GREMLIN Database
Q97XN2 - Partial transposase in ISC1316
UniProt: Q97XN2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 123 (114)
Sequences: 3504 (1996)
Seq/√Len: 186.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_D11_K3.4321.00
29_N32_K3.0281.00
81_A109_Q2.7961.00
54_R70_L2.7701.00
61_L68_F2.5361.00
24_V118_L2.5131.00
34_V46_H2.3271.00
52_E56_I2.2771.00
25_M57_L2.1721.00
14_K18_E2.0511.00
71_V114_I1.9751.00
21_D66_K1.7871.00
79_T86_V1.7861.00
75_Y78_M1.7301.00
95_S103_H1.6791.00
9_Y52_E1.6391.00
39_K42_R1.6351.00
52_E55_T1.6331.00
58_E70_L1.6111.00
76_T114_I1.5981.00
9_Y56_I1.5891.00
78_M90_L1.5461.00
17_A61_L1.5461.00
25_M68_F1.5391.00
87_R90_L1.5321.00
82_R102_Y1.4691.00
10_M59_Y1.4581.00
92_G106_K1.4571.00
13_G56_I1.4491.00
10_M56_I1.4351.00
45_L50_F1.4331.00
87_R91_T1.4121.00
94_F104_I1.3971.00
6_R52_E1.3891.00
78_M88_E1.3771.00
53_F57_L1.3611.00
25_M70_L1.3181.00
17_A66_K1.3151.00
26_E73_P1.2991.00
94_F102_Y1.2741.00
25_M54_R1.2411.00
27_D70_L1.2311.00
10_M60_Q1.1971.00
112_S116_Y1.1921.00
15_Y19_H1.1841.00
29_N73_P1.1721.00
85_Y97_S1.1721.00
9_Y53_F1.1681.00
23_V61_L1.1441.00
71_V117_S1.1341.00
6_R56_I1.1321.00
36_K42_R1.1311.00
17_A64_Y1.1261.00
87_R94_F1.0921.00
10_M13_G1.0911.00
61_L66_K1.0571.00
93_V103_H1.0571.00
81_A104_I1.0491.00
108_Y112_S1.0261.00
8_I12_L1.0151.00
87_R97_S1.0131.00
85_Y98_H1.0111.00
14_K64_Y1.0091.00
104_I108_Y1.0030.99
36_K39_K0.9980.99
58_E62_I0.9980.99
36_K40_V0.9860.99
2_K6_R0.9620.99
30_V51_Y0.9590.99
13_G53_F0.9340.99
56_I59_Y0.9290.99
27_D73_P0.9260.99
24_V114_I0.9150.99
76_T117_S0.9080.99
104_I112_S0.9020.99
13_G59_Y0.8890.99
88_E91_T0.8750.99
92_G105_V0.8700.99
108_Y111_L0.8670.98
58_E68_F0.8570.98
9_Y13_G0.8470.98
12_L53_F0.8450.98
24_V69_T0.8450.98
18_E22_T0.8390.98
69_T118_L0.8370.98
73_P76_T0.8330.98
12_L15_Y0.8250.98
81_A112_S0.8170.98
79_T117_S0.8060.98
9_Y49_G0.8060.98
51_Y55_T0.8030.97
30_V50_F0.7940.97
91_T106_K0.7900.97
60_Q63_K0.7820.97
81_A116_Y0.7810.97
6_R10_M0.7710.97
75_Y117_S0.7690.97
5_R47_D0.7670.97
55_T58_E0.7650.97
41_M44_R0.7640.97
33_L45_L0.7570.96
81_A102_Y0.7380.96
82_R112_S0.7370.96
17_A23_V0.7220.95
13_G60_Q0.7210.95
16_F23_V0.7190.95
13_G57_L0.7180.95
88_E94_F0.6980.94
27_D54_R0.6830.94
34_V42_R0.6750.93
22_T69_T0.6730.93
112_S115_L0.6600.93
59_Y63_K0.6590.93
109_Q113_N0.6560.92
90_L106_K0.6500.92
79_T116_Y0.6460.92
22_T67_K0.6450.92
93_V104_I0.6450.92
71_V118_L0.6430.92
24_V115_L0.6400.91
78_M86_V0.6330.91
84_G113_N0.6190.90
14_K17_A0.6190.90
72_D75_Y0.6080.89
110_V113_N0.6030.89
36_K41_M0.6030.89
18_E64_Y0.6020.89
8_I53_F0.5990.89
86_V90_L0.5980.88
58_E67_K0.5960.88
17_A20_Y0.5960.88
76_T113_N0.5910.88
28_I73_P0.5740.86
36_K44_R0.5720.86
4_L8_I0.5720.86
79_T84_G0.5690.86
41_M45_L0.5660.86
48_I51_Y0.5640.85
85_Y89_D0.5610.85
85_Y94_F0.5610.85
22_T118_L0.5600.85
3_N6_R0.5560.85
54_R58_E0.5540.84
42_R46_H0.5510.84
40_V44_R0.5510.84
95_S102_Y0.5490.84
82_R104_I0.5480.84
95_S104_I0.5480.84
32_K73_P0.5480.84
24_V117_S0.5400.83
20_Y66_K0.5400.83
20_Y115_L0.5360.82
32_K45_L0.5280.81
91_T94_F0.5280.81
77_S90_L0.5260.81
36_K46_H0.5240.81
16_F108_Y0.5240.81
15_Y23_V0.5230.81
3_N7_D0.5230.81
32_K36_K0.5220.81
44_R48_I0.5220.81
72_D117_S0.5210.81
10_M14_K0.5190.80
102_Y112_S0.5180.80
30_V45_L0.5170.80
17_A68_F0.5130.80
39_K46_H0.5130.80
54_R68_F0.5110.79
34_V39_K0.5080.79
81_A110_V0.5060.79
14_K60_Q0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yuzA 2 0.8455 86.7 0.887 Contact Map
2k4xA 1 0.4309 86.7 0.887 Contact Map
1qypA 1 0.3496 86.1 0.888 Contact Map
3j20Y 1 0.3902 81.2 0.894 Contact Map
4d02A 2 0.3984 80.5 0.895 Contact Map
6rxnA 1 0.2846 78.8 0.897 Contact Map
4aybP 1 0.3252 77.4 0.898 Contact Map
2m4yA 1 0.3089 74.2 0.901 Contact Map
4c2mI 1 0.4146 74.2 0.901 Contact Map
1h7bA 2 0.5935 72.7 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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