GREMLIN Database
Q97XP4 - Uncharacterized protein
UniProt: Q97XP4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 360 (343)
Sequences: 743 (573)
Seq/√Len: 30.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
340_R347_D6.7301.00
13_N220_N6.1181.00
20_F219_L5.2261.00
56_N201_L4.1741.00
8_E41_E3.9861.00
55_S59_S3.9771.00
7_E10_D3.7381.00
59_S99_E3.6381.00
157_D161_N3.1811.00
268_K284_N3.0091.00
300_L318_M2.9441.00
128_G204_A2.9091.00
272_I297_V2.8561.00
270_M288_V2.8541.00
60_F96_N2.7591.00
56_N197_L2.7361.00
46_I115_L2.5901.00
196_S199_T2.5100.99
236_M289_T2.4380.99
51_G207_G2.4260.99
228_L231_L2.4150.99
270_M281_A2.3710.99
268_K283_I2.3710.99
224_L303_L2.3520.99
14_L213_L2.3270.99
328_L333_A2.2700.99
115_L125_V2.2660.99
332_E335_R2.2300.99
12_Q37_K2.2180.99
102_T128_G2.1680.98
62_L98_V2.1660.98
198_P202_N2.1540.98
233_A322_I2.0460.98
227_L231_L1.9750.97
237_F270_M1.9530.97
296_T322_I1.9230.97
56_N198_P1.9180.97
69_A140_M1.8950.96
236_M321_G1.8950.96
197_L201_L1.8820.96
18_A111_S1.8780.96
71_I253_S1.8630.96
340_R345_D1.8590.96
61_V100_Y1.8570.96
67_M177_A1.8560.96
217_K221_Q1.8270.95
255_G274_F1.7800.95
235_I318_M1.7760.95
130_G143_F1.7360.94
54_Y61_V1.7340.94
299_D302_T1.7320.94
11_L33_G1.6950.93
241_V311_I1.6900.93
199_T202_N1.6880.93
20_F215_I1.6660.93
50_T53_K1.6500.92
12_Q33_G1.6180.91
93_F164_I1.6150.91
77_I302_T1.6110.91
8_E37_K1.6050.91
48_V209_L1.6020.91
240_K313_Y1.5880.91
224_L227_L1.5860.91
287_I290_T1.5620.90
261_G267_E1.5600.90
153_I173_S1.5380.89
256_N271_K1.5350.89
87_L117_T1.5320.89
13_N217_K1.5260.89
42_I120_K1.5110.88
331_K335_R1.4960.88
90_Y191_A1.4960.88
278_F308_T1.4860.87
178_R252_F1.4590.86
26_G107_G1.4590.86
212_A289_T1.4430.86
65_A138_L1.4330.85
272_I278_F1.4330.85
130_G195_T1.4260.85
290_T346_V1.4090.84
49_V54_Y1.4060.84
214_E217_K1.3900.84
225_D229_D1.3840.83
73_M109_V1.3790.83
142_T204_A1.3740.83
223_R304_K1.3670.83
289_T321_G1.3660.82
87_L121_T1.3660.82
49_V100_Y1.3600.82
179_I183_R1.3580.82
259_I306_I1.3530.82
131_M135_F1.3340.81
87_L101_I1.3320.81
102_T200_Y1.3200.80
259_I317_V1.3160.80
270_M283_I1.3110.80
86_A191_A1.3100.80
273_D282_R1.3070.80
21_L215_I1.2940.79
67_M190_I1.2930.79
259_I319_V1.2920.79
181_T188_A1.2770.78
86_A90_Y1.2730.78
239_G259_I1.2720.78
105_E134_A1.2720.78
71_I248_V1.2630.77
328_L337_V1.2530.77
219_L227_L1.2500.76
65_A190_I1.2390.76
249_E254_K1.2310.75
165_V173_S1.2290.75
232_K323_P1.2270.75
218_L222_M1.2260.75
38_R42_I1.2260.75
64_S101_I1.2110.74
283_I288_V1.2040.74
10_D213_L1.1990.73
251_G276_N1.1960.73
282_R287_I1.1890.73
142_T205_V1.1840.72
38_R205_V1.1680.71
16_T305_P1.1620.71
84_K121_T1.1620.71
144_Y336_Y1.1620.71
91_S97_E1.1510.70
287_I346_V1.1510.70
67_M181_T1.1420.70
168_I173_S1.1340.69
138_L190_I1.1260.68
329_R350_P1.1230.68
242_V260_D1.1140.68
26_G134_A1.1130.68
251_G255_G1.1090.67
333_A337_V1.1090.67
107_G134_A1.0970.66
10_D217_K1.0960.66
91_S98_V1.0950.66
65_A82_E1.0930.66
282_R285_N1.0930.66
222_M226_D1.0870.66
281_A288_V1.0820.65
24_G27_G1.0780.65
248_V253_S1.0770.65
214_E230_L1.0730.65
258_I269_T1.0690.64
103_P145_F1.0660.64
257_V317_V1.0660.64
235_I320_I1.0600.64
138_L192_L1.0570.63
38_R41_E1.0540.63
290_T347_D1.0480.63
157_D174_E1.0470.63
84_K117_T1.0450.63
54_Y200_Y1.0440.62
78_P82_E1.0410.62
153_I272_I1.0390.62
146_Y203_T1.0370.62
33_G37_K1.0340.62
129_D152_P1.0320.62
65_A130_G1.0290.61
175_K345_D1.0280.61
85_K88_E1.0280.61
183_R250_R1.0270.61
257_V311_I1.0150.60
88_E91_S1.0110.60
13_N221_Q1.0080.60
89_V162_V1.0040.59
54_Y197_L0.9960.59
224_L231_L0.9920.58
22_G307_T0.9910.58
333_A336_Y0.9910.58
105_E108_G0.9870.58
67_M138_L0.9860.58
327_K333_A0.9860.58
324_S348_F0.9790.57
86_A156_F0.9680.57
212_A325_S0.9620.56
236_M281_A0.9610.56
88_E121_T0.9610.56
19_S22_G0.9530.55
313_Y316_K0.9490.55
335_R340_R0.9460.55
165_V176_I0.9440.55
128_G156_F0.9420.55
105_E132_G0.9390.54
325_S337_V0.9380.54
261_G265_Y0.9370.54
51_G206_L0.9360.54
14_L115_L0.9320.54
297_V317_V0.9320.54
16_T304_K0.9250.53
85_K89_V0.9090.52
47_E122_G0.9090.52
65_A192_L0.9070.52
224_L228_L0.9050.52
90_Y153_I0.9040.51
67_M188_A0.9030.51
53_K126_V0.8960.51
142_T186_G0.8940.51
245_Q258_I0.8940.51
262_I272_I0.8860.50
54_Y59_S0.8850.50
246_R308_T0.8800.50
7_E213_L0.8770.49
115_L118_S0.8760.49
55_S58_K0.8750.49
102_T204_A0.8740.49
14_L334_L0.8730.49
52_M206_L0.8710.49
23_T294_L0.8700.49
83_A189_Y0.8640.48
175_K183_R0.8630.48
327_K344_Y0.8610.48
142_T327_K0.8610.48
240_K316_K0.8600.48
272_I291_V0.8470.47
51_G200_Y0.8410.46
109_V190_I0.8410.46
6_I53_K0.8400.46
235_I238_K0.8400.46
257_V272_I0.8360.46
71_I308_T0.8350.46
252_F275_Q0.8250.45
181_T329_R0.8230.45
241_V306_I0.8220.45
97_E123_I0.8210.45
105_E294_L0.8190.45
135_F140_M0.8190.45
48_V106_M0.8140.44
145_F328_L0.8090.44
90_Y194_G0.8080.44
129_D132_G0.8040.43
280_V346_V0.8020.43
30_Y347_D0.8010.43
238_K318_M0.8000.43
54_Y100_Y0.7990.43
227_L320_I0.7990.43
95_D198_P0.7990.43
137_E252_F0.7970.43
56_N59_S0.7940.43
20_F298_L0.7930.43
100_Y330_T0.7920.42
65_A180_I0.7900.42
291_V334_L0.7890.42
227_L303_L0.7880.42
141_T327_K0.7880.42
40_L257_V0.7870.42
291_V342_F0.7860.42
297_V319_V0.7840.42
178_R185_G0.7830.42
9_R13_N0.7790.41
163_S180_I0.7780.41
98_V123_I0.7730.41
6_I48_V0.7730.41
92_K349_I0.7720.41
22_G26_G0.7700.41
100_Y186_G0.7690.41
213_L217_K0.7670.41
223_R241_V0.7660.40
63_G141_T0.7650.40
113_I117_T0.7650.40
270_M319_V0.7640.40
202_N290_T0.7620.40
243_D316_K0.7550.40
104_L141_T0.7550.40
69_A248_V0.7530.39
140_M337_V0.7500.39
236_M330_T0.7490.39
48_V193_Y0.7480.39
242_V258_I0.7470.39
126_V164_I0.7440.39
13_N213_L0.7420.39
166_Q320_I0.7410.39
236_M270_M0.7400.38
20_F303_L0.7360.38
75_E110_N0.7360.38
22_G105_E0.7300.38
155_I159_R0.7290.38
155_I190_I0.7220.37
90_Y236_M0.7190.37
255_G276_N0.7120.36
34_L275_Q0.7110.36
20_F218_L0.7110.36
15_I111_S0.7110.36
250_R286_D0.7100.36
210_S213_L0.7090.36
224_L318_M0.7060.36
202_N260_D0.7000.35
198_P346_V0.7000.35
145_F337_V0.7000.35
137_E261_G0.6990.35
67_M173_S0.6980.35
53_K302_T0.6970.35
22_G25_G0.6960.35
55_S196_S0.6940.35
154_V268_K0.6930.35
34_L313_Y0.6900.35
242_V269_T0.6880.35
11_L272_I0.6870.35
262_I266_S0.6850.34
188_A330_T0.6830.34
63_G104_L0.6820.34
32_G111_S0.6810.34
333_A338_G0.6770.34
54_Y99_E0.6720.33
106_M212_A0.6710.33
278_F291_V0.6700.33
29_P256_N0.6680.33
258_I321_G0.6680.33
86_A189_Y0.6640.33
107_G251_G0.6640.33
241_V285_N0.6620.33
298_L320_I0.6610.33
90_Y154_V0.6560.32
273_D280_V0.6540.32
53_K207_G0.6540.32
61_V200_Y0.6530.32
110_N131_M0.6530.32
22_G27_G0.6530.32
177_A181_T0.6500.32
25_G105_E0.6490.32
70_P140_M0.6490.32
261_G268_K0.6490.32
334_L348_F0.6490.32
50_T95_D0.6480.32
50_T207_G0.6450.32
28_D310_R0.6450.32
126_V235_I0.6450.32
219_L303_L0.6450.32
75_E131_M0.6430.31
106_M131_M0.6420.31
66_M189_Y0.6390.31
228_L233_A0.6350.31
91_S118_S0.6350.31
20_F296_T0.6350.31
6_I257_V0.6340.31
226_D248_V0.6340.31
135_F338_G0.6340.31
75_E108_G0.6340.31
50_T335_R0.6310.31
158_E307_T0.6310.31
260_D269_T0.6310.31
99_E121_T0.6310.31
72_V75_E0.6290.30
280_V344_Y0.6290.30
76_K184_Y0.6290.30
271_K284_N0.6290.30
27_G134_A0.6270.30
74_I309_D0.6270.30
200_Y204_A0.6260.30
128_G209_L0.6260.30
62_L191_A0.6240.30
324_S328_L0.6240.30
22_G132_G0.6220.30
272_I295_I0.6220.30
218_L226_D0.6220.30
61_V197_L0.6210.30
36_L39_E0.6200.30
210_S317_V0.6190.30
330_T333_A0.6190.30
267_E284_N0.6180.30
14_L212_A0.6180.30
175_K180_I0.6160.30
229_D235_I0.6160.30
101_I111_S0.6160.30
25_G107_G0.6130.29
233_A291_V0.6130.29
251_G275_Q0.6130.29
241_V249_E0.6120.29
125_V153_I0.6110.29
245_Q278_F0.6110.29
234_I267_E0.6110.29
101_I193_Y0.6100.29
66_M187_S0.6090.29
176_I190_I0.6080.29
275_Q279_L0.6080.29
279_L291_V0.6080.29
20_F222_M0.6080.29
233_A323_P0.6060.29
135_F279_L0.6060.29
17_G24_G0.6050.29
52_M148_V0.6040.29
59_S348_F0.6030.29
89_V92_K0.6000.28
143_F186_G0.6000.28
141_T194_G0.5980.28
50_T228_L0.5980.28
20_F227_L0.5970.28
323_P337_V0.5970.28
106_M208_T0.5960.28
53_K319_V0.5960.28
62_L101_I0.5930.28
332_E336_Y0.5920.28
18_A125_V0.5880.28
21_L124_P0.5870.28
22_G212_A0.5870.28
111_S158_E0.5860.28
131_M291_V0.5850.27
64_S87_L0.5850.27
265_Y283_I0.5850.27
110_N114_P0.5840.27
43_V222_M0.5820.27
30_Y240_K0.5820.27
40_L43_V0.5820.27
39_E119_A0.5780.27
151_S155_I0.5780.27
96_N196_S0.5780.27
106_M111_S0.5770.27
223_R229_D0.5770.27
135_F337_V0.5760.27
126_V197_L0.5740.27
110_N129_D0.5730.27
75_E240_K0.5720.27
100_Y327_K0.5720.27
15_I20_F0.5690.26
145_F333_A0.5690.26
76_K158_E0.5690.26
78_P188_A0.5670.26
126_V142_T0.5650.26
207_G225_D0.5640.26
74_I169_D0.5640.26
12_Q169_D0.5640.26
12_Q59_S0.5630.26
125_V250_R0.5620.26
257_V297_V0.5610.26
294_L339_P0.5600.26
26_G105_E0.5600.26
60_F99_E0.5590.26
128_G206_L0.5590.26
15_I112_T0.5570.26
52_M297_V0.5570.26
97_E221_Q0.5560.26
275_Q308_T0.5560.26
111_S305_P0.5540.26
334_L339_P0.5530.25
228_L235_I0.5520.25
299_D306_I0.5510.25
159_R173_S0.5510.25
161_N233_A0.5510.25
198_P201_L0.5510.25
246_R312_K0.5500.25
69_A274_F0.5470.25
61_V102_T0.5460.25
207_G223_R0.5460.25
231_L331_K0.5460.25
32_G305_P0.5440.25
28_D120_K0.5440.25
46_I119_A0.5400.25
181_T186_G0.5400.25
6_I47_E0.5400.25
18_A103_P0.5390.25
265_Y268_K0.5390.25
51_G125_V0.5390.25
93_F145_F0.5380.25
241_V319_V0.5370.25
56_N210_S0.5370.25
211_L214_E0.5360.24
176_I180_I0.5360.24
148_V199_T0.5350.24
142_T146_Y0.5340.24
340_R344_Y0.5330.24
172_W175_K0.5320.24
145_F303_L0.5320.24
31_I114_P0.5310.24
98_V268_K0.5300.24
71_I348_F0.5300.24
45_K49_V0.5290.24
186_G204_A0.5290.24
153_I303_L0.5280.24
172_W176_I0.5280.24
131_M338_G0.5280.24
340_R346_V0.5280.24
297_V300_L0.5270.24
103_P278_F0.5270.24
35_M66_M0.5270.24
160_G343_G0.5260.24
18_A142_T0.5250.24
217_K220_N0.5240.24
16_T220_N0.5240.24
9_R47_E0.5230.24
10_D49_V0.5230.24
215_I321_G0.5230.24
163_S321_G0.5210.24
90_Y211_L0.5210.24
231_L322_I0.5200.24
94_T126_V0.5200.24
90_Y121_T0.5200.24
10_D259_I0.5180.23
173_S337_V0.5180.23
262_I316_K0.5170.23
36_L46_I0.5160.23
135_F274_F0.5160.23
333_A348_F0.5160.23
17_G25_G0.5150.23
105_E110_N0.5130.23
36_L275_Q0.5120.23
40_L196_S0.5110.23
90_Y94_T0.5100.23
72_V248_V0.5090.23
212_A298_L0.5090.23
6_I178_R0.5090.23
72_V313_Y0.5080.23
137_E182_V0.5080.23
143_F204_A0.5060.23
119_A241_V0.5050.23
14_L295_I0.5050.23
244_V274_F0.5030.23
46_I49_V0.5030.23
25_G134_A0.5030.23
169_D203_T0.5020.22
40_L281_A0.5020.22
107_G255_G0.5010.22
181_T196_S0.5010.22
103_P143_F0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o3iA 3 0.9111 100 0.106 Contact Map
1f4pA 1 0.3944 41.6 0.969 Contact Map
5nulA 1 0.375 22.1 0.973 Contact Map
4qw2A 1 0.2972 20.5 0.974 Contact Map
2fz5A 1 0.375 17.1 0.975 Contact Map
4oxxA 1 0.4056 16.1 0.975 Contact Map
2hnaA 1 0.3917 14.6 0.975 Contact Map
1khiA 1 0.3278 14 0.975 Contact Map
4heqA 2 0.3833 13.5 0.976 Contact Map
2m6rA 1 0.4056 13 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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