GREMLIN Database
Q97XP7 - Uncharacterized protein
UniProt: Q97XP7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 159 (139)
Sequences: 13422 (8821)
Seq/√Len: 748.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_Q59_I3.1401.00
21_L36_L3.0991.00
101_E114_R2.8151.00
108_D140_R2.6671.00
118_N122_K2.4011.00
30_D48_R2.3831.00
66_Q121_A2.2951.00
15_D47_R2.1801.00
50_K54_S2.1751.00
21_L28_I2.1641.00
58_K64_V2.1561.00
14_K39_L1.8741.00
58_K62_V1.8671.00
100_Y116_F1.8471.00
49_V53_N1.8451.00
21_L24_Q1.7871.00
96_N126_E1.7701.00
125_D129_K1.7671.00
39_L43_A1.7611.00
80_K137_Q1.7231.00
31_A35_K1.6901.00
85_L88_Q1.6751.00
119_N122_K1.6631.00
28_I36_L1.6591.00
32_K35_K1.6281.00
31_A41_K1.6281.00
122_K125_D1.6221.00
92_K95_A1.5641.00
39_L44_V1.5401.00
40_S43_A1.5191.00
18_I33_L1.5171.00
98_L122_K1.5021.00
30_D45_R1.4721.00
89_F93_L1.4721.00
90_I94_I1.4591.00
92_K133_D1.4501.00
13_D17_R1.4391.00
37_V44_V1.4231.00
87_E91_N1.3871.00
27_N59_I1.3851.00
22_L48_R1.3451.00
28_I33_L1.3421.00
32_K36_L1.2991.00
74_D103_T1.2941.00
24_Q36_L1.2921.00
14_K17_R1.2781.00
49_V52_Q1.2741.00
80_K138_D1.2501.00
29_S32_K1.2411.00
25_D36_L1.2211.00
82_D137_Q1.2211.00
124_K146_K1.2111.00
90_I146_K1.2071.00
70_I118_N1.1881.00
21_L33_L1.1711.00
14_K37_V1.1501.00
12_D47_R1.1431.00
17_R21_L1.1101.00
74_D114_R1.1091.00
28_I32_K1.0961.00
102_V113_I1.0791.00
96_N130_I1.0751.00
26_A59_I1.0741.00
17_R20_K1.0561.00
117_H122_K1.0441.00
88_Q92_K1.0431.00
103_T114_R1.0411.00
78_K138_D1.0371.00
99_V115_L1.0241.00
90_I111_L1.0201.00
96_N129_K1.0191.00
64_V67_N1.0171.00
20_K24_Q1.0171.00
91_N94_I1.0161.00
105_Y112_L1.0111.00
117_H123_L1.0111.00
30_D34_G1.0091.00
80_K108_D1.0021.00
115_L126_E0.9981.00
98_L130_I0.9901.00
71_P119_N0.9901.00
34_G44_V0.9841.00
17_R37_V0.9701.00
117_H126_E0.9691.00
27_N52_Q0.9461.00
124_K128_L0.9381.00
73_A120_I0.9371.00
41_K45_R0.9191.00
30_D41_K0.9181.00
91_N95_A0.9141.00
31_A45_R0.9101.00
75_L115_L0.9011.00
103_T144_V0.9011.00
99_V102_V0.9001.00
45_R49_V0.8991.00
78_K142_S0.8911.00
65_L116_F0.8861.00
51_L56_I0.8691.00
34_G39_L0.8681.00
104_E128_L0.8621.00
11_L16_I0.8531.00
99_V113_I0.8471.00
79_L113_I0.8461.00
83_I86_R0.8451.00
88_Q91_N0.8421.00
15_D50_K0.8421.00
93_L102_V0.8421.00
103_T147_T0.8281.00
26_A32_K0.8281.00
127_S141_I0.8231.00
26_A61_G0.8031.00
16_I20_K0.8001.00
78_K140_R0.7921.00
12_D15_D0.7921.00
106_M143_Y0.7911.00
18_I47_R0.7881.00
42_T46_L0.7841.00
33_L44_V0.7811.00
108_D138_D0.7811.00
78_K109_W0.7801.00
77_V113_I0.7751.00
109_W140_R0.7691.00
18_I44_V0.7551.00
76_L112_L0.7541.00
92_K96_N0.7431.00
87_E90_I0.7371.00
121_A124_K0.7341.00
56_I67_N0.7311.00
18_I28_I0.7161.00
21_L25_D0.7151.00
70_I98_L0.7101.00
33_L48_R0.7071.00
89_F111_L0.7031.00
126_E130_I0.6941.00
11_L56_I0.6931.00
25_D28_I0.6931.00
13_D16_I0.6861.00
73_A81_N0.6851.00
76_L142_S0.6821.00
46_L49_V0.6701.00
98_L126_E0.6691.00
70_I116_F0.6671.00
105_Y109_W0.6621.00
46_L50_K0.6621.00
74_D116_F0.6601.00
86_R111_L0.6591.00
120_I143_Y0.6581.00
81_N86_R0.6561.00
121_A125_D0.6561.00
18_I21_L0.6541.00
15_D51_L0.6541.00
87_E128_L0.6511.00
93_L113_I0.6481.00
88_Q135_A0.6451.00
74_D81_N0.6431.00
34_G41_K0.6421.00
47_R51_L0.6331.00
18_I48_R0.6321.00
90_I148_Y0.6311.00
78_K108_D0.6181.00
128_L132_S0.6171.00
63_V68_L0.6171.00
81_N89_F0.6141.00
30_D44_V0.6141.00
23_N60_V0.6081.00
18_I51_L0.6041.00
126_E131_I0.6041.00
74_D144_V0.6041.00
19_L51_L0.6011.00
127_S139_Y0.6001.00
104_E111_L0.5881.00
122_K126_E0.5841.00
55_G58_K0.5831.00
14_K43_A0.5781.00
96_N133_D0.5741.00
42_T45_R0.5731.00
62_V65_L0.5701.00
120_I145_V0.5661.00
100_Y114_R0.5661.00
64_V68_L0.5621.00
82_D85_L0.5541.00
105_Y144_V0.5521.00
98_L118_N0.5511.00
96_N99_V0.5501.00
127_S130_I0.5471.00
50_K53_N0.5451.00
105_Y142_S0.5451.00
76_L144_V0.5411.00
37_V43_A0.5391.00
115_L123_L0.5381.00
80_K109_W0.5361.00
20_K23_N0.5311.00
74_D112_L0.5261.00
92_K134_K0.5231.00
24_Q28_I0.5211.00
10_Y54_S0.5191.00
31_A34_G0.5191.00
71_P121_A0.5161.00
85_L134_K0.5161.00
29_S34_G0.5141.00
16_I23_N0.5131.00
126_E129_K0.5081.00
104_E124_K0.5081.00
108_D142_S0.5051.00
25_D32_K0.5051.00
76_L103_T0.5051.00
19_L63_V0.5031.00
94_I102_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ch7A 1 0.9245 100 0.179 Contact Map
4un1B 1 0.9371 100 0.209 Contact Map
4un1A 1 0.8868 100 0.244 Contact Map
2e1cA 1 0.9182 100 0.247 Contact Map
4pcqA 2 0.9182 100 0.249 Contact Map
2ia0A 2 0.9119 100 0.26 Contact Map
2p5vA 5 0.9623 100 0.264 Contact Map
2cg4A 6 0.9182 100 0.285 Contact Map
3i4pA 5 0.9245 100 0.288 Contact Map
2pn6A 5 0.9182 100 0.289 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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