Q97XP8 - SULSO - GREMLIN Contacts

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Q97XP8 - N-methylhydantoinase A (HuyA-1)

UniProt:	Q97XP8	Sequences: MIRVGIDIGGAFTDVVVYNEENGEISWAKVETTPDDPSNGVLEAIDEAKVNLGYVNTIIHGQTLAINTIVERKGAKVGLITTKGFRDILEIQRANRRDMYNFRYKKPTPFVPRYLRLEVTERIKSNGDILTSLNENEVVEAIKKLKAENVEAIAVSFINSYVNPIHELKVGEIIKRVDPNIIVTLSHEVTREWREYERTSTAVLNAYVMPKMSKYLSKLENEFKNRGFKGNYFAMLSNGGMATFDYAKRFPIYTLESGPVAGVIGAIKISDILGEKNIIAMDGGSTTTKASLVRNLEPNINTDYYVGRDKYNPGYPVKVPTLDIVEIGNGGTSIARIDETSNLKVGPRAAGAYPGPVAYGKGGKDVTVTDAYIVCGFLNQEELLGGKIKVNKRLAEEAISNIAKYYNMSIEEVSYGIVKIANDNAVNAVRLISVQRGYDPREFTLVAYGGSGPMFAPFVAEELDIKKIIVPFLPAGVFSAWGMLVSDIRHDLVLSYPLRIDKESSVDLINEKFNELESKIRSILISEGFKEKDIIMLRYAEMRYYGQEHTVKVSVMPGEIGNRELEEIERRFHEAHEIAYAFTLDSPIEIVNFHVSGIVKAKTIVLKRIERDNSSIDKALVGKRKVFYDGKYEEWNVYNKEYLPINYQIVGPAIIEDPTSTSLVLEGQTGMLDSYGNLIIERD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	683 (647)
Sequences:	2781 (1955)
Seq/√Len:	76.8

SULSO - Q97XP8 Q97UR6 Q97WV4 Q97XP3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
157_F	170_V	6.351	1.00
135_E	169_K	5.186	1.00
139_V	176_R	4.673	1.00
124_K	128_D	4.656	1.00
121_E	129_I	4.517	1.00
171_G	185_L	4.371	1.00
83_K	120_T	4.081	1.00
120_T	137_E	3.876	1.00
392_K	396_E	3.870	1.00
625_K	634_E	3.850	1.00
138_V	170_V	3.570	1.00
400_S	404_K	3.436	1.00
517_E	538_R	3.227	1.00
86_R	118_E	3.205	1.00
135_E	173_I	3.164	1.00
171_G	175_K	3.096	1.00
520_I	597_G	3.041	1.00
143_K	147_A	3.019	1.00
169_K	172_E	3.016	1.00
156_S	199_T	2.973	1.00
673_D	677_N	2.941	1.00
35_D	39_N	2.900	1.00
82_T	121_E	2.836	1.00
139_V	177_V	2.812	1.00
513_F	538_R	2.799	1.00
623_K	634_E	2.789	1.00
78_G	145_L	2.719	1.00
79_L	199_T	2.657	1.00
409_S	412_E	2.625	1.00
78_G	117_L	2.601	1.00
336_R	348_R	2.588	1.00
399_I	417_I	2.536	1.00
124_K	130_L	2.523	1.00
171_G	188_E	2.495	1.00
569_E	573_H	2.492	1.00
74_G	207_Y	2.471	1.00
535_I	600_K	2.453	1.00
98_D	101_N	2.449	1.00
444_T	467_K	2.445	1.00
134_N	137_E	2.402	1.00
494_L	515_E	2.392	1.00
76_K	112_P	2.374	1.00
155_V	185_L	2.360	1.00
335_A	417_I	2.326	1.00
120_T	131_T	2.314	1.00
143_K	177_V	2.296	1.00
391_N	394_L	2.292	1.00
396_E	411_E	2.289	1.00
461_E	668_Q	2.282	1.00
139_V	173_I	2.271	1.00
142_I	174_I	2.258	1.00
146_K	177_V	2.210	1.00
184_T	202_A	2.194	1.00
113_R	148_E	2.182	1.00
668_Q	680_I	2.171	1.00
628_Y	635_W	2.163	1.00
43_E	47_E	2.138	1.00
357_V	394_L	2.095	1.00
639_N	642_Y	2.045	1.00
403_A	410_I	2.027	1.00
146_K	151_E	2.024	1.00
575_A	578_I	2.011	1.00
32_T	64_L	2.004	1.00
627_F	632_Y	2.003	1.00
517_E	521_R	1.998	1.00
626_V	635_W	1.992	1.00
628_Y	666_E	1.990	1.00
672_L	678_L	1.989	1.00
411_E	632_Y	1.975	1.00
360_G	391_N	1.971	1.00
648_Q	669_T	1.945	1.00
394_L	398_A	1.939	1.00
123_I	129_I	1.929	1.00
133_L	170_V	1.907	1.00
133_L	166_H	1.901	1.00
644_P	647_Y	1.887	1.00
155_V	174_I	1.879	1.00
123_I	166_H	1.863	1.00
280_A	291_S	1.860	1.00
270_S	278_I	1.850	1.00
536_M	597_G	1.846	1.00
400_S	410_I	1.840	1.00
169_K	173_I	1.828	1.00
402_I	413_V	1.819	1.00
275_E	467_K	1.819	1.00
529_F	599_V	1.812	1.00
650_V	669_T	1.807	1.00
577_E	583_T	1.803	1.00
137_E	141_A	1.800	1.00
444_T	469_I	1.800	1.00
372_Y	455_F	1.795	1.00
393_R	396_E	1.794	1.00
80_I	119_V	1.791	1.00
494_L	512_K	1.774	1.00
374_V	399_I	1.764	1.00
648_Q	671_M	1.743	1.00
662_S	678_L	1.741	1.00
625_K	632_Y	1.740	1.00
353_Y	361_K	1.738	1.00
155_V	170_V	1.738	1.00
143_K	146_K	1.723	1.00
164_P	168_L	1.717	1.00
268_K	271_D	1.709	1.00
373_I	378_L	1.685	1.00
89_L	203_V	1.683	1.00
133_L	169_K	1.682	1.00
457_P	665_L	1.665	1.00
334_I	367_T	1.654	1.00
73_K	348_R	1.642	1.00
338_D	344_K	1.637	1.00
153_I	174_I	1.634	1.00
168_L	172_E	1.634	1.00
78_G	141_A	1.619	1.00
573_H	583_T	1.619	1.00
287_T	326_E	1.615	1.00
640_K	657_D	1.612	1.00
36_D	39_N	1.610	1.00
34_P	352_A	1.610	1.00
154_A	202_A	1.609	1.00
15_V	44_A	1.604	1.00
422_N	455_F	1.598	1.00
76_K	151_E	1.590	1.00
93_R	197_E	1.586	0.99
120_T	134_N	1.586	0.99
494_L	519_K	1.586	0.99
396_E	400_S	1.584	0.99
182_I	209_M	1.584	0.99
261_A	483_M	1.580	0.99
155_V	171_G	1.579	0.99
567_E	571_R	1.577	0.99
72_R	315_Y	1.573	0.99
75_A	151_E	1.569	0.99
405_Y	413_V	1.563	0.99
72_R	207_Y	1.557	0.99
374_V	395_A	1.554	0.99
374_V	410_I	1.545	0.99
256_E	287_T	1.515	0.99
168_L	188_E	1.511	0.99
608_R	674_S	1.504	0.99
340_T	344_K	1.502	0.99
665_L	668_Q	1.500	0.99
119_V	138_V	1.493	0.99
136_N	139_V	1.492	0.99
173_I	177_V	1.486	0.99
525_I	531_E	1.485	0.99
256_E	289_K	1.482	0.99
172_E	176_R	1.481	0.99
649_I	670_G	1.474	0.99
252_I	319_V	1.470	0.99
336_R	344_K	1.468	0.99
121_E	131_T	1.462	0.99
160_S	187_H	1.458	0.99
123_I	163_N	1.454	0.99
670_G	678_L	1.440	0.99
289_K	326_E	1.439	0.99
60_H	215_Y	1.437	0.99
279_I	429_V	1.435	0.99
394_L	397_E	1.432	0.99
540_A	593_F	1.425	0.99
39_N	43_E	1.416	0.99
492_L	520_I	1.410	0.99
624_R	656_E	1.406	0.99
664_V	670_G	1.405	0.99
537_L	598_I	1.397	0.99
621_V	639_N	1.392	0.99
544_Y	576_H	1.390	0.99
655_I	670_G	1.389	0.99
514_N	517_E	1.385	0.99
654_I	663_L	1.382	0.99
70_V	287_T	1.381	0.99
489_R	596_S	1.365	0.98
402_I	405_Y	1.357	0.98
498_L	508_L	1.352	0.98
447_A	453_P	1.335	0.98
19_N	22_N	1.335	0.98
281_M	288_T	1.335	0.98
194_R	550_T	1.334	0.98
16_V	477_V	1.323	0.98
500_I	569_E	1.319	0.98
569_E	588_I	1.318	0.98
447_A	456_A	1.317	0.98
620_L	638_Y	1.315	0.98
646_N	672_L	1.314	0.98
373_I	390_V	1.313	0.98
168_L	187_H	1.311	0.98
540_A	568_I	1.310	0.98
544_Y	573_H	1.307	0.98
457_P	668_Q	1.306	0.98
358_A	373_I	1.305	0.98
256_E	326_E	1.304	0.98
570_R	574_E	1.302	0.98
377_F	418_V	1.295	0.98
4_V	45_I	1.295	0.98
664_V	680_I	1.293	0.98
395_A	399_I	1.279	0.98
213_S	248_K	1.279	0.98
403_A	408_M	1.276	0.98
467_K	679_I	1.276	0.98
541_E	592_N	1.273	0.98
493_V	592_N	1.272	0.98
564_E	567_E	1.270	0.98
83_K	118_E	1.269	0.98
335_A	371_A	1.264	0.97
401_N	405_Y	1.259	0.97
522_S	526_S	1.255	0.97
514_N	518_S	1.255	0.97
133_L	138_V	1.251	0.97
521_R	534_I	1.248	0.97
135_E	139_V	1.247	0.97
357_V	398_A	1.245	0.97
82_T	129_I	1.244	0.97
517_E	536_M	1.242	0.97
32_T	40_G	1.241	0.97
68_T	211_K	1.241	0.97
536_M	595_V	1.236	0.97
381_E	622_G	1.232	0.97
492_L	523_I	1.222	0.97
384_L	388_I	1.218	0.97
635_W	666_E	1.218	0.97
220_E	245_D	1.217	0.97
368_V	421_A	1.214	0.97
165_I	168_L	1.214	0.97
530_K	533_D	1.213	0.97
83_K	137_E	1.212	0.97
266_A	280_A	1.206	0.97
146_K	178_D	1.205	0.97
46_D	226_R	1.203	0.97
612_D	647_Y	1.200	0.97
540_A	590_I	1.200	0.97
609_I	676_G	1.200	0.97
510_N	538_R	1.199	0.96
415_Y	630_G	1.195	0.96
192_E	318_K	1.193	0.96
212_M	254_T	1.189	0.96
111_V	203_V	1.180	0.96
397_E	400_S	1.176	0.96
649_I	653_A	1.175	0.96
408_M	413_V	1.173	0.96
541_E	552_K	1.172	0.96
539_Y	552_K	1.169	0.96
81_T	88_I	1.165	0.96
512_K	515_E	1.163	0.96
525_I	534_I	1.160	0.96
77_V	152_A	1.152	0.96
543_R	589_E	1.148	0.96
184_T	205_N	1.148	0.96
88_I	195_E	1.144	0.95
173_I	176_R	1.143	0.95
139_V	143_K	1.141	0.95
117_L	145_L	1.139	0.95
28_A	31_E	1.138	0.95
393_R	397_E	1.138	0.95
271_D	276_K	1.137	0.95
80_I	141_A	1.134	0.95
619_A	642_Y	1.132	0.95
186_S	202_A	1.130	0.95
190_T	318_K	1.126	0.95
379_N	656_E	1.124	0.95
618_K	642_Y	1.120	0.95
373_I	392_K	1.119	0.95
372_Y	422_N	1.116	0.95
623_K	636_N	1.115	0.95
640_K	678_L	1.114	0.95
457_P	680_I	1.112	0.95
117_L	141_A	1.109	0.95
545_Y	587_P	1.108	0.95
117_L	144_K	1.105	0.94
379_N	383_L	1.103	0.94
138_V	141_A	1.102	0.94
628_Y	663_L	1.097	0.94
494_L	516_L	1.091	0.94
158_I	195_E	1.090	0.94
275_E	679_I	1.088	0.94
65_A	208_V	1.087	0.94
377_F	458_F	1.085	0.94
142_I	170_V	1.084	0.94
68_T	73_K	1.083	0.94
541_E	594_H	1.081	0.94
277_N	442_E	1.080	0.94
238_N	491_D	1.080	0.94
47_E	387_K	1.073	0.94
571_R	575_A	1.071	0.93
38_S	218_K	1.068	0.93
551_V	579_A	1.067	0.93
620_L	623_K	1.064	0.93
232_Y	244_F	1.064	0.93
35_D	353_Y	1.062	0.93
379_N	624_R	1.061	0.93
129_I	132_S	1.058	0.93
270_S	446_V	1.052	0.93
571_R	574_E	1.050	0.93
119_V	141_A	1.048	0.93
83_K	131_T	1.043	0.93
643_L	672_L	1.037	0.92
510_N	514_N	1.036	0.92
146_K	180_N	1.034	0.92
19_N	24_E	1.029	0.92
576_H	583_T	1.029	0.92
492_L	519_K	1.028	0.92
518_S	522_S	1.027	0.92
637_V	654_I	1.022	0.92
640_K	662_S	1.021	0.92
513_F	517_E	1.013	0.91
279_I	440_P	1.011	0.91
576_H	582_F	1.010	0.91
372_Y	377_F	1.009	0.91
153_I	178_D	1.009	0.91
350_A	367_T	1.004	0.91
42_L	46_D	1.003	0.91
51_N	54_Y	1.002	0.91
488_I	529_F	0.999	0.91
406_Y	413_V	0.998	0.91
419_K	629_D	0.994	0.91
263_V	291_S	0.992	0.91
3_R	56_N	0.992	0.91
193_W	495_S	0.989	0.90
174_I	178_D	0.988	0.90
620_L	642_Y	0.984	0.90
272_I	675_Y	0.983	0.90
422_N	458_F	0.982	0.90
6_I	58_I	0.982	0.90
283_G	372_Y	0.981	0.90
343_L	413_V	0.980	0.90
395_A	398_A	0.978	0.90
415_Y	419_K	0.976	0.90
72_R	108_T	0.973	0.90
403_A	413_V	0.973	0.90
289_K	312_N	0.973	0.90
156_S	186_S	0.965	0.89
477_V	659_T	0.959	0.89
312_N	326_E	0.959	0.89
423_D	462_E	0.958	0.89
144_K	148_E	0.956	0.89
138_V	173_I	0.955	0.89
655_I	678_L	0.955	0.89
534_I	597_G	0.955	0.89
255_L	317_V	0.954	0.89
216_L	234_A	0.950	0.89
624_R	637_V	0.949	0.89
419_K	462_E	0.949	0.89
399_I	403_A	0.948	0.88
645_I	676_G	0.947	0.88
87_D	113_R	0.947	0.88
641_E	658_P	0.946	0.88
65_A	254_T	0.945	0.88
165_I	169_K	0.944	0.88
609_I	645_I	0.944	0.88
475_A	660_S	0.944	0.88
70_V	326_E	0.942	0.88
657_D	662_S	0.941	0.88
357_V	364_K	0.941	0.88
380_Q	392_K	0.941	0.88
638_Y	643_L	0.940	0.88
495_S	592_N	0.939	0.88
276_K	295_N	0.939	0.88
519_K	522_S	0.937	0.88
142_I	178_D	0.937	0.88
41_V	219_L	0.936	0.88
160_S	202_A	0.935	0.88
3_R	18_Y	0.934	0.88
184_T	189_V	0.934	0.88
573_H	588_I	0.933	0.88
521_R	531_E	0.933	0.88
490_H	523_I	0.932	0.88
209_M	251_P	0.932	0.88
447_A	470_V	0.931	0.88
80_I	157_F	0.926	0.87
216_L	244_F	0.924	0.87
136_N	140_E	0.921	0.87
366_V	401_N	0.921	0.87
653_A	664_V	0.920	0.87
145_L	150_V	0.919	0.87
543_R	550_T	0.916	0.87
52_L	55_V	0.916	0.87
78_G	150_V	0.914	0.87
621_V	642_Y	0.912	0.86
40_G	44_A	0.909	0.86
533_D	602_K	0.909	0.86
77_V	203_V	0.908	0.86
112_P	150_V	0.906	0.86
627_F	631_K	0.905	0.86
374_V	396_E	0.904	0.86
256_E	324_I	0.899	0.86
205_N	209_M	0.899	0.86
366_V	399_I	0.898	0.86
487_D	603_T	0.896	0.86
516_L	519_K	0.896	0.86
287_T	312_N	0.894	0.85
81_T	195_E	0.893	0.85
515_E	519_K	0.891	0.85
175_K	183_V	0.889	0.85
620_L	636_N	0.888	0.85
424_N	427_N	0.887	0.85
19_N	23_G	0.884	0.85
500_I	542_M	0.883	0.85
5_G	484_L	0.883	0.85
141_A	145_L	0.881	0.85
542_M	588_I	0.881	0.85
341_S	344_K	0.880	0.84
76_K	150_V	0.880	0.84
79_L	156_S	0.878	0.84
544_Y	584_L	0.877	0.84
138_V	142_I	0.872	0.84
476_G	660_S	0.871	0.84
513_F	593_F	0.871	0.84
619_A	638_Y	0.871	0.84
159_N	162_V	0.871	0.84
415_Y	627_F	0.870	0.84
140_E	143_K	0.870	0.84
4_V	55_V	0.868	0.84
501_D	504_S	0.867	0.84
382_E	389_K	0.864	0.83
33_T	40_G	0.863	0.83
512_K	593_F	0.862	0.83
28_A	47_E	0.861	0.83
626_V	654_I	0.861	0.83
360_G	394_L	0.860	0.83
411_E	625_K	0.859	0.83
201_T	252_I	0.859	0.83
487_D	598_I	0.849	0.82
460_A	465_I	0.849	0.82
395_A	410_I	0.848	0.82
457_P	664_V	0.848	0.82
489_R	598_I	0.846	0.82
616_I	619_A	0.845	0.82
3_R	57_T	0.845	0.82
278_I	446_V	0.845	0.82
78_G	153_I	0.844	0.82
335_A	399_I	0.842	0.82
280_A	287_T	0.839	0.82
88_I	199_T	0.837	0.81
618_K	647_Y	0.835	0.81
290_A	327_I	0.834	0.81
616_I	647_Y	0.832	0.81
475_A	659_T	0.832	0.81
121_E	166_H	0.831	0.81
42_L	222_E	0.830	0.81
132_S	169_K	0.830	0.81
655_I	664_V	0.829	0.81
496_Y	512_K	0.829	0.81
145_L	148_E	0.827	0.81
80_I	178_D	0.827	0.81
15_V	28_A	0.827	0.81
574_E	578_I	0.827	0.81
144_K	147_A	0.825	0.80
142_I	177_V	0.824	0.80
635_W	654_I	0.823	0.80
460_A	468_I	0.822	0.80
236_L	253_Y	0.820	0.80
338_D	341_S	0.819	0.80
30_V	43_E	0.818	0.80
357_V	366_V	0.817	0.80
321_T	326_E	0.817	0.80
151_E	180_N	0.817	0.80
383_L	386_G	0.815	0.80
475_A	640_K	0.815	0.80
119_V	170_V	0.814	0.80
505_S	509_I	0.812	0.79
461_E	680_I	0.811	0.79
135_E	172_E	0.809	0.79
240_G	489_R	0.809	0.79
52_L	230_G	0.809	0.79
61_G	261_A	0.808	0.79
51_N	55_V	0.806	0.79
2_I	17_V	0.803	0.79
507_D	511_E	0.803	0.79
511_E	514_N	0.803	0.79
66_I	71_E	0.803	0.79
397_E	401_N	0.802	0.79
235_M	483_M	0.800	0.78
438_Y	443_F	0.800	0.78
492_L	595_V	0.800	0.78
269_I	478_F	0.799	0.78
288_T	326_E	0.799	0.78
160_S	186_S	0.798	0.78
156_S	202_A	0.798	0.78
275_E	444_T	0.797	0.78
31_E	352_A	0.797	0.78
256_E	312_N	0.797	0.78
86_R	113_R	0.796	0.78
481_W	606_L	0.795	0.78
119_V	133_L	0.794	0.78
164_P	187_H	0.794	0.78
45_I	58_I	0.791	0.78
520_I	536_M	0.789	0.77
4_V	17_V	0.788	0.77
228_F	231_N	0.788	0.77
38_S	222_E	0.788	0.77
506_V	510_N	0.788	0.77
476_G	640_K	0.788	0.77
501_D	587_P	0.787	0.77
37_P	64_L	0.787	0.77
470_V	680_I	0.785	0.77
271_D	293_V	0.783	0.77
521_R	525_I	0.779	0.77
469_I	679_I	0.778	0.76
61_G	483_M	0.777	0.76
553_V	575_A	0.775	0.76
217_S	221_N	0.775	0.76
256_E	325_V	0.774	0.76
283_G	421_A	0.771	0.76
213_S	217_S	0.771	0.76
290_A	428_A	0.770	0.76
283_G	455_F	0.766	0.75
69_I	255_L	0.766	0.75
421_A	425_A	0.765	0.75
192_E	493_V	0.764	0.75
262_G	448_Y	0.762	0.75
236_L	242_A	0.761	0.75
638_Y	649_I	0.761	0.75
537_L	554_S	0.760	0.75
222_E	225_N	0.760	0.75
635_W	663_L	0.759	0.75
70_V	212_M	0.757	0.74
534_I	599_V	0.757	0.74
70_V	340_T	0.754	0.74
649_I	655_I	0.753	0.74
573_H	576_H	0.753	0.74
280_A	448_Y	0.752	0.74
429_V	432_I	0.751	0.74
521_R	536_M	0.745	0.73
119_V	137_E	0.743	0.73
29_K	33_T	0.742	0.73
357_V	395_A	0.741	0.73
292_L	438_Y	0.741	0.73
222_E	226_R	0.741	0.73
398_A	401_N	0.741	0.73
453_P	660_S	0.740	0.73
265_G	478_F	0.739	0.73
80_I	170_V	0.739	0.73
69_I	204_L	0.738	0.73
639_N	658_P	0.737	0.72
279_I	433_S	0.737	0.72
280_A	289_K	0.734	0.72
150_V	153_I	0.732	0.72
283_G	451_S	0.731	0.72
325_V	431_L	0.731	0.72
172_E	175_K	0.730	0.72
498_L	505_S	0.728	0.72
508_L	511_E	0.727	0.71
357_V	403_A	0.725	0.71
37_P	40_G	0.723	0.71
383_L	388_I	0.722	0.71
283_G	368_V	0.721	0.71
337_I	402_I	0.720	0.71
8_I	37_P	0.720	0.71
34_P	37_P	0.720	0.71
337_I	405_Y	0.719	0.71
508_L	512_K	0.718	0.70
530_K	534_I	0.717	0.70
140_E	144_K	0.716	0.70
638_Y	647_Y	0.716	0.70
140_E	147_A	0.715	0.70
43_E	46_D	0.715	0.70
154_A	206_A	0.715	0.70
92_Q	96_R	0.713	0.70
621_V	656_E	0.711	0.70
514_N	574_E	0.711	0.70
70_V	256_E	0.709	0.70
539_Y	554_S	0.709	0.70
549_H	580_Y	0.708	0.69
505_S	508_L	0.708	0.69
174_I	177_V	0.706	0.69
82_T	85_F	0.704	0.69
516_L	595_V	0.704	0.69
396_E	410_I	0.703	0.69
113_R	145_L	0.703	0.69
36_D	218_K	0.701	0.69
621_V	638_Y	0.700	0.69
80_I	153_I	0.699	0.68
205_N	252_I	0.699	0.68
273_L	469_I	0.698	0.68
628_Y	631_K	0.698	0.68
175_K	188_E	0.697	0.68
37_P	41_V	0.697	0.68
110_F	207_Y	0.697	0.68
511_E	515_E	0.696	0.68
134_N	138_V	0.696	0.68
372_Y	448_Y	0.695	0.68
283_G	326_E	0.694	0.68
189_V	202_A	0.694	0.68
177_V	180_N	0.693	0.68
147_A	177_V	0.693	0.68
145_L	149_N	0.693	0.68
504_S	509_I	0.688	0.67
129_I	166_H	0.686	0.67
290_A	478_F	0.686	0.67
185_L	188_E	0.681	0.66
401_N	410_I	0.679	0.66
313_P	324_I	0.679	0.66
151_E	177_V	0.679	0.66
141_A	174_I	0.679	0.66
570_R	583_T	0.678	0.66
141_A	144_K	0.677	0.66
399_I	405_Y	0.677	0.66
280_A	479_S	0.677	0.66
514_N	538_R	0.677	0.66
616_I	644_P	0.677	0.66
142_I	173_I	0.676	0.66
273_L	478_F	0.675	0.66
145_L	153_I	0.675	0.66
77_V	154_A	0.675	0.66
247_A	261_A	0.674	0.66
154_A	186_S	0.674	0.66
80_I	174_I	0.673	0.66
377_F	628_Y	0.672	0.65
626_V	663_L	0.672	0.65
168_L	171_G	0.672	0.65
6_I	41_V	0.671	0.65
402_I	578_I	0.670	0.65
160_S	164_P	0.670	0.65
124_K	163_N	0.670	0.65
364_K	398_A	0.669	0.65
673_D	679_I	0.669	0.65
220_E	224_K	0.668	0.65
92_Q	106_K	0.667	0.65
290_A	326_E	0.666	0.65
81_T	156_S	0.665	0.65
66_I	260_V	0.665	0.65
185_L	189_V	0.665	0.65
624_R	654_I	0.664	0.64
428_A	432_I	0.664	0.64
256_E	288_T	0.663	0.64
608_R	675_Y	0.663	0.64
281_M	372_Y	0.662	0.64
619_A	622_G	0.661	0.64
287_T	290_A	0.660	0.64
88_I	102_F	0.660	0.64
425_A	455_F	0.657	0.64
58_I	232_Y	0.657	0.64
381_E	389_K	0.655	0.63
528_G	599_V	0.654	0.63
425_A	459_V	0.653	0.63
291_S	433_S	0.651	0.63
367_T	643_L	0.651	0.63
456_A	468_I	0.651	0.63
377_F	626_V	0.650	0.63
72_R	313_P	0.650	0.63
509_I	593_F	0.650	0.63
34_P	353_Y	0.649	0.63
372_Y	454_M	0.647	0.62
653_A	670_G	0.647	0.62
499_R	545_Y	0.646	0.62
377_F	663_L	0.646	0.62
368_V	417_I	0.643	0.62
458_F	665_L	0.642	0.62
610_E	644_P	0.641	0.62
403_A	409_S	0.641	0.62
277_N	295_N	0.638	0.61
180_N	217_S	0.638	0.61
550_T	576_H	0.638	0.61
448_Y	479_S	0.637	0.61
294_R	438_Y	0.637	0.61
92_Q	97_R	0.637	0.61
80_I	145_L	0.634	0.61
533_D	600_K	0.634	0.61
492_L	527_E	0.633	0.61
399_I	402_I	0.633	0.61
81_T	157_F	0.633	0.61
513_F	536_M	0.632	0.61
200_S	316_P	0.632	0.61
280_A	326_E	0.632	0.61
30_V	44_A	0.631	0.61
567_E	570_R	0.631	0.61
292_L	433_S	0.628	0.60
119_V	153_I	0.628	0.60
256_E	280_A	0.628	0.60
66_I	326_E	0.627	0.60
495_S	549_H	0.627	0.60
65_A	71_E	0.627	0.60
357_V	362_G	0.626	0.60
608_R	612_D	0.625	0.60
496_Y	593_F	0.625	0.60
152_A	209_M	0.624	0.60
487_D	601_A	0.624	0.60
513_F	540_A	0.623	0.60
542_M	568_I	0.623	0.60
400_S	405_Y	0.621	0.59
52_L	228_F	0.621	0.59
637_V	656_E	0.620	0.59
476_G	657_D	0.619	0.59
655_I	672_L	0.618	0.59
277_N	443_F	0.618	0.59
345_V	420_I	0.617	0.59
399_I	413_V	0.617	0.59
96_R	428_A	0.617	0.59
617_D	625_K	0.617	0.59
268_K	485_V	0.617	0.59
73_K	672_L	0.616	0.59
626_V	631_K	0.615	0.59
35_D	361_K	0.614	0.58
460_A	668_Q	0.614	0.58
575_A	579_A	0.614	0.58
132_S	166_H	0.613	0.58
7_D	14_D	0.612	0.58
483_M	550_T	0.612	0.58
391_N	396_E	0.611	0.58
199_T	203_V	0.611	0.58
628_Y	633_E	0.610	0.58
94_A	483_M	0.610	0.58
266_A	278_I	0.610	0.58
623_K	648_Q	0.609	0.58
504_S	507_D	0.609	0.58
37_P	43_E	0.607	0.58
75_A	214_K	0.607	0.58
470_V	662_S	0.607	0.58
39_N	222_E	0.605	0.57
19_N	25_I	0.605	0.57
9_G	14_D	0.604	0.57
366_V	374_V	0.604	0.57
453_P	475_A	0.603	0.57
421_A	455_F	0.603	0.57
90_E	106_K	0.603	0.57
193_W	550_T	0.602	0.57
69_I	314_G	0.601	0.57
391_N	397_E	0.601	0.57
37_P	237_S	0.600	0.57
66_I	454_M	0.598	0.56
486_S	601_A	0.598	0.56
88_I	576_H	0.597	0.56
66_I	288_T	0.597	0.56
446_V	469_I	0.595	0.56
645_I	674_S	0.594	0.56
126_N	130_L	0.593	0.56
490_H	527_E	0.592	0.56
487_D	599_V	0.590	0.55
123_I	133_L	0.590	0.55
328_G	333_S	0.589	0.55
135_E	138_V	0.589	0.55
143_K	172_E	0.589	0.55
646_N	671_M	0.589	0.55
402_I	417_I	0.588	0.55
612_D	674_S	0.588	0.55
616_I	620_L	0.588	0.55
146_K	153_I	0.588	0.55
260_V	322_L	0.587	0.55
427_N	435_Q	0.587	0.55
235_M	261_A	0.587	0.55
10_G	14_D	0.586	0.55
30_V	40_G	0.586	0.55
215_Y	260_V	0.585	0.55
208_V	211_K	0.583	0.55
136_N	147_A	0.583	0.55
204_L	327_I	0.583	0.55
433_S	438_Y	0.582	0.54
612_D	639_N	0.582	0.54
235_M	479_S	0.581	0.54
613_N	618_K	0.580	0.54
185_L	202_A	0.580	0.54
42_L	226_R	0.579	0.54
273_L	677_N	0.579	0.54
110_F	203_V	0.578	0.54
475_A	657_D	0.578	0.54
366_V	417_I	0.577	0.54
326_E	329_N	0.575	0.54
537_L	596_S	0.575	0.54
96_R	100_Y	0.573	0.53
491_D	594_H	0.573	0.53
611_R	645_I	0.572	0.53
165_I	172_E	0.572	0.53
214_K	218_K	0.571	0.53
613_N	647_Y	0.571	0.53
570_R	650_V	0.570	0.53
552_K	594_H	0.570	0.53
123_I	160_S	0.570	0.53
574_E	577_E	0.569	0.53
335_A	368_V	0.569	0.53
529_F	533_D	0.568	0.53
237_S	256_E	0.567	0.53
590_I	598_I	0.567	0.53
527_E	599_V	0.566	0.52
39_N	45_I	0.566	0.52
141_A	149_N	0.564	0.52
368_V	455_F	0.563	0.52
191_R	202_A	0.563	0.52
287_T	311_Y	0.563	0.52
68_T	71_E	0.562	0.52
556_M	567_E	0.562	0.52
50_V	54_Y	0.560	0.52
428_A	476_G	0.560	0.52
554_S	571_R	0.559	0.52
235_M	463_L	0.559	0.52
372_Y	421_A	0.558	0.51
639_N	655_I	0.558	0.51
502_K	617_D	0.558	0.51
533_D	623_K	0.557	0.51
242_A	246_Y	0.557	0.51
247_A	254_T	0.556	0.51
337_I	413_V	0.556	0.51
137_E	140_E	0.556	0.51
11_A	14_D	0.555	0.51
58_I	228_F	0.555	0.51
200_S	313_P	0.555	0.51
219_L	223_F	0.554	0.51
110_F	204_L	0.553	0.51
195_E	547_Q	0.553	0.51
8_I	41_V	0.553	0.51
289_K	313_P	0.553	0.51
66_I	287_T	0.552	0.51
396_E	570_R	0.552	0.51
85_F	486_S	0.552	0.51
603_T	606_L	0.551	0.51
524_L	565_L	0.550	0.50
7_D	10_G	0.550	0.50
44_A	205_N	0.550	0.50
374_V	414_S	0.550	0.50
499_R	587_P	0.550	0.50
96_R	377_F	0.550	0.50
401_N	404_K	0.549	0.50
35_D	43_E	0.549	0.50
17_V	26_S	0.549	0.50
366_V	398_A	0.548	0.50
289_K	324_I	0.548	0.50
175_K	180_N	0.547	0.50
45_I	516_L	0.547	0.50
87_D	96_R	0.547	0.50
141_A	170_V	0.547	0.50
174_I	183_V	0.546	0.50
327_I	427_N	0.546	0.50
547_Q	576_H	0.546	0.50
487_D	600_K	0.545	0.50
136_N	172_E	0.545	0.50
664_V	668_Q	0.545	0.50
403_A	407_N	0.545	0.50
94_A	548_E	0.544	0.50
289_K	321_T	0.544	0.50
123_I	165_I	0.544	0.50
524_L	534_I	0.543	0.50
71_E	479_S	0.543	0.50
34_P	64_L	0.543	0.50
529_F	534_I	0.542	0.49
234_A	254_T	0.542	0.49
420_I	423_D	0.542	0.49
372_Y	418_V	0.542	0.49
18_Y	23_G	0.541	0.49
493_V	541_E	0.540	0.49
283_G	425_A	0.540	0.49
82_T	131_T	0.540	0.49
143_K	175_K	0.540	0.49
390_V	464_D	0.539	0.49
420_I	427_N	0.539	0.49
10_G	13_T	0.539	0.49
80_I	138_V	0.539	0.49
18_Y	22_N	0.538	0.49
281_M	459_V	0.538	0.49
61_G	324_I	0.538	0.49
93_R	440_P	0.538	0.49
325_V	432_I	0.537	0.49
94_A	99_M	0.537	0.49
40_G	291_S	0.537	0.49
429_V	459_V	0.537	0.49
53_G	638_Y	0.536	0.49
393_R	606_L	0.536	0.49
168_L	511_E	0.536	0.49
509_I	590_I	0.536	0.49
154_A	184_T	0.535	0.48
237_S	324_I	0.535	0.48
192_E	430_R	0.534	0.48
366_V	395_A	0.534	0.48
133_L	157_F	0.534	0.48
2_I	5_G	0.534	0.48
242_A	483_M	0.533	0.48
2_I	41_V	0.533	0.48
630_G	633_E	0.533	0.48
132_S	138_V	0.532	0.48
263_V	280_A	0.532	0.48
556_M	571_R	0.532	0.48
421_A	424_N	0.532	0.48
525_I	528_G	0.530	0.48
28_A	44_A	0.530	0.48
570_R	617_D	0.530	0.48
8_I	384_L	0.530	0.48
40_G	47_E	0.529	0.48
507_D	650_V	0.529	0.48
617_D	620_L	0.529	0.48
59_I	483_M	0.527	0.47
623_K	639_N	0.527	0.47
205_N	247_A	0.527	0.47
171_G	183_V	0.527	0.47
317_V	591_V	0.526	0.47
657_D	660_S	0.526	0.47
292_L	328_G	0.525	0.47
412_E	415_Y	0.524	0.47
217_S	220_E	0.524	0.47
372_Y	430_R	0.523	0.47
143_K	655_I	0.523	0.47
90_E	156_S	0.523	0.47
401_N	565_L	0.523	0.47
142_I	153_I	0.522	0.47
452_G	456_A	0.522	0.47
54_Y	625_K	0.522	0.47
404_K	633_E	0.522	0.47
422_N	443_F	0.521	0.47
134_N	169_K	0.521	0.47
25_I	168_L	0.521	0.47
289_K	325_V	0.521	0.47
515_E	518_S	0.520	0.47
132_S	137_E	0.519	0.46
37_P	45_I	0.519	0.46
143_K	151_E	0.519	0.46
65_A	212_M	0.519	0.46
129_I	165_I	0.519	0.46
193_W	478_F	0.519	0.46
415_Y	631_K	0.518	0.46
204_L	317_V	0.518	0.46
37_P	430_R	0.518	0.46
620_L	647_Y	0.518	0.46
97_R	241_M	0.518	0.46
143_K	173_I	0.518	0.46
15_V	40_G	0.518	0.46
290_A	451_S	0.517	0.46
264_I	485_V	0.516	0.46
217_S	248_K	0.516	0.46
649_I	664_V	0.516	0.46
495_S	580_Y	0.516	0.46
423_D	427_N	0.515	0.46
500_I	590_I	0.514	0.46
397_E	608_R	0.513	0.46
542_M	593_F	0.513	0.46
411_E	627_F	0.513	0.46
323_D	436_R	0.513	0.46
152_A	182_I	0.512	0.46
643_L	649_I	0.512	0.46
334_I	348_R	0.512	0.46
90_E	113_R	0.512	0.46
143_K	180_N	0.512	0.46
601_A	604_I	0.512	0.46
288_T	459_V	0.512	0.46
364_K	407_N	0.511	0.45
583_T	588_I	0.511	0.45
525_I	532_K	0.511	0.45
288_T	325_V	0.510	0.45
538_R	595_V	0.509	0.45
412_E	630_G	0.509	0.45
461_E	667_G	0.509	0.45
117_L	148_E	0.509	0.45
520_I	595_V	0.509	0.45
622_G	638_Y	0.509	0.45
274_G	667_G	0.508	0.45
643_L	648_Q	0.508	0.45
265_G	313_P	0.508	0.45
168_L	185_L	0.508	0.45
7_D	11_A	0.508	0.45
609_I	617_D	0.507	0.45
622_G	637_V	0.507	0.45
288_T	445_L	0.507	0.45
29_K	32_T	0.506	0.45
382_E	621_V	0.506	0.45
360_G	388_I	0.506	0.45
65_A	287_T	0.506	0.45
483_M	548_E	0.506	0.45
136_N	664_V	0.505	0.45
40_G	43_E	0.505	0.45
165_I	607_K	0.505	0.45
409_S	567_E	0.504	0.45
266_A	446_V	0.504	0.45
125_S	161_Y	0.504	0.45
36_D	222_E	0.504	0.45
175_K	185_L	0.503	0.44
50_V	288_T	0.503	0.44
204_L	313_P	0.502	0.44
446_V	471_P	0.502	0.44
580_Y	674_S	0.502	0.44
447_A	468_I	0.501	0.44
200_S	203_V	0.500	0.44
9_G	13_T	0.500	0.44
31_E	353_Y	0.500	0.44
456_A	470_V	0.500	0.44
533_D	599_V	0.500	0.44
204_L	254_T	0.500	0.44

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3cetA	2	0.4539	100	0.767	Contact Map
3hz6A	1	0.6428	100	0.878	Contact Map
3ifrA	2	0.6384	100	0.88	Contact Map
2itmA	2	0.6252	99.3	0.945	Contact Map
2zf5O	3	0.6442	99.2	0.946	Contact Map
4a2aA	1	0.5081	99	0.95	Contact Map
2w40A	3	0.6428	99	0.951	Contact Map
2d4wA	2	0.6515	98.9	0.951	Contact Map
2dpnA	2	0.6486	98.9	0.952	Contact Map
3g25A	3	0.6369	98.9	0.953	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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