GREMLIN Database
Q97XM7 - Partial transposon ISC1190
UniProt: Q97XM7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 260 (254)
Sequences: 4615 (3489)
Seq/√Len: 218.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_A99_V5.0161.00
18_Y92_K3.1191.00
162_S184_E3.0531.00
124_I175_E2.9361.00
213_V225_F2.7661.00
76_L95_A2.7051.00
123_S126_R2.6191.00
166_F177_R2.5111.00
229_C253_L2.4101.00
47_A95_A2.3671.00
169_G177_R2.3371.00
46_V66_Y2.3031.00
220_G224_R2.2811.00
14_K25_E2.2731.00
117_W121_T2.2591.00
221_D224_R2.1231.00
87_S233_V2.1091.00
123_S130_R2.0891.00
219_F228_Y2.0751.00
8_I36_V2.0641.00
125_A129_N2.0531.00
235_S240_V2.0301.00
173_R177_R2.0211.00
124_I178_K1.9591.00
118_D255_S1.9311.00
48_I68_V1.9091.00
6_A19_F1.9071.00
8_I15_L1.9001.00
117_W182_E1.8961.00
194_L197_T1.8951.00
170_E173_R1.8691.00
45_K69_R1.8411.00
60_K108_S1.8231.00
201_I206_G1.8111.00
120_V178_K1.7921.00
184_E187_D1.7871.00
115_S212_R1.7811.00
154_R172_E1.7611.00
182_E185_L1.7401.00
196_F203_R1.7341.00
208_I256_S1.7151.00
97_L101_I1.7141.00
123_S170_E1.6851.00
17_V36_V1.6661.00
205_L256_S1.6501.00
8_I58_L1.6471.00
131_L171_L1.6231.00
11_S16_V1.6161.00
121_T124_I1.5851.00
29_N32_G1.5771.00
61_Y64_K1.5711.00
61_Y65_E1.5671.00
189_V196_F1.5391.00
13_D238_K1.5341.00
170_E177_R1.5301.00
16_V25_E1.5211.00
85_K233_V1.5161.00
18_Y93_K1.5081.00
48_I59_A1.4861.00
121_T178_K1.4781.00
179_R182_E1.4771.00
77_K80_K1.4741.00
245_I254_R1.4451.00
166_F180_E1.4351.00
168_L172_E1.4261.00
24_Y39_V1.4231.00
124_I128_K1.4141.00
124_I171_L1.4101.00
80_K94_L1.4001.00
47_A71_I1.3891.00
171_L175_E1.3701.00
117_W204_T1.3561.00
212_R250_D1.3421.00
169_G176_A1.3401.00
152_V156_E1.3331.00
150_N154_R1.3291.00
154_R158_N1.3261.00
150_N157_D1.3201.00
46_V62_L1.3201.00
201_I205_L1.3191.00
187_D191_K1.3181.00
169_G173_R1.3131.00
195_I206_G1.3041.00
11_S14_K1.3041.00
118_D252_V1.2931.00
7_G96_E1.2931.00
40_L46_V1.2881.00
127_V130_R1.2821.00
123_S127_V1.2761.00
177_R180_E1.2651.00
6_A40_L1.2631.00
182_E186_E1.2571.00
153_L157_D1.2371.00
126_R129_N1.2361.00
119_F130_R1.2291.00
147_K151_E1.2281.00
116_Q120_V1.2171.00
104_E107_T1.2101.00
27_Q32_G1.2071.00
33_F61_Y1.1901.00
8_I17_V1.1871.00
74_F78_K1.1671.00
148_N151_E1.1661.00
45_K67_D1.1481.00
93_K97_L1.1411.00
12_K136_I1.1401.00
55_H70_I1.1391.00
37_K61_Y1.1391.00
10_I15_L1.1291.00
131_L164_I1.1231.00
17_V39_V1.1171.00
175_E179_R1.1141.00
6_A17_V1.1121.00
149_L152_V1.1061.00
117_W178_K1.1041.00
71_I76_L1.1021.00
150_N153_L1.0941.00
142_D145_S1.0931.00
213_V216_V1.0911.00
145_S157_D1.0841.00
122_R126_R1.0761.00
33_F57_N1.0721.00
127_V131_L1.0671.00
114_T252_V1.0601.00
141_R149_L1.0591.00
6_A46_V1.0561.00
176_A180_E1.0561.00
59_A68_V1.0521.00
150_N156_E1.0441.00
186_E203_R1.0421.00
32_G35_G1.0391.00
121_T125_A1.0371.00
152_V155_G1.0361.00
86_K91_D1.0291.00
26_F39_V1.0131.00
153_L156_E1.0111.00
143_S146_R1.0091.00
192_D210_L1.0061.00
151_E154_R1.0011.00
5_V100_S0.9941.00
6_A44_C0.9921.00
155_G158_N0.9921.00
114_T207_C0.9921.00
247_K254_R0.9891.00
38_Q41_P0.9801.00
111_K212_R0.9661.00
59_A70_I0.9611.00
158_N161_L0.9491.00
5_V99_V0.9421.00
58_L62_L0.9371.00
69_R99_V0.9331.00
26_F32_G0.9331.00
146_R150_N0.9230.99
147_K150_N0.9210.99
148_N152_V0.9120.99
50_S73_P0.9060.99
163_E166_F0.9030.99
36_V40_L0.9010.99
10_I48_I0.9010.99
236_S240_V0.9000.99
84_G248_R0.8950.99
53_I136_I0.8860.99
84_G227_A0.8830.99
113_L181_I0.8820.99
148_N157_D0.8770.99
142_D146_R0.8750.99
224_R227_A0.8700.99
152_V157_D0.8700.99
85_K90_N0.8690.99
95_A98_V0.8670.99
116_Q163_E0.8580.99
166_F170_E0.8580.99
151_E155_G0.8580.99
161_L165_R0.8570.99
196_F206_G0.8560.99
149_L153_L0.8560.99
147_K157_D0.8500.99
173_R176_A0.8500.99
114_T185_L0.8440.99
245_I249_G0.8440.99
114_T211_A0.8430.99
45_K99_V0.8340.99
166_F184_E0.8280.99
17_V26_F0.8260.99
33_F39_V0.8220.99
116_Q166_F0.8210.99
11_S15_L0.8180.99
144_L152_V0.8170.99
37_K65_E0.8170.99
79_F101_I0.8120.99
146_R149_L0.8070.99
184_E188_L0.8050.99
128_K171_L0.8000.98
40_L62_L0.7960.98
7_G92_K0.7920.98
31_Q35_G0.7910.98
114_T208_I0.7910.98
228_Y250_D0.7900.98
127_V171_L0.7890.98
148_N153_L0.7880.98
232_L246_S0.7820.98
153_L158_N0.7810.98
118_D122_R0.7810.98
150_N155_G0.7780.98
212_R252_V0.7750.98
15_L28_N0.7740.98
106_T191_K0.7700.98
145_S149_L0.7700.98
150_N172_E0.7660.98
162_S165_R0.7640.98
233_V240_V0.7590.98
48_I95_A0.7530.98
50_S70_I0.7530.98
235_S241_V0.7480.98
176_A179_R0.7460.98
125_A128_K0.7460.98
154_R157_D0.7440.98
127_V167_L0.7400.97
16_V89_K0.7290.97
119_F123_S0.7290.97
186_E190_P0.7260.97
174_L178_K0.7240.97
48_I70_I0.7240.97
159_A162_S0.7230.97
127_V170_E0.7210.97
185_L189_V0.7210.97
43_G67_D0.7210.97
145_S148_N0.7200.97
51_T54_Y0.7190.97
174_L177_R0.7180.97
182_E189_V0.7140.97
41_P65_E0.7130.97
209_I253_L0.7120.97
72_N75_I0.7070.97
215_D218_R0.7030.97
208_I212_R0.7030.97
143_S149_L0.7030.97
47_A76_L0.7030.97
104_E108_S0.7020.97
201_I209_I0.7020.97
162_S173_R0.7000.96
18_Y96_E0.6980.96
35_G38_Q0.6930.96
151_E156_E0.6880.96
170_E174_L0.6880.96
87_S235_S0.6850.96
73_P212_R0.6850.96
167_L170_E0.6840.96
159_A184_E0.6790.96
175_E178_K0.6770.96
255_S258_L0.6760.96
15_L58_L0.6750.96
142_D148_N0.6750.96
88_D236_S0.6750.96
180_E184_E0.6720.96
162_S166_F0.6720.96
129_N133_R0.6660.95
32_G36_V0.6650.95
151_E157_D0.6650.95
106_T109_E0.6640.95
148_N155_G0.6640.95
15_L26_F0.6610.95
147_K154_R0.6610.95
108_S112_E0.6600.95
37_K41_P0.6580.95
116_Q181_I0.6570.95
79_F98_V0.6550.95
127_V174_L0.6540.95
43_G66_Y0.6540.95
76_L98_V0.6500.95
144_L147_K0.6450.94
115_S252_V0.6430.94
6_A62_L0.6360.94
148_N156_E0.6320.94
34_E38_Q0.6310.94
98_V102_G0.6310.94
143_S147_K0.6280.94
160_A163_E0.6250.94
204_T208_I0.6230.93
105_F109_E0.6220.93
172_E176_A0.6210.93
213_V229_C0.6200.93
120_V174_L0.6190.93
146_R153_L0.6160.93
110_A192_D0.6150.93
120_V181_I0.6140.93
30_K34_E0.6130.93
234_E243_R0.6130.93
159_A163_E0.6130.93
222_K227_A0.6130.93
143_S155_G0.6090.93
41_P66_Y0.6090.93
143_S148_N0.6070.93
121_T182_E0.6050.92
71_I98_V0.6030.92
119_F126_R0.6030.92
10_I54_Y0.6010.92
57_N139_G0.6010.92
32_G39_V0.5990.92
165_R169_G0.5980.92
74_F248_R0.5970.92
186_E189_V0.5960.92
115_S250_D0.5960.92
245_I258_L0.5910.92
145_S151_E0.5900.91
124_I174_L0.5890.91
31_Q39_V0.5840.91
79_F97_L0.5800.91
120_V177_R0.5790.91
145_S154_R0.5770.91
142_D147_K0.5770.91
214_G218_R0.5710.90
252_V256_S0.5700.90
16_V236_S0.5700.90
97_L100_S0.5680.90
143_S156_E0.5680.90
144_L151_E0.5660.90
229_C256_S0.5630.89
226_V233_V0.5620.89
120_V124_I0.5620.89
147_K155_G0.5610.89
20_Q23_Y0.5610.89
189_V207_C0.5590.89
110_A188_L0.5570.89
209_I225_F0.5560.89
113_L184_E0.5560.89
198_I201_I0.5550.89
145_S152_V0.5550.89
128_K132_R0.5540.89
172_E175_E0.5520.89
37_K66_Y0.5520.89
33_F58_L0.5510.88
76_L94_L0.5500.88
130_R133_R0.5480.88
182_E204_T0.5470.88
239_S242_S0.5460.88
239_S243_R0.5460.88
150_N158_N0.5420.88
212_R229_C0.5390.87
183_E187_D0.5380.87
112_E134_D0.5370.87
38_Q65_E0.5360.87
113_L117_W0.5360.87
17_V40_L0.5360.87
128_K145_S0.5350.87
149_L156_E0.5340.87
183_E186_E0.5330.87
25_E28_N0.5320.87
208_I252_V0.5300.86
188_L191_K0.5300.86
11_S237_G0.5280.86
246_S249_G0.5280.86
118_D208_I0.5270.86
116_Q119_F0.5270.86
225_F258_L0.5240.86
11_S58_L0.5220.86
130_R167_L0.5220.86
103_S111_K0.5210.86
7_G62_L0.5200.85
64_K105_F0.5180.85
252_V255_S0.5180.85
136_I141_R0.5160.85
15_L139_G0.5140.85
74_F84_G0.5130.85
50_S254_R0.5130.85
103_S108_S0.5130.85
180_E183_E0.5130.85
28_N33_F0.5120.85
4_P19_F0.5120.85
193_S197_T0.5100.84
82_I248_R0.5090.84
148_N158_N0.5090.84
44_C66_Y0.5080.84
142_D150_N0.5080.84
247_K251_A0.5060.84
162_S180_E0.5060.84
116_Q127_V0.5040.84
11_S55_H0.5020.83
143_S151_E0.5000.83
234_E239_S0.5000.83
189_V192_D0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b0xA 1 0.5808 89.9 0.923 Contact Map
2a1jA 1 0.2269 87.1 0.927 Contact Map
3psiA 1 0.8346 86 0.928 Contact Map
3psfA 1 0.8577 84.8 0.929 Contact Map
1z00B 1 0.2808 84.2 0.93 Contact Map
1keaA 2 0.65 81.4 0.932 Contact Map
1hjrA 2 0.4038 79.9 0.933 Contact Map
1vq8Y 1 0 78.8 0.933 Contact Map
2a1jB 2 0.2885 77.6 0.934 Contact Map
1nu0A 1 0.3808 72.3 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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