GREMLIN Database
Q97XK2 - Transposase ISC1190
UniProt: Q97XK2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (308)
Sequences: 4567 (3497)
Seq/√Len: 199.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_A99_V4.2301.00
282_K287_G3.2031.00
125_I176_E3.0991.00
195_L311_P2.7121.00
18_Y92_A2.6271.00
226_F299_A2.6061.00
167_F178_R2.5401.00
281_H284_N2.4831.00
170_D178_R2.4351.00
76_L95_L2.3671.00
214_V226_F2.2471.00
124_S127_R2.2301.00
163_S185_E2.2111.00
47_A95_L2.1841.00
230_C256_L2.1581.00
78_K81_D2.1531.00
118_W122_T2.1091.00
210_I302_T2.0981.00
125_I179_K2.0531.00
275_K279_E2.0401.00
46_V66_Y2.0341.00
87_S236_V2.0231.00
248_I292_T2.0071.00
198_T311_P1.9971.00
221_G225_R1.9671.00
296_R300_V1.9481.00
14_K25_E1.9461.00
174_R178_R1.9391.00
118_W183_E1.9271.00
238_S243_V1.9131.00
124_S131_R1.8771.00
171_E174_R1.8541.00
8_I36_V1.8481.00
222_N225_R1.8261.00
195_L305_V1.8201.00
126_V130_N1.8131.00
119_D258_R1.7711.00
6_A19_F1.7701.00
199_I302_T1.7581.00
150_L153_V1.7561.00
171_E178_R1.7431.00
8_I15_L1.7411.00
202_I207_G1.7331.00
124_S171_E1.7301.00
45_K69_R1.7171.00
220_F229_Y1.7141.00
121_I179_K1.6761.00
232_L295_A1.6661.00
125_I172_L1.6541.00
310_K313_D1.6421.00
146_S149_N1.6401.00
286_K289_K1.6381.00
230_C299_A1.6241.00
77_K80_K1.6051.00
132_L172_L1.6031.00
196_I302_T1.5861.00
116_S213_R1.5861.00
185_E188_D1.5841.00
48_I68_V1.5561.00
305_V311_P1.5551.00
17_V36_V1.5231.00
8_I58_L1.5201.00
97_E101_S1.5101.00
206_L259_A1.5061.00
209_I259_A1.4991.00
122_T125_I1.4911.00
60_K109_S1.4801.00
180_R183_E1.4781.00
304_A308_Y1.4651.00
199_I305_V1.4611.00
149_N152_E1.4571.00
280_E284_N1.4561.00
274_I301_I1.4461.00
197_F204_R1.4451.00
61_Y64_K1.4451.00
13_D241_K1.4431.00
279_E283_E1.4361.00
274_I294_C1.4361.00
195_L198_T1.4221.00
11_S16_V1.4181.00
29_N32_G1.4081.00
16_V25_E1.4031.00
122_T179_K1.3971.00
262_L265_L1.3761.00
268_I278_Y1.3741.00
264_A295_A1.3741.00
154_L157_E1.3701.00
183_E186_L1.3671.00
170_D174_R1.3651.00
24_Y39_V1.3451.00
132_L165_V1.3451.00
278_Y294_C1.3421.00
48_I59_A1.3341.00
153_V156_G1.3331.00
190_V197_F1.3311.00
264_A298_L1.3201.00
167_F181_E1.3111.00
85_K236_V1.3101.00
18_Y93_K1.3081.00
277_F297_K1.3071.00
285_L289_K1.2991.00
150_L157_E1.2741.00
145_L153_V1.2641.00
146_S157_E1.2591.00
172_L176_E1.2581.00
258_R262_L1.2571.00
119_D255_V1.2451.00
187_E204_R1.2451.00
227_V233_D1.2421.00
118_W205_T1.2421.00
149_N153_V1.2261.00
124_S128_V1.2221.00
27_Q32_G1.2171.00
40_L46_V1.2111.00
264_A294_C1.2091.00
278_Y290_L1.2051.00
125_I129_K1.2041.00
149_N157_E1.1941.00
146_S153_V1.1921.00
188_D192_K1.1821.00
128_V131_R1.1771.00
199_I298_L1.1741.00
272_P276_R1.1691.00
303_W307_Y1.1671.00
146_S151_N1.1671.00
47_A71_I1.1671.00
261_Y295_A1.1661.00
169_L173_E1.1641.00
227_V296_R1.1611.00
213_R253_D1.1591.00
145_L149_N1.1581.00
118_W179_K1.1561.00
202_I206_L1.1551.00
11_S14_K1.1551.00
170_D177_V1.1521.00
120_F131_R1.1441.00
150_L156_G1.1431.00
149_N154_L1.1411.00
117_Q121_I1.1161.00
145_L150_L1.1141.00
146_S155_R1.1141.00
8_I17_V1.1111.00
127_R130_N1.1061.00
147_K151_N1.0871.00
206_L263_A1.0861.00
196_I207_G1.0851.00
16_V23_Y1.0841.00
153_V157_E1.0831.00
123_R127_R1.0821.00
261_Y292_T1.0811.00
150_L154_L1.0731.00
46_V62_L1.0701.00
71_I76_L1.0691.00
304_A307_Y1.0681.00
248_I257_R1.0681.00
37_K61_Y1.0671.00
174_R177_V1.0621.00
149_N156_G1.0611.00
147_K154_L1.0581.00
10_V15_L1.0521.00
146_S154_L1.0521.00
23_Y93_K1.0461.00
202_I302_T1.0451.00
74_L78_K1.0441.00
6_A46_V1.0421.00
151_N154_L1.0361.00
301_I305_V1.0321.00
281_H290_L1.0321.00
151_N155_R1.0291.00
115_T255_V1.0271.00
45_K67_D1.0251.00
7_G96_A1.0181.00
33_F57_N1.0131.00
145_L152_E1.0121.00
80_K94_K1.0081.00
93_K97_E1.0041.00
6_A17_V1.0011.00
277_F281_H0.9951.00
264_A291_I0.9951.00
17_V39_V0.9941.00
176_E180_R0.9911.00
263_A298_L0.9891.00
282_K290_L0.9861.00
33_F61_Y0.9861.00
183_E187_E0.9851.00
143_D153_V0.9720.99
305_V310_K0.9660.99
105_E108_T0.9640.99
158_D161_V0.9620.99
277_F294_C0.9560.99
143_D146_S0.9540.99
277_F293_A0.9530.99
86_K91_D0.9520.99
146_S156_G0.9450.99
281_H286_K0.9440.99
265_L287_G0.9400.99
114_S182_I0.9330.99
12_K137_I0.9320.99
261_Y265_L0.9270.99
160_I163_S0.9260.99
148_K151_N0.9220.99
287_G291_I0.9190.99
196_I306_L0.9190.99
260_F299_A0.9180.99
128_V132_L0.9160.99
151_N156_G0.9100.99
55_H70_I0.9090.99
178_R181_E0.9020.99
185_E189_L0.9010.99
146_S152_E0.9000.99
5_V99_V0.9000.99
6_A40_L0.9000.99
26_F39_V0.8980.99
59_A68_V0.8950.99
150_L155_R0.8910.99
26_F32_G0.8850.99
147_K150_L0.8850.99
59_A70_I0.8800.99
115_T186_L0.8770.99
167_F185_E0.8760.99
148_K152_E0.8740.99
217_V306_L0.8680.99
202_I298_L0.8560.99
176_E179_K0.8480.99
250_R257_R0.8460.99
147_K153_V0.8440.99
128_V172_L0.8380.98
38_Q41_P0.8370.98
265_L268_I0.8370.98
278_Y287_G0.8370.98
84_G228_A0.8350.98
32_G35_G0.8310.98
10_V48_I0.8300.98
117_Q167_F0.8290.98
145_L154_L0.8250.98
73_P213_R0.8250.98
152_E156_G0.8210.98
195_L309_N0.8210.98
121_I182_I0.8190.98
122_T126_V0.8170.98
214_V217_V0.8150.98
146_S150_L0.8140.98
145_L155_R0.8120.98
5_V100_I0.8120.98
288_K291_I0.8110.98
144_S156_G0.8100.98
261_Y288_K0.8070.98
69_R99_V0.8030.98
143_D147_K0.8020.98
281_H285_L0.7990.98
274_I298_L0.7990.98
145_L148_K0.7970.98
277_F280_E0.7960.98
15_L28_N0.7940.98
112_K213_R0.7930.98
95_L98_L0.7910.98
239_S243_V0.7910.98
115_T208_C0.7900.98
143_D149_N0.7880.98
144_S148_K0.7810.98
16_V89_K0.7760.97
115_T209_I0.7740.97
292_T295_A0.7740.97
31_Q35_G0.7710.97
6_A44_C0.7700.97
272_P275_K0.7670.97
177_V181_E0.7660.97
129_K172_L0.7640.97
107_T192_K0.7610.97
167_F171_E0.7610.97
15_L26_F0.7590.97
45_K99_V0.7570.97
197_F207_G0.7540.97
193_D211_L0.7540.97
273_I312_F0.7490.97
50_S73_P0.7470.97
213_R255_V0.7430.97
233_D250_R0.7400.97
11_S15_L0.7390.97
145_L156_G0.7370.97
115_T212_A0.7370.97
36_V40_L0.7340.96
175_L178_R0.7320.96
238_S244_V0.7300.96
302_T305_V0.7300.96
265_L295_A0.7260.96
168_L171_E0.7260.96
144_S149_N0.7240.96
117_Q182_I0.7240.96
51_T54_Y0.7200.96
32_G36_V0.7180.96
276_R280_E0.7160.96
17_V26_F0.7140.96
119_D123_R0.7130.96
265_L288_K0.7110.96
132_L169_L0.7090.96
268_I282_K0.7090.96
105_E109_S0.7080.96
85_K90_N0.7070.96
229_Y253_D0.7070.96
225_R228_A0.7040.96
84_G251_R0.7040.96
144_S157_E0.7020.95
144_S147_K0.7020.95
40_L62_L0.6980.95
18_Y23_Y0.6970.95
267_A274_I0.6960.95
72_N75_V0.6960.95
30_K34_E0.6940.95
187_E191_P0.6930.95
144_S155_R0.6920.95
128_V168_L0.6900.95
71_I98_L0.6890.95
79_F98_L0.6890.95
235_L249_S0.6830.95
286_K290_L0.6780.95
222_N303_W0.6760.94
233_D249_S0.6750.94
252_G257_R0.6740.94
236_V243_V0.6730.94
122_T183_E0.6720.94
128_V171_E0.6700.94
216_D219_R0.6680.94
184_E188_D0.6680.94
280_E283_E0.6660.94
50_S70_I0.6650.94
145_L157_E0.6640.94
98_L102_M0.6590.94
109_S113_E0.6570.94
190_V208_C0.6570.94
156_G162_L0.6560.94
32_G39_V0.6560.94
210_I256_L0.6540.93
7_G92_A0.6540.93
43_G67_D0.6520.93
107_T110_E0.6520.93
262_L288_K0.6500.93
37_K41_P0.6500.93
181_E185_E0.6490.93
175_L179_K0.6470.93
144_S154_L0.6430.93
145_L151_N0.6370.93
143_D154_L0.6370.93
233_D236_V0.6360.92
128_V175_L0.6340.92
15_L58_L0.6320.92
289_K293_A0.6310.92
262_L266_T0.6310.92
34_E38_Q0.6290.92
278_Y282_K0.6280.92
270_V275_K0.6280.92
199_I202_I0.6270.92
120_F124_S0.6260.92
58_L62_L0.6220.92
116_S255_V0.6220.92
214_V230_C0.6210.92
125_I175_L0.6200.91
202_I210_I0.6190.91
88_D239_S0.6180.91
7_G62_L0.6170.91
268_I291_I0.6170.91
171_E175_L0.6160.91
79_F101_S0.6080.91
37_K66_Y0.6080.91
160_I185_E0.6070.91
265_L291_I0.6070.91
144_S150_L0.6070.91
74_L251_R0.6070.91
6_A62_L0.6040.90
76_L98_L0.6000.90
209_I213_R0.5980.90
53_I137_I0.5980.90
259_A263_A0.5970.90
281_H293_A0.5960.90
265_L269_K0.5940.90
166_R170_D0.5930.90
260_F295_A0.5910.89
31_Q39_V0.5890.89
131_R168_L0.5880.89
217_V303_W0.5870.89
130_N134_R0.5850.89
143_D157_E0.5830.89
76_L94_K0.5820.89
48_I70_I0.5810.89
43_G66_Y0.5800.89
33_F39_V0.5780.88
10_V54_Y0.5770.88
131_R134_R0.5760.88
227_V300_V0.5750.88
143_D151_N0.5750.88
48_I95_L0.5750.88
77_K81_D0.5740.88
121_I175_L0.5730.88
177_V180_R0.5720.88
148_K155_R0.5720.88
143_D152_E0.5690.88
172_L175_L0.5680.88
300_V303_W0.5670.87
33_F58_L0.5670.87
167_F170_D0.5660.87
90_N94_K0.5650.87
28_N33_F0.5640.87
258_R261_Y0.5610.87
25_E28_N0.5610.87
186_L208_C0.5600.87
233_D257_R0.5590.87
307_Y310_K0.5590.87
248_I293_A0.5570.87
223_K303_W0.5540.86
143_D156_G0.5540.86
279_E282_K0.5540.86
87_S238_S0.5520.86
119_D209_I0.5470.86
163_S174_R0.5460.85
146_S158_D0.5460.85
114_S185_E0.5460.85
173_E177_V0.5450.85
215_G219_R0.5450.85
11_S240_G0.5440.85
126_V129_K0.5420.85
276_R279_E0.5410.85
202_I263_A0.5380.85
117_Q131_R0.5380.85
116_S253_D0.5370.84
117_Q128_V0.5350.84
113_E135_D0.5340.84
41_P66_Y0.5340.84
111_A186_L0.5330.84
34_E37_K0.5320.84
235_L246_R0.5320.84
205_T209_I0.5310.84
74_L84_G0.5300.84
62_L298_L0.5270.83
147_K156_G0.5250.83
271_N301_I0.5230.83
301_I304_A0.5230.83
18_Y96_A0.5210.83
228_A233_D0.5190.82
173_E176_E0.5180.82
157_E162_L0.5170.82
247_G289_K0.5160.82
268_I294_C0.5160.82
266_T270_V0.5150.82
163_S166_R0.5140.82
248_I252_G0.5140.82
132_L168_L0.5140.82
147_K157_E0.5110.81
84_G235_L0.5100.81
111_A189_L0.5090.81
17_V40_L0.5080.81
183_E205_T0.5080.81
111_A193_D0.5060.81
237_E246_R0.5050.81
121_I178_R0.5030.80
232_L296_R0.5030.80
183_E204_R0.5020.80
271_N275_K0.5020.80
223_K300_V0.5020.80
170_D181_E0.5010.80
34_E123_R0.5000.80
218_K307_Y0.5000.80
186_L190_V0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hjrA 2 0.3323 91.1 0.936 Contact Map
4ep4A 2 0.3418 90.8 0.936 Contact Map
1nu0A 1 0.307 87.2 0.94 Contact Map
3c1yA 5 0.7532 80 0.945 Contact Map
1pu6A 1 0.6013 79.3 0.946 Contact Map
1kftA 1 0.1709 77.2 0.947 Contact Map
1vhxA 2 0.3228 76.3 0.947 Contact Map
3fhfA 1 0.6171 72.5 0.949 Contact Map
2a1jA 1 0.1867 72.1 0.949 Contact Map
4ofaA 1 0.4304 71.4 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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