GREMLIN Database
Q97XP6 - Cytosine permease (CodB)
UniProt: Q97XP6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 453 (409)
Sequences: 4783 (3073)
Seq/√Len: 151.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
361_A423_F7.1061.00
361_A427_I5.9561.00
81_G225_P4.4591.00
401_L425_S4.3671.00
60_I254_L4.0101.00
398_A425_S3.4791.00
365_I423_F3.3591.00
398_A429_I3.2401.00
398_A402_G3.1921.00
402_G422_G3.1061.00
65_S210_I3.0961.00
83_Y234_A3.0271.00
402_G425_S2.9911.00
183_A187_A2.9661.00
62_A206_L2.8811.00
357_G361_A2.7471.00
206_L210_I2.7391.00
362_D367_K2.6851.00
365_I427_I2.6621.00
20_P23_S2.5961.00
405_I421_T2.5911.00
55_T58_Q2.5601.00
375_D378_K2.5561.00
267_L270_N2.5301.00
311_R314_I2.4001.00
396_I400_A2.3961.00
24_R85_G2.3631.00
358_I399_L2.3521.00
393_I397_L2.3441.00
182_I251_F2.3191.00
191_G194_T2.2651.00
293_N296_N2.2621.00
69_V214_I2.2561.00
37_V295_D2.1871.00
179_A183_A2.1621.00
233_S236_D2.1471.00
59_A257_V2.0941.00
416_I420_V2.0801.00
431_Y434_K2.0451.00
14_Y23_S2.0451.00
357_G419_L2.0391.00
103_I396_I2.0261.00
153_T320_G2.0211.00
232_K236_D1.9971.00
406_G418_S1.9951.00
122_T152_M1.9831.00
78_A228_S1.9781.00
143_V147_W1.9391.00
118_Y293_N1.9251.00
235_K239_Y1.9241.00
387_K390_N1.9231.00
99_W102_K1.9101.00
270_N274_E1.9001.00
421_T425_S1.8141.00
125_F148_G1.8141.00
402_G421_T1.8071.00
425_S429_I1.7971.00
150_I154_I1.7761.00
14_Y17_K1.7641.00
158_V162_M1.7461.00
358_I398_A1.7441.00
95_P362_D1.7381.00
80_V91_M1.7351.00
149_G324_T1.7301.00
61_I206_L1.7261.00
118_Y323_G1.7201.00
49_A59_A1.7001.00
94_H371_N1.6971.00
310_M318_I1.6891.00
101_G306_N1.6701.00
117_W120_V1.6511.00
152_M293_N1.6481.00
357_G422_G1.6451.00
116_G344_F1.6381.00
165_F168_Y1.6141.00
56_F60_I1.6121.00
27_F236_D1.6041.00
401_L421_T1.5801.00
310_M314_I1.5791.00
75_S242_F1.5651.00
404_I408_F1.5591.00
423_F427_I1.5541.00
96_L395_G1.5371.00
385_N390_N1.5281.00
271_A275_L1.5231.00
378_K381_E1.5211.00
427_I431_Y1.5141.00
317_V321_V1.4941.00
91_M225_P1.4821.00
130_S144_A1.4741.00
176_W180_I1.4691.00
62_A209_G1.4651.00
397_L429_I1.4631.00
395_G426_Y1.4591.00
26_G29_N1.4521.00
63_V257_V1.4491.00
420_V423_F1.4481.00
424_L428_I1.4471.00
57_S61_I1.4451.00
49_A209_G1.4391.00
391_I396_I1.4351.00
146_I150_I1.4291.00
316_S320_G1.4271.00
29_N168_Y1.4011.00
395_G398_A1.3961.00
119_A323_G1.3941.00
271_A274_E1.3891.00
268_I271_A1.3871.00
63_V253_I1.3851.00
103_I391_I1.3771.00
428_I431_Y1.3621.00
265_S270_N1.3621.00
81_G228_S1.3601.00
72_I76_L1.3381.00
420_V424_L1.3321.00
400_A404_I1.3271.00
182_I255_G1.3261.00
155_M166_L1.3161.00
418_S422_G1.3111.00
354_A418_S1.3091.00
142_G146_I1.3081.00
79_A234_A1.3081.00
358_I395_G1.3031.00
79_A83_Y1.3031.00
127_I267_L1.3031.00
65_S206_L1.2981.00
246_I250_P1.2971.00
360_L364_Y1.2971.00
99_W390_N1.2931.00
300_G319_N1.2891.00
236_D240_A1.2661.00
121_E296_N1.2581.00
409_V417_N1.2531.00
61_I65_S1.2511.00
362_D366_V1.2501.00
114_G223_I1.2371.00
356_G360_L1.2331.00
310_M315_A1.2321.00
64_L250_P1.2321.00
227_I299_S1.2221.00
312_R316_S1.2111.00
54_L62_A1.2021.00
69_V210_I1.1961.00
126_G144_A1.1931.00
230_F302_L1.1731.00
107_L352_L1.1661.00
206_L209_G1.1621.00
195_V198_A1.1581.00
358_I402_G1.1561.00
96_L100_G1.1541.00
357_G423_F1.1521.00
394_A429_I1.1511.00
270_N273_L1.1381.00
388_Y393_I1.1341.00
198_A261_L1.1331.00
413_I417_N1.1331.00
428_I432_I1.1291.00
375_D384_P1.1080.99
12_D17_K1.1060.99
119_A326_I1.1050.99
366_V427_I1.1040.99
156_T316_S1.1020.99
325_A329_Y1.1020.99
14_Y19_V1.1010.99
239_Y243_A1.1000.99
77_T359_V1.0930.99
165_F169_F1.0860.99
180_I183_A1.0790.99
394_A430_Y1.0780.99
116_G345_I1.0740.99
161_R165_F1.0710.99
93_R101_G1.0650.99
35_S248_L1.0570.99
218_S353_P1.0560.99
62_A66_G1.0540.99
394_A398_A1.0510.99
73_L221_T1.0490.99
62_A210_I1.0460.99
305_V315_A1.0410.99
139_F143_V1.0380.99
121_E293_N1.0300.99
71_G75_S1.0260.99
98_R386_N1.0210.99
423_F426_Y1.0200.99
185_V259_I1.0190.99
41_I289_Q1.0190.99
426_Y430_Y1.0180.99
398_A426_Y1.0100.99
255_G259_I1.0050.99
63_V67_T1.0030.99
122_T149_G1.0000.99
132_I279_V0.9980.99
269_T274_E0.9970.99
79_A364_Y0.9950.99
14_Y20_P0.9910.99
63_V250_P0.9820.99
47_G256_G0.9800.99
361_A366_V0.9760.99
225_P228_S0.9720.99
394_A397_L0.9670.99
103_I400_A0.9650.98
398_A422_G0.9610.98
371_N377_H0.9580.98
186_L258_A0.9580.98
99_W386_N0.9580.98
132_I283_L0.9550.98
251_F255_G0.9530.98
79_A369_Y0.9490.98
221_T356_G0.9480.98
106_L307_L0.9420.98
96_L399_L0.9420.98
186_L190_G0.9410.98
403_S406_G0.9400.98
405_I408_F0.9390.98
66_G213_T0.9370.98
398_A423_F0.9360.98
361_A365_I0.9350.98
389_Y393_I0.9310.98
88_T225_P0.9300.98
156_T320_G0.9300.98
424_L427_I0.9280.98
90_V93_R0.9210.98
66_G210_I0.9170.98
80_V84_S0.9120.98
76_L364_Y0.9110.98
180_I184_I0.9010.98
381_E386_N0.9000.98
95_P359_V0.8980.98
118_Y297_L0.8970.98
297_L320_G0.8940.98
191_G195_V0.8930.97
430_Y433_I0.8930.97
207_L211_S0.8920.97
67_T253_I0.8910.97
30_V228_S0.8910.97
244_H248_L0.8890.97
100_G396_I0.8880.97
95_P358_I0.8880.97
131_E270_N0.8870.97
385_N388_Y0.8860.97
39_G174_H0.8800.97
206_L213_T0.8800.97
117_W345_I0.8740.97
250_P254_L0.8740.97
67_T216_L0.8710.97
78_A237_A0.8670.97
133_F139_F0.8650.97
196_M199_V0.8640.97
231_A234_A0.8600.97
68_V246_I0.8600.97
401_L408_F0.8590.97
350_D410_N0.8580.97
155_M290_F0.8570.97
288_G292_I0.8550.97
175_I179_A0.8550.97
107_L348_L0.8540.97
70_L217_Y0.8480.97
412_G417_N0.8480.97
118_Y320_G0.8410.96
172_P175_I0.8400.96
268_I272_M0.8390.96
211_S416_I0.8360.96
44_I259_I0.8360.96
96_L104_A0.8350.96
121_E289_Q0.8340.96
417_N420_V0.8320.96
123_W126_G0.8310.96
229_R298_Y0.8300.96
400_A403_S0.8300.96
298_Y302_L0.8280.96
48_G124_L0.8270.96
393_I396_I0.8250.96
299_S303_S0.8240.96
34_F89_Y0.8230.96
118_Y121_E0.8230.96
89_Y303_S0.8200.96
60_I64_L0.8200.96
20_P24_R0.8150.96
366_V430_Y0.8140.96
58_Q61_I0.8140.96
210_I214_I0.8140.96
78_A81_G0.8130.96
167_S291_I0.8120.96
125_F289_Q0.8080.95
132_I282_L0.8050.95
84_S371_N0.7990.95
386_N389_Y0.7980.95
200_P203_H0.7970.95
386_N390_N0.7960.95
318_I322_I0.7950.95
16_L90_V0.7920.95
397_L400_A0.7890.95
219_A352_L0.7860.95
75_S238_G0.7860.95
212_A342_E0.7860.95
421_T424_L0.7850.95
185_V255_G0.7840.95
43_V46_A0.7820.95
236_D239_Y0.7820.95
288_G291_I0.7810.95
402_G418_S0.7770.94
403_S408_F0.7740.94
192_F195_V0.7730.94
180_I277_M0.7690.94
71_G289_Q0.7690.94
26_G232_K0.7650.94
28_F32_L0.7650.94
82_A237_A0.7620.94
321_V324_T0.7590.94
392_N430_Y0.7580.94
405_I417_N0.7550.94
39_G292_I0.7540.94
38_Y248_L0.7500.93
214_I419_L0.7460.93
93_R362_D0.7460.93
393_I433_I0.7460.93
126_G130_S0.7450.93
37_V220_G0.7450.93
93_R306_N0.7440.93
174_H292_I0.7440.93
122_T293_N0.7430.93
88_T299_S0.7430.93
314_I317_V0.7420.93
123_W127_I0.7400.93
48_G260_V0.7400.93
362_D430_Y0.7370.93
108_L299_S0.7360.93
300_G303_S0.7340.93
276_G280_G0.7300.92
397_L401_L0.7290.92
160_Y230_F0.7280.92
76_L365_I0.7280.92
54_L58_Q0.7270.92
71_G246_I0.7270.92
394_A433_I0.7250.92
93_R98_R0.7240.92
245_I249_Y0.7240.92
29_N164_S0.7220.92
223_I227_I0.7180.92
358_I366_V0.7160.92
41_I44_I0.7110.91
109_I304_L0.7090.91
392_N395_G0.7070.91
185_V189_K0.7060.91
31_F243_A0.7060.91
190_G195_V0.7040.91
92_W101_G0.7000.91
324_T328_A0.7000.91
282_L291_I0.6990.91
214_I218_S0.6970.91
77_T224_S0.6950.90
67_T249_Y0.6930.90
313_E331_G0.6930.90
199_V203_H0.6930.90
179_A401_L0.6910.90
12_D298_Y0.6880.90
99_W389_Y0.6870.90
425_S428_I0.6870.90
174_H288_G0.6870.90
133_F144_A0.6850.90
45_W48_G0.6850.90
105_G303_S0.6850.90
64_L254_L0.6840.90
358_I422_G0.6840.90
119_A123_W0.6820.90
167_S294_T0.6820.90
31_F35_S0.6810.90
312_R315_A0.6810.90
139_F144_A0.6800.89
82_A231_A0.6790.89
56_F261_L0.6790.89
59_A63_V0.6770.89
207_L210_I0.6750.89
92_W95_P0.6750.89
74_G77_T0.6750.89
365_I368_K0.6740.89
80_V359_V0.6720.89
327_A331_G0.6720.89
145_A328_A0.6720.89
38_Y249_Y0.6700.89
301_S315_A0.6670.89
42_A126_G0.6650.88
314_I329_Y0.6610.88
403_S407_Y0.6600.88
194_T197_A0.6600.88
102_K307_L0.6600.88
129_M144_A0.6580.88
172_P176_W0.6550.88
340_P343_N0.6530.87
42_A289_Q0.6530.87
77_T360_L0.6530.87
213_T216_L0.6520.87
132_I286_V0.6500.87
142_G328_A0.6500.87
289_Q292_I0.6490.87
27_F240_A0.6490.87
27_F233_S0.6480.87
269_T272_M0.6480.87
354_A402_G0.6470.87
195_V321_V0.6460.87
43_V216_L0.6460.87
74_G219_A0.6460.87
177_L284_I0.6450.87
402_G405_I0.6440.87
311_R315_A0.6440.87
74_G224_S0.6430.87
92_W355_M0.6420.87
64_L235_K0.6420.87
381_E385_N0.6420.87
247_F251_F0.6400.86
380_Y400_A0.6380.86
43_V256_G0.6380.86
285_I289_Q0.6370.86
401_L404_I0.6360.86
86_L90_V0.6360.86
197_A203_H0.6350.86
190_G193_H0.6350.86
394_A434_K0.6340.86
114_G300_G0.6340.86
242_F246_I0.6330.86
78_A241_W0.6310.86
116_G331_G0.6300.86
17_K20_P0.6300.86
11_Y15_S0.6300.86
105_G307_L0.6280.85
197_A428_I0.6270.85
184_I187_A0.6270.85
239_Y242_F0.6260.85
402_G406_G0.6250.85
56_F258_A0.6250.85
126_G252_L0.6240.85
37_V217_Y0.6240.85
58_Q206_L0.6230.85
159_G298_Y0.6220.85
204_M207_L0.6220.85
118_Y152_M0.6210.85
287_F291_I0.6210.85
153_T317_V0.6200.85
375_D380_Y0.6200.85
152_M155_M0.6190.85
37_V249_Y0.6180.84
76_L360_L0.6180.84
188_L193_H0.6170.84
105_G306_N0.6160.84
191_G196_M0.6150.84
75_S78_A0.6150.84
153_T157_Y0.6130.84
193_H199_V0.6100.84
54_L209_G0.6090.84
189_K192_F0.6090.84
340_P344_F0.6080.84
198_A201_T0.6080.84
118_Y153_T0.6050.83
260_V263_T0.6040.83
64_L147_W0.6040.83
193_H196_M0.6040.83
233_S237_A0.6040.83
198_A202_S0.6030.83
82_A234_A0.6030.83
421_T430_Y0.6030.83
36_S171_I0.6020.83
320_G324_T0.6020.83
321_V325_A0.6000.83
49_A260_V0.5970.82
30_V231_A0.5960.82
148_G290_F0.5950.82
113_T345_I0.5940.82
16_L93_R0.5940.82
375_D381_E0.5940.82
402_G423_F0.5940.82
264_G272_M0.5940.82
406_G410_N0.5930.82
107_L355_M0.5930.82
50_L260_V0.5930.82
193_H236_D0.5920.82
48_G81_G0.5920.82
29_N157_Y0.5900.82
184_I188_L0.5880.81
324_T327_A0.5870.81
259_I263_T0.5860.81
380_Y386_N0.5850.81
75_S248_L0.5840.81
40_A43_V0.5840.81
56_F257_V0.5840.81
350_D407_Y0.5830.81
68_V250_P0.5830.81
177_L281_V0.5820.81
30_V78_A0.5820.81
217_Y245_I0.5810.81
22_D424_L0.5810.81
86_L91_M0.5810.81
194_T199_V0.5790.80
45_W124_L0.5790.80
243_A247_F0.5770.80
130_S139_F0.5750.80
113_T219_A0.5750.80
371_N376_P0.5750.80
140_S143_V0.5740.80
124_L289_Q0.5740.80
70_L74_G0.5730.80
46_A212_A0.5720.80
181_G217_Y0.5710.80
301_S306_N0.5690.79
269_T275_L0.5680.79
169_F172_P0.5680.79
234_A238_G0.5680.79
12_D15_S0.5680.79
94_H367_K0.5670.79
108_L223_I0.5670.79
154_I405_I0.5670.79
38_Y89_Y0.5670.79
407_Y410_N0.5660.79
115_I305_V0.5660.79
99_W391_I0.5660.79
316_S319_N0.5660.79
49_A53_G0.5660.79
66_G70_L0.5660.79
55_T359_V0.5650.79
223_I226_D0.5650.79
125_F155_M0.5640.79
361_A426_Y0.5630.79
267_L273_L0.5620.78
291_I295_D0.5600.78
179_A251_F0.5600.78
68_V431_Y0.5570.78
313_E317_V0.5570.78
376_P385_N0.5550.78
367_K371_N0.5550.78
392_N433_I0.5550.78
417_N421_T0.5540.78
215_G349_G0.5530.77
20_P230_F0.5520.77
150_I339_T0.5520.77
243_A397_L0.5520.77
304_L315_A0.5510.77
70_L222_I0.5510.77
231_A237_A0.5490.77
88_T108_L0.5480.77
395_G430_Y0.5480.77
43_V252_L0.5460.76
143_V146_I0.5460.76
46_A342_E0.5460.76
114_G299_S0.5450.76
428_I433_I0.5430.76
388_Y397_L0.5430.76
70_L220_G0.5430.76
156_T297_L0.5420.76
37_V289_Q0.5420.76
420_V428_I0.5410.76
165_F170_T0.5400.76
98_R379_R0.5400.76
167_S292_I0.5390.76
44_I252_L0.5380.75
151_L154_I0.5380.75
237_A241_W0.5370.75
396_I433_I0.5370.75
272_M275_L0.5370.75
109_I220_G0.5350.75
365_I369_Y0.5350.75
223_I299_S0.5350.75
352_L415_A0.5350.75
360_L419_L0.5340.75
94_H376_P0.5330.75
398_A401_L0.5330.75
277_M281_V0.5320.75
42_A120_V0.5320.75
192_F196_M0.5320.75
217_Y220_G0.5310.75
264_G402_G0.5310.75
215_G353_P0.5300.74
169_F176_W0.5290.74
115_I348_L0.5280.74
220_G341_F0.5280.74
72_I384_P0.5270.74
314_I331_G0.5270.74
176_W183_A0.5250.74
389_Y432_I0.5250.74
83_Y369_Y0.5230.73
38_Y47_G0.5230.73
270_N275_L0.5220.73
297_L301_S0.5210.73
401_L429_I0.5210.73
40_A44_I0.5200.73
194_T367_K0.5200.73
36_S167_S0.5200.73
57_S60_I0.5190.73
33_V53_G0.5190.73
115_I322_I0.5180.73
344_F348_L0.5180.73
209_G213_T0.5170.73
238_G242_F0.5150.72
27_F30_V0.5140.72
178_I288_G0.5140.72
368_K389_Y0.5130.72
166_L291_I0.5130.72
227_I295_D0.5120.72
52_Y205_S0.5120.72
304_L307_L0.5110.72
15_S305_V0.5110.72
114_G296_N0.5110.72
322_I326_I0.5080.71
65_S270_N0.5080.71
147_W154_I0.5050.71
134_P144_A0.5040.71
124_L348_L0.5040.71
387_K391_I0.5040.71
120_V155_M0.5030.71
133_F147_W0.5020.70
315_A329_Y0.5020.70
19_V85_G0.5010.70
135_N139_F0.5010.70
36_S292_I0.5010.70
359_V424_L0.5000.70
100_G391_I0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jlnA 1 0.9514 100 0.17 Contact Map
3dh4A 3 0.8631 99.4 0.849 Contact Map
4djkA 2 0.8565 99.3 0.853 Contact Map
2xq2A 2 0.8675 99.3 0.854 Contact Map
3l1lA 2 0.8631 99.3 0.856 Contact Map
3giaA 1 0.8742 99.3 0.859 Contact Map
4wgvA 2 0.7704 98 0.908 Contact Map
4us3A 1 0.8234 97.8 0.911 Contact Map
2a65A 2 0.9139 97.6 0.916 Contact Map
4xp4A 1 0.9205 93.7 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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