GREMLIN Database
Q97XP2 - Uncharacterized protein
UniProt: Q97XP2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 348 (337)
Sequences: 747 (575)
Seq/√Len: 31.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_N217_T6.0941.00
17_I216_L5.1711.00
53_E198_I4.4131.00
52_D56_D4.1971.00
5_V38_L4.0291.00
4_S7_D3.8551.00
56_D96_T3.3411.00
154_D158_N3.1591.00
53_E194_G3.0101.00
265_E281_E2.9231.00
297_Y314_R2.8951.00
267_S285_L2.8651.00
43_D112_F2.8221.00
324_W329_G2.7301.00
57_F93_K2.7081.00
125_G201_A2.6881.00
336_M341_I2.6711.00
11_L210_L2.5301.00
193_S196_E2.5281.00
269_I294_L2.4870.99
48_T204_G2.4810.99
296_D299_N2.4430.99
265_E280_K2.4260.99
233_I286_S2.3710.99
328_G331_E2.2870.99
267_S278_F2.2400.99
112_F122_L2.2400.99
233_I317_E2.2050.99
59_I95_V2.1950.99
9_Y34_K2.1370.98
99_T125_G2.1050.98
195_K199_N2.0670.98
68_L250_A2.0660.98
15_S108_S2.0160.98
194_G198_I2.0160.98
214_K218_E2.0110.98
293_N318_I2.0010.97
230_G318_I1.9940.97
64_M174_A1.8500.96
66_S137_M1.8350.96
58_I97_K1.8340.96
17_I212_L1.8250.96
252_G271_F1.7990.95
234_F267_S1.7780.95
51_V58_I1.7730.95
127_Y140_M1.7260.94
232_I314_R1.7100.94
150_L170_A1.7050.94
8_L30_Y1.6840.93
5_V34_K1.6690.93
84_L114_A1.6580.93
47_Y50_E1.6160.92
87_L188_S1.5760.91
45_V206_V1.5740.90
238_I307_L1.5740.90
237_K309_Y1.5690.90
284_I287_I1.5650.90
39_Q117_M1.5640.90
9_Y30_Y1.5390.89
209_A286_S1.5390.89
275_Y304_S1.5290.89
256_I315_V1.5020.88
324_W333_I1.4940.88
253_M268_E1.4820.88
83_S188_S1.4700.87
23_G104_G1.4580.87
53_E195_K1.4490.86
83_S87_L1.4490.86
284_I342_K1.4420.86
215_T219_Q1.4410.86
99_T197_Y1.4390.86
196_E199_N1.4360.86
62_G135_L1.4360.86
128_E132_F1.4190.85
10_N214_K1.4100.85
139_T201_A1.4070.85
84_L118_S1.4000.84
286_S317_E1.3980.84
90_F161_I1.3970.84
127_Y192_A1.3960.84
175_R249_F1.3910.84
236_G256_I1.3900.84
258_G264_G1.3860.84
269_I275_Y1.3690.83
287_I342_K1.3650.83
220_G300_N1.3650.83
256_I302_V1.3430.82
267_S280_K1.3430.82
176_S180_G1.3410.82
336_M342_K1.3190.81
68_L245_N1.3180.81
46_E51_V1.3150.80
64_M187_I1.3150.80
246_I251_I1.3070.80
139_T202_I1.3070.80
270_I279_L1.3050.80
18_L212_L1.2910.79
256_I313_V1.2870.79
102_E131_A1.2860.79
70_G106_I1.2860.79
51_V197_Y1.2830.79
46_E97_K1.2800.79
225_I228_A1.2790.79
178_T185_G1.2770.78
84_L98_I1.2720.78
62_G79_E1.2500.77
229_R319_P1.2460.77
327_V331_E1.2450.77
7_D210_L1.2440.77
280_K285_L1.2390.76
62_G187_I1.2380.76
21_G24_G1.2380.76
104_G131_A1.2350.76
329_G332_K1.2290.76
329_G333_I1.2270.76
279_L284_I1.2200.75
3_I45_V1.2140.75
10_N218_E1.1910.73
135_L187_I1.1860.73
100_S142_F1.1780.72
278_F285_L1.1750.72
64_M178_T1.1750.72
75_P79_E1.1670.72
61_V98_I1.1670.72
88_T95_V1.1640.72
248_G273_N1.1640.72
221_L225_I1.1590.71
141_H332_K1.1560.71
211_E214_K1.1510.71
88_T94_E1.1490.71
35_A39_Q1.1460.70
54_D57_F1.1440.70
279_L282_G1.1330.69
23_G131_A1.1280.69
13_I301_I1.1240.69
35_A202_I1.1200.69
135_L189_L1.1190.68
19_G303_T1.1170.68
85_M88_T1.1060.68
172_S341_I1.1060.68
81_Y118_S1.1030.67
11_L330_Y1.1030.67
331_E336_M1.0990.67
239_V257_D1.0960.67
62_G127_Y1.0880.66
255_K266_N1.0850.66
216_L224_M1.0850.66
48_T197_Y1.0840.66
112_F115_S1.0820.66
243_R304_S1.0740.65
238_I302_V1.0670.65
64_M135_L1.0650.65
323_K329_G1.0560.64
16_S19_G1.0540.64
326_E329_G1.0530.64
30_Y34_K1.0440.63
35_A38_L1.0430.63
245_N250_A1.0410.63
309_Y312_K1.0340.62
62_G189_L1.0320.62
232_I316_L1.0300.62
162_I173_I1.0280.62
222_D226_N1.0270.62
125_G153_C1.0170.61
20_S291_I1.0120.61
220_G238_I1.0090.60
17_I295_I0.9990.60
288_S330_Y0.9930.59
3_I44_Y0.9830.58
102_E105_G0.9820.58
108_S155_E0.9810.58
51_V194_G0.9770.58
269_I288_S0.9740.58
154_D171_E0.9710.57
102_E129_G0.9670.57
7_D214_K0.9670.57
13_I300_N0.9660.57
137_M333_I0.9640.57
254_A269_I0.9640.57
225_I230_G0.9560.56
3_I332_K0.9490.56
48_T203_L0.9470.55
162_I170_A0.9450.55
254_A307_L0.9450.55
178_T325_K0.9390.55
53_E56_D0.9370.55
237_K312_K0.9360.55
211_E227_L0.9360.55
81_Y114_A0.9340.54
209_A321_S0.9330.54
134_E249_F0.9270.54
254_A313_V0.9270.54
232_I235_E0.9240.54
44_Y119_K0.9240.54
259_L312_K0.9180.53
336_M340_E0.9170.53
4_S210_L0.9130.53
143_A200_G0.9110.53
139_T183_G0.9090.52
85_M118_S0.9070.52
102_E291_I0.9060.52
142_F324_W0.9040.52
139_T323_K0.9030.52
83_S153_C0.9030.52
126_D129_G0.8990.52
172_S180_G0.8930.51
66_S245_N0.8920.51
294_L313_V0.8840.50
45_V103_I0.8760.50
249_F272_K0.8750.50
242_K255_K0.8690.49
138_T323_K0.8660.49
64_M185_G0.8650.49
321_S333_I0.8630.49
68_L304_S0.8620.49
11_L112_F0.8620.49
142_F333_I0.8580.48
126_D149_P0.8550.48
248_G252_G0.8460.47
110_V114_A0.8450.47
80_Y186_Y0.8440.47
150_L269_I0.8430.47
132_F137_M0.8410.47
221_L318_I0.8390.47
99_T201_A0.8340.46
87_L191_P0.8320.46
134_E258_G0.8320.46
207_S331_E0.8300.46
36_K42_I0.8260.46
19_G102_E0.8260.46
233_I278_F0.8220.45
10_N210_L0.8210.45
180_G247_G0.8200.45
19_G23_G0.8140.45
294_L315_V0.8120.45
107_N128_E0.8110.44
156_R170_A0.8080.44
74_I299_N0.8080.44
148_T152_I0.8080.44
152_I187_I0.8030.44
132_F334_K0.8020.44
295_I316_L0.8020.44
82_R85_M0.7980.43
19_G24_G0.7940.43
175_R182_G0.7940.43
60_G138_T0.7930.43
275_Y288_S0.7930.43
71_I166_D0.7900.43
86_T159_C0.7870.43
59_I188_S0.7820.42
50_E123_I0.7770.42
50_E315_V0.7730.41
19_G22_G0.7720.41
214_K217_T0.7700.41
122_L150_L0.7690.41
207_S210_L0.7680.41
97_K183_G0.7660.41
323_K340_E0.7610.40
69_I73_K0.7590.40
319_P333_I0.7570.40
219_Q223_E0.7540.40
12_A108_S0.7530.40
64_M170_A0.7510.40
60_G299_N0.7500.40
212_L216_L0.7490.40
106_I187_I0.7490.40
72_E105_G0.7430.39
238_I315_V0.7420.39
51_V97_K0.7420.39
277_G342_K0.7420.39
17_I123_I0.7420.39
69_I72_E0.7400.39
103_I128_E0.7400.39
8_L269_I0.7360.39
17_I219_Q0.7330.38
268_E281_E0.7330.38
33_V36_K0.7300.38
58_I197_Y0.7290.38
25_N306_S0.7280.38
149_P153_C0.7250.38
230_G319_P0.7250.38
87_L91_L0.7240.38
204_G260_E0.7240.38
103_I209_A0.7240.38
26_P253_M0.7220.37
233_I267_S0.7210.37
92_R195_K0.7190.37
49_D203_L0.7160.37
87_L233_I0.7160.37
101_I138_T0.7160.37
60_G101_I0.7160.37
107_N126_D0.7140.37
267_S315_V0.7030.36
97_K326_E0.7020.36
14_G21_G0.7020.36
67_P137_M0.7000.36
37_M254_A0.6990.36
22_G102_E0.6970.36
228_A318_I0.6950.35
123_I161_I0.6940.35
97_K323_K0.6920.35
240_D312_K0.6900.35
103_I108_S0.6880.35
252_G273_N0.6870.35
257_D266_N0.6850.35
15_S100_S0.6850.35
52_D193_S0.6830.35
63_G70_G0.6820.34
197_Y201_A0.6820.34
259_L269_I0.6800.34
6_N10_N0.6790.34
72_E237_K0.6790.34
49_D145_Y0.6790.34
96_T118_S0.6730.34
36_K40_M0.6730.34
62_G177_I0.6720.34
18_L105_G0.6720.34
160_V177_I0.6720.34
329_G334_K0.6710.34
17_I215_T0.6710.34
103_I205_T0.6700.34
66_S271_F0.6690.34
210_L214_K0.6670.33
29_G108_S0.6660.33
140_M183_G0.6650.33
288_S338_V0.6640.33
202_I306_S0.6630.33
139_T143_A0.6580.33
294_L297_Y0.6580.33
287_I336_M0.6580.33
47_Y204_G0.6560.33
86_T89_K0.6540.32
15_S139_T0.6540.32
88_T92_R0.6540.32
58_I194_G0.6530.32
11_L209_A0.6520.32
270_I277_G0.6510.32
47_Y331_E0.6500.32
172_S177_I0.6500.32
7_D46_E0.6500.32
235_E314_R0.6470.32
226_N229_R0.6450.32
43_D116_L0.6450.32
255_K317_E0.6430.32
104_G248_G0.6420.32
248_G272_K0.6400.31
82_R86_T0.6380.31
320_V324_W0.6380.31
24_G131_A0.6380.31
18_L24_G0.6370.31
53_E207_S0.6360.31
242_K275_Y0.6350.31
19_G129_G0.6350.31
137_M324_W0.6350.31
233_I316_L0.6310.31
68_L278_F0.6310.31
173_I177_I0.6300.31
93_K193_S0.6300.31
83_S186_Y0.6300.31
71_I305_D0.6300.31
115_S122_L0.6290.31
157_E339_K0.6280.31
87_L150_L0.6280.31
98_I190_Y0.6250.30
38_L316_L0.6240.30
14_G22_G0.6200.30
166_D223_E0.6190.30
173_I187_I0.6190.30
100_S275_Y0.6170.30
72_E107_N0.6160.30
45_V190_Y0.6130.30
207_S313_V0.6120.30
169_R172_S0.6110.29
69_I309_Y0.6080.29
167_N212_L0.6050.29
199_N287_I0.6040.29
209_A295_I0.6040.29
51_V96_T0.6030.29
20_S248_G0.6020.29
18_L121_P0.6020.29
95_V120_K0.6020.29
248_G291_I0.6010.29
73_K181_F0.5990.29
185_G326_E0.5990.29
87_L208_L0.5950.28
108_S301_I0.5940.28
50_E204_G0.5940.28
32_I269_I0.5940.28
9_Y166_D0.5930.28
22_G104_G0.5920.28
254_A294_L0.5920.28
31_K309_Y0.5920.28
241_V271_F0.5910.28
31_K272_K0.5900.28
122_L247_G0.5880.28
15_S122_L0.5870.28
63_G186_Y0.5870.28
49_D327_V0.5860.28
19_G209_A0.5860.28
166_D200_G0.5850.28
149_P152_I0.5850.28
140_M201_A0.5850.28
29_G104_G0.5840.28
239_V255_K0.5830.28
128_E288_S0.5830.28
73_K155_E0.5800.27
328_G332_K0.5800.27
51_V123_I0.5790.27
17_I293_N0.5780.27
7_D83_S0.5760.27
276_L288_S0.5750.27
70_G267_S0.5750.27
158_N321_S0.5720.27
22_G131_A0.5720.27
116_L238_I0.5710.27
142_F329_G0.5700.27
107_N111_P0.5700.27
93_K195_K0.5700.27
277_G340_E0.5690.27
95_V191_P0.5670.27
54_D265_E0.5670.27
14_G24_G0.5660.27
155_E303_T0.5620.26
68_L171_E0.5610.26
123_I232_I0.5610.26
132_F276_L0.5610.26
240_D309_Y0.5600.26
221_L228_A0.5590.26
100_S140_M0.5590.26
33_V272_K0.5580.26
66_S249_F0.5570.26
41_N122_L0.5570.26
61_V84_L0.5560.26
212_L317_E0.5560.26
320_V325_K0.5550.26
28_L111_P0.5540.26
210_L301_I0.5540.26
58_I99_T0.5540.26
128_E304_S0.5530.26
138_T191_P0.5530.26
76_A256_I0.5530.26
84_L96_T0.5520.26
162_I192_A0.5520.26
230_G249_F0.5500.26
62_G101_I0.5490.25
324_W332_K0.5470.25
98_I331_E0.5460.25
36_K116_L0.5460.25
169_R173_I0.5460.25
98_I108_S0.5450.25
60_G276_L0.5450.25
47_Y92_R0.5440.25
243_R308_R0.5440.25
241_V313_V0.5440.25
221_L226_N0.5410.25
156_R321_S0.5410.25
235_E260_E0.5400.25
272_K304_S0.5400.25
134_E179_V0.5370.25
108_S206_V0.5370.25
296_D302_V0.5360.25
90_F142_F0.5350.25
67_P252_G0.5340.25
46_E267_S0.5340.25
32_I113_M0.5330.24
178_T183_G0.5330.24
119_K269_I0.5330.24
329_G337_V0.5310.24
127_Y188_S0.5310.24
94_E173_I0.5300.24
269_I292_I0.5290.24
63_G184_R0.5270.24
102_E107_N0.5270.24
125_G203_L0.5260.24
57_F96_T0.5260.24
84_L88_T0.5250.24
143_A328_G0.5250.24
38_L44_Y0.5250.24
170_A333_I0.5230.24
23_G102_E0.5220.24
69_I237_K0.5220.24
208_L211_E0.5210.24
115_S119_K0.5210.24
50_E299_N0.5210.24
230_G288_S0.5210.24
75_P185_G0.5190.24
270_I305_D0.5190.24
108_S303_T0.5180.24
38_L42_I0.5170.24
27_F237_K0.5160.23
43_D46_E0.5160.23
59_I93_K0.5150.23
163_E316_L0.5150.23
66_S104_G0.5150.23
52_D302_V0.5100.23
124_D207_S0.5100.23
302_V311_V0.5100.23
12_A17_I0.5090.23
125_G197_Y0.5090.23
230_G250_A0.5080.23
230_G329_G0.5020.23
60_G185_G0.5020.23
254_A287_I0.5020.23
9_Y56_D0.5010.23
274_E289_P0.5000.23
21_G171_E0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o3iA 3 0.9368 100 0.112 Contact Map
1f4pA 1 0.4023 53.3 0.966 Contact Map
4oxxA 1 0.4224 37.3 0.969 Contact Map
2nx2A 1 0.1638 35.3 0.97 Contact Map
4h2dA 1 0.431 34.8 0.97 Contact Map
4heqA 2 0.3966 31.9 0.97 Contact Map
3f6rA 1 0.4023 26.1 0.971 Contact Map
2hnaA 1 0.4052 25.1 0.972 Contact Map
5nulA 1 0.3879 20 0.973 Contact Map
1ycgA 5 0.4282 19.5 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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