Q97XP2 - SULSO - GREMLIN Contacts

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Q97XP2 - Uncharacterized protein

UniProt:	Q97XP2	Sequences: MRISVNDLYNLAIGSSILGSGGGGNPFLGYKIVKAKMLQMNIDYVEYTDEVDEDRDFIIGVGGMGSPLIGIEKIPAGHEYYRSLMTLTKFLRKEVTKITSIEIGGINSVVPFMASLMSKKPLIDGDYEGRAFPELYMTTMHFAGYRATPLSICDERENCVIIETVDNFRAESIARSITVGFGGRGYISLYPASGKEYINGAILGTVSLALELGKTLTEQGLDEMINLARGKIIFEGKIVDVKRFNIGGFAIGMAKIDGLEEYRGENSEIIFKNEYLGFLKEGKILSISPEIINLIDYNNNIVTSDSLRYGVKVRVLEIPVSNKWKEVGGYEKIKEMVVKEIKKIHQLP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	348 (337)
Sequences:	747 (575)
Seq/√Len:	31.3

SULSO - Q97XP2 Q97XP4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
10_N	217_T	6.094	1.00
17_I	216_L	5.171	1.00
53_E	198_I	4.413	1.00
52_D	56_D	4.197	1.00
5_V	38_L	4.029	1.00
4_S	7_D	3.855	1.00
56_D	96_T	3.341	1.00
154_D	158_N	3.159	1.00
53_E	194_G	3.010	1.00
265_E	281_E	2.923	1.00
297_Y	314_R	2.895	1.00
267_S	285_L	2.865	1.00
43_D	112_F	2.822	1.00
324_W	329_G	2.730	1.00
57_F	93_K	2.708	1.00
125_G	201_A	2.688	1.00
336_M	341_I	2.671	1.00
11_L	210_L	2.530	1.00
193_S	196_E	2.528	1.00
269_I	294_L	2.487	0.99
48_T	204_G	2.481	0.99
296_D	299_N	2.443	0.99
265_E	280_K	2.426	0.99
233_I	286_S	2.371	0.99
328_G	331_E	2.287	0.99
267_S	278_F	2.240	0.99
112_F	122_L	2.240	0.99
233_I	317_E	2.205	0.99
59_I	95_V	2.195	0.99
9_Y	34_K	2.137	0.98
99_T	125_G	2.105	0.98
195_K	199_N	2.067	0.98
68_L	250_A	2.066	0.98
15_S	108_S	2.016	0.98
194_G	198_I	2.016	0.98
214_K	218_E	2.011	0.98
293_N	318_I	2.001	0.97
230_G	318_I	1.994	0.97
64_M	174_A	1.850	0.96
66_S	137_M	1.835	0.96
58_I	97_K	1.834	0.96
17_I	212_L	1.825	0.96
252_G	271_F	1.799	0.95
234_F	267_S	1.778	0.95
51_V	58_I	1.773	0.95
127_Y	140_M	1.726	0.94
232_I	314_R	1.710	0.94
150_L	170_A	1.705	0.94
8_L	30_Y	1.684	0.93
5_V	34_K	1.669	0.93
84_L	114_A	1.658	0.93
47_Y	50_E	1.616	0.92
87_L	188_S	1.576	0.91
45_V	206_V	1.574	0.90
238_I	307_L	1.574	0.90
237_K	309_Y	1.569	0.90
284_I	287_I	1.565	0.90
39_Q	117_M	1.564	0.90
9_Y	30_Y	1.539	0.89
209_A	286_S	1.539	0.89
275_Y	304_S	1.529	0.89
256_I	315_V	1.502	0.88
324_W	333_I	1.494	0.88
253_M	268_E	1.482	0.88
83_S	188_S	1.470	0.87
23_G	104_G	1.458	0.87
53_E	195_K	1.449	0.86
83_S	87_L	1.449	0.86
284_I	342_K	1.442	0.86
215_T	219_Q	1.441	0.86
99_T	197_Y	1.439	0.86
196_E	199_N	1.436	0.86
62_G	135_L	1.436	0.86
128_E	132_F	1.419	0.85
10_N	214_K	1.410	0.85
139_T	201_A	1.407	0.85
84_L	118_S	1.400	0.84
286_S	317_E	1.398	0.84
90_F	161_I	1.397	0.84
127_Y	192_A	1.396	0.84
175_R	249_F	1.391	0.84
236_G	256_I	1.390	0.84
258_G	264_G	1.386	0.84
269_I	275_Y	1.369	0.83
287_I	342_K	1.365	0.83
220_G	300_N	1.365	0.83
256_I	302_V	1.343	0.82
267_S	280_K	1.343	0.82
176_S	180_G	1.341	0.82
336_M	342_K	1.319	0.81
68_L	245_N	1.318	0.81
46_E	51_V	1.315	0.80
64_M	187_I	1.315	0.80
246_I	251_I	1.307	0.80
139_T	202_I	1.307	0.80
270_I	279_L	1.305	0.80
18_L	212_L	1.291	0.79
256_I	313_V	1.287	0.79
102_E	131_A	1.286	0.79
70_G	106_I	1.286	0.79
51_V	197_Y	1.283	0.79
46_E	97_K	1.280	0.79
225_I	228_A	1.279	0.79
178_T	185_G	1.277	0.78
84_L	98_I	1.272	0.78
62_G	79_E	1.250	0.77
229_R	319_P	1.246	0.77
327_V	331_E	1.245	0.77
7_D	210_L	1.244	0.77
280_K	285_L	1.239	0.76
62_G	187_I	1.238	0.76
21_G	24_G	1.238	0.76
104_G	131_A	1.235	0.76
329_G	332_K	1.229	0.76
329_G	333_I	1.227	0.76
279_L	284_I	1.220	0.75
3_I	45_V	1.214	0.75
10_N	218_E	1.191	0.73
135_L	187_I	1.186	0.73
100_S	142_F	1.178	0.72
278_F	285_L	1.175	0.72
64_M	178_T	1.175	0.72
75_P	79_E	1.167	0.72
61_V	98_I	1.167	0.72
88_T	95_V	1.164	0.72
248_G	273_N	1.164	0.72
221_L	225_I	1.159	0.71
141_H	332_K	1.156	0.71
211_E	214_K	1.151	0.71
88_T	94_E	1.149	0.71
35_A	39_Q	1.146	0.70
54_D	57_F	1.144	0.70
279_L	282_G	1.133	0.69
23_G	131_A	1.128	0.69
13_I	301_I	1.124	0.69
35_A	202_I	1.120	0.69
135_L	189_L	1.119	0.68
19_G	303_T	1.117	0.68
85_M	88_T	1.106	0.68
172_S	341_I	1.106	0.68
81_Y	118_S	1.103	0.67
11_L	330_Y	1.103	0.67
331_E	336_M	1.099	0.67
239_V	257_D	1.096	0.67
62_G	127_Y	1.088	0.66
255_K	266_N	1.085	0.66
216_L	224_M	1.085	0.66
48_T	197_Y	1.084	0.66
112_F	115_S	1.082	0.66
243_R	304_S	1.074	0.65
238_I	302_V	1.067	0.65
64_M	135_L	1.065	0.65
323_K	329_G	1.056	0.64
16_S	19_G	1.054	0.64
326_E	329_G	1.053	0.64
30_Y	34_K	1.044	0.63
35_A	38_L	1.043	0.63
245_N	250_A	1.041	0.63
309_Y	312_K	1.034	0.62
62_G	189_L	1.032	0.62
232_I	316_L	1.030	0.62
162_I	173_I	1.028	0.62
222_D	226_N	1.027	0.62
125_G	153_C	1.017	0.61
20_S	291_I	1.012	0.61
220_G	238_I	1.009	0.60
17_I	295_I	0.999	0.60
288_S	330_Y	0.993	0.59
3_I	44_Y	0.983	0.58
102_E	105_G	0.982	0.58
108_S	155_E	0.981	0.58
51_V	194_G	0.977	0.58
269_I	288_S	0.974	0.58
154_D	171_E	0.971	0.57
102_E	129_G	0.967	0.57
7_D	214_K	0.967	0.57
13_I	300_N	0.966	0.57
137_M	333_I	0.964	0.57
254_A	269_I	0.964	0.57
225_I	230_G	0.956	0.56
3_I	332_K	0.949	0.56
48_T	203_L	0.947	0.55
162_I	170_A	0.945	0.55
254_A	307_L	0.945	0.55
178_T	325_K	0.939	0.55
53_E	56_D	0.937	0.55
237_K	312_K	0.936	0.55
211_E	227_L	0.936	0.55
81_Y	114_A	0.934	0.54
209_A	321_S	0.933	0.54
134_E	249_F	0.927	0.54
254_A	313_V	0.927	0.54
232_I	235_E	0.924	0.54
44_Y	119_K	0.924	0.54
259_L	312_K	0.918	0.53
336_M	340_E	0.917	0.53
4_S	210_L	0.913	0.53
143_A	200_G	0.911	0.53
139_T	183_G	0.909	0.52
85_M	118_S	0.907	0.52
102_E	291_I	0.906	0.52
142_F	324_W	0.904	0.52
139_T	323_K	0.903	0.52
83_S	153_C	0.903	0.52
126_D	129_G	0.899	0.52
172_S	180_G	0.893	0.51
66_S	245_N	0.892	0.51
294_L	313_V	0.884	0.50
45_V	103_I	0.876	0.50
249_F	272_K	0.875	0.50
242_K	255_K	0.869	0.49
138_T	323_K	0.866	0.49
64_M	185_G	0.865	0.49
321_S	333_I	0.863	0.49
68_L	304_S	0.862	0.49
11_L	112_F	0.862	0.49
142_F	333_I	0.858	0.48
126_D	149_P	0.855	0.48
248_G	252_G	0.846	0.47
110_V	114_A	0.845	0.47
80_Y	186_Y	0.844	0.47
150_L	269_I	0.843	0.47
132_F	137_M	0.841	0.47
221_L	318_I	0.839	0.47
99_T	201_A	0.834	0.46
87_L	191_P	0.832	0.46
134_E	258_G	0.832	0.46
207_S	331_E	0.830	0.46
36_K	42_I	0.826	0.46
19_G	102_E	0.826	0.46
233_I	278_F	0.822	0.45
10_N	210_L	0.821	0.45
180_G	247_G	0.820	0.45
19_G	23_G	0.814	0.45
294_L	315_V	0.812	0.45
107_N	128_E	0.811	0.44
156_R	170_A	0.808	0.44
74_I	299_N	0.808	0.44
148_T	152_I	0.808	0.44
152_I	187_I	0.803	0.44
132_F	334_K	0.802	0.44
295_I	316_L	0.802	0.44
82_R	85_M	0.798	0.43
19_G	24_G	0.794	0.43
175_R	182_G	0.794	0.43
60_G	138_T	0.793	0.43
275_Y	288_S	0.793	0.43
71_I	166_D	0.790	0.43
86_T	159_C	0.787	0.43
59_I	188_S	0.782	0.42
50_E	123_I	0.777	0.42
50_E	315_V	0.773	0.41
19_G	22_G	0.772	0.41
214_K	217_T	0.770	0.41
122_L	150_L	0.769	0.41
207_S	210_L	0.768	0.41
97_K	183_G	0.766	0.41
323_K	340_E	0.761	0.40
69_I	73_K	0.759	0.40
319_P	333_I	0.757	0.40
219_Q	223_E	0.754	0.40
12_A	108_S	0.753	0.40
64_M	170_A	0.751	0.40
60_G	299_N	0.750	0.40
212_L	216_L	0.749	0.40
106_I	187_I	0.749	0.40
72_E	105_G	0.743	0.39
238_I	315_V	0.742	0.39
51_V	97_K	0.742	0.39
277_G	342_K	0.742	0.39
17_I	123_I	0.742	0.39
69_I	72_E	0.740	0.39
103_I	128_E	0.740	0.39
8_L	269_I	0.736	0.39
17_I	219_Q	0.733	0.38
268_E	281_E	0.733	0.38
33_V	36_K	0.730	0.38
58_I	197_Y	0.729	0.38
25_N	306_S	0.728	0.38
149_P	153_C	0.725	0.38
230_G	319_P	0.725	0.38
87_L	91_L	0.724	0.38
204_G	260_E	0.724	0.38
103_I	209_A	0.724	0.38
26_P	253_M	0.722	0.37
233_I	267_S	0.721	0.37
92_R	195_K	0.719	0.37
49_D	203_L	0.716	0.37
87_L	233_I	0.716	0.37
101_I	138_T	0.716	0.37
60_G	101_I	0.716	0.37
107_N	126_D	0.714	0.37
267_S	315_V	0.703	0.36
97_K	326_E	0.702	0.36
14_G	21_G	0.702	0.36
67_P	137_M	0.700	0.36
37_M	254_A	0.699	0.36
22_G	102_E	0.697	0.36
228_A	318_I	0.695	0.35
123_I	161_I	0.694	0.35
97_K	323_K	0.692	0.35
240_D	312_K	0.690	0.35
103_I	108_S	0.688	0.35
252_G	273_N	0.687	0.35
257_D	266_N	0.685	0.35
15_S	100_S	0.685	0.35
52_D	193_S	0.683	0.35
63_G	70_G	0.682	0.34
197_Y	201_A	0.682	0.34
259_L	269_I	0.680	0.34
6_N	10_N	0.679	0.34
72_E	237_K	0.679	0.34
49_D	145_Y	0.679	0.34
96_T	118_S	0.673	0.34
36_K	40_M	0.673	0.34
62_G	177_I	0.672	0.34
18_L	105_G	0.672	0.34
160_V	177_I	0.672	0.34
329_G	334_K	0.671	0.34
17_I	215_T	0.671	0.34
103_I	205_T	0.670	0.34
66_S	271_F	0.669	0.34
210_L	214_K	0.667	0.33
29_G	108_S	0.666	0.33
140_M	183_G	0.665	0.33
288_S	338_V	0.664	0.33
202_I	306_S	0.663	0.33
139_T	143_A	0.658	0.33
294_L	297_Y	0.658	0.33
287_I	336_M	0.658	0.33
47_Y	204_G	0.656	0.33
86_T	89_K	0.654	0.32
15_S	139_T	0.654	0.32
88_T	92_R	0.654	0.32
58_I	194_G	0.653	0.32
11_L	209_A	0.652	0.32
270_I	277_G	0.651	0.32
47_Y	331_E	0.650	0.32
172_S	177_I	0.650	0.32
7_D	46_E	0.650	0.32
235_E	314_R	0.647	0.32
226_N	229_R	0.645	0.32
43_D	116_L	0.645	0.32
255_K	317_E	0.643	0.32
104_G	248_G	0.642	0.32
248_G	272_K	0.640	0.31
82_R	86_T	0.638	0.31
320_V	324_W	0.638	0.31
24_G	131_A	0.638	0.31
18_L	24_G	0.637	0.31
53_E	207_S	0.636	0.31
242_K	275_Y	0.635	0.31
19_G	129_G	0.635	0.31
137_M	324_W	0.635	0.31
233_I	316_L	0.631	0.31
68_L	278_F	0.631	0.31
173_I	177_I	0.630	0.31
93_K	193_S	0.630	0.31
83_S	186_Y	0.630	0.31
71_I	305_D	0.630	0.31
115_S	122_L	0.629	0.31
157_E	339_K	0.628	0.31
87_L	150_L	0.628	0.31
98_I	190_Y	0.625	0.30
38_L	316_L	0.624	0.30
14_G	22_G	0.620	0.30
166_D	223_E	0.619	0.30
173_I	187_I	0.619	0.30
100_S	275_Y	0.617	0.30
72_E	107_N	0.616	0.30
45_V	190_Y	0.613	0.30
207_S	313_V	0.612	0.30
169_R	172_S	0.611	0.29
69_I	309_Y	0.608	0.29
167_N	212_L	0.605	0.29
199_N	287_I	0.604	0.29
209_A	295_I	0.604	0.29
51_V	96_T	0.603	0.29
20_S	248_G	0.602	0.29
18_L	121_P	0.602	0.29
95_V	120_K	0.602	0.29
248_G	291_I	0.601	0.29
73_K	181_F	0.599	0.29
185_G	326_E	0.599	0.29
87_L	208_L	0.595	0.28
108_S	301_I	0.594	0.28
50_E	204_G	0.594	0.28
32_I	269_I	0.594	0.28
9_Y	166_D	0.593	0.28
22_G	104_G	0.592	0.28
254_A	294_L	0.592	0.28
31_K	309_Y	0.592	0.28
241_V	271_F	0.591	0.28
31_K	272_K	0.590	0.28
122_L	247_G	0.588	0.28
15_S	122_L	0.587	0.28
63_G	186_Y	0.587	0.28
49_D	327_V	0.586	0.28
19_G	209_A	0.586	0.28
166_D	200_G	0.585	0.28
149_P	152_I	0.585	0.28
140_M	201_A	0.585	0.28
29_G	104_G	0.584	0.28
239_V	255_K	0.583	0.28
128_E	288_S	0.583	0.28
73_K	155_E	0.580	0.27
328_G	332_K	0.580	0.27
51_V	123_I	0.579	0.27
17_I	293_N	0.578	0.27
7_D	83_S	0.576	0.27
276_L	288_S	0.575	0.27
70_G	267_S	0.575	0.27
158_N	321_S	0.572	0.27
22_G	131_A	0.572	0.27
116_L	238_I	0.571	0.27
142_F	329_G	0.570	0.27
107_N	111_P	0.570	0.27
93_K	195_K	0.570	0.27
277_G	340_E	0.569	0.27
95_V	191_P	0.567	0.27
54_D	265_E	0.567	0.27
14_G	24_G	0.566	0.27
155_E	303_T	0.562	0.26
68_L	171_E	0.561	0.26
123_I	232_I	0.561	0.26
132_F	276_L	0.561	0.26
240_D	309_Y	0.560	0.26
221_L	228_A	0.559	0.26
100_S	140_M	0.559	0.26
33_V	272_K	0.558	0.26
66_S	249_F	0.557	0.26
41_N	122_L	0.557	0.26
61_V	84_L	0.556	0.26
212_L	317_E	0.556	0.26
320_V	325_K	0.555	0.26
28_L	111_P	0.554	0.26
210_L	301_I	0.554	0.26
58_I	99_T	0.554	0.26
128_E	304_S	0.553	0.26
138_T	191_P	0.553	0.26
76_A	256_I	0.553	0.26
84_L	96_T	0.552	0.26
162_I	192_A	0.552	0.26
230_G	249_F	0.550	0.26
62_G	101_I	0.549	0.25
324_W	332_K	0.547	0.25
98_I	331_E	0.546	0.25
36_K	116_L	0.546	0.25
169_R	173_I	0.546	0.25
98_I	108_S	0.545	0.25
60_G	276_L	0.545	0.25
47_Y	92_R	0.544	0.25
243_R	308_R	0.544	0.25
241_V	313_V	0.544	0.25
221_L	226_N	0.541	0.25
156_R	321_S	0.541	0.25
235_E	260_E	0.540	0.25
272_K	304_S	0.540	0.25
134_E	179_V	0.537	0.25
108_S	206_V	0.537	0.25
296_D	302_V	0.536	0.25
90_F	142_F	0.535	0.25
67_P	252_G	0.534	0.25
46_E	267_S	0.534	0.25
32_I	113_M	0.533	0.24
178_T	183_G	0.533	0.24
119_K	269_I	0.533	0.24
329_G	337_V	0.531	0.24
127_Y	188_S	0.531	0.24
94_E	173_I	0.530	0.24
269_I	292_I	0.529	0.24
63_G	184_R	0.527	0.24
102_E	107_N	0.527	0.24
125_G	203_L	0.526	0.24
57_F	96_T	0.526	0.24
84_L	88_T	0.525	0.24
143_A	328_G	0.525	0.24
38_L	44_Y	0.525	0.24
170_A	333_I	0.523	0.24
23_G	102_E	0.522	0.24
69_I	237_K	0.522	0.24
208_L	211_E	0.521	0.24
115_S	119_K	0.521	0.24
50_E	299_N	0.521	0.24
230_G	288_S	0.521	0.24
75_P	185_G	0.519	0.24
270_I	305_D	0.519	0.24
108_S	303_T	0.518	0.24
38_L	42_I	0.517	0.24
27_F	237_K	0.516	0.23
43_D	46_E	0.516	0.23
59_I	93_K	0.515	0.23
163_E	316_L	0.515	0.23
66_S	104_G	0.515	0.23
52_D	302_V	0.510	0.23
124_D	207_S	0.510	0.23
302_V	311_V	0.510	0.23
12_A	17_I	0.509	0.23
125_G	197_Y	0.509	0.23
230_G	250_A	0.508	0.23
230_G	329_G	0.502	0.23
60_G	185_G	0.502	0.23
254_A	287_I	0.502	0.23
9_Y	56_D	0.501	0.23
274_E	289_P	0.500	0.23
21_G	171_E	0.500	0.23

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2o3iA	3	0.9368	100	0.112	Contact Map
1f4pA	1	0.4023	53.3	0.966	Contact Map
4oxxA	1	0.4224	37.3	0.969	Contact Map
2nx2A	1	0.1638	35.3	0.97	Contact Map
4h2dA	1	0.431	34.8	0.97	Contact Map
4heqA	2	0.3966	31.9	0.97	Contact Map
3f6rA	1	0.4023	26.1	0.971	Contact Map
2hnaA	1	0.4052	25.1	0.972	Contact Map
5nulA	1	0.3879	20	0.973	Contact Map
1ycgA	5	0.4282	19.5	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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