GREMLIN Database
Q97XM6 - Uncharacterized protein
UniProt: Q97XM6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 231 (208)
Sequences: 1633 (1027)
Seq/√Len: 71.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_A110_F8.6031.00
222_E225_K4.0541.00
76_E79_V4.0221.00
80_I112_A3.7981.00
6_A178_L3.5301.00
147_G158_T3.1881.00
147_G150_E3.0871.00
6_A165_L2.9831.00
82_H98_H2.8811.00
132_L137_E2.6001.00
96_Y132_L2.5861.00
213_T217_K2.5861.00
111_L140_A2.5361.00
147_G154_L2.4761.00
117_V139_V2.4421.00
101_L110_F2.2021.00
194_D198_L2.2001.00
80_I165_L2.1221.00
139_V164_L2.0901.00
96_Y137_E2.0221.00
45_L167_L1.9841.00
155_R158_T1.9821.00
111_L164_L1.8921.00
168_E171_R1.8441.00
82_H96_Y1.8381.00
96_Y134_V1.8221.00
68_S101_L1.7901.00
4_M165_L1.7871.00
140_A144_S1.7291.00
171_R179_F1.7241.00
150_E154_L1.7161.00
123_G127_G1.6500.99
196_Y199_Y1.6150.99
154_L158_T1.6130.99
118_D121_K1.6080.99
197_K200_L1.6000.99
109_L166_L1.5890.99
180_Y205_V1.5820.99
46_T51_V1.5760.99
134_V137_E1.5630.99
155_R159_Q1.5600.99
29_D59_I1.5400.99
45_L110_F1.5070.99
113_H136_S1.4910.99
25_A29_D1.4420.99
193_E198_L1.4410.99
42_V79_V1.4290.99
185_R220_E1.4290.99
3_R8_Y1.4010.98
191_R194_D1.3960.98
150_E153_K1.3500.98
205_V227_L1.3390.98
195_Y200_L1.3210.98
198_L203_G1.3120.97
195_Y198_L1.2940.97
89_K134_V1.2930.97
112_A165_L1.2910.97
146_Y149_K1.2810.97
56_H97_S1.2750.97
148_I152_D1.2670.97
194_D202_N1.2400.96
80_I167_L1.2200.96
143_L166_L1.2090.96
139_V154_L1.2050.96
196_Y200_L1.1930.95
47_T75_G1.1900.95
16_K71_D1.1840.95
199_Y202_N1.1820.95
199_Y212_Y1.1820.95
86_A89_K1.1660.95
149_K153_K1.1630.95
51_V72_S1.1490.94
29_D40_W1.1440.94
78_K178_L1.1310.94
55_S62_D1.1240.94
15_L42_V1.1140.93
18_L73_L1.1050.93
27_Q32_S1.1040.93
29_D33_D1.0960.93
156_D159_Q1.0890.93
82_H112_A1.0770.92
102_E144_S1.0770.92
87_S116_S1.0540.91
36_H83_A1.0450.91
147_G159_Q1.0390.91
10_R15_L1.0380.91
20_N24_R1.0290.90
206_Y218_G1.0200.90
8_Y78_K1.0170.90
153_K156_D1.0030.89
109_L134_V1.0030.89
132_L140_A1.0020.89
59_I82_H1.0010.89
118_D122_L0.9980.89
194_D200_L0.9960.89
78_K167_L0.9930.89
1_M5_L0.9890.89
96_Y140_A0.9860.88
100_Y134_V0.9850.88
125_M145_I0.9750.88
77_V204_A0.9680.88
149_K157_V0.9600.87
5_L21_C0.9550.87
57_L206_Y0.9440.86
76_E167_L0.9430.86
85_Q88_D0.9420.86
150_E158_T0.9360.86
45_L104_N0.9290.85
4_M112_A0.9280.85
29_D32_S0.9240.85
40_W58_P0.9200.85
23_V26_S0.9180.85
198_L202_N0.9170.85
147_G151_V0.9070.84
180_Y226_L0.9040.84
28_K87_S0.9000.83
98_H134_V0.8970.83
102_E141_K0.8940.83
221_V227_L0.8910.83
125_M150_E0.8910.83
148_I151_V0.8910.83
180_Y227_L0.8870.83
65_N69_I0.8850.82
197_K201_H0.8830.82
78_K123_G0.8730.82
146_Y219_E0.8720.81
51_V76_E0.8690.81
11_D77_V0.8690.81
123_G138_L0.8630.81
191_R195_Y0.8610.81
120_Y127_G0.8600.81
45_L169_I0.8520.80
89_K136_S0.8500.80
80_I178_L0.8400.79
153_K159_Q0.8390.79
3_R207_S0.8290.78
160_S163_N0.8250.78
19_A25_A0.8200.77
151_V159_Q0.8170.77
63_K67_E0.8170.77
193_E196_Y0.8130.77
147_G153_K0.8070.76
118_D151_V0.8040.76
195_Y202_N0.8020.76
66_L210_L0.8020.76
55_S94_V0.8020.76
45_L168_E0.8010.76
212_Y217_K0.7990.75
21_C26_S0.7970.75
44_A73_L0.7950.75
46_T72_S0.7910.75
3_R9_G0.7910.75
197_K203_G0.7890.75
59_I97_S0.7890.75
116_S164_L0.7870.74
151_V155_R0.7840.74
3_R25_A0.7820.74
2_C5_L0.7820.74
113_H135_D0.7790.74
87_S136_S0.7770.73
53_Y65_N0.7730.73
119_K123_G0.7650.72
187_D220_E0.7610.72
150_E155_R0.7580.72
155_R185_R0.7560.71
97_S185_R0.7560.71
200_L203_G0.7510.71
163_N206_Y0.7500.71
37_G60_F0.7460.70
130_P141_K0.7450.70
94_V179_F0.7440.70
152_D156_D0.7420.70
123_G126_I0.7380.70
50_L201_H0.7360.69
169_I209_S0.7340.69
8_Y28_K0.7340.69
87_S117_V0.7340.69
148_I226_L0.7280.68
109_L143_L0.7270.68
130_P205_V0.7200.68
202_N211_A0.7160.67
141_K163_N0.7130.67
9_G26_S0.7110.67
4_M163_N0.7080.66
5_L81_I0.7070.66
22_L25_A0.7060.66
24_R28_K0.7000.65
93_S133_M0.6950.65
36_H60_F0.6950.65
19_A27_Q0.6940.65
101_L225_K0.6930.65
83_A209_S0.6900.64
47_T131_T0.6890.64
166_L186_K0.6880.64
119_K127_G0.6870.64
183_Y224_G0.6840.64
121_K149_K0.6840.64
152_D155_R0.6830.64
1_M4_M0.6790.63
128_I131_T0.6650.61
26_S208_S0.6610.61
39_G114_N0.6600.61
67_E71_D0.6590.61
44_A53_Y0.6550.60
121_K205_V0.6530.60
88_D116_S0.6470.59
2_C114_N0.6460.59
42_V66_L0.6460.59
153_K158_T0.6460.59
45_L50_L0.6430.59
28_K33_D0.6400.59
164_L181_Y0.6390.58
204_A210_L0.6370.58
85_Q98_H0.6320.58
72_S94_V0.6290.57
52_Y101_L0.6290.57
161_A185_R0.6240.57
151_V158_T0.6220.56
44_A76_E0.6200.56
55_S97_S0.6190.56
116_S161_A0.6170.56
53_Y62_D0.6160.56
7_Y10_R0.6140.55
148_I179_F0.6140.55
36_H79_V0.6130.55
133_M137_E0.6120.55
170_N217_K0.6110.55
121_K126_I0.6050.54
4_M96_Y0.6030.54
117_V160_S0.6030.54
82_H132_L0.6030.54
10_R211_A0.6030.54
54_R145_I0.6030.54
85_Q90_N0.6020.54
148_I155_R0.6010.54
25_A208_S0.5980.53
21_C25_A0.5970.53
47_T77_V0.5970.53
29_D35_I0.5910.53
18_L189_I0.5910.53
36_H114_N0.5900.53
15_L19_A0.5870.52
43_A76_E0.5870.52
55_S72_S0.5860.52
5_L19_A0.5850.52
4_M82_H0.5840.52
45_L65_N0.5840.52
148_I219_E0.5820.52
99_P115_G0.5810.51
40_W182_N0.5800.51
3_R150_E0.5780.51
36_H85_Q0.5780.51
39_G84_R0.5710.50
20_N25_A0.5700.50
171_R228_V0.5680.50
104_N168_E0.5680.50
80_I110_F0.5670.50
3_R34_D0.5640.49
34_D214_G0.5630.49
38_D60_F0.5630.49
41_G115_G0.5610.49
56_H61_E0.5610.49
97_S134_V0.5570.48
29_D34_D0.5570.48
25_A38_D0.5560.48
98_H137_E0.5540.48
35_I87_S0.5540.48
165_L185_R0.5530.48
9_G25_A0.5520.48
36_H98_H0.5480.47
124_E130_P0.5470.47
25_A35_I0.5460.47
131_T146_Y0.5460.47
10_R47_T0.5460.47
100_Y111_L0.5440.47
86_A90_N0.5420.47
128_I217_K0.5410.47
178_L224_G0.5400.46
131_T153_K0.5400.46
147_G155_R0.5380.46
104_N170_N0.5380.46
54_R101_L0.5370.46
138_L145_I0.5370.46
37_G61_E0.5370.46
118_D148_I0.5350.46
126_I203_G0.5350.46
27_Q35_I0.5340.46
125_M149_K0.5340.46
19_A23_V0.5300.45
132_L144_S0.5280.45
38_D61_E0.5270.45
109_L184_Y0.5260.45
126_I142_Y0.5250.45
41_G99_P0.5220.44
67_E222_E0.5210.44
56_H221_V0.5200.44
180_Y221_V0.5190.44
62_D137_E0.5190.44
23_V59_I0.5180.44
23_V56_H0.5170.44
26_S60_F0.5160.43
21_C29_D0.5160.43
195_Y199_Y0.5140.43
79_V111_L0.5120.43
71_D167_L0.5100.43
114_N163_N0.5080.43
119_K140_A0.5080.43
196_Y201_H0.5070.42
52_Y146_Y0.5060.42
55_S213_T0.5040.42
121_K219_E0.5010.42
97_S184_Y0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mdnA 4 0.7965 100 0.433 Contact Map
4zflA 5 0.8918 100 0.442 Contact Map
1te5A 2 0.9264 100 0.485 Contact Map
4amvA 2 0.8658 100 0.585 Contact Map
1ao0A 3 0.8831 99.9 0.6 Contact Map
1xffA 2 0.8658 99.9 0.606 Contact Map
1ecfA 4 0.8961 99.9 0.615 Contact Map
1ea0A 1 0.9004 99.7 0.722 Contact Map
1jgtA 2 0.7489 99.7 0.734 Contact Map
1ofdA 1 0.8831 99.7 0.735 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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