GREMLIN Database
Q97XK5 - Transposase ISC1217
UniProt: Q97XK5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 354 (299)
Sequences: 1057 (822)
Seq/√Len: 47.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
189_F205_G3.8241.00
129_I179_L3.4291.00
145_I178_S3.3581.00
36_L303_F3.0571.00
166_K174_E3.0511.00
89_I172_L3.0081.00
287_L307_K2.8361.00
221_P227_Q2.7501.00
87_L179_L2.6871.00
91_D192_W2.6441.00
89_I187_K2.5991.00
223_S228_G2.5651.00
90_D274_R2.4901.00
228_G232_V2.4071.00
204_V271_W2.3681.00
90_D278_E2.2861.00
143_H178_S2.2691.00
155_E158_R2.2531.00
150_R154_E2.2381.00
128_V281_I2.2321.00
220_V223_S2.2081.00
88_I132_K2.1141.00
274_R278_E2.0961.00
222_V226_P2.0431.00
223_S227_Q2.0381.00
142_I182_L2.0180.99
224_E228_G2.0130.99
127_L193_Y1.9930.99
143_H175_F1.9800.99
85_V131_V1.8960.99
76_V80_V1.8950.99
220_V229_E1.8920.99
278_E285_K1.8850.99
72_L75_V1.8580.99
222_V228_G1.8400.99
223_S226_P1.8210.99
145_I174_E1.8100.99
220_V227_Q1.7960.99
293_S299_R1.7610.99
91_D168_K1.7430.98
91_D193_Y1.7300.98
62_N65_D1.7270.98
130_G139_I1.6880.98
152_V155_E1.6800.98
90_D285_K1.6630.98
26_T30_K1.6580.98
32_V59_T1.6500.98
22_I25_M1.6480.98
275_W278_E1.6340.98
145_I301_S1.6050.97
221_P228_G1.6040.97
294_F299_R1.5850.97
194_V205_G1.5640.97
22_I30_K1.5410.97
193_Y274_R1.5390.97
75_V80_V1.5310.96
242_L267_I1.5130.96
63_N292_G1.5040.96
227_Q232_V1.5040.96
221_P226_P1.4980.96
95_H117_H1.4880.96
49_I52_E1.4860.96
222_V229_E1.4680.95
43_G46_A1.4540.95
240_K244_I1.4450.95
89_I129_I1.4380.95
93_H121_E1.4370.95
93_H114_C1.4260.95
221_P225_F1.4140.94
109_A122_S1.3860.94
64_L306_L1.3840.94
296_T307_K1.3790.94
274_R285_K1.3750.94
170_D173_L1.3700.93
91_D275_W1.3670.93
202_N258_T1.3670.93
193_Y285_K1.3640.93
152_V158_R1.3530.93
86_L270_T1.3440.93
223_S230_Y1.3190.92
279_V283_E1.3130.92
222_V227_Q1.3090.92
194_V200_Q1.3060.92
240_K245_D1.3020.92
168_K193_Y1.2950.91
33_A37_L1.2820.91
206_E253_R1.2790.91
199_L205_G1.2660.90
220_V228_G1.2620.90
69_Q302_G1.2530.90
303_F310_S1.2530.90
90_D275_W1.2520.90
211_A256_F1.2510.90
48_E51_Q1.2450.90
94_D102_M1.2410.89
228_G231_L1.2290.89
130_G281_I1.2250.89
25_M29_R1.2240.89
21_V24_S1.2200.89
19_N23_L1.2110.88
75_V79_L1.2100.88
92_T278_E1.2090.88
225_F228_G1.2050.88
72_L76_V1.2050.88
114_C121_E1.2020.88
297_W301_S1.1940.88
108_G288_G1.1930.88
230_Y233_E1.1920.88
295_L303_F1.1700.87
103_P300_N1.1620.86
39_G49_I1.1530.86
147_Y165_F1.1490.86
275_W285_K1.1470.85
243_V246_D1.1470.85
186_S270_T1.1460.85
223_S232_V1.1420.85
190_D278_E1.1370.85
220_V232_V1.1320.85
102_M124_I1.1300.85
154_E157_K1.1270.84
276_D311_L1.1270.84
96_K109_A1.1210.84
224_E227_Q1.1180.84
63_N69_Q1.1110.84
260_L263_T1.1080.83
129_I175_F1.0960.83
63_N67_A1.0890.82
240_K243_V1.0880.82
203_T258_T1.0840.82
292_G300_N1.0820.82
40_A45_N1.0810.82
86_L188_V1.0810.82
167_T170_D1.0710.81
188_V270_T1.0700.81
304_V307_K1.0670.81
93_H112_F1.0630.81
29_R67_A1.0620.81
145_I171_A1.0600.81
103_P297_W1.0570.80
108_G148_I1.0520.80
115_R192_W1.0500.80
221_P233_E1.0470.80
244_I247_Y1.0460.80
299_R303_F1.0410.79
114_C125_Q1.0350.79
88_I188_V1.0330.79
221_P224_E1.0330.79
224_E230_Y1.0320.79
166_K177_S1.0320.79
211_A254_Y1.0300.79
195_N210_S1.0280.78
275_W314_V1.0260.78
306_L310_S1.0260.78
130_G280_L1.0230.78
28_T31_D1.0220.78
231_L234_Y1.0200.78
154_E162_E1.0180.78
153_E157_K1.0180.78
28_T33_A1.0170.78
274_R281_I1.0100.77
285_K314_V1.0100.77
240_K257_S1.0090.77
22_I29_R1.0080.77
57_Y61_L1.0060.77
200_Q205_G1.0050.77
239_I243_V0.9990.76
220_V226_P0.9980.76
20_E25_M0.9860.75
94_D126_L0.9830.75
277_I285_K0.9790.75
153_E156_L0.9640.74
71_N76_V0.9600.73
90_D277_I0.9560.73
171_A175_F0.9510.73
125_Q168_K0.9450.72
141_V280_L0.9430.72
58_E62_N0.9380.72
92_T275_W0.9350.71
32_V35_R0.9280.71
204_V257_S0.9260.71
38_L41_V0.9260.71
226_P229_E0.9190.70
127_L171_A0.9180.70
207_L211_A0.9100.69
101_A129_I0.9090.69
246_D249_G0.9090.69
21_V25_M0.9080.69
87_L184_V0.9080.69
205_G256_F0.9050.69
281_I285_K0.9010.69
76_V308_A0.9000.69
103_P124_I0.9000.69
255_F271_W0.8980.68
141_V311_L0.8960.68
28_T36_L0.8960.68
34_K38_L0.8950.68
184_V282_R0.8920.68
128_V141_V0.8910.68
24_S71_N0.8850.67
252_R309_L0.8840.67
170_D234_Y0.8840.67
225_F232_V0.8820.67
33_A36_L0.8800.67
92_T274_R0.8780.67
126_L300_N0.8760.66
90_D193_Y0.8750.66
124_I300_N0.8740.66
224_E231_L0.8740.66
124_I148_I0.8730.66
224_E229_E0.8730.66
141_V312_L0.8720.66
159_R162_E0.8690.66
115_R121_E0.8650.65
221_P229_E0.8650.65
220_V225_F0.8610.65
112_F124_I0.8560.65
127_L145_I0.8540.64
215_E218_R0.8540.64
189_F194_V0.8530.64
139_I280_L0.8520.64
112_F115_R0.8470.64
190_D274_R0.8460.64
18_V34_K0.8410.63
220_V224_E0.8380.63
227_Q233_E0.8370.63
122_S149_P0.8330.62
71_N77_K0.8310.62
249_G257_S0.8300.62
281_I284_L0.8270.62
127_L172_L0.8250.62
94_D304_V0.8250.62
114_C275_W0.8250.62
38_L46_A0.8210.61
37_L309_L0.8210.61
110_Q151_K0.8180.61
207_L278_E0.8160.61
168_K192_W0.8160.61
153_E158_R0.8160.61
77_K80_V0.8150.61
221_P231_L0.8140.61
91_D281_I0.8080.60
284_L289_L0.8060.60
139_I276_D0.8060.60
257_S293_S0.8050.60
245_D251_G0.8040.60
114_C120_F0.8010.59
227_Q230_Y0.8010.59
126_L304_V0.7980.59
117_H121_E0.7970.59
36_L40_A0.7950.59
221_P232_V0.7930.59
98_Y295_L0.7890.58
193_Y275_W0.7880.58
159_R163_V0.7870.58
90_D168_K0.7860.58
147_Y168_K0.7810.58
207_L256_F0.7810.58
189_F192_W0.7770.57
91_D277_I0.7740.57
191_S208_K0.7730.57
92_T285_K0.7700.56
230_Y235_L0.7680.56
74_E210_S0.7670.56
64_L302_G0.7640.56
111_I122_S0.7600.55
21_V27_G0.7600.55
73_I77_K0.7590.55
95_H121_E0.7580.55
82_D136_N0.7560.55
129_I187_K0.7510.55
157_K162_E0.7460.54
127_L168_K0.7450.54
83_H156_L0.7450.54
94_D128_V0.7440.54
196_S290_E0.7420.54
125_Q149_P0.7400.53
48_E52_E0.7400.53
43_G142_I0.7400.53
279_V282_R0.7380.53
40_A306_L0.7380.53
103_P301_S0.7360.53
93_H120_F0.7320.53
192_W275_W0.7290.52
18_V21_V0.7290.52
48_E293_S0.7270.52
94_D303_F0.7260.52
98_Y109_A0.7250.52
27_G77_K0.7250.52
153_E162_E0.7210.52
83_H233_E0.7150.51
102_M146_A0.7140.51
90_D190_D0.7140.51
225_F229_E0.7130.51
241_L254_Y0.7130.51
223_S231_L0.7100.50
45_N311_L0.7090.50
45_N50_A0.7080.50
32_V63_N0.7080.50
18_V37_L0.7070.50
277_I287_L0.7070.50
29_R32_V0.7040.50
127_L147_Y0.7040.50
144_I311_L0.7040.50
271_W274_R0.7020.50
79_L316_Y0.7010.50
44_R291_G0.6970.49
100_R176_L0.6970.49
278_E281_I0.6930.49
132_K273_N0.6910.49
259_D262_D0.6900.48
71_N75_V0.6890.48
192_W208_K0.6860.48
114_C117_H0.6860.48
29_R68_A0.6860.48
158_R163_V0.6860.48
40_A109_A0.6850.48
22_I26_T0.6850.48
193_Y278_E0.6780.47
111_I118_K0.6750.47
18_V33_A0.6680.46
26_T32_V0.6660.46
112_F121_E0.6660.46
69_Q305_A0.6650.46
29_R33_A0.6640.46
227_Q231_L0.6640.46
21_V34_K0.6580.45
275_W281_I0.6520.45
189_F208_K0.6500.44
102_M126_L0.6500.44
49_I292_G0.6480.44
127_L289_L0.6480.44
29_R296_T0.6480.44
93_H125_Q0.6470.44
123_A245_D0.6450.44
102_M292_G0.6440.44
77_K182_L0.6430.44
288_G291_G0.6410.44
120_F308_A0.6390.43
20_E24_S0.6390.43
25_M30_K0.6350.43
127_L274_R0.6340.43
72_L80_V0.6310.43
208_K212_R0.6310.43
39_G60_V0.6300.43
150_R187_K0.6290.42
255_F268_I0.6280.42
20_E178_S0.6270.42
257_S267_I0.6230.42
278_E314_V0.6220.42
26_T29_R0.6200.42
239_I248_K0.6170.41
282_R285_K0.6140.41
83_H180_S0.6120.41
95_H114_C0.6110.41
129_I176_L0.6100.41
82_D263_T0.6050.40
302_G305_A0.6050.40
66_K248_K0.6050.40
97_L121_E0.6040.40
71_N74_E0.6010.40
65_D299_R0.6010.40
102_M122_S0.6000.40
177_S213_V0.5960.39
23_L30_K0.5960.39
156_L159_R0.5940.39
156_L163_V0.5920.39
112_F149_P0.5920.39
32_V62_N0.5900.39
45_N63_N0.5900.39
161_E174_E0.5890.39
168_K171_A0.5890.39
289_L304_V0.5870.38
263_T266_D0.5870.38
113_Y183_N0.5870.38
68_A302_G0.5830.38
298_V302_G0.5820.38
178_S273_N0.5800.38
300_N304_V0.5800.38
102_M300_N0.5800.38
111_I253_R0.5770.37
31_D68_A0.5760.37
301_S305_A0.5730.37
21_V213_V0.5730.37
69_Q306_L0.5710.37
116_A290_E0.5700.37
92_T289_L0.5700.37
60_V63_N0.5680.37
44_R50_A0.5650.36
58_E178_S0.5610.36
70_V310_S0.5610.36
44_R98_Y0.5590.36
60_V142_I0.5580.36
191_S207_L0.5580.36
210_S250_Y0.5570.36
111_I121_E0.5570.36
82_D269_T0.5560.36
111_I120_F0.5520.35
46_A147_Y0.5510.35
46_A293_S0.5510.35
161_E164_K0.5480.35
295_L310_S0.5480.35
86_L272_E0.5480.35
58_E292_G0.5450.35
114_C290_E0.5450.35
57_Y275_W0.5430.34
114_C123_A0.5420.34
168_K194_V0.5410.34
74_E265_E0.5390.34
101_A246_D0.5390.34
115_R120_F0.5390.34
36_L293_S0.5360.34
71_N322_G0.5340.34
123_A271_W0.5310.33
299_R306_L0.5310.33
27_G31_D0.5310.33
296_T311_L0.5300.33
190_D285_K0.5280.33
21_V262_D0.5280.33
62_N67_A0.5280.33
123_A203_T0.5260.33
98_Y108_G0.5260.33
102_M293_S0.5260.33
239_I242_L0.5250.33
85_V185_K0.5240.33
75_V78_K0.5230.33
50_A312_L0.5220.32
292_G299_R0.5220.32
76_V79_L0.5220.32
90_D130_G0.5210.32
38_L157_K0.5210.32
40_A284_L0.5210.32
172_L209_S0.5210.32
87_L255_F0.5200.32
142_I160_G0.5170.32
156_L162_E0.5160.32
67_A148_I0.5150.32
92_T304_V0.5130.32
91_D191_S0.5120.32
54_E67_A0.5090.31
172_L198_T0.5080.31
188_V273_N0.5080.31
154_E164_K0.5070.31
146_A297_W0.5060.31
283_E286_A0.5050.31
67_A302_G0.5050.31
197_R251_G0.5030.31
36_L299_R0.5010.31
148_I152_V0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9322 99.9 0.719 Contact Map
2kkoA 2 0.3023 15.1 0.967 Contact Map
3hdeA 2 0.2825 15.1 0.967 Contact Map
4pc4A 1 0.5734 13.9 0.967 Contact Map
3hdfA 1 0.2797 11 0.969 Contact Map
2j49A 1 0.2288 10.9 0.969 Contact Map
3qfiA 1 0.2571 10 0.969 Contact Map
1xjuA 2 0.2881 9.5 0.97 Contact Map
1xjtA 1 0.2881 8.8 0.97 Contact Map
2zkzA 2 0.2514 8.6 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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