Q97XP4 - SULSO - GREMLIN Contacts

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Q97XP4 - Uncharacterized protein

UniProt:	Q97XP4	Sequences: METYFIEERDLQNLITGASFLGTGGGGDPYIGGLMLKRELEIVKKIEVVTGMKYSNSKSFVLGSAMMGAPIVMIEKIPNSSEAKKALEVYSKFTDNEVEYITPLEMGGVNSTIPLITSAKTGIPVVDGDGMGRAFPELQMTTFYFYGVQPSPIVIFDERGNVSIVQGIDGYWSEKIARIITVRYGGSAYIALYGTSLPTYLNTAVLGTLSLALEIGKLLNQMRLDDLLDLLKAIIMFKGKVVDVQRRVERGFSKGNVIIDGIENYSEKTMKIDFQNEFLVARINNDIVTTVPDLITVLDLFTLKPITTDRIKYGQKVMVIGIPSSGKLRTKEALRYVGPRAFGYDVDFIPLEERWKKVEN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	360 (343)
Sequences:	743 (573)
Seq/√Len:	30.9

SULSO - Q97XP4 Q97XP2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
340_R	347_D	6.730	1.00
13_N	220_N	6.118	1.00
20_F	219_L	5.226	1.00
56_N	201_L	4.174	1.00
8_E	41_E	3.986	1.00
55_S	59_S	3.977	1.00
7_E	10_D	3.738	1.00
59_S	99_E	3.638	1.00
157_D	161_N	3.181	1.00
268_K	284_N	3.009	1.00
300_L	318_M	2.944	1.00
128_G	204_A	2.909	1.00
272_I	297_V	2.856	1.00
270_M	288_V	2.854	1.00
60_F	96_N	2.759	1.00
56_N	197_L	2.736	1.00
46_I	115_L	2.590	1.00
196_S	199_T	2.510	0.99
236_M	289_T	2.438	0.99
51_G	207_G	2.426	0.99
228_L	231_L	2.415	0.99
270_M	281_A	2.371	0.99
268_K	283_I	2.371	0.99
224_L	303_L	2.352	0.99
14_L	213_L	2.327	0.99
328_L	333_A	2.270	0.99
115_L	125_V	2.266	0.99
332_E	335_R	2.230	0.99
12_Q	37_K	2.218	0.99
102_T	128_G	2.168	0.98
62_L	98_V	2.166	0.98
198_P	202_N	2.154	0.98
233_A	322_I	2.046	0.98
227_L	231_L	1.975	0.97
237_F	270_M	1.953	0.97
296_T	322_I	1.923	0.97
56_N	198_P	1.918	0.97
69_A	140_M	1.895	0.96
236_M	321_G	1.895	0.96
197_L	201_L	1.882	0.96
18_A	111_S	1.878	0.96
71_I	253_S	1.863	0.96
340_R	345_D	1.859	0.96
61_V	100_Y	1.857	0.96
67_M	177_A	1.856	0.96
217_K	221_Q	1.827	0.95
255_G	274_F	1.780	0.95
235_I	318_M	1.776	0.95
130_G	143_F	1.736	0.94
54_Y	61_V	1.734	0.94
299_D	302_T	1.732	0.94
11_L	33_G	1.695	0.93
241_V	311_I	1.690	0.93
199_T	202_N	1.688	0.93
20_F	215_I	1.666	0.93
50_T	53_K	1.650	0.92
12_Q	33_G	1.618	0.91
93_F	164_I	1.615	0.91
77_I	302_T	1.611	0.91
8_E	37_K	1.605	0.91
48_V	209_L	1.602	0.91
240_K	313_Y	1.588	0.91
224_L	227_L	1.586	0.91
287_I	290_T	1.562	0.90
261_G	267_E	1.560	0.90
153_I	173_S	1.538	0.89
256_N	271_K	1.535	0.89
87_L	117_T	1.532	0.89
13_N	217_K	1.526	0.89
42_I	120_K	1.511	0.88
331_K	335_R	1.496	0.88
90_Y	191_A	1.496	0.88
278_F	308_T	1.486	0.87
178_R	252_F	1.459	0.86
26_G	107_G	1.459	0.86
212_A	289_T	1.443	0.86
65_A	138_L	1.433	0.85
272_I	278_F	1.433	0.85
130_G	195_T	1.426	0.85
290_T	346_V	1.409	0.84
49_V	54_Y	1.406	0.84
214_E	217_K	1.390	0.84
225_D	229_D	1.384	0.83
73_M	109_V	1.379	0.83
142_T	204_A	1.374	0.83
223_R	304_K	1.367	0.83
289_T	321_G	1.366	0.82
87_L	121_T	1.366	0.82
49_V	100_Y	1.360	0.82
179_I	183_R	1.358	0.82
259_I	306_I	1.353	0.82
131_M	135_F	1.334	0.81
87_L	101_I	1.332	0.81
102_T	200_Y	1.320	0.80
259_I	317_V	1.316	0.80
270_M	283_I	1.311	0.80
86_A	191_A	1.310	0.80
273_D	282_R	1.307	0.80
21_L	215_I	1.294	0.79
67_M	190_I	1.293	0.79
259_I	319_V	1.292	0.79
181_T	188_A	1.277	0.78
86_A	90_Y	1.273	0.78
239_G	259_I	1.272	0.78
105_E	134_A	1.272	0.78
71_I	248_V	1.263	0.77
328_L	337_V	1.253	0.77
219_L	227_L	1.250	0.76
65_A	190_I	1.239	0.76
249_E	254_K	1.231	0.75
165_V	173_S	1.229	0.75
232_K	323_P	1.227	0.75
218_L	222_M	1.226	0.75
38_R	42_I	1.226	0.75
64_S	101_I	1.211	0.74
283_I	288_V	1.204	0.74
10_D	213_L	1.199	0.73
251_G	276_N	1.196	0.73
282_R	287_I	1.189	0.73
142_T	205_V	1.184	0.72
38_R	205_V	1.168	0.71
16_T	305_P	1.162	0.71
84_K	121_T	1.162	0.71
144_Y	336_Y	1.162	0.71
91_S	97_E	1.151	0.70
287_I	346_V	1.151	0.70
67_M	181_T	1.142	0.70
168_I	173_S	1.134	0.69
138_L	190_I	1.126	0.68
329_R	350_P	1.123	0.68
242_V	260_D	1.114	0.68
26_G	134_A	1.113	0.68
251_G	255_G	1.109	0.67
333_A	337_V	1.109	0.67
107_G	134_A	1.097	0.66
10_D	217_K	1.096	0.66
91_S	98_V	1.095	0.66
65_A	82_E	1.093	0.66
282_R	285_N	1.093	0.66
222_M	226_D	1.087	0.66
281_A	288_V	1.082	0.65
24_G	27_G	1.078	0.65
248_V	253_S	1.077	0.65
214_E	230_L	1.073	0.65
258_I	269_T	1.069	0.64
103_P	145_F	1.066	0.64
257_V	317_V	1.066	0.64
235_I	320_I	1.060	0.64
138_L	192_L	1.057	0.63
38_R	41_E	1.054	0.63
290_T	347_D	1.048	0.63
157_D	174_E	1.047	0.63
84_K	117_T	1.045	0.63
54_Y	200_Y	1.044	0.62
78_P	82_E	1.041	0.62
153_I	272_I	1.039	0.62
146_Y	203_T	1.037	0.62
33_G	37_K	1.034	0.62
129_D	152_P	1.032	0.62
65_A	130_G	1.029	0.61
175_K	345_D	1.028	0.61
85_K	88_E	1.028	0.61
183_R	250_R	1.027	0.61
257_V	311_I	1.015	0.60
88_E	91_S	1.011	0.60
13_N	221_Q	1.008	0.60
89_V	162_V	1.004	0.59
54_Y	197_L	0.996	0.59
224_L	231_L	0.992	0.58
22_G	307_T	0.991	0.58
333_A	336_Y	0.991	0.58
105_E	108_G	0.987	0.58
67_M	138_L	0.986	0.58
327_K	333_A	0.986	0.58
324_S	348_F	0.979	0.57
86_A	156_F	0.968	0.57
212_A	325_S	0.962	0.56
236_M	281_A	0.961	0.56
88_E	121_T	0.961	0.56
19_S	22_G	0.953	0.55
313_Y	316_K	0.949	0.55
335_R	340_R	0.946	0.55
165_V	176_I	0.944	0.55
128_G	156_F	0.942	0.55
105_E	132_G	0.939	0.54
325_S	337_V	0.938	0.54
261_G	265_Y	0.937	0.54
51_G	206_L	0.936	0.54
14_L	115_L	0.932	0.54
297_V	317_V	0.932	0.54
16_T	304_K	0.925	0.53
85_K	89_V	0.909	0.52
47_E	122_G	0.909	0.52
65_A	192_L	0.907	0.52
224_L	228_L	0.905	0.52
90_Y	153_I	0.904	0.51
67_M	188_A	0.903	0.51
53_K	126_V	0.896	0.51
142_T	186_G	0.894	0.51
245_Q	258_I	0.894	0.51
262_I	272_I	0.886	0.50
54_Y	59_S	0.885	0.50
246_R	308_T	0.880	0.50
7_E	213_L	0.877	0.49
115_L	118_S	0.876	0.49
55_S	58_K	0.875	0.49
102_T	204_A	0.874	0.49
14_L	334_L	0.873	0.49
52_M	206_L	0.871	0.49
23_T	294_L	0.870	0.49
83_A	189_Y	0.864	0.48
175_K	183_R	0.863	0.48
327_K	344_Y	0.861	0.48
142_T	327_K	0.861	0.48
240_K	316_K	0.860	0.48
272_I	291_V	0.847	0.47
51_G	200_Y	0.841	0.46
109_V	190_I	0.841	0.46
6_I	53_K	0.840	0.46
235_I	238_K	0.840	0.46
257_V	272_I	0.836	0.46
71_I	308_T	0.835	0.46
252_F	275_Q	0.825	0.45
181_T	329_R	0.823	0.45
241_V	306_I	0.822	0.45
97_E	123_I	0.821	0.45
105_E	294_L	0.819	0.45
135_F	140_M	0.819	0.45
48_V	106_M	0.814	0.44
145_F	328_L	0.809	0.44
90_Y	194_G	0.808	0.44
129_D	132_G	0.804	0.43
280_V	346_V	0.802	0.43
30_Y	347_D	0.801	0.43
238_K	318_M	0.800	0.43
54_Y	100_Y	0.799	0.43
227_L	320_I	0.799	0.43
95_D	198_P	0.799	0.43
137_E	252_F	0.797	0.43
56_N	59_S	0.794	0.43
20_F	298_L	0.793	0.43
100_Y	330_T	0.792	0.42
65_A	180_I	0.790	0.42
291_V	334_L	0.789	0.42
227_L	303_L	0.788	0.42
141_T	327_K	0.788	0.42
40_L	257_V	0.787	0.42
291_V	342_F	0.786	0.42
297_V	319_V	0.784	0.42
178_R	185_G	0.783	0.42
9_R	13_N	0.779	0.41
163_S	180_I	0.778	0.41
98_V	123_I	0.773	0.41
6_I	48_V	0.773	0.41
92_K	349_I	0.772	0.41
22_G	26_G	0.770	0.41
100_Y	186_G	0.769	0.41
213_L	217_K	0.767	0.41
223_R	241_V	0.766	0.40
63_G	141_T	0.765	0.40
113_I	117_T	0.765	0.40
270_M	319_V	0.764	0.40
202_N	290_T	0.762	0.40
243_D	316_K	0.755	0.40
104_L	141_T	0.755	0.40
69_A	248_V	0.753	0.39
140_M	337_V	0.750	0.39
236_M	330_T	0.749	0.39
48_V	193_Y	0.748	0.39
242_V	258_I	0.747	0.39
126_V	164_I	0.744	0.39
13_N	213_L	0.742	0.39
166_Q	320_I	0.741	0.39
236_M	270_M	0.740	0.38
20_F	303_L	0.736	0.38
75_E	110_N	0.736	0.38
22_G	105_E	0.730	0.38
155_I	159_R	0.729	0.38
155_I	190_I	0.722	0.37
90_Y	236_M	0.719	0.37
255_G	276_N	0.712	0.36
34_L	275_Q	0.711	0.36
20_F	218_L	0.711	0.36
15_I	111_S	0.711	0.36
250_R	286_D	0.710	0.36
210_S	213_L	0.709	0.36
224_L	318_M	0.706	0.36
202_N	260_D	0.700	0.35
198_P	346_V	0.700	0.35
145_F	337_V	0.700	0.35
137_E	261_G	0.699	0.35
67_M	173_S	0.698	0.35
53_K	302_T	0.697	0.35
22_G	25_G	0.696	0.35
55_S	196_S	0.694	0.35
154_V	268_K	0.693	0.35
34_L	313_Y	0.690	0.35
242_V	269_T	0.688	0.35
11_L	272_I	0.687	0.35
262_I	266_S	0.685	0.34
188_A	330_T	0.683	0.34
63_G	104_L	0.682	0.34
32_G	111_S	0.681	0.34
333_A	338_G	0.677	0.34
54_Y	99_E	0.672	0.33
106_M	212_A	0.671	0.33
278_F	291_V	0.670	0.33
29_P	256_N	0.668	0.33
258_I	321_G	0.668	0.33
86_A	189_Y	0.664	0.33
107_G	251_G	0.664	0.33
241_V	285_N	0.662	0.33
298_L	320_I	0.661	0.33
90_Y	154_V	0.656	0.32
273_D	280_V	0.654	0.32
53_K	207_G	0.654	0.32
61_V	200_Y	0.653	0.32
110_N	131_M	0.653	0.32
22_G	27_G	0.653	0.32
177_A	181_T	0.650	0.32
25_G	105_E	0.649	0.32
70_P	140_M	0.649	0.32
261_G	268_K	0.649	0.32
334_L	348_F	0.649	0.32
50_T	95_D	0.648	0.32
50_T	207_G	0.645	0.32
28_D	310_R	0.645	0.32
126_V	235_I	0.645	0.32
219_L	303_L	0.645	0.32
75_E	131_M	0.643	0.31
106_M	131_M	0.642	0.31
66_M	189_Y	0.639	0.31
228_L	233_A	0.635	0.31
91_S	118_S	0.635	0.31
20_F	296_T	0.635	0.31
6_I	257_V	0.634	0.31
226_D	248_V	0.634	0.31
135_F	338_G	0.634	0.31
75_E	108_G	0.634	0.31
50_T	335_R	0.631	0.31
158_E	307_T	0.631	0.31
260_D	269_T	0.631	0.31
99_E	121_T	0.631	0.31
72_V	75_E	0.629	0.30
280_V	344_Y	0.629	0.30
76_K	184_Y	0.629	0.30
271_K	284_N	0.629	0.30
27_G	134_A	0.627	0.30
74_I	309_D	0.627	0.30
200_Y	204_A	0.626	0.30
128_G	209_L	0.626	0.30
62_L	191_A	0.624	0.30
324_S	328_L	0.624	0.30
22_G	132_G	0.622	0.30
272_I	295_I	0.622	0.30
218_L	226_D	0.622	0.30
61_V	197_L	0.621	0.30
36_L	39_E	0.620	0.30
210_S	317_V	0.619	0.30
330_T	333_A	0.619	0.30
267_E	284_N	0.618	0.30
14_L	212_A	0.618	0.30
175_K	180_I	0.616	0.30
229_D	235_I	0.616	0.30
101_I	111_S	0.616	0.30
25_G	107_G	0.613	0.29
233_A	291_V	0.613	0.29
251_G	275_Q	0.613	0.29
241_V	249_E	0.612	0.29
125_V	153_I	0.611	0.29
245_Q	278_F	0.611	0.29
234_I	267_E	0.611	0.29
101_I	193_Y	0.610	0.29
66_M	187_S	0.609	0.29
176_I	190_I	0.608	0.29
275_Q	279_L	0.608	0.29
279_L	291_V	0.608	0.29
20_F	222_M	0.608	0.29
233_A	323_P	0.606	0.29
135_F	279_L	0.606	0.29
17_G	24_G	0.605	0.29
52_M	148_V	0.604	0.29
59_S	348_F	0.603	0.29
89_V	92_K	0.600	0.28
143_F	186_G	0.600	0.28
141_T	194_G	0.598	0.28
50_T	228_L	0.598	0.28
20_F	227_L	0.597	0.28
323_P	337_V	0.597	0.28
106_M	208_T	0.596	0.28
53_K	319_V	0.596	0.28
62_L	101_I	0.593	0.28
332_E	336_Y	0.592	0.28
18_A	125_V	0.588	0.28
21_L	124_P	0.587	0.28
22_G	212_A	0.587	0.28
111_S	158_E	0.586	0.28
131_M	291_V	0.585	0.27
64_S	87_L	0.585	0.27
265_Y	283_I	0.585	0.27
110_N	114_P	0.584	0.27
43_V	222_M	0.582	0.27
30_Y	240_K	0.582	0.27
40_L	43_V	0.582	0.27
39_E	119_A	0.578	0.27
151_S	155_I	0.578	0.27
96_N	196_S	0.578	0.27
106_M	111_S	0.577	0.27
223_R	229_D	0.577	0.27
135_F	337_V	0.576	0.27
126_V	197_L	0.574	0.27
110_N	129_D	0.573	0.27
75_E	240_K	0.572	0.27
100_Y	327_K	0.572	0.27
15_I	20_F	0.569	0.26
145_F	333_A	0.569	0.26
76_K	158_E	0.569	0.26
78_P	188_A	0.567	0.26
126_V	142_T	0.565	0.26
207_G	225_D	0.564	0.26
74_I	169_D	0.564	0.26
12_Q	169_D	0.564	0.26
12_Q	59_S	0.563	0.26
125_V	250_R	0.562	0.26
257_V	297_V	0.561	0.26
294_L	339_P	0.560	0.26
26_G	105_E	0.560	0.26
60_F	99_E	0.559	0.26
128_G	206_L	0.559	0.26
15_I	112_T	0.557	0.26
52_M	297_V	0.557	0.26
97_E	221_Q	0.556	0.26
275_Q	308_T	0.556	0.26
111_S	305_P	0.554	0.26
334_L	339_P	0.553	0.25
228_L	235_I	0.552	0.25
299_D	306_I	0.551	0.25
159_R	173_S	0.551	0.25
161_N	233_A	0.551	0.25
198_P	201_L	0.551	0.25
246_R	312_K	0.550	0.25
69_A	274_F	0.547	0.25
61_V	102_T	0.546	0.25
207_G	223_R	0.546	0.25
231_L	331_K	0.546	0.25
32_G	305_P	0.544	0.25
28_D	120_K	0.544	0.25
46_I	119_A	0.540	0.25
181_T	186_G	0.540	0.25
6_I	47_E	0.540	0.25
18_A	103_P	0.539	0.25
265_Y	268_K	0.539	0.25
51_G	125_V	0.539	0.25
93_F	145_F	0.538	0.25
241_V	319_V	0.537	0.25
56_N	210_S	0.537	0.25
211_L	214_E	0.536	0.24
176_I	180_I	0.536	0.24
148_V	199_T	0.535	0.24
142_T	146_Y	0.534	0.24
340_R	344_Y	0.533	0.24
172_W	175_K	0.532	0.24
145_F	303_L	0.532	0.24
31_I	114_P	0.531	0.24
98_V	268_K	0.530	0.24
71_I	348_F	0.530	0.24
45_K	49_V	0.529	0.24
186_G	204_A	0.529	0.24
153_I	303_L	0.528	0.24
172_W	176_I	0.528	0.24
131_M	338_G	0.528	0.24
340_R	346_V	0.528	0.24
297_V	300_L	0.527	0.24
103_P	278_F	0.527	0.24
35_M	66_M	0.527	0.24
160_G	343_G	0.526	0.24
18_A	142_T	0.525	0.24
217_K	220_N	0.524	0.24
16_T	220_N	0.524	0.24
9_R	47_E	0.523	0.24
10_D	49_V	0.523	0.24
215_I	321_G	0.523	0.24
163_S	321_G	0.521	0.24
90_Y	211_L	0.521	0.24
231_L	322_I	0.520	0.24
94_T	126_V	0.520	0.24
90_Y	121_T	0.520	0.24
10_D	259_I	0.518	0.23
173_S	337_V	0.518	0.23
262_I	316_K	0.517	0.23
36_L	46_I	0.516	0.23
135_F	274_F	0.516	0.23
333_A	348_F	0.516	0.23
17_G	25_G	0.515	0.23
105_E	110_N	0.513	0.23
36_L	275_Q	0.512	0.23
40_L	196_S	0.511	0.23
90_Y	94_T	0.510	0.23
72_V	248_V	0.509	0.23
212_A	298_L	0.509	0.23
6_I	178_R	0.509	0.23
72_V	313_Y	0.508	0.23
137_E	182_V	0.508	0.23
143_F	204_A	0.506	0.23
119_A	241_V	0.505	0.23
14_L	295_I	0.505	0.23
244_V	274_F	0.503	0.23
46_I	49_V	0.503	0.23
25_G	134_A	0.503	0.23
169_D	203_T	0.502	0.22
40_L	281_A	0.502	0.22
107_G	255_G	0.501	0.22
181_T	196_S	0.501	0.22
103_P	143_F	0.500	0.22

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2o3iA	3	0.9111	100	0.106	Contact Map
1f4pA	1	0.3944	41.6	0.969	Contact Map
5nulA	1	0.375	22.1	0.973	Contact Map
4qw2A	1	0.2972	20.5	0.974	Contact Map
2fz5A	1	0.375	17.1	0.975	Contact Map
4oxxA	1	0.4056	16.1	0.975	Contact Map
2hnaA	1	0.3917	14.6	0.975	Contact Map
1khiA	1	0.3278	14	0.975	Contact Map
4heqA	2	0.3833	13.5	0.976	Contact Map
2m6rA	1	0.4056	13	0.976	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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