GREMLIN Database
Q97XM0 - Amino acid transporter related protein
UniProt: Q97XM0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 462 (421)
Sequences: 24933 (16227)
Seq/√Len: 790.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_V351_F4.4681.00
332_K345_I4.3481.00
395_I399_K3.3121.00
63_L252_G3.1401.00
335_S345_I3.1161.00
238_N242_K2.9421.00
337_H340_R2.9251.00
22_G234_K2.8951.00
233_A239_N2.6651.00
87_Y326_D2.6621.00
235_D238_N2.6311.00
103_S323_M2.6221.00
185_I261_A2.5861.00
337_H344_H2.5261.00
332_K335_S2.5171.00
324_S334_S2.5171.00
146_L355_A2.5031.00
27_L246_T2.4091.00
292_I296_I2.3711.00
183_I187_S2.3691.00
23_Y246_T2.3511.00
75_I397_V2.2681.00
231_E325_V2.2521.00
91_E99_A2.2261.00
387_F419_G2.2201.00
23_Y239_N2.1061.00
153_V347_S2.0891.00
416_A420_Y2.0691.00
348_L352_I2.0681.00
444_L448_G2.0621.00
154_I158_L2.0581.00
150_I355_A2.0551.00
157_Y344_H2.0451.00
232_E318_R2.0421.00
23_Y27_L2.0241.00
283_I286_K2.0231.00
26_V233_A2.0041.00
161_R165_K2.0011.00
321_Y325_V2.0001.00
242_K246_T1.9731.00
270_N287_T1.9711.00
145_G358_F1.9611.00
172_I176_T1.9431.00
146_L358_F1.9341.00
72_R390_N1.9251.00
94_L395_I1.9241.00
406_G409_L1.8761.00
16_L336_I1.8751.00
22_G25_E1.8721.00
64_I68_L1.8571.00
91_E96_K1.8451.00
107_T350_T1.8451.00
442_L446_V1.8361.00
327_K331_S1.8351.00
94_L391_I1.8301.00
411_V415_E1.8271.00
95_G98_V1.8111.00
333_L349_F1.7861.00
267_G270_N1.7371.00
418_I422_F1.7351.00
412_A416_A1.7341.00
194_N199_A1.7231.00
150_I351_F1.7181.00
235_D239_N1.7121.00
283_I287_T1.6971.00
90_I102_A1.6951.00
435_V438_G1.6921.00
25_E168_L1.6911.00
47_A55_L1.6741.00
337_H342_T1.6371.00
156_S310_T1.6251.00
245_F249_L1.6161.00
137_P140_I1.6111.00
390_N418_I1.6031.00
114_I354_T1.6021.00
157_Y348_L1.5981.00
118_Y309_A1.5871.00
102_A388_V1.5791.00
197_T200_Y1.5691.00
30_G247_A1.5671.00
340_R344_H1.5601.00
58_A212_G1.5561.00
21_V25_E1.5531.00
176_T180_A1.5531.00
424_A428_T1.5461.00
420_Y424_A1.5431.00
149_A354_T1.5391.00
27_L250_L1.5381.00
395_I398_K1.5371.00
415_E418_I1.5271.00
448_G451_I1.5231.00
413_I417_I1.5171.00
449_G453_L1.5101.00
195_T198_L1.4901.00
249_L253_I1.4881.00
401_N404_N1.4861.00
414_V418_I1.4841.00
158_L340_R1.4801.00
286_K294_L1.4801.00
121_M148_N1.4621.00
194_N198_L1.4601.00
177_G300_L1.4561.00
104_M448_G1.4531.00
125_V144_L1.4401.00
229_L314_N1.4361.00
450_I454_T1.4341.00
320_M346_A1.4331.00
345_I349_F1.4291.00
54_A209_L1.4271.00
316_V350_T1.4141.00
331_S335_S1.4121.00
235_D242_K1.4101.00
432_N435_V1.4071.00
118_Y149_A1.3961.00
197_T202_P1.3941.00
90_I388_V1.3941.00
391_I395_I1.3931.00
153_V348_L1.3931.00
331_S334_S1.3891.00
413_I416_A1.3871.00
70_A248_A1.3831.00
286_K291_T1.3801.00
321_Y336_I1.3681.00
193_I197_T1.3571.00
18_K341_R1.3551.00
199_A202_P1.3531.00
149_A351_F1.3491.00
186_F261_A1.3441.00
451_I455_L1.3421.00
140_I143_P1.3411.00
194_N197_T1.3411.00
97_K452_Y1.3401.00
295_I299_A1.3401.00
335_S344_H1.3391.00
415_E419_G1.3351.00
422_F425_T1.3341.00
146_L150_I1.3321.00
411_V414_V1.3311.00
410_I414_V1.3301.00
80_V92_R1.3211.00
277_Y283_I1.3211.00
198_L201_V1.3191.00
175_I179_I1.3161.00
317_T347_S1.3161.00
121_M302_I1.3091.00
62_A216_G1.2941.00
182_S257_V1.2801.00
436_L439_V1.2781.00
70_A244_V1.2771.00
69_D390_N1.2761.00
16_L321_Y1.2741.00
239_N242_K1.2721.00
443_V446_V1.2661.00
25_E164_L1.2631.00
21_V164_L1.2521.00
94_L98_V1.2501.00
195_T200_Y1.2451.00
64_I417_I1.2421.00
23_Y242_K1.2391.00
435_V439_V1.2361.00
236_P241_A1.2331.00
412_A415_E1.2191.00
415_E422_F1.2191.00
21_V26_V1.2181.00
34_G251_L1.2141.00
93_G392_S1.2101.00
253_I257_V1.2101.00
83_A231_E1.2071.00
434_P437_I1.2051.00
117_V308_C1.2001.00
196_F199_A1.1911.00
107_T320_M1.1901.00
423_Y427_I1.1871.00
71_T245_F1.1871.00
88_A92_R1.1871.00
56_P260_E1.1861.00
139_W143_P1.1841.00
189_I264_V1.1831.00
320_M329_L1.1821.00
418_I421_V1.1661.00
443_V447_V1.1651.00
419_G422_F1.1571.00
152_S309_A1.1561.00
181_T185_I1.1501.00
26_V243_G1.1451.00
439_V443_V1.1431.00
30_G226_V1.1381.00
24_R28_A1.1271.00
289_G293_L1.1171.00
433_V436_L1.1121.00
180_A184_L1.1101.00
268_V271_M1.1071.00
345_I348_L1.1061.00
419_G423_Y1.1031.00
411_V416_A1.1031.00
234_K239_N1.1021.00
142_I146_L1.0991.00
31_I250_L1.0991.00
139_W142_I1.0981.00
433_V437_I1.0921.00
434_P438_G1.0911.00
416_A419_G1.0911.00
77_A89_F1.0871.00
155_I166_F1.0831.00
185_I265_G1.0821.00
65_M421_V1.0801.00
73_L86_I1.0791.00
147_V151_V1.0781.00
195_T199_A1.0701.00
82_S88_A1.0631.00
325_V334_S1.0621.00
194_N200_Y1.0581.00
153_V157_Y1.0561.00
432_N436_L1.0531.00
279_A283_I1.0461.00
440_L443_V1.0371.00
433_V438_G1.0361.00
446_V450_I1.0351.00
336_I341_R1.0331.00
187_S192_D1.0321.00
165_K169_I1.0321.00
166_F170_M1.0301.00
29_Q229_L1.0271.00
413_I419_G1.0261.00
197_T201_V1.0241.00
54_A202_P1.0151.00
75_I78_R1.0141.00
352_I356_L1.0121.00
167_T310_T1.0031.00
20_V234_K1.0021.00
82_S92_R0.9991.00
92_R400_N0.9961.00
413_I418_I0.9941.00
97_K449_G0.9921.00
87_Y322_A0.9791.00
35_A38_A0.9791.00
100_F104_M0.9771.00
186_F190_P0.9731.00
41_I44_L0.9691.00
445_W449_G0.9661.00
72_R415_E0.9651.00
408_I411_V0.9611.00
438_G442_L0.9591.00
415_E421_V0.9551.00
60_A256_I0.9521.00
150_I154_I0.9471.00
398_K401_N0.9471.00
436_L440_L0.9461.00
79_Y404_N0.9441.00
170_M307_A0.9431.00
425_T428_T0.9431.00
160_I314_N0.9401.00
122_G144_L0.9381.00
221_T382_F0.9371.00
125_V302_I0.9301.00
179_I183_I0.9241.00
28_A168_L0.9241.00
405_I409_L0.9171.00
387_F423_Y0.9151.00
411_V418_I0.9081.00
424_A427_I0.9081.00
196_F200_Y0.9071.00
68_L417_I0.9061.00
410_I415_E0.9061.00
143_P147_V0.9041.00
410_I413_I0.9031.00
152_S310_T0.9021.00
31_I251_L0.9011.00
391_I419_G0.9011.00
78_R405_I0.8951.00
90_I98_V0.8901.00
440_L444_L0.8901.00
125_V129_I0.8891.00
230_G240_I0.8871.00
151_V306_L0.8871.00
394_L416_A0.8871.00
84_G87_Y0.8861.00
267_G287_T0.8761.00
56_P263_T0.8741.00
175_I254_T0.8741.00
116_F218_L0.8711.00
91_E326_D0.8671.00
157_Y337_H0.8641.00
224_E228_V0.8621.00
157_Y342_T0.8611.00
442_L445_W0.8601.00
116_F375_G0.8581.00
20_V161_R0.8581.00
122_G145_G0.8561.00
211_L215_F0.8561.00
265_G284_L0.8551.00
187_S191_P0.8531.00
104_M329_L0.8531.00
252_G256_I0.8481.00
63_L220_F0.8471.00
203_P206_I0.8461.00
408_I415_E0.8451.00
182_S261_A0.8441.00
313_T351_F0.8441.00
441_T444_L0.8431.00
246_T250_L0.8411.00
35_A174_E0.8371.00
448_G452_Y0.8361.00
387_F391_I0.8361.00
437_I444_L0.8351.00
181_T285_A0.8311.00
84_G88_A0.8301.00
25_E165_K0.8271.00
333_L345_I0.8211.00
432_N438_G0.8201.00
418_I424_A0.8161.00
270_N273_T0.8111.00
451_I454_T0.8081.00
422_F426_V0.8061.00
411_V419_G0.8051.00
329_L333_L0.7981.00
165_K168_L0.7961.00
403_L406_G0.7941.00
344_H348_L0.7931.00
44_L47_A0.7921.00
260_E264_V0.7921.00
122_G141_W0.7901.00
182_S186_F0.7901.00
412_A418_I0.7881.00
377_T381_G0.7881.00
439_V442_L0.7881.00
16_L232_E0.7861.00
438_G441_T0.7861.00
408_I412_A0.7851.00
60_A64_I0.7841.00
174_E304_S0.7831.00
225_T315_C0.7821.00
67_L71_T0.7781.00
205_K208_N0.7781.00
57_L209_L0.7761.00
121_M306_L0.7731.00
53_G263_T0.7721.00
121_M305_N0.7691.00
189_I192_D0.7671.00
380_F441_T0.7661.00
90_I392_S0.7641.00
67_L245_F0.7621.00
438_G444_L0.7591.00
419_G428_T0.7591.00
413_I420_Y0.7561.00
154_I157_Y0.7561.00
419_G426_V0.7551.00
416_A424_A0.7521.00
351_F355_A0.7521.00
24_R168_L0.7481.00
277_Y280_P0.7471.00
394_L398_K0.7461.00
420_Y423_Y0.7451.00
76_I393_M0.7451.00
95_G453_L0.7411.00
291_T295_I0.7391.00
409_L413_I0.7351.00
406_G412_A0.7341.00
439_V444_L0.7331.00
444_L451_I0.7321.00
392_S396_V0.7291.00
144_L147_V0.7291.00
189_I261_A0.7241.00
444_L447_V0.7241.00
206_I210_G0.7241.00
187_S190_P0.7231.00
111_F353_F0.7231.00
152_S313_T0.7231.00
42_G120_I0.7201.00
397_V401_N0.7191.00
40_T43_T0.7171.00
439_V453_L0.7171.00
142_I358_F0.7151.00
450_I453_L0.7151.00
332_K349_F0.7151.00
421_V428_T0.7131.00
158_L162_P0.7131.00
98_V388_V0.7121.00
16_L318_R0.7091.00
186_F257_V0.7081.00
182_S258_G0.7071.00
56_P60_A0.7071.00
97_K101_V0.7021.00
149_A358_F0.7021.00
76_I89_F0.7021.00
352_I355_A0.6991.00
20_V160_I0.6981.00
48_A55_L0.6971.00
68_L72_R0.6931.00
34_G247_A0.6921.00
448_G455_L0.6921.00
337_H341_R0.6921.00
119_L374_T0.6911.00
27_L243_G0.6851.00
47_A51_A0.6841.00
221_T386_I0.6831.00
317_T346_A0.6811.00
235_D241_A0.6811.00
449_G452_Y0.6791.00
136_L139_W0.6771.00
156_S347_S0.6751.00
444_L452_Y0.6731.00
442_L448_G0.6721.00
24_R165_K0.6721.00
415_E427_I0.6701.00
32_A171_S0.6691.00
106_Y110_I0.6681.00
445_W448_G0.6681.00
73_L389_V0.6631.00
405_I411_V0.6621.00
36_P255_Y0.6601.00
432_N437_I0.6601.00
413_I421_V0.6601.00
115_I374_T0.6591.00
23_Y243_G0.6581.00
146_L359_I0.6571.00
206_I209_L0.6571.00
241_A244_V0.6561.00
113_V378_T0.6551.00
57_L61_I0.6551.00
195_T201_V0.6551.00
33_S311_G0.6541.00
27_L30_G0.6541.00
246_T249_L0.6531.00
421_V424_A0.6511.00
446_V449_G0.6501.00
439_V449_G0.6501.00
93_G395_I0.6501.00
164_L168_L0.6501.00
20_V24_R0.6501.00
290_G293_L0.6491.00
452_Y455_L0.6471.00
162_P165_K0.6471.00
447_V451_I0.6471.00
94_L392_S0.6461.00
157_Y347_S0.6461.00
57_L60_A0.6451.00
87_Y103_S0.6431.00
269_N273_T0.6411.00
393_M397_V0.6411.00
370_I373_A0.6411.00
324_S333_L0.6411.00
46_G50_F0.6391.00
419_G427_I0.6381.00
184_L188_K0.6371.00
156_S314_N0.6371.00
109_Y382_F0.6361.00
418_I428_T0.6361.00
194_N202_P0.6351.00
87_Y91_E0.6351.00
112_A377_T0.6291.00
257_V261_A0.6271.00
55_L259_S0.6261.00
115_I357_Y0.6261.00
441_T449_G0.6251.00
292_I295_I0.6251.00
15_G18_K0.6251.00
110_I312_F0.6241.00
442_L449_G0.6231.00
418_I425_T0.6221.00
313_T317_T0.6221.00
157_Y340_R0.6201.00
320_M349_F0.6191.00
66_V223_Y0.6181.00
402_A405_I0.6181.00
416_A427_I0.6171.00
124_M301_L0.6171.00
250_L254_T0.6151.00
435_V444_L0.6131.00
93_G396_V0.6121.00
68_L414_V0.6121.00
421_V425_T0.6111.00
412_A419_G0.6111.00
419_G425_T0.6101.00
31_I35_A0.6101.00
195_T202_P0.6091.00
333_L346_A0.6051.00
105_A385_A0.6041.00
413_I427_I0.6011.00
435_V442_L0.6001.00
148_N309_A0.6001.00
184_L289_G0.6001.00
87_Y99_A0.5991.00
128_G299_A0.5981.00
435_V441_T0.5981.00
418_I423_Y0.5971.00
150_I153_V0.5971.00
393_M415_E0.5951.00
406_G411_V0.5941.00
280_P285_A0.5941.00
227_S244_V0.5931.00
152_S306_L0.5931.00
77_A240_I0.5931.00
126_P141_W0.5921.00
419_G424_A0.5921.00
414_V422_F0.5911.00
439_V448_G0.5911.00
125_V148_N0.5901.00
415_E428_T0.5871.00
258_G281_G0.5871.00
438_G445_W0.5851.00
416_A421_V0.5851.00
111_F350_T0.5831.00
412_A427_I0.5831.00
193_I196_F0.5831.00
83_A321_Y0.5821.00
421_V427_I0.5811.00
221_T224_E0.5811.00
415_E420_Y0.5801.00
408_I414_V0.5791.00
279_A282_L0.5781.00
117_V309_A0.5781.00
436_L443_V0.5781.00
77_A227_S0.5771.00
438_G452_Y0.5741.00
142_I145_G0.5741.00
381_G385_A0.5741.00
168_L172_I0.5731.00
35_A254_T0.5731.00
415_E424_A0.5731.00
285_A288_F0.5721.00
240_I244_V0.5721.00
159_G162_P0.5701.00
443_V450_I0.5691.00
173_A177_G0.5681.00
434_P439_V0.5681.00
31_I34_G0.5661.00
33_S312_F0.5661.00
394_L419_G0.5661.00
411_V422_F0.5651.00
415_E425_T0.5651.00
411_V426_V0.5641.00
86_I224_E0.5631.00
299_A303_N0.5631.00
318_R321_Y0.5621.00
33_S36_P0.5611.00
442_L453_L0.5601.00
413_I422_F0.5601.00
59_V219_A0.5591.00
316_V320_M0.5591.00
44_L259_S0.5561.00
418_I427_I0.5561.00
173_A300_L0.5551.00
37_A117_V0.5551.00
441_T445_W0.5551.00
122_G125_V0.5541.00
148_N306_L0.5541.00
339_K344_H0.5531.00
74_S78_R0.5531.00
437_I445_W0.5531.00
410_I418_I0.5521.00
110_I315_C0.5521.00
45_T48_A0.5521.00
414_V428_T0.5521.00
153_V313_T0.5511.00
258_G262_F0.5511.00
436_L442_L0.5501.00
90_I99_A0.5501.00
304_S307_A0.5481.00
285_A293_L0.5481.00
198_L264_V0.5481.00
343_P346_A0.5461.00
233_A240_I0.5461.00
372_I375_G0.5461.00
417_I421_V0.5451.00
56_P256_I0.5451.00
416_A428_T0.5441.00
149_A355_A0.5431.00
61_I213_V0.5431.00
416_A422_F0.5431.00
356_L359_I0.5401.00
444_L449_G0.5391.00
76_I93_G0.5391.00
137_P141_W0.5391.00
70_A223_Y0.5391.00
31_I171_S0.5371.00
406_G419_G0.5371.00
231_E321_Y0.5371.00
109_Y381_G0.5361.00
412_A426_V0.5361.00
438_G448_G0.5361.00
188_K191_P0.5351.00
62_A217_I0.5351.00
162_P166_F0.5351.00
24_R27_L0.5351.00
228_V315_C0.5341.00
177_G296_I0.5341.00
79_Y400_N0.5331.00
163_S314_N0.5321.00
94_L99_A0.5291.00
436_L445_W0.5291.00
236_P239_N0.5291.00
164_L310_T0.5291.00
75_I406_G0.5291.00
33_S225_T0.5291.00
151_V155_I0.5271.00
190_P195_T0.5241.00
261_A264_V0.5231.00
127_T298_T0.5211.00
409_L412_A0.5201.00
105_A384_I0.5201.00
441_T446_V0.5191.00
127_T130_E0.5191.00
410_I416_A0.5171.00
194_N264_V0.5171.00
438_G453_L0.5171.00
128_G298_T0.5171.00
411_V428_T0.5151.00
344_H347_S0.5151.00
53_G268_V0.5141.00
371_F375_G0.5141.00
268_V272_S0.5141.00
266_W283_I0.5141.00
113_V116_F0.5141.00
281_G285_A0.5131.00
444_L450_I0.5121.00
86_I228_V0.5111.00
232_E343_P0.5111.00
97_K453_L0.5071.00
204_P208_N0.5071.00
355_A358_F0.5061.00
59_V255_Y0.5051.00
38_A174_E0.5051.00
250_L257_V0.5051.00
441_T452_Y0.5041.00
238_N241_A0.5031.00
150_I348_L0.5011.00
210_G424_A0.5011.00
46_G49_A0.5011.00
349_F353_F0.5011.00
285_A289_G0.5001.00
70_A74_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9026 100 0.274 Contact Map
3giaA 1 0.9156 100 0.332 Contact Map
4djkA 2 0.9091 100 0.338 Contact Map
3dh4A 3 0.8939 99.1 0.842 Contact Map
2xq2A 2 0.8918 99 0.85 Contact Map
2jlnA 1 0.8853 98.9 0.853 Contact Map
4wgvA 2 0.7987 98 0.889 Contact Map
2a65A 2 0.9199 97.5 0.901 Contact Map
4us3A 1 0.8615 97.1 0.907 Contact Map
4xp4A 1 0.9264 96.9 0.91 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0133 seconds.