Q97XK2 - SULSO - GREMLIN Contacts

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Q97XK2 - Transposase ISC1190

UniProt:	Q97XK2	Sequences: MEAPVAGIDVSKDKLVVYFQGKYYEFQNNKQGFEGVKQVLPKGCKVAIESTGIYHINLAKYLGKEYDVRIINPLVLKKFKDIRGKKSDKNDAKKLAELVISMGSEFTTSEAKESTSQWDFITRSIVRVKNRLRRDLILLGYKDSLSKKNLNEVLRGEDNIVLSEVRFLLDELERLEVRKREIEEELEDLVPKDSLIFTIPGIGRTLGCIILARVGDVKRFGNKKRFVAYCGLDPLVESSGKSVVSRGISRRGDAVLRRAFYLAALTAIKVNPIIKRFYEEHKENLKGKKLITACARKLAVITWAVLYYNKPFDASE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	316 (308)
Sequences:	4567 (3497)
Seq/√Len:	199.3

SULSO - Q97XK2 Q97Y59 Q97WC0 Q97VS0 Q97WZ5 Q97ZN4 Q97X07 Q97X26 Q97UF7 Q97X12 Q97X29 Q97UQ6 Q97YE1 Q97XM7 Q97UU8 Q97Y06 Q97VB2 Q97Z62 Q97XR9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
47_A	99_V	4.230	1.00
282_K	287_G	3.203	1.00
125_I	176_E	3.099	1.00
195_L	311_P	2.712	1.00
18_Y	92_A	2.627	1.00
226_F	299_A	2.606	1.00
167_F	178_R	2.540	1.00
281_H	284_N	2.483	1.00
170_D	178_R	2.435	1.00
76_L	95_L	2.367	1.00
214_V	226_F	2.247	1.00
124_S	127_R	2.230	1.00
163_S	185_E	2.211	1.00
47_A	95_L	2.184	1.00
230_C	256_L	2.158	1.00
78_K	81_D	2.153	1.00
118_W	122_T	2.109	1.00
210_I	302_T	2.098	1.00
125_I	179_K	2.053	1.00
275_K	279_E	2.040	1.00
46_V	66_Y	2.034	1.00
87_S	236_V	2.023	1.00
248_I	292_T	2.007	1.00
198_T	311_P	1.997	1.00
221_G	225_R	1.967	1.00
296_R	300_V	1.948	1.00
14_K	25_E	1.946	1.00
174_R	178_R	1.939	1.00
118_W	183_E	1.927	1.00
238_S	243_V	1.913	1.00
124_S	131_R	1.877	1.00
171_E	174_R	1.854	1.00
8_I	36_V	1.848	1.00
222_N	225_R	1.826	1.00
195_L	305_V	1.820	1.00
126_V	130_N	1.813	1.00
119_D	258_R	1.771	1.00
6_A	19_F	1.770	1.00
199_I	302_T	1.758	1.00
150_L	153_V	1.756	1.00
171_E	178_R	1.743	1.00
8_I	15_L	1.741	1.00
202_I	207_G	1.733	1.00
124_S	171_E	1.730	1.00
45_K	69_R	1.717	1.00
220_F	229_Y	1.714	1.00
121_I	179_K	1.676	1.00
232_L	295_A	1.666	1.00
125_I	172_L	1.654	1.00
310_K	313_D	1.642	1.00
146_S	149_N	1.640	1.00
286_K	289_K	1.638	1.00
230_C	299_A	1.624	1.00
77_K	80_K	1.605	1.00
132_L	172_L	1.603	1.00
196_I	302_T	1.586	1.00
116_S	213_R	1.586	1.00
185_E	188_D	1.584	1.00
48_I	68_V	1.556	1.00
305_V	311_P	1.555	1.00
17_V	36_V	1.523	1.00
8_I	58_L	1.520	1.00
97_E	101_S	1.510	1.00
206_L	259_A	1.506	1.00
209_I	259_A	1.499	1.00
122_T	125_I	1.491	1.00
60_K	109_S	1.480	1.00
180_R	183_E	1.478	1.00
304_A	308_Y	1.465	1.00
199_I	305_V	1.461	1.00
149_N	152_E	1.457	1.00
280_E	284_N	1.456	1.00
274_I	301_I	1.446	1.00
197_F	204_R	1.445	1.00
61_Y	64_K	1.445	1.00
13_D	241_K	1.443	1.00
279_E	283_E	1.436	1.00
274_I	294_C	1.436	1.00
195_L	198_T	1.422	1.00
11_S	16_V	1.418	1.00
29_N	32_G	1.408	1.00
16_V	25_E	1.403	1.00
122_T	179_K	1.397	1.00
262_L	265_L	1.376	1.00
268_I	278_Y	1.374	1.00
264_A	295_A	1.374	1.00
154_L	157_E	1.370	1.00
183_E	186_L	1.367	1.00
170_D	174_R	1.365	1.00
24_Y	39_V	1.345	1.00
132_L	165_V	1.345	1.00
278_Y	294_C	1.342	1.00
48_I	59_A	1.334	1.00
153_V	156_G	1.333	1.00
190_V	197_F	1.331	1.00
264_A	298_L	1.320	1.00
167_F	181_E	1.311	1.00
85_K	236_V	1.310	1.00
18_Y	93_K	1.308	1.00
277_F	297_K	1.307	1.00
285_L	289_K	1.299	1.00
150_L	157_E	1.274	1.00
145_L	153_V	1.264	1.00
146_S	157_E	1.259	1.00
172_L	176_E	1.258	1.00
258_R	262_L	1.257	1.00
119_D	255_V	1.245	1.00
187_E	204_R	1.245	1.00
227_V	233_D	1.242	1.00
118_W	205_T	1.242	1.00
149_N	153_V	1.226	1.00
124_S	128_V	1.222	1.00
27_Q	32_G	1.217	1.00
40_L	46_V	1.211	1.00
264_A	294_C	1.209	1.00
278_Y	290_L	1.205	1.00
125_I	129_K	1.204	1.00
149_N	157_E	1.194	1.00
146_S	153_V	1.192	1.00
188_D	192_K	1.182	1.00
128_V	131_R	1.177	1.00
199_I	298_L	1.174	1.00
272_P	276_R	1.169	1.00
303_W	307_Y	1.167	1.00
146_S	151_N	1.167	1.00
47_A	71_I	1.167	1.00
261_Y	295_A	1.166	1.00
169_L	173_E	1.164	1.00
227_V	296_R	1.161	1.00
213_R	253_D	1.159	1.00
145_L	149_N	1.158	1.00
118_W	179_K	1.156	1.00
202_I	206_L	1.155	1.00
11_S	14_K	1.155	1.00
170_D	177_V	1.152	1.00
120_F	131_R	1.144	1.00
150_L	156_G	1.143	1.00
149_N	154_L	1.141	1.00
117_Q	121_I	1.116	1.00
145_L	150_L	1.114	1.00
146_S	155_R	1.114	1.00
8_I	17_V	1.111	1.00
127_R	130_N	1.106	1.00
147_K	151_N	1.087	1.00
206_L	263_A	1.086	1.00
196_I	207_G	1.085	1.00
16_V	23_Y	1.084	1.00
153_V	157_E	1.083	1.00
123_R	127_R	1.082	1.00
261_Y	292_T	1.081	1.00
150_L	154_L	1.073	1.00
46_V	62_L	1.070	1.00
71_I	76_L	1.069	1.00
304_A	307_Y	1.068	1.00
248_I	257_R	1.068	1.00
37_K	61_Y	1.067	1.00
174_R	177_V	1.062	1.00
149_N	156_G	1.061	1.00
147_K	154_L	1.058	1.00
10_V	15_L	1.052	1.00
146_S	154_L	1.052	1.00
23_Y	93_K	1.046	1.00
202_I	302_T	1.045	1.00
74_L	78_K	1.044	1.00
6_A	46_V	1.042	1.00
151_N	154_L	1.036	1.00
301_I	305_V	1.032	1.00
281_H	290_L	1.032	1.00
151_N	155_R	1.029	1.00
115_T	255_V	1.027	1.00
45_K	67_D	1.025	1.00
7_G	96_A	1.018	1.00
33_F	57_N	1.013	1.00
145_L	152_E	1.012	1.00
80_K	94_K	1.008	1.00
93_K	97_E	1.004	1.00
6_A	17_V	1.001	1.00
277_F	281_H	0.995	1.00
264_A	291_I	0.995	1.00
17_V	39_V	0.994	1.00
176_E	180_R	0.991	1.00
263_A	298_L	0.989	1.00
282_K	290_L	0.986	1.00
33_F	61_Y	0.986	1.00
183_E	187_E	0.985	1.00
143_D	153_V	0.972	0.99
305_V	310_K	0.966	0.99
105_E	108_T	0.964	0.99
158_D	161_V	0.962	0.99
277_F	294_C	0.956	0.99
143_D	146_S	0.954	0.99
277_F	293_A	0.953	0.99
86_K	91_D	0.952	0.99
146_S	156_G	0.945	0.99
281_H	286_K	0.944	0.99
265_L	287_G	0.940	0.99
114_S	182_I	0.933	0.99
12_K	137_I	0.932	0.99
261_Y	265_L	0.927	0.99
160_I	163_S	0.926	0.99
148_K	151_N	0.922	0.99
287_G	291_I	0.919	0.99
196_I	306_L	0.919	0.99
260_F	299_A	0.918	0.99
128_V	132_L	0.916	0.99
151_N	156_G	0.910	0.99
55_H	70_I	0.909	0.99
178_R	181_E	0.902	0.99
185_E	189_L	0.901	0.99
146_S	152_E	0.900	0.99
5_V	99_V	0.900	0.99
6_A	40_L	0.900	0.99
26_F	39_V	0.898	0.99
59_A	68_V	0.895	0.99
150_L	155_R	0.891	0.99
26_F	32_G	0.885	0.99
147_K	150_L	0.885	0.99
59_A	70_I	0.880	0.99
115_T	186_L	0.877	0.99
167_F	185_E	0.876	0.99
148_K	152_E	0.874	0.99
217_V	306_L	0.868	0.99
202_I	298_L	0.856	0.99
176_E	179_K	0.848	0.99
250_R	257_R	0.846	0.99
147_K	153_V	0.844	0.99
128_V	172_L	0.838	0.98
38_Q	41_P	0.837	0.98
265_L	268_I	0.837	0.98
278_Y	287_G	0.837	0.98
84_G	228_A	0.835	0.98
32_G	35_G	0.831	0.98
10_V	48_I	0.830	0.98
117_Q	167_F	0.829	0.98
145_L	154_L	0.825	0.98
73_P	213_R	0.825	0.98
152_E	156_G	0.821	0.98
195_L	309_N	0.821	0.98
121_I	182_I	0.819	0.98
122_T	126_V	0.817	0.98
214_V	217_V	0.815	0.98
146_S	150_L	0.814	0.98
145_L	155_R	0.812	0.98
5_V	100_I	0.812	0.98
288_K	291_I	0.811	0.98
144_S	156_G	0.810	0.98
261_Y	288_K	0.807	0.98
69_R	99_V	0.803	0.98
143_D	147_K	0.802	0.98
281_H	285_L	0.799	0.98
274_I	298_L	0.799	0.98
145_L	148_K	0.797	0.98
277_F	280_E	0.796	0.98
15_L	28_N	0.794	0.98
112_K	213_R	0.793	0.98
95_L	98_L	0.791	0.98
239_S	243_V	0.791	0.98
115_T	208_C	0.790	0.98
143_D	149_N	0.788	0.98
144_S	148_K	0.781	0.98
16_V	89_K	0.776	0.97
115_T	209_I	0.774	0.97
292_T	295_A	0.774	0.97
31_Q	35_G	0.771	0.97
6_A	44_C	0.770	0.97
272_P	275_K	0.767	0.97
177_V	181_E	0.766	0.97
129_K	172_L	0.764	0.97
107_T	192_K	0.761	0.97
167_F	171_E	0.761	0.97
15_L	26_F	0.759	0.97
45_K	99_V	0.757	0.97
197_F	207_G	0.754	0.97
193_D	211_L	0.754	0.97
273_I	312_F	0.749	0.97
50_S	73_P	0.747	0.97
213_R	255_V	0.743	0.97
233_D	250_R	0.740	0.97
11_S	15_L	0.739	0.97
145_L	156_G	0.737	0.97
115_T	212_A	0.737	0.97
36_V	40_L	0.734	0.96
175_L	178_R	0.732	0.96
238_S	244_V	0.730	0.96
302_T	305_V	0.730	0.96
265_L	295_A	0.726	0.96
168_L	171_E	0.726	0.96
144_S	149_N	0.724	0.96
117_Q	182_I	0.724	0.96
51_T	54_Y	0.720	0.96
32_G	36_V	0.718	0.96
276_R	280_E	0.716	0.96
17_V	26_F	0.714	0.96
119_D	123_R	0.713	0.96
265_L	288_K	0.711	0.96
132_L	169_L	0.709	0.96
268_I	282_K	0.709	0.96
105_E	109_S	0.708	0.96
85_K	90_N	0.707	0.96
229_Y	253_D	0.707	0.96
225_R	228_A	0.704	0.96
84_G	251_R	0.704	0.96
144_S	157_E	0.702	0.95
144_S	147_K	0.702	0.95
40_L	62_L	0.698	0.95
18_Y	23_Y	0.697	0.95
267_A	274_I	0.696	0.95
72_N	75_V	0.696	0.95
30_K	34_E	0.694	0.95
187_E	191_P	0.693	0.95
144_S	155_R	0.692	0.95
128_V	168_L	0.690	0.95
71_I	98_L	0.689	0.95
79_F	98_L	0.689	0.95
235_L	249_S	0.683	0.95
286_K	290_L	0.678	0.95
222_N	303_W	0.676	0.94
233_D	249_S	0.675	0.94
252_G	257_R	0.674	0.94
236_V	243_V	0.673	0.94
122_T	183_E	0.672	0.94
128_V	171_E	0.670	0.94
216_D	219_R	0.668	0.94
184_E	188_D	0.668	0.94
280_E	283_E	0.666	0.94
50_S	70_I	0.665	0.94
145_L	157_E	0.664	0.94
98_L	102_M	0.659	0.94
109_S	113_E	0.657	0.94
190_V	208_C	0.657	0.94
156_G	162_L	0.656	0.94
32_G	39_V	0.656	0.94
210_I	256_L	0.654	0.93
7_G	92_A	0.654	0.93
43_G	67_D	0.652	0.93
107_T	110_E	0.652	0.93
262_L	288_K	0.650	0.93
37_K	41_P	0.650	0.93
181_E	185_E	0.649	0.93
175_L	179_K	0.647	0.93
144_S	154_L	0.643	0.93
145_L	151_N	0.637	0.93
143_D	154_L	0.637	0.93
233_D	236_V	0.636	0.92
128_V	175_L	0.634	0.92
15_L	58_L	0.632	0.92
289_K	293_A	0.631	0.92
262_L	266_T	0.631	0.92
34_E	38_Q	0.629	0.92
278_Y	282_K	0.628	0.92
270_V	275_K	0.628	0.92
199_I	202_I	0.627	0.92
120_F	124_S	0.626	0.92
58_L	62_L	0.622	0.92
116_S	255_V	0.622	0.92
214_V	230_C	0.621	0.92
125_I	175_L	0.620	0.91
202_I	210_I	0.619	0.91
88_D	239_S	0.618	0.91
7_G	62_L	0.617	0.91
268_I	291_I	0.617	0.91
171_E	175_L	0.616	0.91
79_F	101_S	0.608	0.91
37_K	66_Y	0.608	0.91
160_I	185_E	0.607	0.91
265_L	291_I	0.607	0.91
144_S	150_L	0.607	0.91
74_L	251_R	0.607	0.91
6_A	62_L	0.604	0.90
76_L	98_L	0.600	0.90
209_I	213_R	0.598	0.90
53_I	137_I	0.598	0.90
259_A	263_A	0.597	0.90
281_H	293_A	0.596	0.90
265_L	269_K	0.594	0.90
166_R	170_D	0.593	0.90
260_F	295_A	0.591	0.89
31_Q	39_V	0.589	0.89
131_R	168_L	0.588	0.89
217_V	303_W	0.587	0.89
130_N	134_R	0.585	0.89
143_D	157_E	0.583	0.89
76_L	94_K	0.582	0.89
48_I	70_I	0.581	0.89
43_G	66_Y	0.580	0.89
33_F	39_V	0.578	0.88
10_V	54_Y	0.577	0.88
131_R	134_R	0.576	0.88
227_V	300_V	0.575	0.88
143_D	151_N	0.575	0.88
48_I	95_L	0.575	0.88
77_K	81_D	0.574	0.88
121_I	175_L	0.573	0.88
177_V	180_R	0.572	0.88
148_K	155_R	0.572	0.88
143_D	152_E	0.569	0.88
172_L	175_L	0.568	0.88
300_V	303_W	0.567	0.87
33_F	58_L	0.567	0.87
167_F	170_D	0.566	0.87
90_N	94_K	0.565	0.87
28_N	33_F	0.564	0.87
258_R	261_Y	0.561	0.87
25_E	28_N	0.561	0.87
186_L	208_C	0.560	0.87
233_D	257_R	0.559	0.87
307_Y	310_K	0.559	0.87
248_I	293_A	0.557	0.87
223_K	303_W	0.554	0.86
143_D	156_G	0.554	0.86
279_E	282_K	0.554	0.86
87_S	238_S	0.552	0.86
119_D	209_I	0.547	0.86
163_S	174_R	0.546	0.85
146_S	158_D	0.546	0.85
114_S	185_E	0.546	0.85
173_E	177_V	0.545	0.85
215_G	219_R	0.545	0.85
11_S	240_G	0.544	0.85
126_V	129_K	0.542	0.85
276_R	279_E	0.541	0.85
202_I	263_A	0.538	0.85
117_Q	131_R	0.538	0.85
116_S	253_D	0.537	0.84
117_Q	128_V	0.535	0.84
113_E	135_D	0.534	0.84
41_P	66_Y	0.534	0.84
111_A	186_L	0.533	0.84
34_E	37_K	0.532	0.84
235_L	246_R	0.532	0.84
205_T	209_I	0.531	0.84
74_L	84_G	0.530	0.84
62_L	298_L	0.527	0.83
147_K	156_G	0.525	0.83
271_N	301_I	0.523	0.83
301_I	304_A	0.523	0.83
18_Y	96_A	0.521	0.83
228_A	233_D	0.519	0.82
173_E	176_E	0.518	0.82
157_E	162_L	0.517	0.82
247_G	289_K	0.516	0.82
268_I	294_C	0.516	0.82
266_T	270_V	0.515	0.82
163_S	166_R	0.514	0.82
248_I	252_G	0.514	0.82
132_L	168_L	0.514	0.82
147_K	157_E	0.511	0.81
84_G	235_L	0.510	0.81
111_A	189_L	0.509	0.81
17_V	40_L	0.508	0.81
183_E	205_T	0.508	0.81
111_A	193_D	0.506	0.81
237_E	246_R	0.505	0.81
121_I	178_R	0.503	0.80
232_L	296_R	0.503	0.80
183_E	204_R	0.502	0.80
271_N	275_K	0.502	0.80
223_K	300_V	0.502	0.80
170_D	181_E	0.501	0.80
34_E	123_R	0.500	0.80
218_K	307_Y	0.500	0.80
186_L	190_V	0.500	0.80

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1hjrA	2	0.3323	91.1	0.936	Contact Map
4ep4A	2	0.3418	90.8	0.936	Contact Map
1nu0A	1	0.307	87.2	0.94	Contact Map
3c1yA	5	0.7532	80	0.945	Contact Map
1pu6A	1	0.6013	79.3	0.946	Contact Map
1kftA	1	0.1709	77.2	0.947	Contact Map
1vhxA	2	0.3228	76.3	0.947	Contact Map
3fhfA	1	0.6171	72.5	0.949	Contact Map
2a1jA	1	0.1867	72.1	0.949	Contact Map
4ofaA	1	0.4304	71.4	0.949	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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