GREMLIN Database
Q97XP1 - Transposase ISC1316
UniProt: Q97XP1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 395 (353)
Sequences: 4601 (2966)
Seq/√Len: 157.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
257_D261_K5.5111.00
279_H282_Q4.3091.00
331_A361_N4.2601.00
311_L318_L3.6561.00
198_L303_L3.1241.00
274_V370_S3.0461.00
275_M307_I2.9691.00
304_R320_L2.9311.00
264_K268_E2.8471.00
302_E306_L2.7021.00
341_S344_D2.6031.00
284_I296_S2.5301.00
159_V171_I2.4521.00
303_L307_I2.4431.00
217_L293_R2.3981.00
325_Y328_K2.3701.00
308_K320_L2.3701.00
302_E305_D2.3501.00
329_T336_V2.3191.00
321_V366_I2.2521.00
267_A311_L2.1991.00
348_V355_I2.1921.00
369_G372_S2.1751.00
260_M306_L2.1611.00
273_V311_L2.1231.00
13_D16_T2.1001.00
223_L240_A2.0831.00
326_T366_I2.0761.00
260_M309_Y2.0571.00
216_A254_L2.0381.00
275_M318_L2.0091.00
333_C352_C1.9951.00
198_L258_L1.9861.00
330_C333_C1.9741.00
263_G306_L1.9691.00
328_K340_L1.9521.00
51_Q55_R1.9261.00
289_R292_R1.9251.00
157_K176_D1.9151.00
345_R358_R1.9131.00
349_C352_C1.8931.00
240_A244_L1.8671.00
256_T302_E1.8651.00
333_C349_C1.8501.00
39_I97_F1.8461.00
36_W40_Y1.8411.00
34_L80_A1.8291.00
308_K312_E1.8271.00
260_M263_G1.8161.00
260_M310_Q1.8131.00
259_Y306_L1.8131.00
271_D316_K1.8021.00
21_K169_I1.7901.00
330_C352_C1.7601.00
235_N238_F1.7571.00
332_K354_W1.7571.00
52_T55_R1.7471.00
347_F356_A1.7141.00
330_C349_C1.6941.00
22_A70_K1.6931.00
286_K292_R1.6741.00
51_Q81_D1.6701.00
35_R83_Y1.6701.00
191_I199_L1.6441.00
135_L171_I1.6011.00
29_K67_E1.5951.00
9_R168_R1.5851.00
230_K240_A1.5771.00
20_L169_I1.5721.00
275_M320_L1.5681.00
259_Y302_E1.5591.00
82_R110_V1.5531.00
275_M304_R1.5401.00
238_F241_K1.5271.00
18_R22_A1.5181.00
226_E230_K1.5121.00
263_G309_Y1.5051.00
74_Q113_Q1.5041.00
346_V355_I1.4951.00
227_L241_K1.4731.00
277_D320_L1.4701.00
347_F354_W1.4621.00
74_Q112_T1.4471.00
17_L21_K1.4441.00
5_G172_T1.4391.00
233_L237_W1.4331.00
188_V367_L1.4281.00
342_L345_R1.4261.00
340_L344_D1.3971.00
200_V360_Y1.3881.00
364_L368_R1.3881.00
308_K318_L1.3791.00
201_T205_E1.3741.00
223_L226_E1.3491.00
189_V201_T1.3361.00
249_E253_N1.3261.00
52_T56_Q1.3231.00
84_Y88_Q1.3141.00
263_G310_Q1.3131.00
276_E323_P1.3061.00
87_R97_F1.3061.00
197_K200_V1.2931.00
168_R249_E1.2931.00
134_T142_T1.2821.00
34_L83_Y1.2791.00
337_K340_L1.2771.00
50_T53_E1.2741.00
335_Y350_P1.2711.00
55_R81_D1.2641.00
286_K289_R1.2621.00
24_L169_I1.2551.00
89_R95_A1.2481.00
295_L300_F1.2361.00
38_D54_L1.2251.00
263_G303_L1.2241.00
220_V244_L1.2221.00
93_G96_R1.2111.00
166_S249_E1.2081.00
188_V272_V1.2051.00
331_A364_L1.2031.00
220_V248_Y1.1951.00
202_S206_Y1.1911.00
27_A79_I1.1901.00
37_A57_L1.1861.00
14_E17_L1.1731.00
216_A251_L1.1711.00
342_L358_R1.1691.00
39_I43_Q1.1691.00
223_L247_A1.1691.00
227_L244_L1.1671.00
189_V270_Y1.1621.00
55_R80_A1.1601.00
164_T168_R1.1591.00
267_A314_Y1.1571.00
164_T167_E1.1501.00
219_K223_L1.1471.00
259_Y303_L1.1381.00
356_A364_L1.1321.00
78_Q81_D1.1321.00
265_W269_H1.1301.00
162_K172_T1.1281.00
12_T16_T1.1281.00
136_K142_T1.1241.00
337_K347_F1.1241.00
306_L309_Y1.1161.00
191_I201_T1.1121.00
279_H323_P1.1111.00
51_Q80_A1.1051.00
85_E89_R1.1041.00
193_V300_F1.1011.00
88_Q92_D1.0970.99
78_Q112_T1.0910.99
321_V369_G1.0830.99
58_A80_A1.0690.99
264_K314_Y1.0600.99
256_T306_L1.0580.99
190_A367_L1.0540.99
263_G307_I1.0530.99
360_Y364_L1.0480.99
195_V298_V1.0470.99
259_Y263_G1.0390.99
329_T369_G1.0360.99
72_Y75_V1.0310.99
89_R93_G1.0260.99
268_E314_Y1.0250.99
337_K341_S1.0210.99
284_I292_R1.0170.99
331_A362_A1.0160.99
227_L240_A1.0140.99
62_R76_V1.0090.99
12_T20_L1.0080.99
267_A273_V1.0080.99
310_Q313_K1.0040.99
331_A356_A1.0040.99
326_T369_G1.0020.99
185_T271_D1.0020.99
197_K208_P1.0010.99
90_F97_F1.0000.99
341_S345_R0.9950.99
40_Y44_R0.9940.99
29_K33_T0.9900.99
224_H228_S0.9880.99
31_Y79_I0.9790.99
356_A360_Y0.9760.99
337_K350_P0.9740.99
111_Y114_S0.9710.99
58_A77_Q0.9700.99
117_K120_Q0.9650.99
286_K290_S0.9650.99
116_W120_Q0.9570.99
328_K338_E0.9520.99
56_Q59_L0.9510.99
328_K336_V0.9490.99
328_K339_D0.9450.98
74_Q78_Q0.9450.98
341_S358_R0.9450.98
323_P326_T0.9430.98
6_F175_V0.9420.98
206_Y357_D0.9370.98
89_R94_L0.9350.98
26_L67_E0.9340.98
90_F98_P0.9330.98
252_K256_T0.9330.98
188_V371_G0.9310.98
267_A316_K0.9310.98
224_H244_L0.9280.98
321_V370_S0.9250.98
193_V304_R0.9230.98
274_V366_I0.9230.98
305_D308_K0.9220.98
25_K28_C0.9210.98
137_L161_V0.9200.98
220_V228_S0.9150.98
344_D347_F0.9150.98
237_W241_K0.9140.98
280_V301_S0.9130.98
221_K224_H0.9110.98
277_D323_P0.9100.98
335_Y351_N0.9090.98
311_L316_K0.9080.98
35_R87_R0.9050.98
164_T249_E0.9030.98
346_V356_A0.9010.98
31_Y86_A0.8990.98
110_V158_R0.8980.98
331_A354_W0.8940.98
223_L244_L0.8910.98
33_T37_A0.8910.98
60_D64_Q0.8900.98
68_Y76_V0.8850.98
41_F45_D0.8850.98
340_L347_F0.8790.98
345_R357_D0.8710.97
259_Y299_A0.8700.97
344_D358_R0.8680.97
82_R160_I0.8670.97
207_F262_L0.8670.97
31_Y83_Y0.8650.97
266_F273_V0.8610.97
212_P254_L0.8580.97
89_R92_D0.8560.97
220_V251_L0.8550.97
335_Y347_F0.8540.97
197_K206_Y0.8530.97
220_V224_H0.8510.97
230_K236_N0.8500.97
77_Q81_D0.8490.97
361_N365_N0.8490.97
272_V317_K0.8450.97
250_Y254_L0.8440.97
291_L295_L0.8430.97
224_H248_Y0.8410.97
8_F171_I0.8370.97
188_V274_V0.8370.97
216_A220_V0.8300.97
59_L62_R0.8270.96
8_F149_R0.8240.96
227_L237_W0.8200.96
200_V206_Y0.8200.96
329_T338_E0.8190.96
247_A251_L0.8170.96
110_V160_I0.8150.96
17_L169_I0.8130.96
364_L367_L0.8120.96
78_Q110_V0.8110.96
264_K310_Q0.8110.96
195_V284_I0.8100.96
55_R59_L0.8090.96
117_K136_K0.8080.96
228_S244_L0.8060.96
262_L265_W0.8050.96
362_A365_N0.8030.96
213_Y216_A0.8020.96
42_Y87_R0.8010.96
160_I172_T0.7990.96
258_L262_L0.7960.96
23_Q27_A0.7910.95
347_F358_R0.7880.95
328_K337_K0.7860.95
25_K29_K0.7840.95
241_K245_A0.7820.95
187_K271_D0.7810.95
41_F49_L0.7790.95
227_L230_K0.7790.95
34_L54_L0.7770.95
272_V319_I0.7770.95
36_W100_E0.7770.95
39_I87_R0.7740.95
360_Y363_S0.7740.95
222_H226_E0.7730.95
186_G271_D0.7730.95
340_L358_R0.7680.95
200_V207_F0.7670.95
74_Q114_S0.7630.94
243_K246_R0.7630.94
325_Y369_G0.7610.94
289_R296_S0.7580.94
331_A368_R0.7560.94
301_S305_D0.7550.94
10_A171_I0.7550.94
223_L243_K0.7530.94
277_D304_R0.7520.94
74_Q77_Q0.7520.94
329_T365_N0.7500.94
147_V150_D0.7490.94
193_V199_L0.7490.94
26_L68_Y0.7480.94
195_V294_R0.7470.94
111_Y137_L0.7470.94
212_P216_A0.7450.94
34_L58_A0.7440.94
134_T137_L0.7420.94
26_L29_K0.7400.94
19_A23_Q0.7390.93
332_K364_L0.7390.93
71_L74_Q0.7360.93
38_D84_Y0.7350.93
194_G200_V0.7330.93
216_A247_A0.7310.93
319_I370_S0.7290.93
205_E265_W0.7260.93
30_I79_I0.7260.93
209_N298_V0.7240.93
226_E229_R0.7230.93
192_D359_D0.7230.93
37_A54_L0.7220.93
189_V202_S0.7220.93
273_V307_I0.7220.93
42_Y46_G0.7200.93
339_D344_D0.7170.92
78_Q82_R0.7120.92
158_R174_V0.7090.92
59_L63_K0.7070.92
221_K225_R0.7050.92
199_L262_L0.7020.92
255_R297_D0.7010.92
268_E272_V0.6990.91
189_V273_V0.6980.91
114_S117_K0.6970.91
132_L137_L0.6950.91
26_L71_L0.6950.91
14_E18_R0.6930.91
109_L113_Q0.6920.91
73_S112_T0.6920.91
225_R228_S0.6910.91
182_L316_K0.6910.91
203_D270_Y0.6910.91
209_N212_P0.6890.91
251_L297_D0.6830.91
116_W138_S0.6820.90
37_A40_Y0.6820.90
309_Y313_K0.6810.90
161_V171_I0.6770.90
80_A84_Y0.6770.90
325_Y329_T0.6740.90
274_V319_I0.6740.90
87_R90_F0.6730.90
216_A250_Y0.6690.90
87_R91_F0.6690.90
202_S363_S0.6680.90
266_F270_Y0.6670.89
79_I83_Y0.6670.89
278_I323_P0.6650.89
115_G138_S0.6640.89
15_Q18_R0.6610.89
120_Q133_I0.6590.89
198_L263_G0.6580.89
9_R170_Y0.6570.89
338_E347_F0.6560.89
72_Y111_Y0.6550.89
5_G174_V0.6530.88
104_H107_Y0.6520.88
196_E200_V0.6520.88
340_L345_R0.6520.88
182_L185_T0.6510.88
184_N187_K0.6510.88
325_Y336_V0.6490.88
202_S360_Y0.6470.88
236_N239_K0.6450.88
53_E56_Q0.6440.88
136_K140_L0.6430.88
282_Q323_P0.6420.88
199_L207_F0.6410.88
11_Y146_I0.6410.88
19_A22_A0.6400.87
140_L143_F0.6400.87
111_Y115_G0.6330.87
221_K228_S0.6330.87
192_D327_S0.6330.87
54_L57_L0.6320.87
71_L76_V0.6320.87
179_F312_E0.6300.87
22_A26_L0.6290.87
37_A41_F0.6290.87
307_I318_L0.6270.86
38_D87_R0.6270.86
83_Y87_R0.6270.86
234_S237_W0.6230.86
20_L24_L0.6220.86
135_L138_S0.6210.86
42_Y91_F0.6180.86
311_L314_Y0.6170.86
40_Y43_Q0.6150.85
207_F210_L0.6150.85
137_L143_F0.6130.85
20_L109_L0.6130.85
91_F94_L0.6120.85
51_Q54_L0.6120.85
81_D112_T0.6100.85
33_T61_L0.6100.85
76_V79_I0.6090.85
198_L298_V0.6080.85
274_V367_L0.6070.85
38_D48_G0.6060.84
59_L73_S0.6030.84
36_W39_I0.6030.84
253_N256_T0.6020.84
7_R162_K0.6010.84
135_L159_V0.6000.84
214_E217_L0.5990.84
282_Q295_L0.5990.84
206_Y360_Y0.5960.84
214_E293_R0.5940.83
332_K356_A0.5940.83
41_F47_K0.5930.83
306_L310_Q0.5930.83
59_L65_D0.5920.83
221_K289_R0.5910.83
199_L303_L0.5900.83
37_A61_L0.5900.83
280_V300_F0.5890.83
57_L60_D0.5870.83
226_E240_A0.5870.83
366_I369_G0.5870.83
74_Q115_G0.5870.83
225_R229_R0.5870.83
47_K53_E0.5860.82
12_T17_L0.5840.82
155_K176_D0.5840.82
145_V148_H0.5830.82
342_L357_D0.5830.82
135_L141_G0.5810.82
233_L238_F0.5790.82
23_Q109_L0.5780.82
348_V354_W0.5780.82
356_A361_N0.5770.82
304_R308_K0.5760.81
7_R172_T0.5750.81
33_T67_E0.5740.81
111_Y116_W0.5730.81
5_G162_K0.5720.81
368_R371_G0.5700.81
337_K358_R0.5690.81
15_Q19_A0.5690.81
116_W159_V0.5650.80
12_T143_F0.5640.80
136_K139_N0.5640.80
193_V280_V0.5640.80
198_L259_Y0.5620.80
75_V109_L0.5610.80
111_Y118_I0.5600.80
21_K164_T0.5600.80
248_Y255_R0.5580.79
48_G84_Y0.5570.79
6_F149_R0.5560.79
335_Y339_D0.5550.79
283_L295_L0.5550.79
213_Y217_L0.5530.79
238_F242_V0.5530.79
168_R253_N0.5500.78
280_V296_S0.5490.78
51_Q59_L0.5490.78
212_P297_D0.5460.78
115_G118_I0.5460.78
214_E294_R0.5460.78
274_V369_G0.5450.78
190_A274_V0.5420.77
8_F147_V0.5420.77
207_F265_W0.5400.77
23_Q71_L0.5400.77
329_T334_G0.5400.77
10_A145_V0.5390.77
322_N325_Y0.5360.77
23_Q26_L0.5350.76
190_A363_S0.5350.76
256_T260_M0.5330.76
133_I136_K0.5320.76
248_Y252_K0.5310.76
132_L136_K0.5310.76
253_N257_D0.5310.76
47_K50_T0.5310.76
7_R256_T0.5300.76
192_D276_E0.5290.76
337_K344_D0.5280.76
49_L54_L0.5270.75
23_Q72_Y0.5260.75
90_F93_G0.5260.75
347_F350_P0.5240.75
323_P369_G0.5230.75
333_C337_K0.5220.75
92_D96_R0.5220.75
59_L80_A0.5210.75
222_H225_R0.5210.75
342_L346_V0.5210.75
292_R296_S0.5210.75
270_Y273_V0.5210.75
31_Y35_R0.5190.74
190_A202_S0.5190.74
80_A83_Y0.5180.74
291_L294_R0.5170.74
286_K291_L0.5160.74
73_S115_G0.5130.73
51_Q56_Q0.5130.73
226_E243_K0.5120.73
274_V371_G0.5110.73
196_E345_R0.5100.73
18_R21_K0.5100.73
119_L136_K0.5090.73
237_W240_A0.5090.73
299_A302_E0.5090.73
23_Q111_Y0.5080.73
324_A328_K0.5080.73
262_L303_L0.5060.72
357_D362_A0.5060.72
91_F98_P0.5040.72
261_K264_K0.5040.72
230_K234_S0.5040.72
41_F48_G0.5030.72
170_Y249_E0.5000.72
22_A25_K0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhxA 2 0.3468 94.1 0.932 Contact Map
1nu0A 1 0.3291 93.6 0.934 Contact Map
1iv0A 1 0.2456 91.9 0.937 Contact Map
4aybP 1 0.1089 87.3 0.943 Contact Map
1ffkW 1 0.1823 85.7 0.944 Contact Map
1qypA 1 0.1165 83.6 0.945 Contact Map
4a17Y 1 0.2228 81.3 0.947 Contact Map
1vd4A 1 0.1418 81.2 0.947 Contact Map
3j20Y 1 0.1266 80.3 0.947 Contact Map
3zf7o 1 0.2228 80 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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