45
288_T325_V0.5100.45
538_R595_V0.5090.45
412_E630_G0.5090.45
461_E667_G0.5090.45
117_L148_E0.5090.45
520_I595_V0.5090.45
622_G638_Y0.5090.45
274_G667_G0.5080.45
643_L648_Q0.5080.45
265_G313_P0.5080.45
168_L185_L0.5080.45
7_D11_A0.5080.45
609_I617_D0.5070.45
622_G637_V0.5070.45
288_T445_L0.5070.45
29_K32_T0.5060.45
382_E621_V0.5060.45
360_G388_I0.5060.45
65_A287_T0.5060.45
483_M548_E0.5060.45
136_N664_V0.5050.45
40_G43_E0.5050.45
165_I607_K0.5050.45
409_S567_E0.5040.45
266_A446_V0.5040.45
125_S161_Y0.5040.45
36_D222_E0.5040.45
175_K185_L0.5030.44
50_V288_T0.5030.44
204_L313_P0.5020.44
446_V471_P0.5020.44
580_Y674_S0.5020.44
447_A468_I0.5010.44
200_S203_V0.5000.44
9_G13_T0.5000.44
31_E353_Y0.5000.44
456_A470_V0.5000.44
533_D599_V0.5000.44
204_L254_T0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cetA 2 0.4539 100 0.767 Contact Map
3hz6A 1 0.6428 100 0.878 Contact Map
3ifrA 2 0.6384 100 0.88 Contact Map
2itmA 2 0.6252 99.3 0.945 Contact Map
2zf5O 3 0.6442 99.2 0.946 Contact Map
4a2aA 1 0.5081 99 0.95 Contact Map
2w40A 3 0.6428 99 0.951 Contact Map
2d4wA 2 0.6515 98.9 0.951 Contact Map
2dpnA 2 0.6486 98.9 0.952 Contact Map
3g25A 3 0.6369 98.9 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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