GREMLIN Database
Q97XL9 - Transposase in ISC1395
UniProt: Q97XL9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 298 (265)
Sequences: 2050 (1725)
Seq/√Len: 106.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_A53_V3.4751.00
163_S274_V3.0881.00
211_F239_N2.9951.00
37_M41_K2.8821.00
214_F231_L2.8001.00
33_Y42_I2.7741.00
139_A142_I2.7601.00
210_N213_I2.7391.00
111_S117_R2.6391.00
245_V249_L2.5411.00
74_K77_N2.5311.00
132_N135_R2.5191.00
32_L42_I2.4481.00
215_A242_V2.3871.00
228_V254_L2.3331.00
50_L54_Y2.3101.00
37_M45_I2.2821.00
160_M229_L2.2611.00
112_H116_W2.2381.00
140_D143_L2.2311.00
33_Y57_I2.1991.00
42_I53_V2.1951.00
132_N136_P2.1941.00
191_A270_W2.1711.00
40_R50_L2.1191.00
39_T54_Y2.1091.00
133_K136_P2.0691.00
139_A143_L2.0191.00
136_P139_A2.0001.00
136_P140_D1.9991.00
41_K44_K1.9871.00
32_L46_L1.9831.00
114_T118_I1.9801.00
113_V117_R1.9411.00
231_L253_L1.9401.00
165_I189_V1.9111.00
41_K45_I1.8661.00
135_R140_D1.8171.00
132_N139_A1.8111.00
230_I256_L1.8031.00
132_N140_D1.8021.00
58_N62_K1.7851.00
111_S114_T1.7791.00
215_A219_R1.7601.00
288_I292_R1.7521.00
214_F218_L1.7491.00
113_V116_W1.7471.00
32_L45_I1.7361.00
110_L114_T1.7311.00
27_A31_L1.7211.00
49_H52_T1.6751.00
240_A244_S1.6341.00
114_T117_R1.5991.00
222_R226_P1.5821.00
264_N267_E1.5651.00
140_D144_R1.5641.00
32_L37_M1.5511.00
40_R44_K1.5421.00
142_I146_R1.5401.00
139_A146_R1.5391.00
80_I118_I1.5381.00
51_S54_Y1.5341.00
198_G201_C1.5331.00
191_A266_I1.5021.00
25_T48_V1.4921.00
42_I46_L1.4901.00
70_Y73_R1.4841.00
135_R139_A1.4791.00
209_V234_A1.4711.00
162_E237_H1.4641.00
215_A245_V1.4541.00
223_N226_P1.4361.00
160_M192_S1.4291.00
215_A241_Y1.4181.00
37_M42_I1.4151.00
73_R77_N1.4141.00
78_K85_I1.4111.00
43_A46_L1.4071.00
25_T46_L1.4031.00
164_G186_K1.4021.00
246_A253_L1.3951.00
271_R275_R1.3701.00
133_K139_A1.3681.00
222_R225_G1.3631.00
266_I270_W1.3591.00
70_Y74_K1.3481.00
137_F141_N1.3460.99
211_F215_A1.3390.99
164_G188_N1.3330.99
133_K140_D1.3190.99
25_T28_R1.3190.99
283_L287_L1.3080.99
289_R293_S1.2990.99
141_N145_G1.2680.99
39_T57_I1.2670.99
290_W294_S1.2620.99
171_R174_G1.2540.99
38_N41_K1.2510.99
39_T50_L1.2440.99
42_I57_I1.2420.99
132_N143_L1.2310.99
110_L115_A1.2160.99
51_S55_R1.2090.99
200_P203_M1.2070.99
99_K112_H1.1820.99
76_R79_K1.1700.99
287_L290_W1.1670.99
244_S248_Q1.1620.99
116_W120_R1.1600.98
57_I61_E1.1590.98
85_I89_E1.1570.98
189_V292_R1.1560.98
159_F256_L1.1560.98
136_P143_L1.1560.98
32_L35_K1.1490.98
231_L246_A1.1440.98
166_H186_K1.1390.98
229_L251_I1.1200.98
192_S217_F1.1180.98
82_E85_I1.1160.98
29_G56_W1.1140.98
55_R58_N1.1130.98
285_T289_R1.1020.98
29_G42_I1.0840.98
282_I291_R1.0550.97
85_I118_I1.0490.97
147_L150_V1.0480.97
127_Y174_G1.0420.97
80_I84_E1.0390.97
272_D276_G1.0280.97
187_L273_L1.0220.97
167_H288_I1.0210.97
143_L146_R1.0190.97
211_F242_V1.0170.97
29_G48_V1.0060.96
199_V202_F0.9920.96
33_Y39_T0.9780.96
103_E109_K0.9770.96
274_V292_R0.9760.96
99_K116_W0.9710.95
30_I60_F0.9670.95
165_I292_R0.9560.95
160_M231_L0.9550.95
60_F68_L0.9540.95
274_V278_I0.9500.95
148_K151_I0.9410.95
28_R35_K0.9400.95
286_L290_W0.9360.94
184_S188_N0.9360.94
199_V204_S0.9340.94
219_R245_V0.9280.94
218_L245_V0.9280.94
30_I33_Y0.9260.94
231_L255_F0.9240.94
268_L271_R0.9210.94
133_K143_L0.9200.94
31_L35_K0.9190.94
102_I115_A0.9160.94
204_S289_R0.9110.94
85_I121_K0.9100.94
212_K241_Y0.9090.94
159_F163_S0.9050.93
256_L261_P0.9050.93
31_L34_L0.9040.93
284_N287_L0.9030.93
48_V53_V0.8990.93
126_P177_N0.8960.93
113_V120_R0.8820.93
159_F230_I0.8800.92
81_D84_E0.8730.92
134_K137_F0.8710.92
211_F241_Y0.8690.92
90_L119_A0.8630.92
235_K238_K0.8610.92
257_P263_L0.8590.91
52_T56_W0.8510.91
135_R142_I0.8470.91
243_F247_S0.8460.91
79_K87_V0.8450.91
233_N267_E0.8440.91
120_R194_P0.8370.90
181_D184_S0.8350.90
28_R34_L0.8280.90
58_N61_E0.8270.90
180_V183_P0.8260.90
146_R149_G0.8230.90
239_N242_V0.8220.90
44_K47_Q0.8220.90
159_F165_I0.8200.89
163_S209_V0.8200.89
80_I85_I0.8160.89
163_S292_R0.8130.89
98_A101_Y0.8110.89
183_P186_K0.8060.89
134_K138_N0.8010.88
35_K45_I0.7990.88
83_K89_E0.7970.88
97_E106_F0.7920.88
273_L277_L0.7910.88
209_V235_K0.7870.87
209_V236_F0.7850.87
127_Y172_R0.7830.87
280_I291_R0.7800.87
173_L176_Y0.7790.87
163_S168_D0.7780.87
150_V153_K0.7720.86
203_M220_L0.7660.86
230_I264_N0.7660.86
275_R282_I0.7630.86
118_I123_L0.7630.86
174_G261_P0.7620.86
216_E220_L0.7610.86
164_G236_F0.7530.85
134_K140_D0.7490.85
142_I149_G0.7460.85
198_G217_F0.7330.84
160_M270_W0.7320.83
246_A251_I0.7320.83
285_T288_I0.7320.83
57_I60_F0.7300.83
93_K96_W0.7290.83
166_H184_S0.7280.83
208_N213_I0.7250.83
283_L291_R0.7250.83
210_N236_F0.7240.83
132_N137_F0.7210.83
40_R54_Y0.7210.83
65_E244_S0.7190.82
30_I34_L0.7180.82
159_F195_L0.7160.82
63_E71_K0.7160.82
291_R294_S0.7100.82
235_K240_A0.7100.82
278_I292_R0.7100.82
230_I259_Y0.7100.82
158_F192_S0.7020.81
160_M217_F0.6960.80
174_G259_Y0.6950.80
279_L282_I0.6910.80
99_K115_A0.6890.80
124_K278_I0.6880.79
233_N259_Y0.6880.79
231_L239_N0.6870.79
54_Y57_I0.6830.79
29_G53_V0.6760.78
160_M214_F0.6750.78
143_L147_L0.6700.78
239_N243_F0.6660.77
128_I256_L0.6600.77
28_R32_L0.6600.77
140_D148_K0.6560.76
277_L280_I0.6550.76
139_A150_V0.6540.76
127_Y130_P0.6530.76
137_F142_I0.6520.76
231_L256_L0.6520.76
64_G71_K0.6500.76
84_E106_F0.6490.75
165_I214_F0.6470.75
214_F229_L0.6460.75
265_P269_V0.6460.75
232_D237_H0.6440.75
167_H170_S0.6430.75
79_K117_R0.6420.75
158_F291_R0.6370.74
99_K103_E0.6370.74
198_G203_M0.6360.74
133_K137_F0.6350.74
51_S58_N0.6310.73
39_T46_L0.6290.73
83_K92_G0.6280.73
153_K156_K0.6270.73
29_G45_I0.6240.73
83_K86_K0.6200.72
159_F265_P0.6190.72
192_S200_P0.6190.72
88_E125_I0.6180.72
234_A259_Y0.6170.72
49_H55_R0.6160.72
162_E288_I0.6150.71
34_L41_K0.6150.71
174_G177_N0.6140.71
282_I285_T0.6120.71
166_H170_S0.6110.71
59_Q70_Y0.6100.71
158_F174_G0.6080.71
270_W277_L0.6060.70
137_F144_R0.6060.70
137_F143_L0.6020.70
30_I215_A0.6010.70
201_C204_S0.5990.69
158_F225_G0.5990.69
121_K210_N0.5980.69
144_R243_F0.5980.69
92_G96_W0.5970.69
215_A239_N0.5950.69
274_V293_S0.5940.69
87_V107_H0.5930.69
45_I62_K0.5920.69
87_V123_L0.5900.68
125_I128_I0.5900.68
100_A104_E0.5890.68
203_M206_Y0.5880.68
245_V248_Q0.5880.68
88_E123_L0.5840.68
265_P268_L0.5790.67
136_P146_R0.5780.67
216_E219_R0.5770.67
138_N143_L0.5750.66
65_E69_F0.5750.66
97_E103_E0.5750.66
160_M256_L0.5740.66
287_L291_R0.5740.66
234_A258_P0.5730.66
227_I251_I0.5730.66
126_P174_G0.5700.66
233_N238_K0.5680.65
262_D265_P0.5680.65
52_T55_R0.5660.65
268_L272_D0.5660.65
89_E92_G0.5660.65
190_L217_F0.5650.65
267_E270_W0.5640.65
38_N42_I0.5630.65
256_L259_Y0.5630.65
133_K144_R0.5620.65
164_G190_L0.5620.65
27_A207_S0.5610.64
158_F194_P0.5610.64
43_A48_V0.5610.64
210_N214_F0.5600.64
162_E165_I0.5600.64
198_G202_F0.5590.64
161_D237_H0.5580.64
25_T229_L0.5560.64
134_K144_R0.5560.64
121_K284_N0.5550.64
154_G159_F0.5550.64
60_F64_G0.5540.64
94_T277_L0.5530.63
188_N234_A0.5520.63
282_I287_L0.5520.63
28_R31_L0.5510.63
136_P144_R0.5510.63
40_R62_K0.5500.63
90_L94_T0.5490.63
35_K42_I0.5470.63
258_P261_P0.5430.62
140_D146_R0.5420.62
266_I274_V0.5420.62
224_S229_L0.5420.62
140_D149_G0.5410.62
212_K219_R0.5380.61
168_D174_G0.5380.61
135_R143_L0.5360.61
175_L254_L0.5330.61
256_L264_N0.5330.61
188_N194_P0.5320.60
103_E108_V0.5320.60
231_L273_L0.5310.60
218_L235_K0.5300.60
72_E219_R0.5300.60
98_A103_E0.5290.60
102_I144_R0.5290.60
274_V282_I0.5280.60
241_Y244_S0.5270.60
26_K36_G0.5260.60
289_R292_R0.5260.60
118_I121_K0.5260.60
181_D188_N0.5250.59
85_I124_K0.5240.59
236_F267_E0.5230.59
49_H104_E0.5220.59
149_G153_K0.5210.59
56_W70_Y0.5190.59
91_Q95_I0.5190.59
48_V52_T0.5190.59
62_K219_R0.5190.59
214_F238_K0.5180.58
134_K150_V0.5180.58
103_E107_H0.5170.58
268_L275_R0.5160.58
271_R288_I0.5160.58
90_L123_L0.5150.58
132_N144_R0.5140.58
167_H183_P0.5130.58
206_Y289_R0.5090.57
144_R148_K0.5070.57
284_N293_S0.5070.57
211_F235_K0.5060.57
193_I265_P0.5060.57
90_L95_I0.5030.56
150_V288_I0.5020.56
152_K253_L0.5020.56
214_F253_L0.5010.56
237_H267_E0.5000.56
45_I55_R0.5000.56
28_R46_L0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u7bA 2 0.9195 100 0.43 Contact Map
3f2kA 1 0.5201 100 0.556 Contact Map
4mdaA 1 0.5168 100 0.557 Contact Map
4fcyA 4 0.8893 99.9 0.642 Contact Map
1u78A 1 0.3356 99.5 0.776 Contact Map
1k78A 1 0.3826 99.3 0.798 Contact Map
2k27A 1 0.4799 99.2 0.803 Contact Map
1pdnC 1 0.3758 99.2 0.807 Contact Map
4fw1A 2 0.453 98.5 0.85 Contact Map
1c6vA 4 0.3926 98.4 0.856 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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