GREMLIN Database
Q97XK7 - Uncharacterized protein
UniProt: Q97XK7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 295 (260)
Sequences: 401 (369)
Seq/√Len: 22.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
199_T217_S6.7641.00
221_I227_F6.5861.00
220_Y286_K5.1311.00
203_L208_K4.3761.00
97_F228_I4.1371.00
204_N211_E4.0421.00
200_R284_I3.7501.00
30_Q40_Y3.5031.00
99_V191_I3.3501.00
29_V227_F3.2451.00
208_K282_E3.1351.00
202_R211_E3.0571.00
77_S85_S2.9571.00
216_W284_I2.9150.99
96_L225_S2.7130.99
10_A14_L2.5780.99
50_A282_E2.5700.99
29_V221_I2.3060.97
210_V214_G2.2930.97
218_E281_K2.2740.97
75_F87_G2.1020.95
48_L91_V2.0310.94
113_N186_D2.0210.94
23_G87_G1.9700.93
19_G26_D1.9580.93
216_W281_K1.8960.92
34_M49_K1.8960.92
98_S226_I1.8460.90
16_P29_V1.8050.89
210_V213_G1.8040.89
102_P153_E1.8010.89
177_L181_R1.7990.89
202_R214_G1.7910.89
184_I232_I1.7430.88
32_D224_G1.7030.86
16_P195_L1.6760.85
200_R218_E1.6510.85
25_V199_T1.6400.84
32_D118_R1.6280.84
277_N281_K1.6070.83
195_L221_I1.5880.82
92_M232_I1.5710.81
49_K87_G1.5630.81
47_P50_A1.5360.80
14_L289_M1.5290.80
216_W224_G1.5250.79
202_R210_V1.5250.79
34_M101_A1.5060.79
16_P40_Y1.5020.78
16_P221_I1.5000.78
94_L229_G1.4870.78
7_L91_V1.4830.77
45_K283_S1.4600.76
145_D173_S1.4500.76
39_I278_I1.4440.75
9_Y224_G1.4370.75
201_N210_V1.4310.75
77_S86_K1.4190.74
112_T186_D1.4180.74
115_L191_I1.4100.74
16_P30_Q1.4040.73
183_A257_H1.3660.71
201_N214_G1.3510.70
165_D183_A1.3320.69
109_Q220_Y1.3230.69
136_L180_N1.3020.67
166_P169_F1.2980.67
94_L112_T1.2780.66
204_N207_T1.2760.66
19_G215_L1.2720.66
29_V203_L1.2680.65
203_L207_T1.2650.65
41_S288_L1.2580.65
203_L210_V1.2470.64
8_A94_L1.2370.63
103_T218_E1.2330.63
45_K107_F1.2160.62
199_T216_W1.2140.62
168_S176_P1.2020.61
11_I109_Q1.1940.61
12_T154_V1.1840.60
40_Y47_P1.1840.60
196_I223_M1.1660.59
117_D177_L1.1610.58
29_V195_L1.1540.58
106_G196_I1.1470.57
41_S227_F1.1430.57
75_F152_V1.1420.57
98_S178_F1.1320.56
68_K144_L1.1310.56
154_V218_E1.1260.56
110_V184_I1.1250.56
71_C165_D1.1240.56
115_L196_I1.0870.53
112_T234_D1.0780.53
201_N216_W1.0770.53
133_L137_G1.0660.52
180_N206_L1.0630.52
104_F203_L1.0520.51
225_S282_E1.0350.50
7_L184_I1.0270.49
30_Q38_I1.0270.49
77_S234_D1.0230.49
41_S87_G1.0200.49
160_K164_F1.0170.48
16_P227_F1.0120.48
151_S225_S1.0100.48
19_G25_V1.0050.48
12_T98_S1.0010.47
13_N216_W0.9930.47
11_I190_V0.9890.47
226_I240_F0.9840.46
32_D95_P0.9800.46
27_M216_W0.9770.46
238_N241_C0.9760.46
38_I216_W0.9720.45
175_L226_I0.9710.45
41_S284_I0.9650.45
151_S208_K0.9640.45
39_I227_F0.9640.45
97_F119_A0.9630.45
73_C226_I0.9620.45
32_D107_F0.9620.45
155_Y190_V0.9600.45
36_Y93_D0.9560.44
13_N198_Y0.9550.44
28_P86_K0.9460.44
13_N223_M0.9450.44
142_A158_E0.9390.43
96_L227_F0.9370.43
143_L179_N0.9350.43
25_V278_I0.9310.43
171_L278_I0.9310.43
201_N213_G0.9300.43
96_L115_L0.9260.42
202_R213_G0.9240.42
199_T203_L0.9240.42
92_M230_G0.9220.42
160_K163_N0.9170.42
47_P229_G0.9110.41
12_T218_E0.9020.41
98_S283_S0.9000.40
115_L195_L0.8990.40
201_N225_S0.8970.40
109_Q225_S0.8880.40
258_F262_F0.8880.40
220_Y281_K0.8860.40
44_F108_V0.8730.39
44_F229_G0.8720.39
25_V217_S0.8690.38
69_G147_Q0.8650.38
43_A185_S0.8650.38
11_I181_R0.8640.38
94_L147_Q0.8640.38
26_D215_L0.8620.38
35_G192_D0.8610.38
217_S223_M0.8600.38
73_C236_V0.8590.38
116_I166_P0.8550.38
142_A145_D0.8500.37
72_C225_S0.8500.37
196_I199_T0.8490.37
10_A281_K0.8490.37
39_I44_F0.8470.37
5_F230_G0.8460.37
30_Q45_K0.8430.37
162_V171_L0.8400.37
107_F196_I0.8300.36
34_M277_N0.8280.36
118_R121_N0.8260.36
6_V229_G0.8250.36
170_K176_P0.8220.35
116_I201_N0.8200.35
25_V107_F0.8190.35
77_S82_E0.8190.35
279_G287_G0.7980.34
37_P93_D0.7880.33
154_V157_T0.7850.33
77_S209_V0.7820.33
5_F203_L0.7820.33
133_L165_D0.7810.33
99_V195_L0.7810.33
123_F150_K0.7800.33
200_R216_W0.7720.32
89_L259_S0.7710.32
197_I208_K0.7710.32
150_K182_L0.7660.32
113_N118_R0.7650.32
14_L210_V0.7630.32
52_C71_C0.7630.32
29_V190_V0.7610.32
193_K281_K0.7600.32
18_A284_I0.7590.32
138_N162_V0.7590.32
151_S154_V0.7590.32
66_K69_G0.7560.31
40_Y43_A0.7550.31
21_G200_R0.7530.31
195_L227_F0.7510.31
162_V169_F0.7490.31
110_V205_L0.7470.31
95_P228_I0.7460.31
110_V119_A0.7420.30
166_P173_S0.7390.30
149_N171_L0.7390.30
175_L257_H0.7380.30
189_R193_K0.7350.30
28_P90_N0.7340.30
126_I136_L0.7320.30
190_V193_K0.7320.30
170_K174_S0.7300.30
39_I194_S0.7280.30
37_P75_F0.7280.30
124_E148_G0.7260.30
33_Q216_W0.7210.29
137_G225_S0.7200.29
90_N232_I0.7190.29
33_Q277_N0.7180.29
234_D282_E0.7160.29
161_V172_L0.7140.29
10_A289_M0.7110.29
281_K286_K0.7030.28
98_S215_L0.6960.28
119_A229_G0.6950.28
171_L259_S0.6930.28
198_Y284_I0.6920.28
172_L176_P0.6910.28
22_Y203_L0.6900.28
9_Y121_N0.6890.27
40_Y198_Y0.6890.27
33_Q281_K0.6890.27
107_F228_I0.6880.27
104_F208_K0.6870.27
27_M281_K0.6850.27
197_I255_L0.6840.27
167_S190_V0.6830.27
258_F261_I0.6830.27
28_P32_D0.6810.27
25_V224_G0.6810.27
45_K281_K0.6800.27
196_I286_K0.6800.27
142_A165_D0.6790.27
5_F208_K0.6780.27
107_F153_E0.6770.27
195_L223_M0.6750.27
124_E165_D0.6740.27
88_M236_V0.6720.27
12_T288_L0.6710.26
194_S220_Y0.6700.26
109_Q289_M0.6700.26
93_D106_G0.6690.26
33_Q195_L0.6690.26
28_P45_K0.6680.26
101_A190_V0.6670.26
107_F224_G0.6640.26
11_I290_K0.6630.26
220_Y289_M0.6580.26
199_T215_L0.6560.26
224_G284_I0.6550.26
191_I196_I0.6550.26
117_D160_K0.6540.26
127_S133_L0.6510.25
117_D173_S0.6500.25
47_P92_M0.6480.25
21_G90_N0.6440.25
30_Q47_P0.6420.25
47_P106_G0.6420.25
41_S221_I0.6400.25
32_D42_S0.6390.25
45_K200_R0.6370.25
39_I43_A0.6360.25
180_N183_A0.6360.25
107_F223_M0.6360.25
135_S145_D0.6350.25
36_Y115_L0.6340.25
129_I140_I0.6330.24
194_S229_G0.6330.24
28_P153_E0.6330.24
43_A200_R0.6320.24
16_P96_L0.6310.24
104_F157_T0.6310.24
33_Q107_F0.6280.24
23_G155_Y0.6220.24
49_K53_A0.6220.24
19_G283_S0.6220.24
104_F151_S0.6210.24
69_G158_E0.6210.24
44_F94_L0.6190.24
84_S239_K0.6180.24
89_L233_I0.6170.24
86_K221_I0.6160.24
95_P122_I0.6150.24
170_K175_L0.6140.24
49_K101_A0.6130.23
39_I271_V0.6130.23
128_H145_D0.6100.23
211_E241_C0.6100.23
103_T113_N0.6100.23
149_N158_E0.6090.23
145_D148_G0.6080.23
210_V218_E0.6080.23
193_K200_R0.6050.23
153_E194_S0.6040.23
36_Y107_F0.6040.23
4_L203_L0.6030.23
49_K197_I0.6010.23
20_R277_N0.6000.23
38_I199_T0.5990.23
38_I200_R0.5980.23
203_L282_E0.5960.23
40_Y286_K0.5950.23
29_V34_M0.5940.23
173_S272_Y0.5910.22
31_R109_Q0.5910.22
153_E195_L0.5900.22
239_K243_E0.5890.22
30_Q154_V0.5870.22
82_E85_S0.5870.22
279_G285_G0.5870.22
196_I220_Y0.5870.22
168_S175_L0.5830.22
104_F109_Q0.5800.22
224_G277_N0.5800.22
13_N32_D0.5800.22
200_R281_K0.5780.22
27_M286_K0.5780.22
31_R113_N0.5730.22
30_Q220_Y0.5660.21
32_D228_I0.5650.21
25_V102_P0.5620.21
8_A229_G0.5620.21
200_R209_V0.5610.21
99_V194_S0.5600.21
201_N218_E0.5530.21
112_T116_I0.5530.21
222_P279_G0.5520.21
97_F206_L0.5520.21
40_Y220_Y0.5510.21
231_M291_V0.5500.20
201_N281_K0.5500.20
137_G171_L0.5480.20
127_S241_C0.5470.20
32_D196_I0.5460.20
82_E148_G0.5440.20
8_A224_G0.5440.20
42_S286_K0.5430.20
84_S148_G0.5430.20
74_L258_F0.5420.20
8_A47_P0.5420.20
141_K144_L0.5370.20
9_Y90_N0.5370.20
129_I163_N0.5360.20
154_V216_W0.5360.20
121_N286_K0.5360.20
191_I220_Y0.5360.20
31_R100_P0.5350.20
73_C94_L0.5350.20
116_I213_G0.5350.20
142_A174_S0.5350.20
123_F127_S0.5330.20
12_T45_K0.5320.20
154_V190_V0.5310.20
36_Y200_R0.5290.20
107_F277_N0.5290.20
34_M112_T0.5280.20
4_L39_I0.5280.20
26_D37_P0.5260.19
118_R223_M0.5230.19
220_Y223_M0.5220.19
160_K263_N0.5220.19
32_D277_N0.5200.19
27_M95_P0.5200.19
86_K93_D0.5190.19
102_P226_I0.5180.19
84_S149_N0.5180.19
12_T208_K0.5170.19
6_V105_D0.5170.19
80_E290_K0.5160.19
52_C75_F0.5150.19
7_L190_V0.5150.19
53_A205_L0.5140.19
196_I214_G0.5120.19
77_S283_S0.5110.19
46_G287_G0.5100.19
106_G187_D0.5050.19
130_N148_G0.5050.19
16_P155_Y0.5040.18
34_M224_G0.5040.18
9_Y14_L0.5020.18
14_L41_S0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3x1lC 3 0.9356 100 0.336 Contact Map
4w8wA 1 0.8136 100 0.341 Contact Map
4qtsC 1 0.4814 100 0.661 Contact Map
4n0lA 1 0.6678 99.9 0.723 Contact Map
4w8vA 1 0.6508 99.9 0.762 Contact Map
3x1lH 1 0.5356 99.9 0.763 Contact Map
4qtsA 1 0.6373 98.6 0.886 Contact Map
3x1lB 1 0.7051 98.2 0.899 Contact Map
4txdA 1 0.7254 91.7 0.941 Contact Map
4l6uA 1 0.5254 77.2 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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