GREMLIN Database
Q97XN3 - Partial transposase in ISC1316
UniProt: Q97XN3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 110 (106)
Sequences: 2508 (1444)
Seq/√Len: 140.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_L96_A2.8361.00
94_F97_K2.7141.00
15_I27_I2.5931.00
79_L103_A2.5151.00
57_T61_Q2.4571.00
22_S105_E2.4051.00
82_S86_K2.2551.00
91_H94_F2.1361.00
24_R105_E2.0621.00
20_E105_E2.0471.00
56_T62_Y2.0071.00
72_A107_Y2.0011.00
53_K56_T1.9451.00
83_L96_A1.7681.00
96_A100_L1.7521.00
89_L93_W1.7481.00
53_K62_Y1.7131.00
47_I55_V1.6731.00
45_V58_S1.6611.00
80_H100_L1.6571.00
83_L97_K1.6331.00
86_K96_A1.5731.00
18_K28_I1.5511.00
97_K101_A1.5121.00
76_V100_L1.4781.00
83_L100_L1.4351.00
38_L41_T1.3831.00
3_V6_D1.3771.00
75_K79_L1.3471.00
20_E24_R1.3341.00
105_E109_F1.3301.00
86_K92_N1.3231.00
26_Y105_E1.3051.00
84_S100_L1.2971.00
55_V63_F1.2951.00
16_I28_I1.2801.00
72_A106_H1.2771.00
70_E73_L1.2731.00
13_K32_D1.2581.00
19_L25_I1.2231.00
80_H104_Y1.1971.00
4_H13_K1.1620.99
69_F72_A1.1620.99
93_W96_A1.1600.99
65_N68_P1.1540.99
14_R30_V1.1510.99
92_N99_K1.1410.99
92_N95_K1.1310.99
86_K90_S1.1300.99
69_F73_L1.1280.99
43_K59_D1.0530.99
79_L82_S1.0520.99
103_A107_Y1.0520.99
7_F31_I1.0500.99
93_W97_K1.0440.99
20_E26_Y1.0330.99
100_L103_A1.0240.99
3_V7_F1.0220.99
72_A103_A1.0190.99
53_K64_P1.0100.99
76_V107_Y0.9980.98
79_L100_L0.9900.98
47_I57_T0.9860.98
18_K25_I0.9660.98
77_R80_H0.9660.98
79_L99_K0.9650.98
82_S85_R0.9560.98
24_R109_F0.9250.97
12_V15_I0.9240.97
68_P72_A0.9200.97
82_S96_A0.9160.97
98_V102_R0.9140.97
77_R84_S0.9130.97
78_E82_S0.9120.97
76_V84_S0.8860.97
76_V104_Y0.8670.96
3_V12_V0.8450.96
75_K103_A0.8260.95
57_T63_F0.8200.95
77_R81_R0.8160.95
83_L93_W0.8140.95
75_K78_E0.8080.94
49_V65_N0.7990.94
18_K30_V0.7980.94
84_S97_K0.7890.94
104_Y108_Y0.7670.93
7_F12_V0.7650.93
52_E56_T0.7620.92
74_T78_E0.7610.92
52_E62_Y0.7550.92
87_R93_W0.7540.92
10_D55_V0.7200.90
45_V57_T0.7090.89
77_R82_S0.7060.89
12_V30_V0.7050.89
8_P31_I0.6970.89
84_S96_A0.6940.88
22_S26_Y0.6940.88
22_S101_A0.6930.88
87_R90_S0.6920.88
51_I67_K0.6850.88
51_I54_L0.6820.88
40_F43_K0.6790.87
51_I65_N0.6640.86
54_L63_F0.6630.86
23_G105_E0.6630.86
37_A40_F0.6590.86
54_L65_N0.6540.85
77_R100_L0.6530.85
73_L77_R0.6490.85
90_S93_W0.6480.85
25_I30_V0.6460.85
45_V59_D0.6440.84
86_K93_W0.6430.84
80_H83_L0.6390.84
86_K99_K0.6340.84
32_D74_T0.6300.83
25_I56_T0.6250.83
63_F68_P0.6230.82
14_R28_I0.6220.82
99_K103_A0.6170.82
83_L86_K0.6140.82
33_Y36_K0.5990.80
20_E109_F0.5960.80
47_I54_L0.5930.79
49_V73_L0.5850.78
25_I49_V0.5840.78
91_H98_V0.5800.78
82_S99_K0.5800.78
103_A106_H0.5790.78
50_G63_F0.5790.78
8_P11_K0.5780.78
3_V54_L0.5770.77
50_G53_K0.5720.77
67_K70_E0.5660.76
20_E108_Y0.5660.76
81_R96_A0.5640.76
10_D13_K0.5610.75
49_V54_L0.5610.75
4_H23_G0.5600.75
81_R85_R0.5420.73
36_K91_H0.5410.73
3_V29_F0.5370.72
79_L83_L0.5340.72
80_H89_L0.5310.71
15_I28_I0.5280.71
38_L44_V0.5250.71
10_D50_G0.5220.70
3_V13_K0.5220.70
73_L80_H0.5200.70
22_S109_F0.5190.70
12_V31_I0.5180.70
95_K98_V0.5160.69
10_D29_F0.5130.69
69_F107_Y0.5130.69
73_L78_E0.5070.68
4_H12_V0.5020.67
50_G55_V0.5010.67
5_R10_D0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1neiA 2 0.4091 84.8 0.881 Contact Map
4ncpA 5 0.9 61.6 0.902 Contact Map
4ogeA 1 0.5273 59.9 0.903 Contact Map
1y7uA 5 0.9364 37.3 0.915 Contact Map
1vpmA 5 0.8091 30.6 0.919 Contact Map
4zv3A 3 0.7818 28.9 0.92 Contact Map
2qq2A 5 0.8364 21.3 0.925 Contact Map
2v1oA 5 0.8182 20.9 0.925 Contact Map
3zyyX 2 0.9 20.8 0.925 Contact Map
2pzhA 4 0.6636 19 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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