Q97XK7 - SULSO - GREMLIN Contacts

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Q97XK7 - Uncharacterized protein

UniProt:	Q97XK7	Sequences: MNGLFVLAYAITNLHPGAGRGYGIVDMPVQRDQMGYPIIYSSAFKGPLKALCAGDAINDHGRIDCKKKGECCCLFGSEPEEEESSKGMLNVMDLPLFSVPAPTFDGFVQVTTNYLIDRARNIFEAISHINGYLGSLGNEIKALLDAQGNKSVEVYDTEAKVVNFDPSSFKLLSSLPLFNNRLAISDDKRVIDKSLIIYTRNRLNLLTKVVEEGGLWSEEYIPMGSIFIGGMIIDNVRNKFCDELSKISCDSRLFLHHFSRIFNADKISEDVYLFYLNIGGKESIGKGLMKVFIGV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	295 (260)
Sequences:	401 (369)
Seq/√Len:	22.9

SULSO - Q97XK7 Q97Y36 CMR4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
199_T	217_S	6.764	1.00
221_I	227_F	6.586	1.00
220_Y	286_K	5.131	1.00
203_L	208_K	4.376	1.00
97_F	228_I	4.137	1.00
204_N	211_E	4.042	1.00
200_R	284_I	3.750	1.00
30_Q	40_Y	3.503	1.00
99_V	191_I	3.350	1.00
29_V	227_F	3.245	1.00
208_K	282_E	3.135	1.00
202_R	211_E	3.057	1.00
77_S	85_S	2.957	1.00
216_W	284_I	2.915	0.99
96_L	225_S	2.713	0.99
10_A	14_L	2.578	0.99
50_A	282_E	2.570	0.99
29_V	221_I	2.306	0.97
210_V	214_G	2.293	0.97
218_E	281_K	2.274	0.97
75_F	87_G	2.102	0.95
48_L	91_V	2.031	0.94
113_N	186_D	2.021	0.94
23_G	87_G	1.970	0.93
19_G	26_D	1.958	0.93
216_W	281_K	1.896	0.92
34_M	49_K	1.896	0.92
98_S	226_I	1.846	0.90
16_P	29_V	1.805	0.89
210_V	213_G	1.804	0.89
102_P	153_E	1.801	0.89
177_L	181_R	1.799	0.89
202_R	214_G	1.791	0.89
184_I	232_I	1.743	0.88
32_D	224_G	1.703	0.86
16_P	195_L	1.676	0.85
200_R	218_E	1.651	0.85
25_V	199_T	1.640	0.84
32_D	118_R	1.628	0.84
277_N	281_K	1.607	0.83
195_L	221_I	1.588	0.82
92_M	232_I	1.571	0.81
49_K	87_G	1.563	0.81
47_P	50_A	1.536	0.80
14_L	289_M	1.529	0.80
216_W	224_G	1.525	0.79
202_R	210_V	1.525	0.79
34_M	101_A	1.506	0.79
16_P	40_Y	1.502	0.78
16_P	221_I	1.500	0.78
94_L	229_G	1.487	0.78
7_L	91_V	1.483	0.77
45_K	283_S	1.460	0.76
145_D	173_S	1.450	0.76
39_I	278_I	1.444	0.75
9_Y	224_G	1.437	0.75
201_N	210_V	1.431	0.75
77_S	86_K	1.419	0.74
112_T	186_D	1.418	0.74
115_L	191_I	1.410	0.74
16_P	30_Q	1.404	0.73
183_A	257_H	1.366	0.71
201_N	214_G	1.351	0.70
165_D	183_A	1.332	0.69
109_Q	220_Y	1.323	0.69
136_L	180_N	1.302	0.67
166_P	169_F	1.298	0.67
94_L	112_T	1.278	0.66
204_N	207_T	1.276	0.66
19_G	215_L	1.272	0.66
29_V	203_L	1.268	0.65
203_L	207_T	1.265	0.65
41_S	288_L	1.258	0.65
203_L	210_V	1.247	0.64
8_A	94_L	1.237	0.63
103_T	218_E	1.233	0.63
45_K	107_F	1.216	0.62
199_T	216_W	1.214	0.62
168_S	176_P	1.202	0.61
11_I	109_Q	1.194	0.61
12_T	154_V	1.184	0.60
40_Y	47_P	1.184	0.60
196_I	223_M	1.166	0.59
117_D	177_L	1.161	0.58
29_V	195_L	1.154	0.58
106_G	196_I	1.147	0.57
41_S	227_F	1.143	0.57
75_F	152_V	1.142	0.57
98_S	178_F	1.132	0.56
68_K	144_L	1.131	0.56
154_V	218_E	1.126	0.56
110_V	184_I	1.125	0.56
71_C	165_D	1.124	0.56
115_L	196_I	1.087	0.53
112_T	234_D	1.078	0.53
201_N	216_W	1.077	0.53
133_L	137_G	1.066	0.52
180_N	206_L	1.063	0.52
104_F	203_L	1.052	0.51
225_S	282_E	1.035	0.50
7_L	184_I	1.027	0.49
30_Q	38_I	1.027	0.49
77_S	234_D	1.023	0.49
41_S	87_G	1.020	0.49
160_K	164_F	1.017	0.48
16_P	227_F	1.012	0.48
151_S	225_S	1.010	0.48
19_G	25_V	1.005	0.48
12_T	98_S	1.001	0.47
13_N	216_W	0.993	0.47
11_I	190_V	0.989	0.47
226_I	240_F	0.984	0.46
32_D	95_P	0.980	0.46
27_M	216_W	0.977	0.46
238_N	241_C	0.976	0.46
38_I	216_W	0.972	0.45
175_L	226_I	0.971	0.45
41_S	284_I	0.965	0.45
151_S	208_K	0.964	0.45
39_I	227_F	0.964	0.45
97_F	119_A	0.963	0.45
73_C	226_I	0.962	0.45
32_D	107_F	0.962	0.45
155_Y	190_V	0.960	0.45
36_Y	93_D	0.956	0.44
13_N	198_Y	0.955	0.44
28_P	86_K	0.946	0.44
13_N	223_M	0.945	0.44
142_A	158_E	0.939	0.43
96_L	227_F	0.937	0.43
143_L	179_N	0.935	0.43
25_V	278_I	0.931	0.43
171_L	278_I	0.931	0.43
201_N	213_G	0.930	0.43
96_L	115_L	0.926	0.42
202_R	213_G	0.924	0.42
199_T	203_L	0.924	0.42
92_M	230_G	0.922	0.42
160_K	163_N	0.917	0.42
47_P	229_G	0.911	0.41
12_T	218_E	0.902	0.41
98_S	283_S	0.900	0.40
115_L	195_L	0.899	0.40
201_N	225_S	0.897	0.40
109_Q	225_S	0.888	0.40
258_F	262_F	0.888	0.40
220_Y	281_K	0.886	0.40
44_F	108_V	0.873	0.39
44_F	229_G	0.872	0.39
25_V	217_S	0.869	0.38
69_G	147_Q	0.865	0.38
43_A	185_S	0.865	0.38
11_I	181_R	0.864	0.38
94_L	147_Q	0.864	0.38
26_D	215_L	0.862	0.38
35_G	192_D	0.861	0.38
217_S	223_M	0.860	0.38
73_C	236_V	0.859	0.38
116_I	166_P	0.855	0.38
142_A	145_D	0.850	0.37
72_C	225_S	0.850	0.37
196_I	199_T	0.849	0.37
10_A	281_K	0.849	0.37
39_I	44_F	0.847	0.37
5_F	230_G	0.846	0.37
30_Q	45_K	0.843	0.37
162_V	171_L	0.840	0.37
107_F	196_I	0.830	0.36
34_M	277_N	0.828	0.36
118_R	121_N	0.826	0.36
6_V	229_G	0.825	0.36
170_K	176_P	0.822	0.35
116_I	201_N	0.820	0.35
25_V	107_F	0.819	0.35
77_S	82_E	0.819	0.35
279_G	287_G	0.798	0.34
37_P	93_D	0.788	0.33
154_V	157_T	0.785	0.33
77_S	209_V	0.782	0.33
5_F	203_L	0.782	0.33
133_L	165_D	0.781	0.33
99_V	195_L	0.781	0.33
123_F	150_K	0.780	0.33
200_R	216_W	0.772	0.32
89_L	259_S	0.771	0.32
197_I	208_K	0.771	0.32
150_K	182_L	0.766	0.32
113_N	118_R	0.765	0.32
14_L	210_V	0.763	0.32
52_C	71_C	0.763	0.32
29_V	190_V	0.761	0.32
193_K	281_K	0.760	0.32
18_A	284_I	0.759	0.32
138_N	162_V	0.759	0.32
151_S	154_V	0.759	0.32
66_K	69_G	0.756	0.31
40_Y	43_A	0.755	0.31
21_G	200_R	0.753	0.31
195_L	227_F	0.751	0.31
162_V	169_F	0.749	0.31
110_V	205_L	0.747	0.31
95_P	228_I	0.746	0.31
110_V	119_A	0.742	0.30
166_P	173_S	0.739	0.30
149_N	171_L	0.739	0.30
175_L	257_H	0.738	0.30
189_R	193_K	0.735	0.30
28_P	90_N	0.734	0.30
126_I	136_L	0.732	0.30
190_V	193_K	0.732	0.30
170_K	174_S	0.730	0.30
39_I	194_S	0.728	0.30
37_P	75_F	0.728	0.30
124_E	148_G	0.726	0.30
33_Q	216_W	0.721	0.29
137_G	225_S	0.720	0.29
90_N	232_I	0.719	0.29
33_Q	277_N	0.718	0.29
234_D	282_E	0.716	0.29
161_V	172_L	0.714	0.29
10_A	289_M	0.711	0.29
281_K	286_K	0.703	0.28
98_S	215_L	0.696	0.28
119_A	229_G	0.695	0.28
171_L	259_S	0.693	0.28
198_Y	284_I	0.692	0.28
172_L	176_P	0.691	0.28
22_Y	203_L	0.690	0.28
9_Y	121_N	0.689	0.27
40_Y	198_Y	0.689	0.27
33_Q	281_K	0.689	0.27
107_F	228_I	0.688	0.27
104_F	208_K	0.687	0.27
27_M	281_K	0.685	0.27
197_I	255_L	0.684	0.27
167_S	190_V	0.683	0.27
258_F	261_I	0.683	0.27
28_P	32_D	0.681	0.27
25_V	224_G	0.681	0.27
45_K	281_K	0.680	0.27
196_I	286_K	0.680	0.27
142_A	165_D	0.679	0.27
5_F	208_K	0.678	0.27
107_F	153_E	0.677	0.27
195_L	223_M	0.675	0.27
124_E	165_D	0.674	0.27
88_M	236_V	0.672	0.27
12_T	288_L	0.671	0.26
194_S	220_Y	0.670	0.26
109_Q	289_M	0.670	0.26
93_D	106_G	0.669	0.26
33_Q	195_L	0.669	0.26
28_P	45_K	0.668	0.26
101_A	190_V	0.667	0.26
107_F	224_G	0.664	0.26
11_I	290_K	0.663	0.26
220_Y	289_M	0.658	0.26
199_T	215_L	0.656	0.26
224_G	284_I	0.655	0.26
191_I	196_I	0.655	0.26
117_D	160_K	0.654	0.26
127_S	133_L	0.651	0.25
117_D	173_S	0.650	0.25
47_P	92_M	0.648	0.25
21_G	90_N	0.644	0.25
30_Q	47_P	0.642	0.25
47_P	106_G	0.642	0.25
41_S	221_I	0.640	0.25
32_D	42_S	0.639	0.25
45_K	200_R	0.637	0.25
39_I	43_A	0.636	0.25
180_N	183_A	0.636	0.25
107_F	223_M	0.636	0.25
135_S	145_D	0.635	0.25
36_Y	115_L	0.634	0.25
129_I	140_I	0.633	0.24
194_S	229_G	0.633	0.24
28_P	153_E	0.633	0.24
43_A	200_R	0.632	0.24
16_P	96_L	0.631	0.24
104_F	157_T	0.631	0.24
33_Q	107_F	0.628	0.24
23_G	155_Y	0.622	0.24
49_K	53_A	0.622	0.24
19_G	283_S	0.622	0.24
104_F	151_S	0.621	0.24
69_G	158_E	0.621	0.24
44_F	94_L	0.619	0.24
84_S	239_K	0.618	0.24
89_L	233_I	0.617	0.24
86_K	221_I	0.616	0.24
95_P	122_I	0.615	0.24
170_K	175_L	0.614	0.24
49_K	101_A	0.613	0.23
39_I	271_V	0.613	0.23
128_H	145_D	0.610	0.23
211_E	241_C	0.610	0.23
103_T	113_N	0.610	0.23
149_N	158_E	0.609	0.23
145_D	148_G	0.608	0.23
210_V	218_E	0.608	0.23
193_K	200_R	0.605	0.23
153_E	194_S	0.604	0.23
36_Y	107_F	0.604	0.23
4_L	203_L	0.603	0.23
49_K	197_I	0.601	0.23
20_R	277_N	0.600	0.23
38_I	199_T	0.599	0.23
38_I	200_R	0.598	0.23
203_L	282_E	0.596	0.23
40_Y	286_K	0.595	0.23
29_V	34_M	0.594	0.23
173_S	272_Y	0.591	0.22
31_R	109_Q	0.591	0.22
153_E	195_L	0.590	0.22
239_K	243_E	0.589	0.22
30_Q	154_V	0.587	0.22
82_E	85_S	0.587	0.22
279_G	285_G	0.587	0.22
196_I	220_Y	0.587	0.22
168_S	175_L	0.583	0.22
104_F	109_Q	0.580	0.22
224_G	277_N	0.580	0.22
13_N	32_D	0.580	0.22
200_R	281_K	0.578	0.22
27_M	286_K	0.578	0.22
31_R	113_N	0.573	0.22
30_Q	220_Y	0.566	0.21
32_D	228_I	0.565	0.21
25_V	102_P	0.562	0.21
8_A	229_G	0.562	0.21
200_R	209_V	0.561	0.21
99_V	194_S	0.560	0.21
201_N	218_E	0.553	0.21
112_T	116_I	0.553	0.21
222_P	279_G	0.552	0.21
97_F	206_L	0.552	0.21
40_Y	220_Y	0.551	0.21
231_M	291_V	0.550	0.20
201_N	281_K	0.550	0.20
137_G	171_L	0.548	0.20
127_S	241_C	0.547	0.20
32_D	196_I	0.546	0.20
82_E	148_G	0.544	0.20
8_A	224_G	0.544	0.20
42_S	286_K	0.543	0.20
84_S	148_G	0.543	0.20
74_L	258_F	0.542	0.20
8_A	47_P	0.542	0.20
141_K	144_L	0.537	0.20
9_Y	90_N	0.537	0.20
129_I	163_N	0.536	0.20
154_V	216_W	0.536	0.20
121_N	286_K	0.536	0.20
191_I	220_Y	0.536	0.20
31_R	100_P	0.535	0.20
73_C	94_L	0.535	0.20
116_I	213_G	0.535	0.20
142_A	174_S	0.535	0.20
123_F	127_S	0.533	0.20
12_T	45_K	0.532	0.20
154_V	190_V	0.531	0.20
36_Y	200_R	0.529	0.20
107_F	277_N	0.529	0.20
34_M	112_T	0.528	0.20
4_L	39_I	0.528	0.20
26_D	37_P	0.526	0.19
118_R	223_M	0.523	0.19
220_Y	223_M	0.522	0.19
160_K	263_N	0.522	0.19
32_D	277_N	0.520	0.19
27_M	95_P	0.520	0.19
86_K	93_D	0.519	0.19
102_P	226_I	0.518	0.19
84_S	149_N	0.518	0.19
12_T	208_K	0.517	0.19
6_V	105_D	0.517	0.19
80_E	290_K	0.516	0.19
52_C	75_F	0.515	0.19
7_L	190_V	0.515	0.19
53_A	205_L	0.514	0.19
196_I	214_G	0.512	0.19
77_S	283_S	0.511	0.19
46_G	287_G	0.510	0.19
106_G	187_D	0.505	0.19
130_N	148_G	0.505	0.19
16_P	155_Y	0.504	0.18
34_M	224_G	0.504	0.18
9_Y	14_L	0.502	0.18
14_L	41_S	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3x1lC	3	0.9356	100	0.336	Contact Map
4w8wA	1	0.8136	100	0.341	Contact Map
4qtsC	1	0.4814	100	0.661	Contact Map
4n0lA	1	0.6678	99.9	0.723	Contact Map
4w8vA	1	0.6508	99.9	0.762	Contact Map
3x1lH	1	0.5356	99.9	0.763	Contact Map
4qtsA	1	0.6373	98.6	0.886	Contact Map
3x1lB	1	0.7051	98.2	0.899	Contact Map
4txdA	1	0.7254	91.7	0.941	Contact Map
4l6uA	1	0.5254	77.2	0.952	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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